WO2006049367A1 - Toothpaste composition comprising essential oil - Google Patents
Toothpaste composition comprising essential oil Download PDFInfo
- Publication number
- WO2006049367A1 WO2006049367A1 PCT/KR2004/003268 KR2004003268W WO2006049367A1 WO 2006049367 A1 WO2006049367 A1 WO 2006049367A1 KR 2004003268 W KR2004003268 W KR 2004003268W WO 2006049367 A1 WO2006049367 A1 WO 2006049367A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oil
- present
- toothpaste composition
- toothpaste
- composition
- Prior art date
Links
- 239000000606 toothpaste Substances 0.000 title claims abstract description 50
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 239000000341 volatile oil Substances 0.000 title claims abstract description 46
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 42
- 239000010501 lemon oil Substances 0.000 claims abstract description 17
- 239000010677 tea tree oil Substances 0.000 claims abstract description 17
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 15
- 235000019501 Lemon oil Nutrition 0.000 claims abstract description 14
- 229940111630 tea tree oil Drugs 0.000 claims abstract description 14
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 19
- 235000019645 odor Nutrition 0.000 abstract description 16
- 208000028169 periodontal disease Diseases 0.000 abstract description 9
- 238000004140 cleaning Methods 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 235000005979 Citrus limon Nutrition 0.000 description 6
- 244000131522 Citrus pyriformis Species 0.000 description 6
- 235000004357 Mentha x piperita Nutrition 0.000 description 6
- 239000003082 abrasive agent Substances 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- -1 poly oxy ethylene Polymers 0.000 description 6
- 244000246386 Mentha pulegium Species 0.000 description 5
- 235000016257 Mentha pulegium Nutrition 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 235000001050 hortel pimenta Nutrition 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- 230000007721 medicinal effect Effects 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 244000178870 Lavandula angustifolia Species 0.000 description 3
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 3
- 241000366182 Melaleuca alternifolia Species 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 238000004040 coloring Methods 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 235000018219 lavender Nutrition 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 229960001866 silicon dioxide Drugs 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000005182 tip of the tongue Anatomy 0.000 description 3
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 2
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 238000000222 aromatherapy Methods 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- SFHUSLFRIKHKPE-UHFFFAOYSA-L chloro-[(2,5-dioxoimidazolidin-4-yl)carbamoylamino]aluminum;hydrate Chemical compound O.NC(=O)NC1NC(=O)N([Al]Cl)C1=O SFHUSLFRIKHKPE-UHFFFAOYSA-L 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229940091249 fluoride supplement Drugs 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000002766 immunoenhancing effect Effects 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 229930003658 monoterpene Natural products 0.000 description 2
- 235000002577 monoterpenes Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229960004029 silicic acid Drugs 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 229960000414 sodium fluoride Drugs 0.000 description 2
- 235000019983 sodium metaphosphate Nutrition 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 244000205574 Acorus calamus Species 0.000 description 1
- 235000011996 Calamus deerratus Nutrition 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- 241001479543 Mentha x piperita Species 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 244000284012 Vetiveria zizanioides Species 0.000 description 1
- 235000007769 Vetiveria zizanioides Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical class NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037358 bacterial metabolism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- GBAOBIBJACZTNA-UHFFFAOYSA-L calcium sulfite Chemical compound [Ca+2].[O-]S([O-])=O GBAOBIBJACZTNA-UHFFFAOYSA-L 0.000 description 1
- 235000010261 calcium sulphite Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
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- 150000002222 fluorine compounds Chemical group 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000001771 mentha piperita Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
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- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000008104 plant cellulose Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
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- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to a toothpaste composition comprising an essential oil to have excellent effects on the removal of mouth odors and the treatment of pe ⁇ riodontal diseases.
- Toothpaste is commercially available in the form of powders, creams and liquid solutions, and in general, includes, an abrasive agent to clean teeth mechanically, a humectant agent to prevent the toothpaste from being dried and hardened upon exposure to air, and some additives such as a binder, a foaming agent and a sweetening agent, which are required to stimulate dental hygiene such as oral cleaning and plaque removal.
- Essential oils are volatile organic compounds extracted from aromatic plants by distillation process, Essential oils contain alcohols, aldehydes, esters, ketones and oxides, each of which has medical effects such as anti-infection, antihistamine and an ⁇ tiallergic actions. Accurate mechanisms of the action of essential oils are unknown, but essential oils, when inhaled into the body, are known to regulate the body's balance by stimulating the cerebral cortex to secrete hormones, leading to a decrease in abnormally enlarged volume of & cells, and have a tonic effect on the nervous system, an effect of stimulating brain fiinction and a sedative effect by stimulating brain cells.
- the present invention aims to provide a toothpaste composition which has excellent effects on the removal of mouth odors and the treatment of periodontal diseases, as well as the basic function of toothpastes, such as oral cleaning and plaque removal, by containing an essential oil having an excellent antibacterial effect a ⁇ inst oral bacteria.
- the present invention provides a toothpaste composition comprising an essential oil.
- the toothpaste composition according to the present invention is characterized by comprising an essential oil plus a base composition including an abrasive agent, a humectant agent and some additives, wherein added the essential oil selected from the group consisting of peppermint oil, lemon oil, tea tree oil, and combinations thereof
- the peppermint oil is in an amount of 0.50-0.85wt%
- the lemon oil in an amount of 0.20-0.65wt%
- the tea tree oil in an amount of 0.07-0.25wt%, based on the total weight of the composition.
- the toothpaste composition comprising essential oils according to the present invention has excellent effects on dental hygiene, especially the removal of mouth odors, and the treatment of periodontal diseases.
- FlG. 1 is a graph showing the effect of a toothpaste composition according to the present invention on the removal of mouth odors. Best Mode for Carrying Out the Invention
- the present invention employs conventional toothpaste compositions as a base composition, which includes an abrasive agent and a humectant agent as basic in ⁇ gredients, as well as some additives such as a binder, a foaming agent, a sweetening agent and a pharmaceutically effective substance.
- the abrasive agent functions to mechanically clean teeth.
- the abrasive include precipitated calcium carbonate, calcium hydrogen phosphate, calcium sulfite, magnesium carbonate, magnesium chloride, hydrated alumina, hydrated silica, silicon dioxide, silica gel, zirconium silicate, aluminum silicate, calcium pyrophosphate, and insoluble metaphosphate.
- one or more abrasive agents selected from the examples are used. If the abrasive qgent has unsuitable particle size, hardness and shape, it may damage the surface of teeth.
- an abrasive qgent to be used in the present invention must meet the following requirements: an uniform particle size of about 1-20 m m, a shape not highly sensitizing and a mohs hardness of about 3.
- the humectant qgent is a basic ingredient essential for formulation into ointments, which prevents toothpaste from being dried and hardened upon exposure to air and makes the surface of toothpaste lustrous.
- examples of the humectant qgent include glycerin, sorbitol, polyethylene glycol and propylene glycol, one or two of which are contained in the present composition.
- the binder prevents solid and liquid components of a powder form of toothpaste from separating from each other, and any one of water-soluble polymers may be used as a binder.
- the binder include sodium carboxymethyl cellulose synthesized from plant cellulose, carrqgeenans extracted from algae, and xanthan gum generated by bacterial metabolism, one or two of which are contained in the present composition.
- the foaming qgent has the following fiinctions: it acts to improve the feeling of using a toothpaste, helps the cleaning action of a toothpaste, promotes dispersion and penetration of a pharmaceutically effective qgent, and fecilitates the removal of impurities in the mouth by reducing surface tension.
- an anionic surfactant kiryl sodium sulfite
- auxiliary qgents are also used according to the feature of pharmaceutical formulations: poly oxy ethylene, copolymers of polyoxypropylene, polyoxyethylene hardened castor oil, and polyoxyethylene ⁇ tty acid esters.
- polyoxy ethylene poly oxy ethylene
- copolymers of polyoxypropylene polyoxyethylene hardened castor oil
- polyoxyethylene ⁇ tty acid esters polyoxyethylene ⁇ tty acid esters
- a variety of pharmaceutically effective agents are employed to increase the therapeutic effects of toothpastes.
- a water-soluble fluoride for example, sodium monofluorophosphate, sodium fluoride, amine fluoride or stannous fluoride.
- These fluorides form apatite fluoride by a substitution reaction with hydroxyapatite of tooth enamel, thus increasing the hardness of teeth.
- Substances effective in inhibiting plaque formation include sodium pyrophosphate, sodium acid pyrophosphate, sodium metaphosphate, potassium pyrophosphate and enzymes.
- Cationic surfactants are used to inhibit bacterial growth in the mouth.
- water-soluble salts providing high osmotic pressure such as sodium chloride or sodium hydrogen carbonate, aminocaproic acid having a hemostatic effect, allantoin derivatives such as aluminum chlorohydroxy allantoinate, and vitamins, such as tocopherol acetate, are used.
- allantoin derivatives such as aluminum chlorohydroxy allantoinate
- vitamins such as tocopherol acetate
- the conventional toothpaste composition may fiirther comprise additives such as an aromatic, a sweetening qgent, a coloring qgent and a preservative.
- additives such as an aromatic, a sweetening qgent, a coloring qgent and a preservative.
- aromatic include spearmint oil, fruit extracts and methyl salicylate.
- the most commonly used sweetening agents are sodium saccharin and xylitol.
- the coloring qgent include titanium dioxide that provides a white color.
- the preservative for preventing toothpastes from deteriorating include methyl paraben.
- One or more of these additives are used in the present invention.
- the most characteristic feature of the present invention is to include an essential oil having a strong inhibitory effect q ⁇ inst oral bacteria in the aforementioned con ⁇ ventional toothpaste composition.
- the essential oil will be described in detail.
- essential oils are used as major components in aromatherapy that has recently gained increasing interest as alternative medicine, and are composed of volatile organic compounds extracted from plants by a distillation process.
- Essential oils are classified according to their original locations in plants into four groups: oils obtained from leaves (e.g., eucalyptus, peppermint, clove, etc.), oils obtained from flowers (e.g., lavender, rose, etc.), oils obtained from branches (e.g., juniper, etc.), oils obtained from stalks (e.g., sandalwood, tea tree, etc.), and oils obtained from roots or fruits (e.g., vetiver, calamus, lemon, etc.)
- the inventor of the present invention found that the essential oils of lavender, clove, peppermint, lemon and tea tree have a strong inhibitory effect against oral bacteria. This finding is described in detail in the aforementioned Official Gazette for Korean Patent Laid-open Publication No. 2003-87380. Based on the finding, the inventor of the present invention performed intensive and thorough researches to apply the above essential oils promoting oral hygiene to daily activities, resulting in the de ⁇ velopment of the toothpaste containing the essential oil according to the present invention. During the researches, among the five essential oils, lavender and clove oils were excluded because they have flavors unsuitable for use in toothpastes. For the remaining peppermint, lemon and tea tree oils, an optimal amount capable of exerting a strong antibacterial effect with no use of polyphosphate or sodium fluoride, used in the cited patent application, was determined.
- Peppermint oil (botanical name: Mentha piperita, origin: USA ) contains menthol and menthone as major components, and has antiseptic, antispasmodic and expectorant effects.
- peppermint oil is preferably used in an amount of 0.50-0.85wt%. If the content of peppermint oil is lower than 0.50wt%, peppermint oil cannot exert its medical effects as described above. If the content of peppermint oil exceeds 0.85wt%, peppermint oil may disturb sleep due to its stimulating effect.
- Lemon oil (botanical name: Citrus limonum, origin: USA ) contains aldehydes and monoterpene hydrocarbons as major components, and is known to have antiseptic, an ⁇ tibacterial and immunoenhancing effects.
- lemon oil was identified to have excellent antibacterial activity as ⁇ inst tooth decay-causing bacteria among oral bacteria.
- lemon oil is preferably used in an amount of 0.20-0.65wt%. If the content of lemon oil is lower than 0.20wt%, lemon oil cannot exert its medical effects as described above. If the content of lemon oil exceeds 0.65wt%, lemon oil is unsuitable for use in toothpastes due to its unique irritating taste.
- Tea tree oil (botanical name: Melaleuca alternifolia, origin: Australia ) contains monoterpene alcohol and cineol as major components, and is known to have an ⁇ tibacterial, antiviral and immunoenhancing effects.
- tea tree oil was identified to have excellent antibacterial activity against tooth decay-causing bacteria among oral bacteria.
- tea tree oil is preferably used in an amount of 0.07-0.25 wt%. If the content of tea tree oil is lower than 0.07wt%, tea tree oil cannot exert its medical effects as described above. If the content of tea tree oil exceeds 0.25wt%, tea tree oil causes irritation of sensitive skin.
- peppermint, lemon and tea tree oils may be used singly or in combinations of two or more.
- an essential oil When an essential oil is mixed with another essential oil, it serves as a balancer improving the effects of the other essential oil as well as exerting its own effects. This synergistic effect is well known in the art.
- peppermint, lemon and tea tree oils may be used singly or in com- binations of two or more within the above range in such a way of being added to a con ⁇ ventional toothpaste composition.
- the above essential oils do not greatly affect beneficial bacteria in the mouth while exerting strong inhibitory activity against harm&l bacteria (causing tooth decay or paradentitis) inhabiting the mouth.
- These effects of essential oils are because natural extracts such as essential oils contain both molecules having antibacterial activity and quencher molecules supplementing and suppressing the activity, whereas antibiotics con ⁇ ventionally used as antibacterial agents are prepared only with molecules having an ⁇ tibacterial activity.
- a conventional toothpaste composition was prepared using silicon dioxide and hydrated silica as abrasives; sorbitol and polyethylene glycol as humectants; tocopherol acetate sodium monofluorophosphate, sodium metaphosphate and aluminum chlorohydroxy allantoinate as pharmaceutically effective agents; sodium carboxymethyl cellulose as a binder; sodium lauryl sulfate as a foaming qgent; sodium saccharin and sylitol as sweetening qgents; titanium dioxide as a coloring qgent; and methyl paraben as a preservative.
- the conventional toothpaste composition was sup ⁇ plemented with essential oils, that is, 0.6wt% of perppermint oil, 0.3wt% of lemon oil and 0.1 wt% of tea tree oil, thus providing a toothpaste composition according to the present invention.
- Mouth odors are typically divided into two types: one is generated in the mouth, and the other comes from the stomach. About 90% of mouth odors are generated in the mouth due to the decomposition of proteins by bacteria inhabiting the mouth. Thus, the degree of mouth odors depends mainly on the kind of bacterial populations in the mouth. That is, mouth odors may be reduced when mouth odor-causing bacteria decrease in cell number, the bacteria show a drop insolution with no change in cell number, or the bacteria display a decrease in adhesion to oral tissue.
- Mouth odors were evaluated by dividing the tongue into three parts: a front part
- the toothpaste composition containing essential oils according to the present invention was evaluated to determine whether it has a therapeutic effect on gum diseases (periodontal diseases), one of the representative oral diseases.
- Periodontal diseases result from the combinational action of several fectors, but the most critical direct cause of periodontal diseases is the infection of the gums with oral bacteria.
- bacterial samples were collected in the gingival sulcus, a space between the teeth and the gums surrounding the teeth, where bacterial populations capable of directly affecting the gums inhabit. Then, the collected bacteria were grown under the same conditions as in the gingival sulcus, that is, anaerobic conditions (absence of oxygen), and total colonies of various bacteria grown were counted.
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Abstract
Disclosed is a toothpaste composition including an essential oil in the base of conventional toothpaste compositions to have strong effect on the removal of mouth odors and oral bacteria. In the present invention, the essential oil is selected from the group consisting of peppermint oil, lemon oil, tea tree oil, and combinations thereof, and when used, the peppermint oil is in an amount of 0.50-0.85wt%, the lemon oil in an amount of 0.20-0.65wt%, and the tea tree oil in an amount of 0.07-0.25wt% based on the total weight of the composition. The toothpaste composition of the present invention has excellent effects on the removal of mouth odors and the treatment of periodontal diseases, in addition to the basic function of toothpastes, such as oral cleaning and plaque removal.
Description
Description
[1] TOOTHPASTE COMPOSITION COMPRISING ESSENTIAL OIL
Technical Field
[2] The present invention relates to a toothpaste composition comprising an essential oil to have excellent effects on the removal of mouth odors and the treatment of pe¬ riodontal diseases. Background Art
[3] Toothpaste is commercially available in the form of powders, creams and liquid solutions, and in general, includes, an abrasive agent to clean teeth mechanically, a humectant agent to prevent the toothpaste from being dried and hardened upon exposure to air, and some additives such as a binder, a foaming agent and a sweetening agent, which are required to stimulate dental hygiene such as oral cleaning and plaque removal.
[4] Recently, aromatherapy using natural essential oils extracted from plants has been recognized as an alternative medical treatment, which was the result of the de¬ velopments of the methods of applying essential oils scientifically and measuring the effects of the treatment objectively.
[5] Essential oils are volatile organic compounds extracted from aromatic plants by distillation process, Essential oils contain alcohols, aldehydes, esters, ketones and oxides, each of which has medical effects such as anti-infection, antihistamine and an¬ tiallergic actions. Accurate mechanisms of the action of essential oils are unknown, but essential oils, when inhaled into the body, are known to regulate the body's balance by stimulating the cerebral cortex to secrete hormones, leading to a decrease in abnormally enlarged volume of & cells, and have a tonic effect on the nervous system, an effect of stimulating brain fiinction and a sedative effect by stimulating brain cells.
[6] Recently, a large number of clinical studies associated with the therapeutic effects of essential oils have also been made in the field of odontology. The inventor of the present invention has developed an essential oil composition having a strong an¬ tibacterial effect against oral bacteria and has applied for a patent in Korea , of which the invention was published in the Official Gazette published by the Korea Industrial Property Office (Korean Patent Laid-open Publication No. 2001-87380) Based on the results of the studies of the former invention, the present invention intends to apply the essential oil composition to toothpastes. Thus, all contents of the former patent ap¬ plication may be referred to the present invention.
Disclosure of Invention Technical Problem
[7] Accordingly, the present invention aims to provide a toothpaste composition which has excellent effects on the removal of mouth odors and the treatment of periodontal diseases, as well as the basic function of toothpastes, such as oral cleaning and plaque removal, by containing an essential oil having an excellent antibacterial effect a^inst oral bacteria. Technical Solution
[8] To accomplish the above object, the present invention provides a toothpaste composition comprising an essential oil. The toothpaste composition according to the present invention is characterized by comprising an essential oil plus a base composition including an abrasive agent, a humectant agent and some additives, wherein added the essential oil selected from the group consisting of peppermint oil, lemon oil, tea tree oil, and combinations thereof Preferably, when used, the peppermint oil is in an amount of 0.50-0.85wt%, the lemon oil in an amount of 0.20-0.65wt%, and the tea tree oil in an amount of 0.07-0.25wt%, based on the total weight of the composition. Advantageous Effects
[9] As described hereinbefore, the toothpaste composition comprising essential oils according to the present invention has excellent effects on dental hygiene, especially the removal of mouth odors, and the treatment of periodontal diseases. Brief Description of the Drawings
[10] FlG. 1 is a graph showing the effect of a toothpaste composition according to the present invention on the removal of mouth odors. Best Mode for Carrying Out the Invention
[11] Hereinafter, the toothpaste composition containing an essential oil according to the present invention will be described in detail with respect to its composition.
[12] The present invention employs conventional toothpaste compositions as a base composition, which includes an abrasive agent and a humectant agent as basic in¬ gredients, as well as some additives such as a binder, a foaming agent, a sweetening agent and a pharmaceutically effective substance.
[13] The abrasive agent functions to mechanically clean teeth. Examples of the abrasive include precipitated calcium carbonate, calcium hydrogen phosphate, calcium sulfite, magnesium carbonate, magnesium chloride, hydrated alumina, hydrated silica, silicon
dioxide, silica gel, zirconium silicate, aluminum silicate, calcium pyrophosphate, and insoluble metaphosphate. In the present invention, one or more abrasive agents selected from the examples are used. If the abrasive qgent has unsuitable particle size, hardness and shape, it may damage the surface of teeth. Thus, an abrasive qgent to be used in the present invention must meet the following requirements: an uniform particle size of about 1-20 m m, a shape not highly sensitizing and a mohs hardness of about 3.
[14] The humectant qgent is a basic ingredient essential for formulation into ointments, which prevents toothpaste from being dried and hardened upon exposure to air and makes the surface of toothpaste lustrous. Examples of the humectant qgent include glycerin, sorbitol, polyethylene glycol and propylene glycol, one or two of which are contained in the present composition.
[15] The binder prevents solid and liquid components of a powder form of toothpaste from separating from each other, and any one of water-soluble polymers may be used as a binder. Commonly used examples of the binder include sodium carboxymethyl cellulose synthesized from plant cellulose, carrqgeenans extracted from algae, and xanthan gum generated by bacterial metabolism, one or two of which are contained in the present composition.
[16] The foaming qgent has the following fiinctions: it acts to improve the feeling of using a toothpaste, helps the cleaning action of a toothpaste, promotes dispersion and penetration of a pharmaceutically effective qgent, and fecilitates the removal of impurities in the mouth by reducing surface tension. Typically, an anionic surfactant, kiryl sodium sulfite, is mainly used, and the following auxiliary qgents are also used according to the feature of pharmaceutical formulations: poly oxy ethylene, copolymers of polyoxypropylene, polyoxyethylene hardened castor oil, and polyoxyethylene ήtty acid esters. One or two of these examples are contained in the present composition.
[17] Recently, a variety of pharmaceutically effective agents are employed to increase the therapeutic effects of toothpastes. To increase the hardness of teeth (to prevent tooth decay), a water-soluble fluoride, for example, sodium monofluorophosphate, sodium fluoride, amine fluoride or stannous fluoride, is used. These fluorides form apatite fluoride by a substitution reaction with hydroxyapatite of tooth enamel, thus increasing the hardness of teeth. Substances effective in inhibiting plaque formation include sodium pyrophosphate, sodium acid pyrophosphate, sodium metaphosphate, potassium pyrophosphate and enzymes. Cationic surfactants are used to inhibit bacterial growth in the mouth. To prevent periodontal diseases, water-soluble salts
providing high osmotic pressure, such as sodium chloride or sodium hydrogen carbonate, aminocaproic acid having a hemostatic effect, allantoin derivatives such as aluminum chlorohydroxy allantoinate, and vitamins, such as tocopherol acetate, are used. One or two of these pharmaceutically effective agents are contained in the present composition.
[18] The conventional toothpaste composition may fiirther comprise additives such as an aromatic, a sweetening qgent, a coloring qgent and a preservative. Examples of the aromatic include spearmint oil, fruit extracts and methyl salicylate. The most commonly used sweetening agents are sodium saccharin and xylitol. Examples of the coloring qgent include titanium dioxide that provides a white color. Examples of the preservative for preventing toothpastes from deteriorating include methyl paraben. One or more of these additives are used in the present invention.
[19] The aforementioned components of a conventional toothpaste composition are provided only to illustrate components commonly used in the art. Thus, the spirit and scope of the present invention includes all components generally used in toothpastes in addition to the aforementioned components.
[20] The most characteristic feature of the present invention is to include an essential oil having a strong inhibitory effect q^inst oral bacteria in the aforementioned con¬ ventional toothpaste composition. Hereafter, the essential oil will be described in detail.
[21] As described above, essential oils are used as major components in aromatherapy that has recently gained increasing interest as alternative medicine, and are composed of volatile organic compounds extracted from plants by a distillation process. Essential oils are classified according to their original locations in plants into four groups: oils obtained from leaves (e.g., eucalyptus, peppermint, clove, etc.), oils obtained from flowers (e.g., lavender, rose, etc.), oils obtained from branches (e.g., juniper, etc.), oils obtained from stalks (e.g., sandalwood, tea tree, etc.), and oils obtained from roots or fruits (e.g., vetiver, calamus, lemon, etc.)
[22] The inventor of the present invention found that the essential oils of lavender, clove, peppermint, lemon and tea tree have a strong inhibitory effect against oral bacteria. This finding is described in detail in the aforementioned Official Gazette for Korean Patent Laid-open Publication No. 2003-87380. Based on the finding, the inventor of the present invention performed intensive and thorough researches to apply the above essential oils promoting oral hygiene to daily activities, resulting in the de¬ velopment of the toothpaste containing the essential oil according to the present
invention. During the researches, among the five essential oils, lavender and clove oils were excluded because they have flavors unsuitable for use in toothpastes. For the remaining peppermint, lemon and tea tree oils, an optimal amount capable of exerting a strong antibacterial effect with no use of polyphosphate or sodium fluoride, used in the cited patent application, was determined.
[23] Hereinafter, the three essential oils contained in the toothpaste composition according to the present invention will be described in more detail.
[24] Peppermint oil (botanical name: Mentha piperita, origin: USA ) contains menthol and menthone as major components, and has antiseptic, antispasmodic and expectorant effects. In accordance with the present invention, peppermint oil is preferably used in an amount of 0.50-0.85wt%. If the content of peppermint oil is lower than 0.50wt%, peppermint oil cannot exert its medical effects as described above. If the content of peppermint oil exceeds 0.85wt%, peppermint oil may disturb sleep due to its stimulating effect.
[25] Lemon oil (botanical name: Citrus limonum, origin: USA ) contains aldehydes and monoterpene hydrocarbons as major components, and is known to have antiseptic, an¬ tibacterial and immunoenhancing effects. In particular, lemon oil was identified to have excellent antibacterial activity as^inst tooth decay-causing bacteria among oral bacteria. In accordance with the present invention, lemon oil is preferably used in an amount of 0.20-0.65wt%. If the content of lemon oil is lower than 0.20wt%, lemon oil cannot exert its medical effects as described above. If the content of lemon oil exceeds 0.65wt%, lemon oil is unsuitable for use in toothpastes due to its unique irritating taste.
[26] Tea tree oil (botanical name: Melaleuca alternifolia, origin: Australia ) contains monoterpene alcohol and cineol as major components, and is known to have an¬ tibacterial, antiviral and immunoenhancing effects. In particular, tea tree oil was identified to have excellent antibacterial activity against tooth decay-causing bacteria among oral bacteria. In accordance with the present invention, tea tree oil is preferably used in an amount of 0.07-0.25 wt%. If the content of tea tree oil is lower than 0.07wt%, tea tree oil cannot exert its medical effects as described above. If the content of tea tree oil exceeds 0.25wt%, tea tree oil causes irritation of sensitive skin.
[27] In the present invention, peppermint, lemon and tea tree oils may be used singly or in combinations of two or more. When an essential oil is mixed with another essential oil, it serves as a balancer improving the effects of the other essential oil as well as exerting its own effects. This synergistic effect is well known in the art. Thus, in the present invention, peppermint, lemon and tea tree oils may be used singly or in com-
binations of two or more within the above range in such a way of being added to a con¬ ventional toothpaste composition.
[28] The accurate mechanism of the antibacterial action of essential oils is unknown, but essential oils have been known to have antibacterial activity by damaging the plasma membrane of bacteria. That is, hydrophobic essential oils easily penetrate the hydrophobic plasma membrane in an aqueous solution, expand the plasma membrane and increase the fluidity of the plasma membrane, leading to an increase in membrane permeability and eventually the death of bacterial cells.
[29] In addition, unlike synthetic compounds used for inhibiting oral bacteria, the above essential oils do not greatly affect beneficial bacteria in the mouth while exerting strong inhibitory activity against harm&l bacteria (causing tooth decay or paradentitis) inhabiting the mouth. These effects of essential oils are because natural extracts such as essential oils contain both molecules having antibacterial activity and quencher molecules supplementing and suppressing the activity, whereas antibiotics con¬ ventionally used as antibacterial agents are prepared only with molecules having an¬ tibacterial activity.
[30] A better understanding of the present invention may be obtained through the following example which is set forth to illustrate, but is not to be construed as the limit of the present invention.
[31] [EXAMPLE]
[32] A conventional toothpaste composition was prepared using silicon dioxide and hydrated silica as abrasives; sorbitol and polyethylene glycol as humectants; tocopherol acetate sodium monofluorophosphate, sodium metaphosphate and aluminum chlorohydroxy allantoinate as pharmaceutically effective agents; sodium carboxymethyl cellulose as a binder; sodium lauryl sulfate as a foaming qgent; sodium saccharin and sylitol as sweetening qgents; titanium dioxide as a coloring qgent; and methyl paraben as a preservative. The conventional toothpaste composition was sup¬ plemented with essential oils, that is, 0.6wt% of perppermint oil, 0.3wt% of lemon oil and 0.1 wt% of tea tree oil, thus providing a toothpaste composition according to the present invention.
[33] Fifty subjects were divided into two groups each of which consisted of 25 in¬ dividuals. For a period of five weeks, one group (control group) brushed teeth using the conventional toothpaste composition, and the other group (test group) used the toothpaste composition of the present invention. During this test period, an increase or decrease in mouth odors and cell number of bacteria responsible for periodontal
diseases were examined.
[34] Mouth odors are typically divided into two types: one is generated in the mouth, and the other comes from the stomach. About 90% of mouth odors are generated in the mouth due to the decomposition of proteins by bacteria inhabiting the mouth. Thus, the degree of mouth odors depends mainly on the kind of bacterial populations in the mouth. That is, mouth odors may be reduced when mouth odor-causing bacteria decrease in cell number, the bacteria show a drop in fonction with no change in cell number, or the bacteria display a decrease in adhesion to oral tissue.
[35] Mouth odors were evaluated by dividing the tongue into three parts: a front part
(lcm away from the tip of the tongue), a middle part (2cm away from the tip of the tongue) and a rear part (3cm away from the tip of the tongue) The results are given in the graph of FlG. 1. As shown in FlG. 1, when the toothpaste composition containing essential oils according to the present invention was used for three weeks, it displayed a similar effect on reducing mouth odors through the whole region of the tongue compared to the conventional toothpaste composition. However, after four weeks, the present toothpaste composition remarkably reduced mouth odors. The essential oils contained in the present toothpaste composition were not identified to display this effect by any one among the three aforementioned mechanisms for the reduction of mouth odors. However, the above test clearly demonstrated that the toothpaste composition containing essential oils according to the present invention has an excellent effect of reducing mouth odors.
[36] Next, the toothpaste composition containing essential oils according to the present invention was evaluated to determine whether it has a therapeutic effect on gum diseases (periodontal diseases), one of the representative oral diseases. Periodontal diseases result from the combinational action of several fectors, but the most critical direct cause of periodontal diseases is the infection of the gums with oral bacteria. Thus, bacterial samples were collected in the gingival sulcus, a space between the teeth and the gums surrounding the teeth, where bacterial populations capable of directly affecting the gums inhabit. Then, the collected bacteria were grown under the same conditions as in the gingival sulcus, that is, anaerobic conditions (absence of oxygen), and total colonies of various bacteria grown were counted.
[37] As a result, when the conventional toothpaste composition was used, bacterial cell number in the gingival sulcus decreased by only 35%. In contrast, the use of the toothpaste composition containing essential oils according to the present invention resulted in a decrease of 86% in bacterial growth. These results indicate that the
present toothpaste composition has an inhibitory effect against periodontal disease- causing bacteria more than twice that of the conventional toothpaste composition.
Claims
Claims
[1] [ CMm 1 1
A toothpaste composition, comprising an essential oil plus a base composition including an abrasive qgent, a humectant qgent and some additives, wherein the essential oil is selected from the group consisting of peppermint oil, lemon oil, tea tree oil, and combinations thereof, and when used, the peppermint oil is in an amount of 0.50-0.85 wt%, the lemon oil in an amount of 0.20-0.65 wt%, and the tea tree oil in an amount of 0.07-0.25 wt% based on the total weight of the composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040089429A KR100760970B1 (en) | 2004-11-04 | 2004-11-04 | Toothpaste composition containing essential oils |
| KR10-2004-0089429 | 2004-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2006049367A1 true WO2006049367A1 (en) | 2006-05-11 |
Family
ID=36319349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2004/003268 WO2006049367A1 (en) | 2004-11-04 | 2004-12-13 | Toothpaste composition comprising essential oil |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR100760970B1 (en) |
| WO (1) | WO2006049367A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825350A (en) * | 2015-04-22 | 2015-08-12 | 林晓莉 | Toothpaste using plant hydrosol and essential oil to substitute essence components |
| CN109568185A (en) * | 2019-01-10 | 2019-04-05 | 德利宝(广州)香料有限公司 | A kind of dentifrice composition and preparation method thereof containing tea oil compounding menthol essence |
| WO2019226921A1 (en) * | 2018-05-23 | 2019-11-28 | The Trustees Of Columbia University In The City Of New York | Alcohol-free botanical oral care products |
| WO2022018478A1 (en) * | 2020-07-20 | 2022-01-27 | Ghoreishi Javad | Oral hygiene compositions |
| CN114177096A (en) * | 2020-12-23 | 2022-03-15 | 贾瓦德·戈雷希 | Oral hygiene compositions and toothpaste |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100806050B1 (en) * | 2006-08-09 | 2008-02-26 | 신동목 | Toothpaste composition |
| KR102079529B1 (en) * | 2018-07-02 | 2020-02-20 | 동의대학교 산학협력단 | Oil composition for preventing and improving periodontal disease |
| KR102123327B1 (en) * | 2018-07-02 | 2020-06-16 | 동의대학교 산학협력단 | Oil composition for spherical cleaning |
| KR102123321B1 (en) * | 2018-07-02 | 2020-06-16 | 동의대학교 산학협력단 | Oil composition for spherical cleaning |
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| US4812308A (en) * | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
| US5186926A (en) * | 1991-06-24 | 1993-02-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Flavor for peroxide-bicarbonate oral compositions |
| US5472684A (en) * | 1993-06-02 | 1995-12-05 | Colgate Palmolive Company | Oral compositions for plaque and gingivitis |
| US5601803A (en) * | 1995-05-26 | 1997-02-11 | Masters; James G. | Silica abrasive dentifrice of reduced stringless and improved flavor |
| US5695746A (en) * | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
| WO1999043293A1 (en) * | 1998-02-27 | 1999-09-02 | Block Drug Company, Inc. | Stable herbal dentifrice |
| WO2000054740A1 (en) * | 1999-03-12 | 2000-09-21 | Myung Woo Jung | Tooth paste composition containing rose-seed oil |
| US6656454B1 (en) * | 1999-03-12 | 2003-12-02 | Cognis Deutschland Gmbh & Co. Kg | Method for producing surfactant granulates |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2134743B1 (en) | 1998-02-06 | 2000-05-01 | Biocosmetics Sl | COMPOSITION FOR THE TREATMENT OF HALITOSIS. |
| US6379652B1 (en) * | 2000-10-16 | 2002-04-30 | Colgate Palmolive Company | Oral compositions for reducing mouth odors |
| KR100951396B1 (en) | 2003-03-17 | 2010-04-07 | 동아제약주식회사 | Toothpaste composition excellent in bad breath removal, plaque removal and antibacterial effect |
| KR20040087380A (en) | 2003-04-07 | 2004-10-14 | 김종철 | Essential oil composition with excellent antibacterial effect on oral bacteria |
-
2004
- 2004-11-04 KR KR1020040089429A patent/KR100760970B1/en not_active Expired - Lifetime
- 2004-12-13 WO PCT/KR2004/003268 patent/WO2006049367A1/en active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812308A (en) * | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
| US5186926A (en) * | 1991-06-24 | 1993-02-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Flavor for peroxide-bicarbonate oral compositions |
| US5472684A (en) * | 1993-06-02 | 1995-12-05 | Colgate Palmolive Company | Oral compositions for plaque and gingivitis |
| US5601803A (en) * | 1995-05-26 | 1997-02-11 | Masters; James G. | Silica abrasive dentifrice of reduced stringless and improved flavor |
| US5695746A (en) * | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
| WO1999043293A1 (en) * | 1998-02-27 | 1999-09-02 | Block Drug Company, Inc. | Stable herbal dentifrice |
| WO2000054740A1 (en) * | 1999-03-12 | 2000-09-21 | Myung Woo Jung | Tooth paste composition containing rose-seed oil |
| US6656454B1 (en) * | 1999-03-12 | 2003-12-02 | Cognis Deutschland Gmbh & Co. Kg | Method for producing surfactant granulates |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825350A (en) * | 2015-04-22 | 2015-08-12 | 林晓莉 | Toothpaste using plant hydrosol and essential oil to substitute essence components |
| WO2019226921A1 (en) * | 2018-05-23 | 2019-11-28 | The Trustees Of Columbia University In The City Of New York | Alcohol-free botanical oral care products |
| CN109568185A (en) * | 2019-01-10 | 2019-04-05 | 德利宝(广州)香料有限公司 | A kind of dentifrice composition and preparation method thereof containing tea oil compounding menthol essence |
| WO2022018478A1 (en) * | 2020-07-20 | 2022-01-27 | Ghoreishi Javad | Oral hygiene compositions |
| CN114177096A (en) * | 2020-12-23 | 2022-03-15 | 贾瓦德·戈雷希 | Oral hygiene compositions and toothpaste |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100760970B1 (en) | 2007-10-04 |
| KR20060041347A (en) | 2006-05-12 |
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