+

WO2006050777A1 - Composition dentifrice - Google Patents

Composition dentifrice Download PDF

Info

Publication number
WO2006050777A1
WO2006050777A1 PCT/EP2005/010876 EP2005010876W WO2006050777A1 WO 2006050777 A1 WO2006050777 A1 WO 2006050777A1 EP 2005010876 W EP2005010876 W EP 2005010876W WO 2006050777 A1 WO2006050777 A1 WO 2006050777A1
Authority
WO
WIPO (PCT)
Prior art keywords
toothpaste
phase
citrate
zinc
agents
Prior art date
Application number
PCT/EP2005/010876
Other languages
English (en)
Inventor
Philip Christopher Waterfield
Original Assignee
Unilever N.V.
Unilever Plc
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever N.V., Unilever Plc, Hindustan Lever Limited filed Critical Unilever N.V.
Publication of WO2006050777A1 publication Critical patent/WO2006050777A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/0233—Distinct layers, e.g. core/shell sticks
    • A61K8/0237—Striped compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Definitions

  • the present invention relates to an oral care composition comprising bioactive zinc salts and chalk.
  • EP-Al-O 740 932 discloses a visually-clear gel type dentifrice comprising a zinc salt which is more water soluble than zinc citrate, an amino acid which can bind zinc and a low refractive index type abrasive silica.
  • US 5 470 561 discloses an anti -plaque mouthwash comprising a zinc salt and triclosan .
  • the composition may also comprise glycine and has a pH of between 4 and 8 , preferably between 5 and 7 , the preferred pH being 6 .
  • GBA-2 052 978 discloses a toothpaste comprising zinc salts with glycine and a pH of from 4.5 to 8.0.
  • US 5 632 972 discloses a method for minimising damage to gingival and periodontal tissue by delivering a first component comprising zinc and a second component comprising a bicarbonate.
  • the present invention provides a toothpaste comprising a first phase and a second phase stored in contact with one another, the first phase comprising calcium carbonate as abrasive and an alkali-metal citrate salt, the second phase comprising a zinc salt .
  • the invention provides a toothpaste which does not form water insoluble zinc species, e.g. zinc hydroxide, upon storage in a closed container such as a toothpaste tube and hence no gassing on the resulting formation of carbon dioxide. This is because the excess citrate in the first phase associates with any water-soluble zinc species which passes from the second phase to the first phase and prevents it from dissociating and reacting with calcium ions in the chalk.
  • water insoluble zinc species e.g. zinc hydroxide
  • the zinc salt is sparingly soluble in water. This reduces the amount of water-soluble zinc species available for migration into the chalk phase.
  • the most preferred zinc salt is zinc citrate.
  • the molar ratio between the zinc ions and the total citrate is from 1:1 to 1:2, there being at least as much, and preferably more, citrate as zinc.
  • the molar ratio between the zinc and the total citrate from 1:1.3 to 1:1.7.
  • zinc citrate is present at from 0.01 to 5% by weight of the toothpaste composition, preferably from 0.5 to 3.0% by weight of the composition.
  • This ratio between the zinc and the citrate salt provides, in this type of formulation, an optimal balance between making enough zinc ions bioavailable, and capable of interacting with bacteria, without forming a deleterious amount of water-insoluble zinc species such as zinc hydroxide.
  • the excess citrate is incorporated into the composition as an alkali metal citric acid salt such as potassium citrate or sodium citrate.
  • the toothpaste composition also comprises water. Preferably, it comprises from 5 to 50% by weight and most preferably from 15 to 35% by weight of the total composition water.
  • the abrasive system employed in the first phase is calcium carbonate based. This does not prevent the use of non- calcium carbonate abrasives in addition, such as silicas, perlite, tungsten carbide and silicon carbide. Further, any of these further abrasives may be employed in either phase.
  • the second phase comprises abrasive silica.
  • the first phase preferably comprises from 10 to 70% by weight of the first phase calcium carbonate, more preferably from 20% and most preferably from 35 to 60% by weight of the first phase calcium carbonate.
  • the second phase preferably comprises from 2 to 20% by weight of the second phase abrasive silica, more preferably from 5 to 12%.
  • Preferred calcium carbonates include fine ground natural chalk since it has a surprising stability with regard to its interactivity with zinc salts.
  • fine ground natural chalk FGNC
  • FGNC fine ground natural chalk
  • suitable examples of such are disclosed in US 2003/0072721 Al (Riley) the contents of which with regards to the definition, types and grades of FGNC are incorporated herein by reference.
  • FGNC is meant chalk which is obtained by milling limestone or marble deposits.
  • the FGNC comprises particulate matter of weight-based median particle size ranging from 1 to 15 ⁇ m and BET surface area ranging from 0.5 to 3 m 2 /g.
  • the toothpaste composition according to the invention also preferably comprises a fluoride ion source such as an alkali metal salt of monofluorophosphate, preferably sodium monofluorophosphate.
  • a fluoride ion source such as an alkali metal salt of monofluorophosphate, preferably sodium monofluorophosphate.
  • Such fluoride ion source will be present at such an amount to provide free fluoride ion at from 100 to 2000 ppm, preferably from 900 to 1500 ppm.
  • the toothpaste according to the invention comprises an agent selected from the group consisting of anti-caries agents, anti-tartar agents, anti-malodour agents, whitening teeth agents, anti-gingivitis agents and mixtures thereof.
  • the first phase comprises from 35 to 45% by weight of the first phase calcium carbonate, from 2 to 4% by weight of the first phase alkali- metal citrate while the second phase comprises from 6 to 10% of the second phase abrasive silica and from 1.5 to 2.5% by weight of the second phase zinc citrate trihydrate.
  • the toothpaste according to the invention comprise further ingredients which are common in the art, such as:
  • antimicrobial agents e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2 ' methylenebis- (4-chloro-6-bromophenol) ;
  • anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.;
  • anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates
  • vitamins such as Vitamins A, C and E;
  • desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
  • anti-calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc. ; biomolecules, e.g. bacteriocins, antibodies, enzymes, etc.;
  • flavours e.g. peppermint and spearmint oils
  • proteinaceous materials such as collagen
  • pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.;
  • surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • Preferred abrasives are chalk and silica, more preferably fine ground natural chalk.
  • Humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.;
  • binders and thickeners such as sodium carboxymethyl- cellulose, hydroxyethyl cellulose (Natrosol ® ) , xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol ® ; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included;
  • bleaching agents such as peroxy compounds e.g. potassium ' peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • Liposomes may also be used to improve delivery or stability of active ingredients.
  • the buffering agent is sodium hydroxide.
  • the two phases are preferably extruded into a toothpaste tube using devices known in the art, for example as described in WO 99/01342 (SKB) . They may be extruded such that they are dispensed side-by-side or such that one forms a stripe within the other.
  • first and second phases are coaxially arranged in and dispensed from a toothpaste tube, the second phase substantially surrounding the first phase.
  • the following example is a toothpaste made by standard processes .
  • the two pastes are coextruded into a toothpaste tube using known processes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une pâte dentifrice qui comprend une première phase et une seconde phase en contact mutuel, la première phase comprenant du carbonate de calcium comme abrasif et un sel de citrate de métal alcalin, la seconde phase comprenant de l'eau et un sel de zinc.
PCT/EP2005/010876 2004-11-15 2005-10-04 Composition dentifrice WO2006050777A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04257064 2004-11-15
EP04257064.8 2004-11-15

Publications (1)

Publication Number Publication Date
WO2006050777A1 true WO2006050777A1 (fr) 2006-05-18

Family

ID=34930800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/010876 WO2006050777A1 (fr) 2004-11-15 2005-10-04 Composition dentifrice

Country Status (1)

Country Link
WO (1) WO2006050777A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007122146A1 (fr) * 2006-04-26 2007-11-01 Unilever Plc Dentifrice
WO2014147630A1 (fr) * 2013-03-19 2014-09-25 Colgate-Palmolive Company Dentifrices à deux phases
JP2016503036A (ja) * 2012-12-24 2016-02-01 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ オーラルケア組成物
WO2016077688A3 (fr) * 2014-11-14 2016-07-14 Colgate-Palmolive Company Composition pour soins buccaux contenant des sels de zinc et du carbonate de calcium
CN106994103A (zh) * 2016-01-26 2017-08-01 白育纶 漱口水组成物
CN107007482A (zh) * 2017-03-13 2017-08-04 广州薇美姿实业有限公司 一种去除口气的口腔护理用品及其制备方法
WO2017167535A1 (fr) * 2016-03-31 2017-10-05 Unilever N.V. Composition de dentifrice

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0740932A1 (fr) * 1995-05-03 1996-11-06 Unilever N.V. Dentifrice sous forme de gel optiquement clair
US5616313A (en) * 1994-06-30 1997-04-01 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
US5948390A (en) * 1997-08-25 1999-09-07 Pfizer Inc. Stable zinc/citrate/CPC oral rinse formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616313A (en) * 1994-06-30 1997-04-01 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Method for treating gingival and periodontal tissues
EP0740932A1 (fr) * 1995-05-03 1996-11-06 Unilever N.V. Dentifrice sous forme de gel optiquement clair
US5948390A (en) * 1997-08-25 1999-09-07 Pfizer Inc. Stable zinc/citrate/CPC oral rinse formulations

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007122146A1 (fr) * 2006-04-26 2007-11-01 Unilever Plc Dentifrice
US10064794B2 (en) 2012-12-24 2018-09-04 Colgate-Palmolive Company Oral care composition
EP2934693A4 (fr) * 2012-12-24 2016-09-14 Colgate Palmolive Co Combinaison de soins buccaux
JP2016503036A (ja) * 2012-12-24 2016-02-01 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ オーラルケア組成物
US20160000667A1 (en) * 2013-03-19 2016-01-07 Colgate-Palmolive Company Two-Phase Dentifrices
CN105120830A (zh) * 2013-03-19 2015-12-02 高露洁-棕榄公司 两相洁齿剂
AU2013382938B2 (en) * 2013-03-19 2015-11-05 Colgate-Palmolive Company Two-phase dentifrices
WO2014147630A1 (fr) * 2013-03-19 2014-09-25 Colgate-Palmolive Company Dentifrices à deux phases
WO2016077688A3 (fr) * 2014-11-14 2016-07-14 Colgate-Palmolive Company Composition pour soins buccaux contenant des sels de zinc et du carbonate de calcium
CN107072896A (zh) * 2014-11-14 2017-08-18 高露洁-棕榄公司 含有锌盐和碳酸钙的口腔护理组合物
US10251823B2 (en) 2014-11-14 2019-04-09 Colgate-Palmolive Company Oral care composition containing zinc salts and calcium carbonate
RU2714131C2 (ru) * 2014-11-14 2020-02-12 Колгейт-Палмолив Компани Композиция для ухода за полостью рта, содержащая соли цинка и карбонат кальция
US10646422B2 (en) 2014-11-14 2020-05-12 Colgate-Palmolive Company Oral care composition containing zinc salts and calcium carbonate
CN107072896B (zh) * 2014-11-14 2021-04-20 高露洁-棕榄公司 含有锌盐和碳酸钙的口腔护理组合物
CN106994103A (zh) * 2016-01-26 2017-08-01 白育纶 漱口水组成物
WO2017167535A1 (fr) * 2016-03-31 2017-10-05 Unilever N.V. Composition de dentifrice
CN107007482A (zh) * 2017-03-13 2017-08-04 广州薇美姿实业有限公司 一种去除口气的口腔护理用品及其制备方法

Similar Documents

Publication Publication Date Title
EP0740932B1 (fr) Dentifrice sous forme de gel optiquement clair
EP1773279B1 (fr) Dentifrice comprenant du carbonate de calcium et du citrate de zinc
US6106811A (en) Oral care composition
EP2046454A1 (fr) Composition pour dentifrice
EP1107725B1 (fr) Pate dentifrice contenant du carbonate de calcium a particules fines et grossieres
EP1843741B1 (fr) Composition dentifrice opaque
EP2349187B1 (fr) Compositions de protection orale
WO2006012977A1 (fr) Composition
EP1183006B1 (fr) Composition a administration orale contenant de la perlite
WO2006050777A1 (fr) Composition dentifrice
EP1263401B1 (fr) Composition orale renfermant 2'-hydroxypropiophenone
US6602491B2 (en) Composition containing alkylhydroxybenzoates
US20030068283A1 (en) Composition
US6436372B2 (en) Oral composition with abrasive mixture of chalk and carbide
EP1408920A1 (fr) Composition orale comprenant des derives de peroxyamidophtalamide
US20030068282A1 (en) Composition
US20070065375A1 (en) Oral composition comprising micron-sized lanthanide metal oxide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05800269

Country of ref document: EP

Kind code of ref document: A1

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载