WO2005025575A1 - Solution de protection destinee a etre utilisee dans des traitements oculaires - Google Patents
Solution de protection destinee a etre utilisee dans des traitements oculaires Download PDFInfo
- Publication number
- WO2005025575A1 WO2005025575A1 PCT/DE2003/002959 DE0302959W WO2005025575A1 WO 2005025575 A1 WO2005025575 A1 WO 2005025575A1 DE 0302959 W DE0302959 W DE 0302959W WO 2005025575 A1 WO2005025575 A1 WO 2005025575A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- eye
- protective solution
- substances
- protective
- used during
- Prior art date
Links
- 230000001681 protective effect Effects 0.000 title claims abstract description 27
- 238000011282 treatment Methods 0.000 title claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 18
- 230000005855 radiation Effects 0.000 claims abstract description 15
- 239000006096 absorbing agent Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 description 17
- 238000001356 surgical procedure Methods 0.000 description 8
- 210000001525 retina Anatomy 0.000 description 6
- 210000004087 cornea Anatomy 0.000 description 5
- 208000010412 Glaucoma Diseases 0.000 description 3
- 210000002159 anterior chamber Anatomy 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- 206010057430 Retinal injury Diseases 0.000 description 2
- 208000008516 Capsule Opacification Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000001722 carbon compounds Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Definitions
- the invention relates to a protective solution, in particular a viscoelastic or a rinsing liquid, for use in eye treatments and eye operations.
- protective solutions in particular viscoelastics or rinsing liquids, are used which, for. B. are applied to the cornea of the eye or - as is usually the case - during the implantation of an intraocular lens as a rinsing liquid, pumped into the anterior chamber of the eye and sucked out of it again.
- the invention has for its object to provide a way in which any damage to the retina can be prevented even during long operations on the eye.
- the protective solution has substances which at least partially filter out specific frequency ranges from light radiation which penetrates the protective solution and enters the eye.
- the light radiation can e.g. B. the radiation of a bright microscope or a treatment laser.
- the invention provides the possibility of filtering out radiation of different specific wavelengths from the visible as well as from the invisible components of the light, which are the cause of retinal damage. This results in the possibility of improving the viscoelastic agents or rinsing liquids that are usually used in eye treatments or eye operations, so that damage to the eye is avoided. Such a possibility was previously not available in ophthalmic surgery of the fundus, therapeutically oriented cataract surgery, glaucoma surgery or refractive surgery.
- the protective solutions are mixed with absorber substances which, depending on the use or application filter out unwanted light radiation during the corresponding operation.
- protective solutions according to the invention can be used to filter out light radiation which is in the UV or also in the IR range.
- the absorber substances must of course be physiologically biocompatible; in particular, they should be designed so that they are attached to the carrier of the protective solution, for.
- a viscoelastic such as methyl cellulose or a sterilized physiological saline are bound so that they can be completely removed with this carrier after the end of eye treatment or eye surgery.
- the invention can e.g. B. used in glaucoma surgery.
- the eye lens must be protected from the relatively long-wave UV rays of an excimer laser that radiates in the range of 308 nm, since these can induce a so-called secondary cataract.
- the trabecular mechanism which is a filter fabric between the Schlemmsch 'canal and the anterior chamber, is removed by means of a laser probe.
- a protective solution e.g. B. washed into the anterior chamber of the eye, damage to the retina can be avoided in glaucoma surgery.
- This protective solution can also be used for laser trepanation of the cornea, the protective solution then being applied to the cornea. After a trepanation The natural protection by the cornea is eliminated, so that the eye lens is intensively exposed to the light radiation of the laser, in this case UV light radiation.
- a protective solution according to the invention can also be used in various operations on the posterior pole of the eye. It is important to specifically suppress heat-transporting light radiation, i.e. radiation that is also effective in the IR range.
- UV absorber substances can be used that are physiologically compatible, i.e. H. are biocompatible; they should also enter into bonds with the carrier substances of the protective solutions, which ensure coupling of the absorber with the carrier substance, so that the absorber substances do not settle in the protective solution and the absorber substance together with the protective solution after the end of the eye treatment or eye operation can be removed.
- Dervates of benzophenone are suitable as absorber substances, in particular for the UV range.
- Other absorbers for specific frequency ranges are known to the person skilled in the art, so z.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Materials For Medical Uses (AREA)
Abstract
Solution de protection, en particulier substance viscoélastique ou liquide de rinçage, destinée à être utilisée dans des traitements oculaires ou lors d'opérations des yeux, qui contient, selon la présente invention, des substances éliminant tout au moins partiellement par filtrage les plages de fréquence spécifiques d'un rayonnement lumineux traversant ladite solution de protection et incident sur l'oeil. A cet effet, les substances absorbantes sont sélectionnées de manière à agir dans la plage des UV.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DE2003/002959 WO2005025575A1 (fr) | 2003-09-04 | 2003-09-04 | Solution de protection destinee a etre utilisee dans des traitements oculaires |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DE2003/002959 WO2005025575A1 (fr) | 2003-09-04 | 2003-09-04 | Solution de protection destinee a etre utilisee dans des traitements oculaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2005025575A1 true WO2005025575A1 (fr) | 2005-03-24 |
Family
ID=34305466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/DE2003/002959 WO2005025575A1 (fr) | 2003-09-04 | 2003-09-04 | Solution de protection destinee a etre utilisee dans des traitements oculaires |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2005025575A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008046933A1 (fr) | 2006-10-16 | 2008-04-24 | Universidad Complutense De Madrid | Dispositif d'éclairage équipé d'un filtre thérapeutique et préventif pour des yeux sains, pseudo-aphaques et/ou subissant un processus de neurodégénérescence |
| WO2008096020A1 (fr) | 2007-02-07 | 2008-08-14 | Universidad Complutense De Madrid Rectorado | Source d'éclairage qui permet de réduire l'émission de longueurs d'onde courte pour protéger les yeux |
| US7832903B2 (en) | 2006-11-07 | 2010-11-16 | Universidad Complutense De Madrid | Illumination system fitted with a therapeutic/prophylactic filter for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration |
| US7914177B2 (en) | 2006-11-07 | 2011-03-29 | Universidad Complutense De Madrid | Prophylaxic/therapeutic vehicle filter component for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686099A (en) * | 1985-12-10 | 1987-08-11 | Victor Palinczar | Aerosol waterproof sunscreen compositions |
| US4788007A (en) * | 1986-11-28 | 1988-11-29 | Baron Neville A | Ophthalmic U.V. absorptive emollient |
| US4853374A (en) * | 1987-06-09 | 1989-08-01 | M.D.R. Group, Inc. | Viscoelastic vitreous substitute with UV blocker |
| EP0356355A1 (fr) * | 1988-08-22 | 1990-02-28 | Neville A. Baron | Liquide ophtalmique pour lunettes de soleil |
-
2003
- 2003-09-04 WO PCT/DE2003/002959 patent/WO2005025575A1/fr unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686099A (en) * | 1985-12-10 | 1987-08-11 | Victor Palinczar | Aerosol waterproof sunscreen compositions |
| US4788007A (en) * | 1986-11-28 | 1988-11-29 | Baron Neville A | Ophthalmic U.V. absorptive emollient |
| US5041244A (en) * | 1986-11-28 | 1991-08-20 | Liquid Sunglasses Corporation | Ophthalmic liquid sunglasses |
| US4853374A (en) * | 1987-06-09 | 1989-08-01 | M.D.R. Group, Inc. | Viscoelastic vitreous substitute with UV blocker |
| EP0356355A1 (fr) * | 1988-08-22 | 1990-02-28 | Neville A. Baron | Liquide ophtalmique pour lunettes de soleil |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008046933A1 (fr) | 2006-10-16 | 2008-04-24 | Universidad Complutense De Madrid | Dispositif d'éclairage équipé d'un filtre thérapeutique et préventif pour des yeux sains, pseudo-aphaques et/ou subissant un processus de neurodégénérescence |
| US7832903B2 (en) | 2006-11-07 | 2010-11-16 | Universidad Complutense De Madrid | Illumination system fitted with a therapeutic/prophylactic filter for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration |
| US7914177B2 (en) | 2006-11-07 | 2011-03-29 | Universidad Complutense De Madrid | Prophylaxic/therapeutic vehicle filter component for healthy eyes, pseudoaphakic eyes or eyes suffering neurodegeneration |
| WO2008096020A1 (fr) | 2007-02-07 | 2008-08-14 | Universidad Complutense De Madrid Rectorado | Source d'éclairage qui permet de réduire l'émission de longueurs d'onde courte pour protéger les yeux |
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