WO2006048665A3 - Composes chimiques - Google Patents
Composes chimiques Download PDFInfo
- Publication number
- WO2006048665A3 WO2006048665A3 PCT/GB2005/004266 GB2005004266W WO2006048665A3 WO 2006048665 A3 WO2006048665 A3 WO 2006048665A3 GB 2005004266 W GB2005004266 W GB 2005004266W WO 2006048665 A3 WO2006048665 A3 WO 2006048665A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sarsapogenin
- polymorphs
- sarsasapogenin
- solvated
- crystalline
- Prior art date
Links
- GMBQZIIUCVWOCD-WWASVFFGSA-N Sarsapogenine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@H]4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 GMBQZIIUCVWOCD-WWASVFFGSA-N 0.000 title abstract 5
- RTMWIZOXNKJHRE-UHFFFAOYSA-N Tigogenin Natural products CC1COC2CC(C)(OC12)C3CCC4C5CCC6CC(O)CCC6(C)C5CCC34C RTMWIZOXNKJHRE-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Virology (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007005473A MX2007005473A (es) | 2004-11-05 | 2005-11-04 | Compuestos quimicos. |
US11/667,035 US20080194530A1 (en) | 2004-11-05 | 2005-11-04 | Chemical Compounds |
CA002584676A CA2584676A1 (fr) | 2004-11-05 | 2005-11-04 | Composes chimiques |
JP2007539637A JP2008519020A (ja) | 2004-11-05 | 2005-11-04 | サルササポゲニンの多形相 |
EP05799915A EP1809650A2 (fr) | 2004-11-05 | 2005-11-04 | Polymorphes de la sarsapogenine |
BRPI0517648-4A BRPI0517648A (pt) | 2004-11-05 | 2005-11-04 | compostos quìmicos |
AU2005300348A AU2005300348A1 (en) | 2004-11-05 | 2005-11-04 | Polymorphs of sarsapogenin |
RU2007119611/04A RU2007119611A (ru) | 2004-11-05 | 2005-11-04 | Полиморфы сарсасапогенина |
CN200580037705XA CN101068827B (zh) | 2004-11-05 | 2005-11-04 | 萨洒皂草配基的多晶型物 |
IL182879A IL182879A0 (en) | 2004-11-05 | 2007-04-30 | Polymorphs of sarsapogenin |
NO20072794A NO20072794L (no) | 2004-11-05 | 2007-06-01 | Kjemiske forbindelser |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0424528A GB0424528D0 (en) | 2004-11-05 | 2004-11-05 | Chemical compounds |
GB0424528.8 | 2004-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006048665A2 WO2006048665A2 (fr) | 2006-05-11 |
WO2006048665A3 true WO2006048665A3 (fr) | 2006-09-08 |
Family
ID=33523268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2005/004266 WO2006048665A2 (fr) | 2004-11-05 | 2005-11-04 | Composes chimiques |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080194530A1 (fr) |
EP (2) | EP1809650A2 (fr) |
JP (1) | JP2008519020A (fr) |
KR (1) | KR20070089798A (fr) |
CN (2) | CN101068827B (fr) |
AU (1) | AU2005300348A1 (fr) |
BR (1) | BRPI0517648A (fr) |
CA (1) | CA2584676A1 (fr) |
GB (1) | GB0424528D0 (fr) |
IL (1) | IL182879A0 (fr) |
MX (1) | MX2007005473A (fr) |
NO (1) | NO20072794L (fr) |
RU (1) | RU2007119611A (fr) |
SG (1) | SG158068A1 (fr) |
TW (1) | TW200635941A (fr) |
WO (1) | WO2006048665A2 (fr) |
ZA (1) | ZA200703630B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012515754A (ja) | 2009-01-24 | 2012-07-12 | ファイトファーム ピーエルシー | 神経栄養因子介在疾患の治療 |
SG187090A1 (en) | 2010-07-20 | 2013-02-28 | Phytopharm Plc | Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders |
JP5881525B2 (ja) * | 2011-05-16 | 2016-03-09 | ライオン株式会社 | サポゲニン安定化組成物の製造方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2306635A (en) * | 1940-08-03 | 1942-12-29 | Parke Davis & Co | Method for the preparation of steroidal carbinols |
US2408827A (en) * | 1944-05-15 | 1946-10-08 | Parke Davis & Co | Steroidal compounds and methods for obtaining the same |
US2774714A (en) * | 1952-10-10 | 1956-12-18 | Emanuel B Hershberg | Process for the extraction of sapogenins from plant materials |
US3019220A (en) * | 1958-07-17 | 1962-01-30 | Julian Lab Inc | Isolation of sapogenins |
US4057543A (en) * | 1976-07-01 | 1977-11-08 | G. D. Searle & Co. | Process for the preparation of 17β-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone |
EP0204661A2 (fr) * | 1985-06-05 | 1986-12-10 | Progenics, Inc. | Compositions contenant des sapogénines pour le traitement de l'obésité et diabète |
CN1096031C (zh) * | 1996-12-23 | 2002-12-11 | 三星电子株式会社 | 打印头喷嘴间距的补偿装置和方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04230696A (ja) * | 1990-12-28 | 1992-08-19 | Sanwa Shiyouyaku Kk | 新規なステロイド系化合物および制癌剤 |
CN1033754C (zh) * | 1993-05-31 | 1997-01-08 | 上海第二医科大学 | 知母皂甙元作为制备β肾上腺素和M胆碱受体双向调节药的用途及其制法 |
KR100632052B1 (ko) | 1998-03-26 | 2006-10-04 | 파이토팜 피엘씨 | 알츠하이머병을 치료하기 위한 스테로이드계 사포게닌 및 이의 유도체 |
GB9923076D0 (en) | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
AT409100B (de) | 2000-07-24 | 2002-05-27 | Evg Entwicklung Verwert Ges | Vorrichtung zum schweissen einer drahtgittermatte |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
CN1642558B (zh) * | 2002-03-27 | 2012-05-30 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
-
2004
- 2004-11-05 GB GB0424528A patent/GB0424528D0/en not_active Ceased
-
2005
- 2005-11-04 SG SG200907351-1A patent/SG158068A1/en unknown
- 2005-11-04 CN CN200580037705XA patent/CN101068827B/zh not_active Expired - Fee Related
- 2005-11-04 EP EP05799915A patent/EP1809650A2/fr not_active Withdrawn
- 2005-11-04 EP EP11155897.9A patent/EP2479183A3/fr not_active Withdrawn
- 2005-11-04 CA CA002584676A patent/CA2584676A1/fr not_active Abandoned
- 2005-11-04 RU RU2007119611/04A patent/RU2007119611A/ru not_active Application Discontinuation
- 2005-11-04 MX MX2007005473A patent/MX2007005473A/es unknown
- 2005-11-04 TW TW094138749A patent/TW200635941A/zh unknown
- 2005-11-04 AU AU2005300348A patent/AU2005300348A1/en not_active Abandoned
- 2005-11-04 KR KR1020077012720A patent/KR20070089798A/ko not_active Withdrawn
- 2005-11-04 JP JP2007539637A patent/JP2008519020A/ja active Pending
- 2005-11-04 CN CN2011100921741A patent/CN102219826A/zh active Pending
- 2005-11-04 WO PCT/GB2005/004266 patent/WO2006048665A2/fr active Application Filing
- 2005-11-04 US US11/667,035 patent/US20080194530A1/en not_active Abandoned
- 2005-11-04 BR BRPI0517648-4A patent/BRPI0517648A/pt not_active IP Right Cessation
-
2007
- 2007-04-30 IL IL182879A patent/IL182879A0/en unknown
- 2007-05-04 ZA ZA200703630A patent/ZA200703630B/xx unknown
- 2007-06-01 NO NO20072794A patent/NO20072794L/no not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2306635A (en) * | 1940-08-03 | 1942-12-29 | Parke Davis & Co | Method for the preparation of steroidal carbinols |
US2408827A (en) * | 1944-05-15 | 1946-10-08 | Parke Davis & Co | Steroidal compounds and methods for obtaining the same |
US2774714A (en) * | 1952-10-10 | 1956-12-18 | Emanuel B Hershberg | Process for the extraction of sapogenins from plant materials |
US3019220A (en) * | 1958-07-17 | 1962-01-30 | Julian Lab Inc | Isolation of sapogenins |
US4057543A (en) * | 1976-07-01 | 1977-11-08 | G. D. Searle & Co. | Process for the preparation of 17β-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone |
EP0204661A2 (fr) * | 1985-06-05 | 1986-12-10 | Progenics, Inc. | Compositions contenant des sapogénines pour le traitement de l'obésité et diabète |
CN1096031C (zh) * | 1996-12-23 | 2002-12-11 | 三星电子株式会社 | 打印头喷嘴间距的补偿装置和方法 |
Non-Patent Citations (12)
Title |
---|
CANDELA J L F ET AL: "NEUVA FUENTE DE SARSAPOGENINA NEW SOURCE OF SARSAPOGENIN", ANALES DE LA REAL SOCIEDAD ESPANOLA DE FISICA Y QUIMICA, SERIE B: QUIMICA, MADRID, ES, 1951, pages 309 - 311, XP008043213, ISSN: 0034-088X * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RABASSA, ROGER ET AL: "Sarsapogenin. Extraction from asparagus", XP002318343, retrieved from STN Database accession no. 1954:25095 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YI, NINGYU ET AL: "Extraction of .beta.-adrenergic receptor- and M cholinergic receptor-regulating (.beta.,5.beta.,25s)-spirostan-3-ol from Anemarrhena asphodeloides Bunge", XP002369130, retrieved from STN Database accession no. 1995:881491 * |
DING ET AL: "Study on the Yin-tonic component of the Chinese herb Zhimu: sarsasapogenin", CAPLUS, 1991, XP002157712 * |
J. SIMPSON ET AL: "SARSASAPOGENIN. ii.", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), vol. 109, 1935, USAMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., pages 573 - 584, XP002318340 * |
MARKER R E ET AL: "Steroidal Sapogenins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 69, no. 9, 25 September 1947 (1947-09-25), pages 2167 - 2230, XP002157706, ISSN: 0002-7863 * |
R. MARKER ET AL: "Sterols. CVII. Steroidal Sapogenins of Aletris, Asparagus and Lilium", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 62, 1940, USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 2620 - 2621, XP002318341 * |
REV. ASOC. BIOQUIM. ARGENTINA ( 1953 ), 18, 33-4, 1953 * |
W. BEHER ET AL: "X-Ray Difffraction Powder Data for the Steroids", ANALYTICAL CHEMISTRY., vol. 27, no. 10, 1955, USAMERICAN CHEMICAL SOCIETY. COLUMBUS., pages 1569 - 1573, XP002318342 * |
WALL M E ET AL: "Steroidal Sapogenins. XXVII. Preparation and Properties of 20-Isosapogenins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 77, 1955, pages 5661 - 5665, XP002293039, ISSN: 0002-7863 * |
WAWER I ET AL: "13C cross-polarization MAS NMR study of some steroidal sapogenins.", SOLID STATE NUCLEAR MAGNETIC RESONANCE. 2001 AUG-SEP, vol. 20, no. 1-2, August 2001 (2001-08-01), pages 35 - 45, XP002388162, ISSN: 0926-2040 * |
YI N ET AL: "Sarsasapogenin: Mechanism in treating senile dementia", SYNTHESIS AND APPLICATIONS OF ISOTOPICALLY LABELLED COMPOUNDS, XX, XX, 14 September 1997 (1997-09-14), pages 315 - 320, XP002117140 * |
Also Published As
Publication number | Publication date |
---|---|
GB0424528D0 (en) | 2004-12-08 |
CN101068827A (zh) | 2007-11-07 |
EP1809650A2 (fr) | 2007-07-25 |
IL182879A0 (en) | 2007-08-19 |
CN102219826A (zh) | 2011-10-19 |
KR20070089798A (ko) | 2007-09-03 |
CA2584676A1 (fr) | 2006-05-11 |
EP2479183A3 (fr) | 2013-08-28 |
AU2005300348A1 (en) | 2006-05-11 |
BRPI0517648A (pt) | 2008-10-14 |
MX2007005473A (es) | 2007-05-24 |
ZA200703630B (en) | 2009-10-28 |
US20080194530A1 (en) | 2008-08-14 |
TW200635941A (en) | 2006-10-16 |
JP2008519020A (ja) | 2008-06-05 |
EP2479183A2 (fr) | 2012-07-25 |
NO20072794L (no) | 2007-07-31 |
RU2007119611A (ru) | 2008-12-10 |
WO2006048665A2 (fr) | 2006-05-11 |
SG158068A1 (en) | 2010-01-29 |
CN101068827B (zh) | 2011-06-08 |
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