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WO2006066912A3 - Detection of a therapeutic antibody in an experimental animal - Google Patents

Detection of a therapeutic antibody in an experimental animal Download PDF

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Publication number
WO2006066912A3
WO2006066912A3 PCT/EP2005/013849 EP2005013849W WO2006066912A3 WO 2006066912 A3 WO2006066912 A3 WO 2006066912A3 EP 2005013849 W EP2005013849 W EP 2005013849W WO 2006066912 A3 WO2006066912 A3 WO 2006066912A3
Authority
WO
WIPO (PCT)
Prior art keywords
experimental animal
therapeutic antibody
sample
antibody
therapeutic
Prior art date
Application number
PCT/EP2005/013849
Other languages
French (fr)
Other versions
WO2006066912A9 (en
WO2006066912A2 (en
Inventor
Helmut Lenz
Kay-Gunnar Stubenrauch
Original Assignee
Hoffmann La Roche
Helmut Lenz
Kay-Gunnar Stubenrauch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34927934&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006066912(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA2589054A priority Critical patent/CA2589054C/en
Priority to BRPI0519354A priority patent/BRPI0519354B8/en
Priority to AT05824356T priority patent/ATE503187T1/en
Priority to US11/792,910 priority patent/US7955806B2/en
Priority to MX2007006895A priority patent/MX2007006895A/en
Priority to CN2005800444980A priority patent/CN101088014B/en
Priority to DE602005027127T priority patent/DE602005027127D1/en
Priority to ES05824356T priority patent/ES2360369T5/en
Priority to JP2007547356A priority patent/JP4664377B2/en
Priority to AU2005318407A priority patent/AU2005318407B2/en
Application filed by Hoffmann La Roche, Helmut Lenz, Kay-Gunnar Stubenrauch filed Critical Hoffmann La Roche
Priority to EP05824356.9A priority patent/EP1853921B2/en
Publication of WO2006066912A2 publication Critical patent/WO2006066912A2/en
Publication of WO2006066912A3 publication Critical patent/WO2006066912A3/en
Publication of WO2006066912A9 publication Critical patent/WO2006066912A9/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9) .
PCT/EP2005/013849 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal WO2006066912A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP05824356.9A EP1853921B2 (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
DE602005027127T DE602005027127D1 (en) 2004-12-23 2005-12-22 DETECTION OF A THERAPEUTIC ANTIBODY IN A TESTIMONY
AT05824356T ATE503187T1 (en) 2004-12-23 2005-12-22 DETECTION OF A THERAPEUTIC ANTIBODIES IN A TESTIMONIAL ANIMAL
US11/792,910 US7955806B2 (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
MX2007006895A MX2007006895A (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal.
CN2005800444980A CN101088014B (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
JP2007547356A JP4664377B2 (en) 2004-12-23 2005-12-22 Detection of therapeutic antibodies in laboratory animals
CA2589054A CA2589054C (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
ES05824356T ES2360369T5 (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
AU2005318407A AU2005318407B2 (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal
BRPI0519354A BRPI0519354B8 (en) 2004-12-23 2005-12-22 method for detecting a therapeutic antibody and using an antibody

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04030545.0 2004-12-23
EP04030545 2004-12-23

Publications (3)

Publication Number Publication Date
WO2006066912A2 WO2006066912A2 (en) 2006-06-29
WO2006066912A3 true WO2006066912A3 (en) 2006-08-10
WO2006066912A9 WO2006066912A9 (en) 2007-02-22

Family

ID=34927934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/013849 WO2006066912A2 (en) 2004-12-23 2005-12-22 Detection of a therapeutic antibody in an experimental animal

Country Status (15)

Country Link
US (1) US7955806B2 (en)
EP (2) EP1853921B2 (en)
JP (2) JP4664377B2 (en)
KR (1) KR100950635B1 (en)
CN (1) CN101088014B (en)
AT (1) ATE503187T1 (en)
AU (2) AU2005318407B2 (en)
BR (1) BRPI0519354B8 (en)
CA (1) CA2589054C (en)
DE (1) DE602005027127D1 (en)
ES (1) ES2360369T5 (en)
MX (1) MX2007006895A (en)
RU (1) RU2393483C2 (en)
SG (1) SG164389A1 (en)
WO (1) WO2006066912A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101506659B (en) * 2006-09-12 2012-12-12 弗·哈夫曼-拉罗切有限公司 Anti-drug antibody assay
EP2067044B1 (en) 2006-09-12 2013-07-03 F. Hoffmann-La Roche AG Anti-drug antibody assay
EP2344884B1 (en) * 2008-10-07 2013-07-31 Gyros Patent Ab Semi-sequential assay for detection of an analyte in a sample
EA201100741A1 (en) 2008-11-10 2012-01-30 Новартис Аг ANTIBODIES TO MODIFIED HUMAN IFR-1 / E PEPTIDES
KR101536388B1 (en) * 2009-10-19 2015-07-22 에프. 호프만-라 로슈 아게 Non-cross-reactive anti igg antibodies
RU2603284C2 (en) 2010-08-17 2016-11-27 Ф.Хоффманн-Ля Рош Аг ANTIBODIES AGAINST HUMAN IgG1
EP2823310B1 (en) 2012-03-08 2018-06-20 F.Hoffmann-La Roche Ag Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes
US20150197579A1 (en) 2012-08-17 2015-07-16 Morphosys Ag Complex-specific antibodies and antibody fragments and its use
RU2015140955A (en) 2013-03-20 2017-04-21 Ф. Хоффманн-Ля Рош Аг SPECIFIC DETERMINATION OF RAT ANTIBODIES IN SERUM OF MICE
JP6985572B2 (en) 2015-11-09 2021-12-22 国立大学法人京都工芸繊維大学 Single-chain antibody screening method and single-chain antibody
CN107703310B (en) * 2017-10-11 2019-08-30 潍坊医学院附属医院 A kind of experimental implementation system for mouse immune antiboidy
WO2021136772A1 (en) * 2020-01-02 2021-07-08 F. Hoffmann-La Roche Ag Method for determining the amount of a therapeutic antibody in the brain

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP1098198A1 (en) * 1999-11-05 2001-05-09 DIESSE DIAGNOSTICA SENESE S.p.A. Method for the qualitative and quantitative determination of class igG human antibodies
US20040214761A1 (en) * 2001-07-06 2004-10-28 Raison Robert Lindsay Method for treating multiple myeloma

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GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4870003A (en) * 1987-06-15 1989-09-26 Coulter Corporation Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans
US4816067A (en) * 1988-06-20 1989-03-28 Gte Products Corporation Process for producing fine spherical particles
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
US5736137A (en) * 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
EP0938334A4 (en) 1996-07-26 2004-12-15 Smithkline Beecham Corp Improved method of treating immune cell mediated systemic diseases
US6525174B1 (en) * 1997-06-06 2003-02-25 Human Genome Sciences, Inc. Precerebellin-like protein
US6413783B1 (en) * 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
JP2000304750A (en) * 1999-04-16 2000-11-02 Fuji Photo Film Co Ltd Luminous label immunoassay and its analysis element
EP2131198B1 (en) * 2001-09-20 2013-03-27 Board of Regents, The University of Texas System Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays
JP4636225B2 (en) * 2002-11-30 2011-02-23 司甫 横山 Test reagent kit

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1098198A1 (en) * 1999-11-05 2001-05-09 DIESSE DIAGNOSTICA SENESE S.p.A. Method for the qualitative and quantitative determination of class igG human antibodies
US20040214761A1 (en) * 2001-07-06 2004-10-28 Raison Robert Lindsay Method for treating multiple myeloma

Non-Patent Citations (3)

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Title
HAZLEWOOD M ET AL: "THE ACQUISITION OF ANTI-PNEUMOCOCCAL CAPSULAR POLYSACCHARIDE HAEMOPHILUS INFLUENZAE TYPE B AND TETANUS TOXOID ANTIBODIES, WITH AGE, IN THE UK", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, OXFORD, GB, vol. 93, no. 2, August 1993 (1993-08-01), pages 157 - 164, XP000892905, ISSN: 0009-9104 *
LEI BO ET AL: "Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND, US, vol. 41, no. 1, January 2000 (2000-01-01), pages 262 - 266, XP002337722, ISSN: 0146-0404 *
NATH D ET AL: "The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site: Comparison with CD22", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 270, no. 44, 1995, pages 26184 - 26191, XP002337724, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2589054A1 (en) 2006-06-29
DE602005027127D1 (en) 2011-05-05
BRPI0519354B8 (en) 2021-07-27
EP1853921B1 (en) 2011-03-23
JP2008525766A (en) 2008-07-17
RU2007128103A (en) 2009-01-27
JP4664377B2 (en) 2011-04-06
ATE503187T1 (en) 2011-04-15
EP2237041A1 (en) 2010-10-06
US20080102474A1 (en) 2008-05-01
CN101088014A (en) 2007-12-12
CN101088014B (en) 2012-10-03
AU2005318407B2 (en) 2009-11-05
JP2011039072A (en) 2011-02-24
KR100950635B1 (en) 2010-04-01
SG164389A1 (en) 2010-09-29
RU2393483C2 (en) 2010-06-27
BRPI0519354A2 (en) 2009-01-20
EP1853921B2 (en) 2021-07-21
AU2010200299A1 (en) 2010-02-18
WO2006066912A9 (en) 2007-02-22
MX2007006895A (en) 2007-06-26
ES2360369T3 (en) 2011-06-03
AU2005318407A1 (en) 2006-06-29
EP1853921A2 (en) 2007-11-14
CA2589054C (en) 2010-11-02
KR20070086642A (en) 2007-08-27
ES2360369T5 (en) 2021-12-13
US7955806B2 (en) 2011-06-07
WO2006066912A2 (en) 2006-06-29
BRPI0519354B1 (en) 2020-06-09

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