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WO2006050091A3 - Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation - Google Patents

Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation Download PDF

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Publication number
WO2006050091A3
WO2006050091A3 PCT/US2005/038925 US2005038925W WO2006050091A3 WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3 US 2005038925 W US2005038925 W US 2005038925W WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound dressings
dispersed
methods
precursor cells
conditioned medium
Prior art date
Application number
PCT/US2005/038925
Other languages
English (en)
Other versions
WO2006050091A2 (fr
Inventor
Kenneth W Carpenter
William G Turnell
Kristin M Defife
Kathryn A Grako
Original Assignee
Medivas Llc
Kenneth W Carpenter
William G Turnell
Kristin M Defife
Kathryn A Grako
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas Llc, Kenneth W Carpenter, William G Turnell, Kristin M Defife, Kathryn A Grako filed Critical Medivas Llc
Priority to EP05825008A priority Critical patent/EP1809310A4/fr
Priority to AU2005302469A priority patent/AU2005302469A1/en
Priority to CA002585740A priority patent/CA2585740A1/fr
Priority to JP2007539165A priority patent/JP2008518666A/ja
Publication of WO2006050091A2 publication Critical patent/WO2006050091A2/fr
Priority to US11/796,267 priority patent/US7794706B2/en
Publication of WO2006050091A3 publication Critical patent/WO2006050091A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des pansements pour blessures, éventuellement implantables par voie chirurgicale, qui contiennent des composants biodégradables, des polymères et des hydrogels possédant des cellules de précurseurs allogènes ou autologues telles que les cellules souches ou les cellules progénitrices dispersées. En variante, les pansements pour blessures peuvent contenir un milieu conditionné obtenu à partir de cellules de précurseurs allogènes dispersés. Les pansements pour blessures favorisent les processus de restauration de tissus sur un site d'application ou d'implantation. Des agents bioactifs supplémentaires peuvent aussi être dispersés à l'intérieur de la matrice polymère / hydrogel, qui peut être formulée pour se biodégrader à une vitesse contrôlée par l'ajustement de la composition. L'invention concerne aussi des procédés pour utiliser ces pansements pour blessures biodégradables en tant que dispositif d'administration ou en tant qu'excipient pour les cellules de précurseurs, un milieu conditionné ou des agents bioactifs, ou en tant que revêtements sur des dispositifs médicaux implantables visant à favoriser la restauration d'un tissu sur le site d'une lésion.
PCT/US2005/038925 2003-10-14 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation WO2006050091A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP05825008A EP1809310A4 (fr) 2004-10-28 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation
AU2005302469A AU2005302469A1 (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
CA002585740A CA2585740A1 (fr) 2004-10-28 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation
JP2007539165A JP2008518666A (ja) 2004-10-28 2005-10-27 生物活性創傷包帯および移植可能な装置ならびに使用法
US11/796,267 US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62344604P 2004-10-28 2004-10-28
US60/623,446 2004-10-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/362,848 Continuation-In-Part US7304122B2 (en) 2000-08-30 2001-08-30 Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/796,267 Continuation-In-Part US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Publications (2)

Publication Number Publication Date
WO2006050091A2 WO2006050091A2 (fr) 2006-05-11
WO2006050091A3 true WO2006050091A3 (fr) 2009-04-09

Family

ID=36319671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038925 WO2006050091A2 (fr) 2003-10-14 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation

Country Status (6)

Country Link
EP (1) EP1809310A4 (fr)
JP (1) JP2008518666A (fr)
CN (1) CN101437528A (fr)
AU (1) AU2005302469A1 (fr)
CA (1) CA2585740A1 (fr)
WO (1) WO2006050091A2 (fr)

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EP1933881B1 (fr) 2005-09-22 2019-03-13 Medivas, LLC Compositions polymères solides pour administration et méthodes d'utilisation de celles-ci
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
US7771739B2 (en) 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
WO2008082721A2 (fr) * 2006-09-05 2008-07-10 Medivas, Llc Compositions liposomales stabilisées par des polymères et leurs méthodes d'utilisation
ES2583371T3 (es) 2006-10-11 2016-09-20 The General Hospital Corporation Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas
WO2008156728A1 (fr) * 2007-06-15 2008-12-24 Neuronyx, Inc. Traitement de maladies et de troubles à l'aide de cellules formant des colonies s'auto-renouvelant cultivées et soumises à une expansion in vitro
WO2009065093A2 (fr) * 2007-11-17 2009-05-22 University Of Medicine And Dentistry Of New Jersey Utilisation de cellules souches pour la cicatrisation de plaie
RU2394593C2 (ru) * 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции
AU2010347212B2 (en) * 2010-09-14 2016-07-14 Cell Ideas Pty Ltd Cell free preparation and uses thereof
US20140179802A1 (en) * 2011-05-02 2014-06-26 Dsm Ip Assets B.V. Fiber comprising a biodegradable polymer
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CN103619910B (zh) 2011-06-23 2016-08-31 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物
EP2912097B1 (fr) * 2012-10-24 2017-07-12 DSM IP Assets B.V. Fibres comprenant des copolymères de polyesteramide pour l'administration de médicaments
CN111514108B (zh) * 2014-04-08 2022-11-29 帝斯曼知识产权资产管理有限公司 用于治疗关节炎病症的可生物降解的聚酯酰胺
JP6338468B2 (ja) * 2014-06-19 2018-06-06 テルモ株式会社 細胞を分散したゲルの製造方法およびその製造方法により製造された細胞分散ゲル
WO2016097297A1 (fr) 2014-12-18 2016-06-23 Dsm Ip Assets B.V. Système d'administration de médicament pour administration de médicaments sensibles aux acides
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105079859B (zh) * 2015-08-20 2018-01-26 广州赛莱拉干细胞科技股份有限公司 一种敷料及其制备方法
US10322034B1 (en) 2015-09-04 2019-06-18 University Of South Florida Hydrocolloid dressing for precise nipple positioning after nipple- or skin-sparing mastectomy
US11254754B2 (en) * 2016-01-17 2022-02-22 Guoming Sun Biocompatible polysaccharide hydrogels and methods of usage
CN105709270B (zh) * 2016-03-18 2019-01-01 中国科学院长春应用化学研究所 一种用于干细胞治疗的水凝胶敷料
CN106581763A (zh) * 2016-12-28 2017-04-26 溯源生命科技股份有限公司 一种干细胞人微型器官的制备方法
CN110831694A (zh) * 2017-03-31 2020-02-21 细尔琳生物医学公司 生物相容性调整细胞培养基组合物及其用途
CN107261213A (zh) * 2017-06-13 2017-10-20 北京恒峰铭成生物科技有限公司 一种活性水凝胶及其制备方法和在手术创伤修复中的应用
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WO2002018477A2 (fr) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Copolyester amides et copolyester urethannes fonctionnels biodegradables et elastomeres

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WO2002018477A2 (fr) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Copolyester amides et copolyester urethannes fonctionnels biodegradables et elastomeres

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YAMAGUCHI ET AL.: "Bone marrow cells differenitate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing.", BRITISH JOURNAL OF DERMATOLOGY., vol. 152, 2005, pages 616 - 622, XP008119299 *

Also Published As

Publication number Publication date
JP2008518666A (ja) 2008-06-05
AU2005302469A1 (en) 2006-05-11
EP1809310A2 (fr) 2007-07-25
CN101437528A (zh) 2009-05-20
EP1809310A4 (fr) 2011-10-26
CA2585740A1 (fr) 2006-05-11
WO2006050091A2 (fr) 2006-05-11

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