+

WO2006066950A3 - Aminoalcools tricycliques, procedes de realisation associes et utilisation comme anti-inflammatoires - Google Patents

Aminoalcools tricycliques, procedes de realisation associes et utilisation comme anti-inflammatoires Download PDF

Info

Publication number
WO2006066950A3
WO2006066950A3 PCT/EP2005/013943 EP2005013943W WO2006066950A3 WO 2006066950 A3 WO2006066950 A3 WO 2006066950A3 EP 2005013943 W EP2005013943 W EP 2005013943W WO 2006066950 A3 WO2006066950 A3 WO 2006066950A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminoalcohols
tricyclic
producing
methods
same
Prior art date
Application number
PCT/EP2005/013943
Other languages
German (de)
English (en)
Other versions
WO2006066950A2 (fr
Inventor
Markus Berger
Norbert Schmees
Heike Schaecke
Stefan Baeurle
Hartmut Rehwinkel
Anne Mengel
Konrad Krolikiewicz
Danja Grossbach
David Voigtlaender
Original Assignee
Schering Ag
Markus Berger
Norbert Schmees
Heike Schaecke
Stefan Baeurle
Hartmut Rehwinkel
Anne Mengel
Konrad Krolikiewicz
Danja Grossbach
David Voigtlaender
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Markus Berger, Norbert Schmees, Heike Schaecke, Stefan Baeurle, Hartmut Rehwinkel, Anne Mengel, Konrad Krolikiewicz, Danja Grossbach, David Voigtlaender filed Critical Schering Ag
Priority to AU2005318354A priority Critical patent/AU2005318354A1/en
Priority to MX2007007420A priority patent/MX2007007420A/es
Priority to JP2007547379A priority patent/JP2008524300A/ja
Priority to BRPI0519710-4A priority patent/BRPI0519710A2/pt
Priority to CA002586973A priority patent/CA2586973A1/fr
Publication of WO2006066950A2 publication Critical patent/WO2006066950A2/fr
Publication of WO2006066950A3 publication Critical patent/WO2006066950A3/fr
Priority to IL183060A priority patent/IL183060A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne des aminoalcools tricycliques de formule (I), des procédés de réalisation associés et leur utilisation en tant qu'anti-inflammatoires.
PCT/EP2005/013943 2004-12-22 2005-12-20 Aminoalcools tricycliques, procedes de realisation associes et utilisation comme anti-inflammatoires WO2006066950A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2005318354A AU2005318354A1 (en) 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents
MX2007007420A MX2007007420A (es) 2004-12-22 2005-12-20 Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso como inhibidores de inflamacion.
JP2007547379A JP2008524300A (ja) 2004-12-22 2005-12-20 三環式アミノアルコール、それらの合成方法および抗炎症薬物としてのそれらの使用
BRPI0519710-4A BRPI0519710A2 (pt) 2004-12-22 2005-12-20 aminoÁlcoois tricÍclicos, processo para sua preparaÇço e seu emprego como anti-inflamatàrio
CA002586973A CA2586973A1 (fr) 2004-12-22 2005-12-20 Amino-alcools tricycliques, processus de synthese et utilisation comme anti-inflammatoires
IL183060A IL183060A0 (en) 2004-12-22 2007-05-08 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004063227.8 2004-12-22
DE102004063227A DE102004063227A1 (de) 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Publications (2)

Publication Number Publication Date
WO2006066950A2 WO2006066950A2 (fr) 2006-06-29
WO2006066950A3 true WO2006066950A3 (fr) 2006-08-17

Family

ID=36250953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/013943 WO2006066950A2 (fr) 2004-12-22 2005-12-20 Aminoalcools tricycliques, procedes de realisation associes et utilisation comme anti-inflammatoires

Country Status (14)

Country Link
JP (1) JP2008524300A (fr)
KR (1) KR20070089948A (fr)
CN (1) CN101087780A (fr)
AR (1) AR055016A1 (fr)
AU (1) AU2005318354A1 (fr)
BR (1) BRPI0519710A2 (fr)
CA (1) CA2586973A1 (fr)
DE (1) DE102004063227A1 (fr)
GT (1) GT200500385A (fr)
IL (1) IL183060A0 (fr)
MX (1) MX2007007420A (fr)
PA (1) PA8657801A1 (fr)
PE (1) PE20061197A1 (fr)
WO (1) WO2006066950A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
RS20060250A (en) 2003-10-08 2008-08-07 Schering Aktiengesellschaft, 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, method for the production thereof, and their use as antiphlogistics
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1834948A1 (fr) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Derives de tetrahydronaphtalene , procedes pour leur production et leur utilisation en tant qu'anti-inflammatoires
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
EP1917963A1 (fr) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Imidazoles cycliques substitués par un groupe phényle, procédé pour leur préparation et leur utilisation comme des agents anti-inflammatoires
EP2072509A1 (fr) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-aryl-1H-quinoline-2-ones : leur procédé de fabrication et leur utilisation en tant qu'agents anti-inflammatoires
AU2013216935C1 (en) 2012-02-08 2017-12-14 John Emmerson Campbell Heteroaryl compounds and methods of use thereof
JP7187437B2 (ja) 2016-07-29 2022-12-12 サノビオン ファーマシューティカルズ インク 化合物および組成物ならびにそれらの使用
US11077090B2 (en) 2016-07-29 2021-08-03 Sunovion Pharmaceuticals Inc. Compounds and compositions and uses thereof
EP3661929B1 (fr) 2017-08-02 2021-07-14 Sunovion Pharmaceuticals Inc. Composés d'isochromane et leurs utilisations
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물
KR102462991B1 (ko) * 2020-11-02 2022-11-04 한국해양과학기술원 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082280A1 (fr) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Mimetiques de glucocorticoiques, procedes de fabrication, compositions pharmaceutiques, et utilisations correspondants
WO2003082827A1 (fr) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Derives de quinoleine et d'isoquinoleine, procede de production de ces derives et leur utilisation comme agents anti-inflammatoires
WO2005034939A1 (fr) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft Derives de tetrahydronaphtalene a substitution 1-amino-2-oxy, procedes pour leur production et leur utilisation en tant qu'anti-inflammatoires
WO2006015870A1 (fr) * 2004-08-12 2006-02-16 Glaxo Group Limited Dérivés de tétrahydronaphthalène servant de modulateurs du récepteur des glucocorticoïdes
WO2006027236A1 (fr) * 2004-09-09 2006-03-16 Bayer Schering Pharma Aktiengesellschaft Derives d'alkylidene-tetrahydronaphtalene, procedes pour leur production et leur utilisation comme anti-inflammatoires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10038639A1 (de) * 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082280A1 (fr) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Mimetiques de glucocorticoiques, procedes de fabrication, compositions pharmaceutiques, et utilisations correspondants
WO2003082827A1 (fr) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Derives de quinoleine et d'isoquinoleine, procede de production de ces derives et leur utilisation comme agents anti-inflammatoires
WO2005034939A1 (fr) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft Derives de tetrahydronaphtalene a substitution 1-amino-2-oxy, procedes pour leur production et leur utilisation en tant qu'anti-inflammatoires
WO2006015870A1 (fr) * 2004-08-12 2006-02-16 Glaxo Group Limited Dérivés de tétrahydronaphthalène servant de modulateurs du récepteur des glucocorticoïdes
WO2006027236A1 (fr) * 2004-09-09 2006-03-16 Bayer Schering Pharma Aktiengesellschaft Derives d'alkylidene-tetrahydronaphtalene, procedes pour leur production et leur utilisation comme anti-inflammatoires

Non-Patent Citations (50)

* Cited by examiner, † Cited by third party
Title
ANN. CHIM., vol. 3, no. 14, 1968, pages 179, 189 *
ARNAU, NARCIS ET AL: "Preparation of benzo[b]thiophenes by palladium(0)-catalyzed intramolecular cyclization of allyl (and propargyl) o-iodophenyl sulfides", TETRAHEDRON , 49(47), 11019-28 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP002381845 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386636, Database accession no. 2448254 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386637, Database accession no. 3605358 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386638, Database accession no. 5423440 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386639, Database accession no. 5497276,1852763 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386640, Database accession no. 7367873, 2410616, 5505207,4382806,1939675 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386641, Database accession no. 7421217,7421218,7421416,7421850,7424378,7424933 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386642, Database accession no. 4177158, 4177159 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386643, Database accession no. 4397145 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386644, Database accession no. 124989,140916 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386645, Database accession no. 1562048,4968192 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386646, Database accession no. 4388530 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386647, Database accession no. 8310753 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386648, Database accession no. 4969029,4965133 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386649, Database accession no. 9390678 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386650, Database accession no. 9485990 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386651, Database accession no. 8145476,8141682 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386652, Database accession no. 6500970 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386653, Database accession no. 4230981,4230980,4230979,4178157,4177274 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386654, Database accession no. 2366975,2370226 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386655, Database accession no. 1937229 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386656, Database accession no. 1281716 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386657, Database accession no. 1283452 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386658, Database accession no. 9324168 *
DATABASE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFURT AM MAIN, DE; XP002386778, Database accession no. 7920048,7918441,7915779 *
HETEROCYCLES, vol. 28, no. 1, 1989, pages 55 - 58 *
HETEROCYCLES, vol. 45, no. 12, 1997, pages 2357 - 2364 *
HETEROCYCLES, vol. 9, 1978, pages 92 *
J. AM. CHEM. SOC., vol. 112, no. 22, 1990, pages 8126 - 8134 *
J. AM. CHEM. SOC., vol. 93, no. 22, 1971, pages 5816 - 5820 *
J. AM. CHEM. SOC., vol. 94, no. 9, 1972, pages 3143 - 3148 *
J. CHEM. SOC. PERKIN TRANS 1, vol. 10, 1990, pages 2691 - 2701 *
J. MED. CHEM., vol. 32, no. 10, 1989, pages 2311 - 2318 *
J. MED. CHEM., vol. 33, no. 6, 1990, pages 1541 - 1544 *
J. MED. CHEM., vol. 38, no. 20, 1995, pages 4056 - 4069 *
J. ORG. CHEM., vol. 51, no. 1, 1986, pages 37 - 40 *
J. ORG. CHEM., vol. 63, no. 20, 1998, pages 6990 - 6998 *
J. ORG. CHEM., vol. 68, no. 8, 2003, pages 3112 - 3120 *
J. ORGANOMET. CHEM., vol. 502, no. 1-2, 1995, pages 169 - 176 *
JUSTUS LIEBIGS ANN. CHEM., vol. 402, 1913, pages 297 *
NIPPON KAGAKU KAISHA, vol. 758, 1979, pages 762 *
ORG. LETT., vol. 5, no. 7, 2003, pages 1055 - 1058 *
PREOBRAZHENSKAYA, MARIA N. ET AL: "Transformation of ascorbigen into 1-deoxy-1-(indol-3-yl)-.alpha.-L- sorbopyranose and 1-deoxy-1-(indol-3-yl)-.alpha.-L-tagatopyranose", TETRAHEDRON: ASYMMETRY , 7(2), 161-6 CODEN: TASYE3; ISSN: 0957-4166, 1996, XP002381844 *
TETRAHEDRON LETTERS, vol. 28, no. 25, 1987, pages 2895 - 2898 *
TETRAHEDRON LETTERS, vol. 29, no. 1, 1988, pages 45 - 48 *
TETRAHEDRON LETTERS, vol. 30, no. 32, 1989, pages 4279 - 4282 *
TETRAHEDRON LETTERS, vol. 33, no. 45, 1992, pages 6879 - 6882 *
TETRAHEDRON LETTERS, vol. 40, no. 37, 1999, pages 6757 - 6760 *
TETRAHEDRON LETTERS, vol. 43, no. 51, 2002, pages 9347 - 9350 *

Also Published As

Publication number Publication date
CA2586973A1 (fr) 2006-06-29
KR20070089948A (ko) 2007-09-04
WO2006066950A2 (fr) 2006-06-29
PA8657801A1 (es) 2006-12-07
BRPI0519710A2 (pt) 2009-03-10
JP2008524300A (ja) 2008-07-10
DE102004063227A1 (de) 2006-07-06
CN101087780A (zh) 2007-12-12
AR055016A1 (es) 2007-08-01
MX2007007420A (es) 2007-07-17
AU2005318354A1 (en) 2006-06-29
IL183060A0 (en) 2007-09-20
GT200500385A (es) 2006-08-03
PE20061197A1 (es) 2006-12-07

Similar Documents

Publication Publication Date Title
WO2007015017A3 (fr) Nouveaux derives de polyquinoleines et leur utilisation therapeutique
WO2005108358A3 (fr) Inhibiteurs de la bace
WO2005123736A8 (fr) Nouveaux 2-benzylaminodihydropteridinones, procede de production associe et leur utilisation en tant que medicaments
WO2007086001A3 (fr) Nouveaux dérivés de pyridine
WO2009042114A3 (fr) Dérivés de phénazine et leurs utilisations
WO2010077740A3 (fr) Nouveaux composés antiviraux, compositions et procédés d'utilisation
WO2005021536A3 (fr) Nouveaux composes
IL183060A0 (en) Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents
WO2007050587A3 (fr) Compositions therapeutiques et procedes
WO2006021379A8 (fr) Derives de dihydropteridinone, procedes pour les produire et utilisation de ceux-ci comme medicaments
WO2006021378A8 (fr) Derives de dihydropteridinone, procede pour les produire et utilisation de ceux-ci comme medicaments
WO2008017074A3 (fr) Teintures et précurseurs et leurs conjugués
MX2007002470A (es) Fenilaminotiazoles sustituidos y su uso.
WO2008008700A3 (fr) Composés thérapeutiques
WO2008073863A3 (fr) Préparation et utilité d'allylamines substituées
WO2007115929A8 (fr) Thiazolyl-dihydro-quinazolines
WO2006026747A3 (fr) Composes de diphenylethylene et leurs utilisations
ATE512968T1 (de) 1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazin-6- carboxamid und 2,3,4,5-tetrahydropyrrolo(1,2-a)- diazepin-7-carboxamid- derivate, ihre herstellung und therapeutische verwendung
WO2006116498A3 (fr) Forme purifiee de tanaproget
WO2006076350A3 (fr) Procedes pour la preparation d'alcools d'aminoethoxybenzyle
WO2006023889A3 (fr) Procedes de preparation d'irbesartan et d'intermediaires associes
WO2006080043A3 (fr) Composes organiques convenant pour le traitement de la maladie d'alzheimer, utilisation et methode de fabrication
WO2008107771A3 (fr) 2',3'-di-o-acyl-5-fluoronucléosides
MX2007002833A (es) Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparacion y su uso como antiinflamatorios.
WO2005105079A3 (fr) Nouveaux imidazoles

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005822488

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2586973

Country of ref document: CA

Ref document number: 183060

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 555063

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2007547379

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/007420

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1020077014116

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 200580044284.3

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2005318354

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 2005822488

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2005318354

Country of ref document: AU

Date of ref document: 20051220

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005318354

Country of ref document: AU

ENP Entry into the national phase

Ref document number: PI0519710

Country of ref document: BR

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载