+

WO2006063189A3 - Systeme d'administration de medicament a desintegration rapide - Google Patents

Systeme d'administration de medicament a desintegration rapide Download PDF

Info

Publication number
WO2006063189A3
WO2006063189A3 PCT/US2005/044523 US2005044523W WO2006063189A3 WO 2006063189 A3 WO2006063189 A3 WO 2006063189A3 US 2005044523 W US2005044523 W US 2005044523W WO 2006063189 A3 WO2006063189 A3 WO 2006063189A3
Authority
WO
WIPO (PCT)
Prior art keywords
chewing gum
gum tablet
layer
quick disintegration
disintegration layer
Prior art date
Application number
PCT/US2005/044523
Other languages
English (en)
Other versions
WO2006063189A2 (fr
Inventor
Christopher Edward Fankhauser
Alexander Mark Schobel
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Christopher Edward Fankhauser
Alexander Mark Schobel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Christopher Edward Fankhauser, Alexander Mark Schobel filed Critical Novartis Ag
Publication of WO2006063189A2 publication Critical patent/WO2006063189A2/fr
Publication of WO2006063189A3 publication Critical patent/WO2006063189A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un système d'administration de médicament multicouche comprenant au moins une couche de gomme et au moins une couche de comprimé à dissolution rapide. La couche de comprimé contient une dose thérapeutiquement efficace d'un médicament et peut se rompre par un processus de mastication qui entraîne la libération du médicament. Cette invention peut notamment servir de système d'administration pour des agents d'hygiène buccale, des substances pharmaceutiques, et des suppléments nutritifs et diététiques. Parmi les systèmes d'administration utiles figurent les systèmes d'administration de nicotine, ainsi que les systèmes d'administration de médicaments contre la toux, les allergies et/ou les troubles sinusiens.
PCT/US2005/044523 2004-12-10 2005-12-08 Systeme d'administration de medicament a desintegration rapide WO2006063189A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63493104P 2004-12-10 2004-12-10
US60/634,931 2004-12-10

Publications (2)

Publication Number Publication Date
WO2006063189A2 WO2006063189A2 (fr) 2006-06-15
WO2006063189A3 true WO2006063189A3 (fr) 2006-09-21

Family

ID=36578595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044523 WO2006063189A2 (fr) 2004-12-10 2005-12-08 Systeme d'administration de medicament a desintegration rapide

Country Status (1)

Country Link
WO (1) WO2006063189A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920856B2 (en) 2009-10-08 2014-12-30 Intercontinental Great Brands Llc Co-extruded layered candy and gum apparatus and methods
US9060526B2 (en) 2009-01-22 2015-06-23 Intercontinental Great Brands Llc Confectionery processing
US9220284B2 (en) 2008-05-02 2015-12-29 Intercontinental Great Brands Llc Multilayered sugar free mannitol confectionery and methods of making same
US9247761B2 (en) 2009-10-30 2016-02-02 Intercontinental Great Brands Llc Sugar free confectionery; methods of making same; and use in preparing multilayered confectionery
JP7214755B2 (ja) 2018-05-17 2023-01-30 フェルティン ファルマ アー／エス 医薬品活性成分に適した錠剤化チューインガム
JP7601779B2 (ja) 2019-03-01 2024-12-17 ノルディックカン・アー／エス 層状構造を有する打錠カンナビノイドチューインガム

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2392823C2 (ru) 2005-12-29 2010-06-27 Вм. Ригли Дж. Компани Жевательная резинка, содержащая блоксополимеры стирола и диена
WO2008112124A2 (fr) * 2007-03-07 2008-09-18 Novartis Ag Films administrables par voie orale
WO2009007768A1 (fr) * 2007-07-06 2009-01-15 Gumlink A/S Comprimé comprenant un polyol
GB2453770A (en) 2007-10-19 2009-04-22 Reckitt Benckiser Healthcare Oral composition comprising a cooling agent
CN101215455B (zh) * 2007-12-26 2011-04-06 解兵 一种笛膜胶及其加工工艺
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
EP2233134A1 (fr) * 2009-03-27 2010-09-29 McNeil AB Dosage intra-buccal multi-portions avec des propriétés organoleptiques
US10548839B2 (en) 2010-03-16 2020-02-04 Wei Tian Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form
ZA201508730B (en) * 2014-12-01 2017-03-29 Michael T Rathogwa Decongestant gum
US10441535B2 (en) * 2014-12-29 2019-10-15 NeuroGum, LLC Nutraceutical confectionary composition containing caffeine and L-theanine
WO2018078548A1 (fr) 2016-10-25 2018-05-03 Catalent U.K. Swindon Zydis Limited Compositions de densités différentes pour comprimé multicouche à désintégration rapide
US10632076B2 (en) 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US10543205B2 (en) 2016-11-18 2020-01-28 Fertin Pharma A/S Oral delivery vehicle containing nicotine
CN110464691B (zh) * 2018-05-10 2021-04-20 北京东方淼森生物科技有限公司 一种桃胶组合物及其应用
US11052047B2 (en) 2018-05-17 2021-07-06 Fertin Pharma A/S Oral tablet suitable for fast release of active pharmaceutical ingredients
US11135157B2 (en) 2018-05-17 2021-10-05 Fertin Pharma A/S Oral tablet for delivery of active ingredients to the throat
US11096896B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Tablet dosage form for buccal absorption of active ingredients
US11058641B2 (en) 2018-05-17 2021-07-13 Fertin Pharma A/S Oral tablet for taste masking of active ingredients
US11096895B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Oral tablet suitable for active pharmaceutical ingredients
US11058633B2 (en) 2018-05-17 2021-07-13 Fertin Pharma A/S Disintegrating oral tablet suitable for active pharmaceutical ingredients
US20190350858A1 (en) 2018-05-17 2019-11-21 Fertin Pharma A/S Oral tablet for delivery of active ingredients to the gastrointestinal tract
US11090263B2 (en) 2018-05-22 2021-08-17 Fertin Pharma A/S Tableted chewing gum suitable for active pharmaceutical ingredients
US11154496B2 (en) 2019-01-25 2021-10-26 Nordiccan A/S Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
US11406593B2 (en) 2019-01-25 2022-08-09 Nordiccan A/S Cannabinoid chewing gum with high intensity sweeteners
US11166910B2 (en) 2019-01-25 2021-11-09 Nordiccan A/S Cannabinoid chewing gum with sugar alcohols
US11191720B2 (en) 2019-01-25 2021-12-07 Nordiccan A/S Chewing gum with improved delivery of cannabinoids
US11013685B2 (en) 2019-01-25 2021-05-25 Nordiccan A/S Cannabinoid chewing gum with improved release of cannabinoids
US10933017B2 (en) 2019-03-01 2021-03-02 Nordiccan A/S Tableted cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
US11253473B2 (en) 2019-03-01 2022-02-22 Nordiccan A/S Method of producing tableted cannabinoid chewing gum
US10799450B2 (en) 2019-03-01 2020-10-13 Medcan Pharma A/S Tableted cannabinoid chewing gum with layered structure
US11471405B2 (en) 2019-03-01 2022-10-18 Nordiccan A/S Tableted chewing gum with enhanced delivery of cannabinoids
DK202370373A1 (en) * 2023-07-07 2025-02-11 Fertin Pharma As Dissolvable orally adhering nicotine tablet
DK202370372A1 (en) * 2023-07-07 2025-02-11 Fertin Pharma As Dissolvable orally adhering tablet

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139589A (en) * 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
WO2004006686A2 (fr) * 2002-07-15 2004-01-22 Bagger-Sørensen & Co. A/S Gomme a macher en tablettes
WO2004073691A1 (fr) * 2003-02-20 2004-09-02 Jagotec Ag Gomme a macher se presentant sous la forme de tablettes multicouche
EP1554935A1 (fr) * 2004-01-19 2005-07-20 Gumlink A/S Pastille de gomme à mâcher à plusieurs couches

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139589A (en) * 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
WO2004006686A2 (fr) * 2002-07-15 2004-01-22 Bagger-Sørensen & Co. A/S Gomme a macher en tablettes
WO2004073691A1 (fr) * 2003-02-20 2004-09-02 Jagotec Ag Gomme a macher se presentant sous la forme de tablettes multicouche
EP1554935A1 (fr) * 2004-01-19 2005-07-20 Gumlink A/S Pastille de gomme à mâcher à plusieurs couches

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9220284B2 (en) 2008-05-02 2015-12-29 Intercontinental Great Brands Llc Multilayered sugar free mannitol confectionery and methods of making same
US9237758B2 (en) 2008-05-02 2016-01-19 Intercontinental Great Brands Llc Multilayered sugar free isomalt confectionery and methods of making same
US9060526B2 (en) 2009-01-22 2015-06-23 Intercontinental Great Brands Llc Confectionery processing
US8920856B2 (en) 2009-10-08 2014-12-30 Intercontinental Great Brands Llc Co-extruded layered candy and gum apparatus and methods
US9247761B2 (en) 2009-10-30 2016-02-02 Intercontinental Great Brands Llc Sugar free confectionery; methods of making same; and use in preparing multilayered confectionery
JP7214755B2 (ja) 2018-05-17 2023-01-30 フェルティン ファルマ アー／エス 医薬品活性成分に適した錠剤化チューインガム
JP7601779B2 (ja) 2019-03-01 2024-12-17 ノルディックカン・アー／エス 層状構造を有する打錠カンナビノイドチューインガム

Also Published As

Publication number Publication date
WO2006063189A2 (fr) 2006-06-15

Similar Documents

Publication Publication Date Title
WO2006063189A3 (fr) Systeme d'administration de medicament a desintegration rapide
WO2007013975A3 (fr) Compositions et procedes destines a controler l'abus de medicaments
WO2007081948A3 (fr) Formulations de médicaments bioadhésifs pour administration par voie transmucosale orale
US20090202635A1 (en) Delivery System, Application, and Method
WO2008060964A3 (fr) Procédés d'administration de médications pour la perte de poids
WO2007079082A3 (fr) Systeme gastrique a impulsions de liberation pour l'administration de medicaments
BRPI0810115A2 (pt) Métodos para administrar um medicamento a um paciente mecanicamente ventilado e para coordenar administração de um fluxo de ás e administração de um medicamento a um paciente mecanismo ventilado e sistema para administrar um medicamento em forma de aerosol a um paciente ventilado.
WO2007031887A3 (fr) Composition pharmaceutique de metformine a liberation lente et procede de production correspondant
WO2006125819A3 (fr) Forme medicamenteuse orale, microparticulaire, anti-mesusage
WO2008142572A3 (fr) Formulation de comprimé à libération contrôlée contenant de l'aluminométasilicate de magnésium
WO2006060547A3 (fr) Systemes et methodes d'administration intra-orale de medicaments
JP2009541479A5 (fr)
EP1542903A4 (fr) Emballage et distribution d'une forme posologique a dissolution rapide
WO2008040534A3 (fr) Formes pharmaceutiques à base de film non muco-adhésif
WO2010066749A3 (fr) Comprimés d'ulipristal acétate
WO2008021113A3 (fr) Méthodes transdermiques et systèmes pour traiter la maladie d'alzheimer
US20190365678A1 (en) Method for Treating Pain
TW200927196A (en) Bilayer composition for the sustained release of acetaminophen and tramadol
WO2007012019A3 (fr) Medicaments contenant famotidine et ibuprofene, et administration desdits medicaments
WO2008099397A3 (fr) Compositions et méthodes permettant d'améliorer l'administration transmuqueuse
WO2006124681A3 (fr) Systeme d'administration orale de medicaments et procedes d'utilisation
WO2010020856A3 (fr) Administration modulée de médicaments depuis un dispositif d’administration composite
WO2007122635A3 (fr) Formulation à libération à libération contrôlée comprenant des médicaments anti-épilepiques
NZ605469A (en) Nalbuphine-based formulations and uses thereof
MX2011009323A (es) Suplemento masticable organico.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05853447

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载