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WO2005117847A3 - Methods and compounds for the treatment of neoplasms - Google Patents

Methods and compounds for the treatment of neoplasms Download PDF

Info

Publication number
WO2005117847A3
WO2005117847A3 PCT/US2005/019324 US2005019324W WO2005117847A3 WO 2005117847 A3 WO2005117847 A3 WO 2005117847A3 US 2005019324 W US2005019324 W US 2005019324W WO 2005117847 A3 WO2005117847 A3 WO 2005117847A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
neoplasms
treatment
methods
neoplasm
Prior art date
Application number
PCT/US2005/019324
Other languages
French (fr)
Other versions
WO2005117847A2 (en
Inventor
Curtis Keith
Margaret S Lee
Michael A Foley
Brent R Stockwell
Original Assignee
Combinatorx Inc
Curtis Keith
Margaret S Lee
Michael A Foley
Brent R Stockwell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc, Curtis Keith, Margaret S Lee, Michael A Foley, Brent R Stockwell filed Critical Combinatorx Inc
Publication of WO2005117847A2 publication Critical patent/WO2005117847A2/en
Publication of WO2005117847A3 publication Critical patent/WO2005117847A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention features compounds of 'formula (I) and their use in preparing 'medicaments for treating a patient having a cancer or other neoplasm. R' R9 R8 R N R7
PCT/US2005/019324 2004-06-02 2005-06-01 Methods and compounds for the treatment of neoplasms WO2005117847A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57617504P 2004-06-02 2004-06-02
US60/576,175 2004-06-02

Publications (2)

Publication Number Publication Date
WO2005117847A2 WO2005117847A2 (en) 2005-12-15
WO2005117847A3 true WO2005117847A3 (en) 2006-01-12

Family

ID=35033330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/019324 WO2005117847A2 (en) 2004-06-02 2005-06-01 Methods and compounds for the treatment of neoplasms

Country Status (1)

Country Link
WO (1) WO2005117847A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS394634B1 (en) * 1960-03-17 1964-04-16
FR8293M (en) * 1967-06-01 1970-11-16
GB1602110A (en) * 1977-04-21 1981-11-04 Lafon Labor Acetamidoxime derivatives
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS394634B1 (en) * 1960-03-17 1964-04-16
FR8293M (en) * 1967-06-01 1970-11-16
GB1602110A (en) * 1977-04-21 1981-11-04 Lafon Labor Acetamidoxime derivatives
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALBRECHT, B. ET AL: "Phenothiazine derivatives. 17. Conversion of [2- or 3-methylphenothiazin-10-yl]propionic acid hydrazides to heterocycles", PHARMAZIE , 27(5), 282-7 CODEN: PHARAT; ISSN: 0031-7144, 1972, XP002348695 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1964, NAKANISHI: "Phenothiazine derivatives", XP002348698, retrieved from STN Database accession no. 1964:432490 *
GODEFROI, ERIK F. ET AL: "Preparation of some derivatives of .beta.-(10- phenothiazinyl)propionic acid and .beta.-(2-chloro-10- phenothiazinyl)propionic acid", JOURNAL OF ORGANIC CHEMISTRY , 21, 1163-8 CODEN: JOCEAH; ISSN: 0022-3263, 1956, XP002348696 *
RAJASEKARAN A ET AL: "Synthesis and analgesic evaluation of some 5-[beta-(10-phenothiazinyl )ethyl]-1-(acyl)-1,2,3,4-tetrazoles", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 39, no. 3, March 2004 (2004-03-01), pages 273 - 279, XP004499763, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
WO2005117847A2 (en) 2005-12-15

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