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WO2006059069A3 - Ion channel - Google Patents

Ion channel Download PDF

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Publication number
WO2006059069A3
WO2006059069A3 PCT/GB2005/004508 GB2005004508W WO2006059069A3 WO 2006059069 A3 WO2006059069 A3 WO 2006059069A3 GB 2005004508 W GB2005004508 W GB 2005004508W WO 2006059069 A3 WO2006059069 A3 WO 2006059069A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
ion channel
kcnma3
homologues
polypeptide
Prior art date
Application number
PCT/GB2005/004508
Other languages
French (fr)
Other versions
WO2006059069A2 (en
Inventor
Samuel Aparicio
Nicola Brice
Jennifer Marie Horwood
Dan Ma
Original Assignee
Paradigm Therapeutics Ltd
Samuel Aparicio
Nicola Brice
Jennifer Marie Horwood
Dan Ma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0426274A external-priority patent/GB0426274D0/en
Application filed by Paradigm Therapeutics Ltd, Samuel Aparicio, Nicola Brice, Jennifer Marie Horwood, Dan Ma filed Critical Paradigm Therapeutics Ltd
Publication of WO2006059069A2 publication Critical patent/WO2006059069A2/en
Publication of WO2006059069A3 publication Critical patent/WO2006059069A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

We disclose KCNMA3 ion channel polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3, SEQ ID NO: 5 or SEQ ID NO: 6, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding KCNMA3 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1, SEQ ID No.2 or SEQ ID NO: 4.
PCT/GB2005/004508 2004-11-30 2005-11-24 Ion channel WO2006059069A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0426274A GB0426274D0 (en) 2004-11-30 2004-11-30 Ion channel
GB0426274.7 2004-11-30
US65007405P 2005-02-04 2005-02-04
US60/650,074 2005-02-04

Publications (2)

Publication Number Publication Date
WO2006059069A2 WO2006059069A2 (en) 2006-06-08
WO2006059069A3 true WO2006059069A3 (en) 2006-08-10

Family

ID=36481237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/004508 WO2006059069A2 (en) 2004-11-30 2005-11-24 Ion channel

Country Status (1)

Country Link
WO (1) WO2006059069A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020754A1 (en) * 1997-10-22 1999-04-29 The Washington University A ph sensitive potassium channel in spermatocytes
WO2002045498A2 (en) * 2000-12-08 2002-06-13 Deltagen, Inc. Transgenic mice containing channel protein target gene disruptions
WO2002048339A2 (en) * 2000-12-11 2002-06-20 Deltagen, Inc. Transgenic mice containing kir5.1 inwardly rectifying potassium channel gene disruptions
WO2003026401A2 (en) * 2001-09-24 2003-04-03 Deltagen, Inc. Kv3.3b POTASSIUM CHANNEL DISRUPTIONS, COMPOSITIONS AND METHODS RELATED THERETO
US6815539B1 (en) * 1997-10-22 2004-11-09 Icagen, Incorporated PH sensitive potassium channel in spermatocytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020754A1 (en) * 1997-10-22 1999-04-29 The Washington University A ph sensitive potassium channel in spermatocytes
US6815539B1 (en) * 1997-10-22 2004-11-09 Icagen, Incorporated PH sensitive potassium channel in spermatocytes
WO2002045498A2 (en) * 2000-12-08 2002-06-13 Deltagen, Inc. Transgenic mice containing channel protein target gene disruptions
WO2002048339A2 (en) * 2000-12-11 2002-06-20 Deltagen, Inc. Transgenic mice containing kir5.1 inwardly rectifying potassium channel gene disruptions
WO2003026401A2 (en) * 2001-09-24 2003-04-03 Deltagen, Inc. Kv3.3b POTASSIUM CHANNEL DISRUPTIONS, COMPOSITIONS AND METHODS RELATED THERETO

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 3 February 1998 (1998-02-03), "Mus musculus pH sensitive maxi K+ channel (Slo3) mRNA, Slo3-1 allele, complete cds.", XP002384001, retrieved from EBI accession no. EM_PRO:AF039213 Database accession no. AF039213 *
DATABASE EMBL [online] 3 May 2002 (2002-05-03), "Homo sapiens potassium channel, subfamily U, member 1, mRNA (cDNA clone IMAGE:4828672).", XP002384000, retrieved from EBI accession no. EM_PRO:BC028701 Database accession no. BC028701 *
DISTERHOFT J F ET AL: "Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease", AGEING RESEARCH REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 3, no. 4, 1 November 2004 (2004-11-01), pages 383 - 406, XP004639315, ISSN: 1568-1637 *
LALONDE ROBERT: "The neurobiological basis of spontaneous alternation", NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, vol. 26, no. 1, January 2002 (2002-01-01), pages 91 - 104, XP002383997, ISSN: 0149-7634 *
SCHREIBER M ET AL: "SLO3, A NOVEL PH-SENSITIVE K+ CHANNEL FROM MAMMALIAN SPERMATOCYTES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 273, no. 6, 6 February 1998 (1998-02-06), pages 3509 - 3516, XP001197289, ISSN: 0021-9258 *
SHI JINGYI ET AL: "Mechanism of magnesium activation of calcium-activated potassium channels.", NATURE. 22 AUG 2002, vol. 418, no. 6900, 22 August 2002 (2002-08-22), pages 876 - 880, XP002383996, ISSN: 0028-0836 *
STRAUSBERG R L ET AL: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 16899 - 16903, XP002372203, ISSN: 0027-8424 *
XIA XIAO-MING ET AL: "Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.", THE JOURNAL OF NEUROSCIENCE : THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE. 16 JUN 2004, vol. 24, no. 24, 16 June 2004 (2004-06-16), pages 5585 - 5591, XP002383995, ISSN: 1529-2401 *

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Publication number Publication date
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