+

WO2005037204A3 - Ntrk1 genetic markers associated with age of onset of alzheimer's disease - Google Patents

Ntrk1 genetic markers associated with age of onset of alzheimer's disease Download PDF

Info

Publication number
WO2005037204A3
WO2005037204A3 PCT/US2004/033689 US2004033689W WO2005037204A3 WO 2005037204 A3 WO2005037204 A3 WO 2005037204A3 US 2004033689 W US2004033689 W US 2004033689W WO 2005037204 A3 WO2005037204 A3 WO 2005037204A3
Authority
WO
WIPO (PCT)
Prior art keywords
onset
age
ntrk1
alzheimer
disease
Prior art date
Application number
PCT/US2004/033689
Other languages
French (fr)
Other versions
WO2005037204A2 (en
Inventor
Jeroen Aerssens
Maria Athanasiou
Carlos Brain
Nadine Cohen
Bradley Dain
R Rex Denton
Richard S Judson
Vural Ozdemir
Carol R Reed
Original Assignee
Genaissance Pharmaceuticals
Jeroen Aerssens
Maria Athanasiou
Carlos Brain
Nadine Cohen
Bradley Dain
R Rex Denton
Richard S Judson
Vural Ozdemir
Carol R Reed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Jeroen Aerssens, Maria Athanasiou, Carlos Brain, Nadine Cohen, Bradley Dain, R Rex Denton, Richard S Judson, Vural Ozdemir, Carol R Reed filed Critical Genaissance Pharmaceuticals
Priority to CA002542629A priority Critical patent/CA2542629A1/en
Priority to AU2004281738A priority patent/AU2004281738A1/en
Priority to JP2006535607A priority patent/JP2007510404A/en
Priority to EP04794919A priority patent/EP1678328A4/en
Publication of WO2005037204A2 publication Critical patent/WO2005037204A2/en
Publication of WO2005037204A3 publication Critical patent/WO2005037204A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Haplotypes in the NTRK1 gene associated with age of onset of Alzheimer’s Disease are disclosed. Compositions and methods for detecting and using these NTRK1 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these NTRK1 haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.
PCT/US2004/033689 2003-10-15 2004-10-14 Ntrk1 genetic markers associated with age of onset of alzheimer's disease WO2005037204A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002542629A CA2542629A1 (en) 2003-10-15 2004-10-14 Ntrk1 genetic markers associated with age of onset of alzheimer's disease
AU2004281738A AU2004281738A1 (en) 2003-10-15 2004-10-14 NTRK1 genetic markers associated with age of onset of Alzheimer's Disease
JP2006535607A JP2007510404A (en) 2003-10-15 2004-10-14 NTRK1 gene marker associated with age of onset of Alzheimer's disease
EP04794919A EP1678328A4 (en) 2003-10-15 2004-10-14 Ntrk1 genetic markers associated with age of onset of alzheimer's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51124703P 2003-10-15 2003-10-15
US60/511,247 2003-10-15

Publications (2)

Publication Number Publication Date
WO2005037204A2 WO2005037204A2 (en) 2005-04-28
WO2005037204A3 true WO2005037204A3 (en) 2006-05-04

Family

ID=34465204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033689 WO2005037204A2 (en) 2003-10-15 2004-10-14 Ntrk1 genetic markers associated with age of onset of alzheimer's disease

Country Status (6)

Country Link
US (1) US20050255488A1 (en)
EP (1) EP1678328A4 (en)
JP (1) JP2007510404A (en)
AU (1) AU2004281738A1 (en)
CA (1) CA2542629A1 (en)
WO (1) WO2005037204A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1709058A4 (en) * 2003-11-24 2008-01-02 Pgxhealth Llc Ntrk1 genetic markers associated with progression of alzheimer's disease
US20050255495A1 (en) * 2003-12-15 2005-11-17 Genaissance Pharmaceuticals SLC5A7 genetic markers associated with age of onset of Alzheimer's disease
US20060154265A1 (en) * 2004-01-22 2006-07-13 Genaissance Pharmaceuticals LDLR genetic markers associated with age of onset of Alzheimer's Disease
US20050277129A1 (en) * 2004-01-22 2005-12-15 Genaissance Pharmaceuticals APOE genetic markers associated with age of onset of Alzheimer's disease
WO2005072152A2 (en) * 2004-01-22 2005-08-11 Genaissance Pharmaceuticals, Inc. Apoc1 genetic markers associated with age of onset of alzheimer's disease
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225069B1 (en) * 2000-02-29 2001-05-01 The Board Of Trustees Of The University Of Arkansas Methods to identify genetic predisposition to alzheimer's disease
US20020128255A1 (en) * 2000-06-30 2002-09-12 Beck James P. Compounds to treat alzheimer's disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990078A (en) * 1995-07-14 1999-11-23 The Trustees Of Columbia University In The City Of New York Means of increasing estrogen receptor levels in neural tissue
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
EP1456668B1 (en) * 2001-12-05 2007-05-02 Sense Proteomic Limited Protein arrays for allelic variants and uses thereof
US20040267458A1 (en) * 2001-12-21 2004-12-30 Judson Richard S. Methods for obtaining and using haplotype data
EP1709058A4 (en) * 2003-11-24 2008-01-02 Pgxhealth Llc Ntrk1 genetic markers associated with progression of alzheimer's disease
US20050255495A1 (en) * 2003-12-15 2005-11-17 Genaissance Pharmaceuticals SLC5A7 genetic markers associated with age of onset of Alzheimer's disease
US20060154265A1 (en) * 2004-01-22 2006-07-13 Genaissance Pharmaceuticals LDLR genetic markers associated with age of onset of Alzheimer's Disease
US20050277129A1 (en) * 2004-01-22 2005-12-15 Genaissance Pharmaceuticals APOE genetic markers associated with age of onset of Alzheimer's disease
WO2005072152A2 (en) * 2004-01-22 2005-08-11 Genaissance Pharmaceuticals, Inc. Apoc1 genetic markers associated with age of onset of alzheimer's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225069B1 (en) * 2000-02-29 2001-05-01 The Board Of Trustees Of The University Of Arkansas Methods to identify genetic predisposition to alzheimer's disease
US20020128255A1 (en) * 2000-06-30 2002-09-12 Beck James P. Compounds to treat alzheimer's disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1678328A4 *

Also Published As

Publication number Publication date
EP1678328A2 (en) 2006-07-12
EP1678328A4 (en) 2008-01-02
AU2004281738A1 (en) 2005-04-28
CA2542629A1 (en) 2005-04-28
US20050255488A1 (en) 2005-11-17
WO2005037204A2 (en) 2005-04-28
JP2007510404A (en) 2007-04-26

Similar Documents

Publication Publication Date Title
WO2004011625A3 (en) Polymorphisms for predicting disease and treatment outcome
WO2007016367A3 (en) Neoplastic disease-related methods, kits, systems and databases
WO2006012361A3 (en) Genetic markers for predicting disease and treatment outcome
WO2005072151A3 (en) Apoe genetic markers associated with age of onset of alzheimer's disease
BR9811441A (en) Protection method to identify individuals at risk of developing diseases associated with different polymorphic forms of natural type p53
WO2006125830A3 (en) Kcnn3 as diagnostic and therapeutic target for neurodegenerative diseases
WO2004047767A3 (en) Methods for identifying risk of breast cancer and treatments thereof
WO2006099259A3 (en) Novel missense mutations and single nucleotide polymorphisms in the rabphillin-3a-like gene and uses thereof
WO2005037204A3 (en) Ntrk1 genetic markers associated with age of onset of alzheimer's disease
WO2005059105A3 (en) Cdk5 genetic markers associated with galantamine response
WO2005072152A3 (en) Apoc1 genetic markers associated with age of onset of alzheimer's disease
WO2005080594A3 (en) Method for determining the risk of developing a neurological disease
WO2005059104A3 (en) Slc5a7 genetic markers associated with age of onset of alzheimer's disease
WO2005072150A3 (en) Ldlr genetic markers associated with age of onset of alzheimer's disease
WO2007095287A3 (en) Protective complement proteins and age-related macular degeneration
WO2003054143A3 (en) Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
WO2000058510A3 (en) Schizophrenia associated genes, proteins and biallelic markers
WO2005042706A3 (en) Ephx2 genetic markers associated with galantamine response
WO2005042762A3 (en) Lrpap1 genetic markers associated with galantamine response
WO2005085473A3 (en) Polymorphisms in the epidermal growth factor receptor gene promoter
WO2005021796A3 (en) Chrna2 genetic markers associated with galantamine response
WO2005052180A3 (en) Ntrk1 genetic markers associated with progression of alzheimer’s disease
WO2004033710A3 (en) Itgb3 gene haplotypes and atorvastatin dose effects on hdl cholesterol
WO2008052016A3 (en) The sortilin-related receptor sorl1 is functionally and genetically associated with alzheimer's disease
WO2006063703A3 (en) Single nucleotide polymorphism (snp) associated to type ii diabetes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2542629

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006535607

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004281738

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2004794919

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2004281738

Country of ref document: AU

Date of ref document: 20041014

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004281738

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2004794919

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载