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WO2005013975A1 - Derives d'indolamide possedant une activite inhibitrice de la glycogene phosphorylase - Google Patents

Derives d'indolamide possedant une activite inhibitrice de la glycogene phosphorylase Download PDF

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Publication number
WO2005013975A1
WO2005013975A1 PCT/GB2004/003364 GB2004003364W WO2005013975A1 WO 2005013975 A1 WO2005013975 A1 WO 2005013975A1 GB 2004003364 W GB2004003364 W GB 2004003364W WO 2005013975 A1 WO2005013975 A1 WO 2005013975A1
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Prior art keywords
alkyl
hydroxy
formula
independently selected
optionally substituted
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PCT/GB2004/003364
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English (en)
Inventor
Alan Martin Birch
Stuart Norman Lile Bennett
Linda Godfrey
Iain Simpson
Paul Robert Owen Whittamore
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Astrazeneca Ab
Astrazeneca Uk Limited
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Application filed by Astrazeneca Ab, Astrazeneca Uk Limited filed Critical Astrazeneca Ab
Priority to DE602004017748T priority Critical patent/DE602004017748D1/de
Priority to JP2006522398A priority patent/JP2007501780A/ja
Priority to EP04743655A priority patent/EP1658067B1/fr
Priority to US10/566,068 priority patent/US20060211760A1/en
Publication of WO2005013975A1 publication Critical patent/WO2005013975A1/fr
Priority to HK06110761.0A priority patent/HK1089965A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the present invention relates to heterocyclic amide derivatives, pharmaceutically acceptable salts and in- vivo hydrolysable esters thereof.
  • These heterocyclic amide possess 5 glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity and thus are potentially useful in methods of treatment of a warm-blooded animal such as man.
  • the invention also relates to processes for the manufacture of said heterocyclic amide derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of 10 medicaments to inhibit glycogen phosphorylase activity in a warm-blooded animal such as man.
  • the liver is the major organ regulating glycaemia in the post-absorptive state.
  • HGO hepatic glucose output
  • Glycogen phosphorylase is a key enzyme in the generation by glycogenolysis of glucose- 1 -phosphate, and hence glucose in liver and also in other tissues 30 such as muscle and neuronal tissue. Liver glycogen phosphorylase a activity is elevated in diabetic animal models including the db/db mouse and the fa/fa rat (Aiston S et al (2000). Diabetalogia 43, 589-597)!
  • heterocyclic amides of the present invention possess glycogen phosphorylase inhibitory activity and accordingly are expected to be of use in the treatment of type 2 diabetes, insulin resistance, syndrome X, hyperinsulinaemia, hyperglucagonaemia, cardiac ischaemia and obesity, particularly type 2 diabetes.
  • A is phenylene or heteroarylene; n is 0, 1 or 2; m is 0, 1 or 2; R 1 is independently selected from halo, nitro, cyano, hydroxy, carboxy, carbamoyl, iV-(l-4C)alkylcarbamoyl, N,N-((l-4C)alkyl) 2 carbamoyl, sulphamoyl, N-(l- 4C)alkylsulphamoyl, N,N-((l-4C)alkyl) 2 sulphamoyl, -S(O) b (l-4C)alkyl (wherein b is 0,l,or 2), -OS(O) 2 (l-4C)alkyl, (l-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (l-4C)alkoxy, (1- 4C)alkanoyl, (l-4C)alkanoyloxy, hydroxy(l-4
  • R 4 is independently selected from halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, carboxy, carbamoyl, (l-4C)alkyl, (2-4C)alkenyl, (2- 4C)alkynyl, (l-4C)alkoxy and (l-4C)alkanoyl; r is 1 or 2; and when r is 1 the group
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl, (2-4C)alkenyl, (l-4C)alkoxy, cyano(l-4C)alkyl, amino(l-4C)alkyl [optionally substituted on nitrogen by 1 or 2 groups selected from (l-4C)alkyl, hydroxy, hydroxy(l-4C)alkyl, dihydroxy(l-4C)alkyl, -CO 2 (l-4C)alkyl, aryl and aryl(l-4C)alkyl], halo(l-4C)alkyl, dihalo(l- 4C)alkyl, trihalo(l-4C)alkyl, hydroxy(l-4C)alkyl, dihydroxy(l-4C)alkyl, (l-4C)alkoxy(l-4C)alkoxy, (l-4C)alkoxy(l-4C)alkyl, hydroxy(l-4C)alkoxy, 5- and 6- membered cyclic acetals and
  • R 9 , R 9' , R 10 and R 10 are independently selected from hydrogen, hydroxy, (l-4C)alkyl (optionally substituted by 1 or 2 R 11 ), (2-4C)alkenyl, (3-7C)cycloalkyl (optionally substituted by 1 or 2 hydroxy groups), cyano((l-4C))alkyl, trihalo(l-4C)alkyl, aryl, heterocyclyl, heterocyclyl(l-4C)alkyl, -CO 2 (l-4C)alkyl; or R 9 and R 10 together with the nitrogen to which they are attached, and/or R 9 and R 10 together with the nitrogen to which they are attached, form a 4- to 6-membered ring where the ring is optionally substituted on carbon by 1 or 2 substituents independently selected from oxo, hydroxy, carboxy, halo, nitro, cyano, carbonyl, (l-4C)alkoxy and heterocyclyl; or the ring may be optionally substituted on two
  • Y, R 3 , R 9 and R 10 (as defined hereinbefore or hereinafter) allows two hydroxy substituents on the alkyl or cycloalkyl group, or one hydroxy substituent and a second substituent linked by a heteroatom (for example alkoxy), then these two substituents are not substituents on the same carbon atom of the alkyl or cycloalkyl group.
  • the invention relates to compounds of formula (1) as hereinabove defined or to a pharmaceutically acceptable salt.
  • the invention relates to compounds of formula (1) as hereinabove defined or to a pro-drug thereof. Suitable examples of pro-drugs of compounds of formula (1) are in- vivo hydrolysable esters of compounds of formula (1).
  • the invention relates to compounds of formula (1) as hereinabove defined or to an in- vivo hydrolysable ester thereof. It is to be understood that, insofar as certain of the compounds of formula (1) defined above may exist in optically active or racemic forms by virtue of one or more asymmetric carbon atoms, the invention includes in its definition any such optically active or racemic form which possesses glycogen phosphorylase inhibition activity.
  • the synthesis of optically active forms may be carried out by standard techniques of organic chemistry well known in the art, for example by synthesis from optically active starting materials or by resolution of a racemic form. Similarly, the above-mentioned activity may be evaluated using the standard laboratory techniques referred to hereinafter.
  • a compound of the formula (1) or a salt thereof may exhibit the phenomenon of tautomerism and that the formulae drawings within this specification can represent only one of the possible tautomeric forms. It is to be understood that the invention encompasses any tautomeric form which has glycogen phosphorylase inhibition activity and is not to be limited merely to any one tautomeric form utilised within the formulae drawings.
  • the formulae drawings within this specification can represent only one of the possible tautomeric forms and it is to be understood that the specification encompasses all possible tautomeric forms of the compounds drawn not just those forms which it has been possible to show graphically herein.
  • certain compounds of the formula (1) and salts thereof can exist in solvated as well as unsolvated forms such as, for example, hydrated forms. It is to be understood that the invention encompasses all such solvated forms which have glycogen phosphorylase inhibition activity. It is also to be understood that certain compounds of the formula (1) may exhibit polymorphism, and that the invention encompasses all such forms which possess glycogen phosphorylase inhibition activity.
  • the present invention relates to the compounds of formula (1) as hereinbefore defined as well as to the salts thereof. Salts for use in pharmaceutical compositions will be pharmaceutically acceptable salts, but other salts may be useful in the production of the compounds of formula (1) and their pharmaceutically acceptable salts.
  • Pharmaceutically acceptable salts of the invention may, for example, include acid addition salts of the compounds of formula (1) as hereinbefore defined which are sufficiently basic to form such salts.
  • Such acid addition salts include for example salts with inorganic or organic acids affording pharmaceutically acceptable anions such as with hydrogen halides (especially hydrochloric or hydrobromic acid of which hydrochloric acid is particularly preferred) or with sulphuric or phosphoric acid, or with trifluoroacetic, citric or maleic acid.
  • Suitable salts include hydrochlorides, hydrobromides, phosphates, sulphates, hydrogen sulphates, alkylsulphonates, arylsulphonates, acetates, benzoates, citrates, maleates, fumarates, succinates, lactates and tartrates.
  • pharmaceutically acceptable salts may be formed with an inorganic or organic base which affords a pharmaceutically acceptable cation.
  • Such salts with inorganic or organic bases include for example an alkali metal salt, such as a sodium or potassium salt, an alkaline earth metal salt such as a calcium or magnesium salt, an ammonium salt or for example a salt with methylamine, dimethylamine, trimethylamine, piperidine, morpholine or tris-(2-hydroxyethyl)amine.
  • the compounds of the invention may be administered in the form of a pro-drug which is broken down in the human or animal body to give a compound of the invention.
  • a prodrug may be used to alter or improve the physical and/or pharmacokinetic profile of the parent compound and can be formed when the parent compound contains a suitable group or substituent which can be derivatised to form a prodrug.
  • pro-drugs examples include in- vivo hydrolysable esters of a compound of the invention or a pharmaceutically-acceptable salt thereof.
  • Various forms of prodrugs are known in the art, for examples see: a) Design of Prodrugs, edited by H. Bundgaard, (Elsevier, 1985) and Methods in Enzymology, Vol. 42, p. 309-396, edited by K. Widder, et al. (Academic Press, 1985); b) A Textbook of Drug Design and Development, edited by Krogsgaard-Larsen and H. Bundgaard, Chapter 5 "Design and Application of Prodrugs", by H. Bundgaard p. 113-191 (1991); c) H.
  • An in-vivo hydrolysable ester of a compound of formula (1) containing carboxy or hydroxy group is, for example.
  • Suitable pharmaceutically acceptable esters for carboxy include (l-6C)alkoxymethyl esters for example methoxymethyl, (l-6C)alkanoyloxymethyl esters for example pivaloyloxymethyl, phthalidyl esters, (3-8C)cycloalkoxycarbonyloxy(l-6C)alkyl esters for example 1-cyclohexylcarbonyloxyethyl; l,3-dioxolen-2-onylmethyl esters for example 5-methyl-l,3-dioxolen-2-onylmethyl; and (l-6C)alkoxycarbonyloxyethyl esters for example 1-methoxycarbonyloxyethyl and may be formed at any carboxy group in the compounds of this
  • Suitable pharmaceutically-acceptable esters for hydroxy include inorganic esters such as phosphate esters (including phosphoramidic cyclic esters) and -acyloxyalkyl ethers and related compounds which as a result of the in-vivo hydrolysis of the ester breakdown to give the parent hydroxy group/s.
  • inorganic esters such as phosphate esters (including phosphoramidic cyclic esters) and -acyloxyalkyl ethers and related compounds which as a result of the in-vivo hydrolysis of the ester breakdown to give the parent hydroxy group/s.
  • oc-acyloxyalkyl ethers include acetoxymethoxy and 2,2-dimethylpropionyloxymethoxy.
  • a selection of in-vivo hydrolysable ester forming groups for hydroxy include (l-lOC)alkanoyl, for example acetyl; benzoyl; phenylacetyl; substituted benzoyl and phenylacetyl, (l-lOC)alkoxycarbonyl (to give alkyl carbonate esters), for example ethoxycarbonyl; di-((l-4C))alkylcarbamoyl and N-(di-((l-4C))alkylaminoethyl)-N-((l- 4C))alkylcarbamoyl (to give carbamates); di-((l-4C))alkylaminoacetyl and carboxyacetyl.
  • (l-lOC)alkanoyl for example acetyl; benzoyl; phenylacetyl; substituted benzoyl and phenylacetyl, (l-lOC)alkoxy
  • ring substituents on phenylacetyl and benzoyl include aminomethyl, ((1- 4C))alkylaminomethyl and di-(((l-4C))alkyl)aminomethyl, and morpholino or piperazino linked from a ring nitrogen atom via a methylene linlcing group to the 3- or 4- position of the benzoyl ring.
  • Other interesting in-vivo hyrolysable esters include, for example, R A C(O)O(l- 6C)alkyl-CO-, wherein R A is for example, benzyloxy-((l-4C))alkyl, or phenyl).
  • Suitable substituents on a phenyl group in such esters include, for example, 4-((l-4C)alkyl)piperazino- (l-4C)alkyl, piperazino-(l-4C)alkyl and morpholino-(CrC )alkyl.
  • alkyl includes both straight-chain and branched-chain alkyl groups. However references to individual alkyl groups such as "propyl” are specific for the straight chain version only and references to individual branched-chain alkyl groups such as t-butyl are specific for the branched chain version only.
  • (1- 4C)alkyl includes methyl, ethyl, propyl, isopropyl and t-butyl and examples of “(l-6C)alkyl” include the examples of "(l-4C)alkyl”and additionally pentyl, 2,3-dimethylpropyl, 3- methylbutyl and hexyl.
  • (2-4C)alkenyl includes vinyl, allyl and 1-propenyl and examples of “(2-6C)alkenyl” include the examples of "(2-4C)alkenyl” and additionally 1-butenyl, 2-butenyl, 3-butenyl, 2- methylbut-2-enyl, 3-methylbut-l-enyl, 1-pentenyl, 3-pentenyl and 4-hexenyl.
  • Examples of "(2-4C)alkynyl” includes ethynyl, 1-propynyl and 2-propynyl and examples of "C 2 .
  • 6 alkynyl include the examples of "(2-4C)alkynyl” and additionally 3-butynyl, 2-pentynyl and 1 -methyl ⁇ ent-2-ynyl .
  • hydroxy(l-4C)alkyl includes hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxyisopropyl and hydroxybutyl.
  • hydroxyethyl includes 1- hydroxyethyl and 2-hydroxyethyl.
  • hydroxypropyl includes 1 -hydroxypropyl, 2- hydroxypropyl and 3 -hydroxypropyl and an analogous convention applies to terms such as hydroxybutyl.
  • dihydroxy(l-4C)alkyl includes dihydroxyethyl, dihydroxypropyl, dihydroxyisopropyl and dihydroxybutyl.
  • dihydroxypropyl includes 1,2- dihydroxypropyl and 1,3-dihydroxypropyl.
  • An analogous convention applies to terms such as dihydroxyisopropyl and dihydroxybutyl.
  • halo refers to fluoro, chloro, bromo and iodo.
  • dihalo(l- 4C)alkyl includes difluoromethyl and dichloromethyl.
  • trihalo(l-4C)alkyl includes trifluoromethyl.
  • Examples of "5- and 6-membered cyclic acetals and mono- and di-methyl derivatives thereof are: l,3-dioxolan-4-yl, 2-methyl-l,3-dioxolan-4-yl, 2,2-dimethyl-l,3-dioxolan-4-yl; 2,2- dimethyl-l,3-dioxan-4-yl; 2,2-dimethyl-l,3-dioxan-5-yl; l,3-dioxan-2-yl.
  • Examples of "(l-4C)alkoxy” and " -O(l-4C)alkyl” include methoxy, ethoxy, propoxy and isopropoxy.
  • Examples of "(l-6C)alkoxy” include the examples of “(l-4C)alkoxy” and additionally butyloxy, t-butyloxy, pentoxy and l,2-(methyl) 2 propoxy.
  • Examples of "(1- 4C)alkanoyl” include formyl, acetyl and propionyl.
  • Examples of "(l-6C)alkanoyl” include the example of “(l-4C)alkanoyl” and additionally butanoyl, pentanoyl, hexanoyl and 1,2- (methyl) 2 ⁇ ropionyl.
  • Examples of "(l-4C)alkanoyloxy” and -CO 2 (l-4C)alkyl include formyloxy, acetoxy and propionoxy.
  • Examples of "(l-6C)alkanoyloxy” include the examples of “(l-4C)alkanoyloxy” and additionally butanoyloxy, pentanoyloxy, hexanoyloxy and 1,2- (methyl) 2 propionyloxy.
  • Examples of "N-((l-4C)alkyl)amino" include methylamino and ethylamino.
  • N-((l-6C)alkyl)amino examples include the examples of “W-((l- 4C)alkyl)amino” and additionally pentylamino, hexylamino and 3-methylbutylamino.
  • Examples of "N,ZV-((l-4C)alkyl) 2 amino” include N-N-(methyl) 2 amino, N-N-(ethyl) 2 amino and N-ethyl-N-methylamino.
  • N,N-((l-6C)alkyl) 2 amino examples include the example of “N,N-((l-4C)alkyl) 2 amino” and additionally N-methyl-N-pentylamino and N,N- (pentyl) 2 amino.
  • N-((l-4C)alkyl)carbamoyl examples are methylcarbamoyl and ethylcarbamoyl.
  • N-((l-6C)alkyl)carbamoyl are the examples of “N-((l- 4C)alkyl)carbamoyl”and additionally pentylcarbamoyl, hexylcarbamoyl and 1,2- (methyl) 2 propylcarbamoyl.
  • N,N-((l-4C)alkyl) 2 carbamoyr are N,N- (methyl) 2 carbamoyl, N,N-(ethyl) 2 carbamoyl and N-methyl-N-ethylcarbamoyl.
  • Examples of "NN-((l-6C)alkyl) 2 carbamoyl” are the examples of "NN-((l-4C)alkyl) 2 carbamoyl” and additionally NN-(pentyl) 2 carbamoyl, N-methyl-N-pentylcarbamoyl and N-ethyl-N- hexylcarbamoyl.
  • Examples of "N-((l-4C)alkyl)sulphamoyl” are N-(methyl)sulphamoyl and N-(ethyl)sulphamoyl.
  • N-((l-6C)alkyl)sul ⁇ hamoyl are the examples of “N-((l- 4C)alkyl)sulphamoyl” and additionally N-pentylsulphamoyl, N-hexylsulphamoyl and 1,2- (methyl) 2 propylsulphamoyl.
  • Examples of "NN-((l-4C)alkyl) sulphamoyl” are N,N-(methyl) 2 sulphamoyl, N,N-(ethyl) 2 sulphamoyl and N-(methyl)-N-(ethyl)sulphamoyl.
  • Examples of "NN-((l-6C)alkyl) 2 Sulphamoyl” are the examples of “N,N-((1- 4C)alkyl) 2 sulphamoyl” and additionally NN-( ⁇ entyl) 2 sulphamoyl, N-methyl-N- pentylsulphamoyl and N-ethyl-N-hexylsulphamoyl.
  • Examples of - ⁇ HSO 2 (l-4C)alkyl are methylsulfonylamino, ethylsulfonylamino, propylsulfonylamino, isopropylsulfonylamino and tert-butylsulf onylamino .
  • Examples of "cyano(l-4C)alkyl” are cyanomethyl, cyanoethyl and cyanopropyl.
  • Examples of "(5-7C)cycloalkyl” are cyclopentyl, cyclohexyl and cycloheptyl.
  • Examples of “(3-8C)cycloalkyl” and “(3-7C)cycloalkyl” include “(5-7C)cycloalkyl", cyclopropyl, cyclobutyl and cyclooctyl.
  • Examples of “(3-6C)cycloalkyl” include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.
  • the term “amino(l-4C)alkyl” includes aminomethyl, aminoethyl, aminopropyl, aminoisopropyl and aminobutyl.
  • aminoethyl includes 1-aminoethyl and 2- aminoethyl.
  • aminopropyl includes 1 -aminopropyl, 2-amino ⁇ ropyl and 3- aminopropyl and an analogous convention applies to terms such as aminoethyl and aminobutyl.
  • (l-4C)alkoxy(l-4C)alkoxy are methoxymethoxy, ethoxymethoxy, ethoxyethoxy and methoxyethoxy.
  • Examples of "hydroxy(l-4C)alkoxy” are hydroxyethoxy and hydroxypropoxy.
  • hydroxypropoxy are 1-hydroxypropoxy, 2- hydroxypropoxy and 3 -hydroxypropoxy.
  • Examples of "(l-4C)alkoxy(l-4C)alkyl” include methoxymethyl, ethoxymethyl, methoxyethyl, isopropoxymethyl, and tert-butoxymethyl.
  • Examples of "(l-4C)alkylS(O) b (wherein b is 0,1 or 2)", “(l-4C)alkylS(O) c (wherein c is 0 to 2)" and “(l-4C)alkylS(O) d (wherein d is 0 to 2)" independently include methylthio, ethylthio, propylthio, methanesulphinyl, ethanesulphinyl, propanesulphinyl, mesyl, ethanesulphonyl, propanesulphonyl and isopropanesulphonyl.
  • Examples of "(1- 4C)alkylS(O) b (l-4C)alkyl-" (wherein b is 0,1 or 2)" include methylsulfonylmethyl, methylsulfinylmehtyl, methylthiomethyl, ethylsulfonylmethyl, ethylsulfinylmethyl and ethylthiomethyl.
  • Examples of "-(l-4C)alkylSO 2 (2-4C)alkenyl” include vinylsulfonylmethyl, vinylsulfonylethyl, and allylsulfonylmethyl.
  • Examples of "(3-6C)cycloalkylS(O) b (wherein b is 0,1 or 2)" include cyclopropylthio, cyclopropylsulphinyl, cyclopropylsulphonyl, cyclobutylthio, cyclobutylsulphinyl, cyclobutylsulphonyl, cyclopentylthio, cyclopentylsulphinyl and cyclopentylsulphonyl.
  • Examples of "arylS(O) b (wherein b is 0,1 or 2)” include phenylthio, phenylsulphinyl and phenylsulfonyl.
  • Examples of “heterocyclylS(O)b (wherein b is 0,1 or 2)” include pyridylthio, pyridylsulfinyl, pyridylsulfonyl, imidazolylthio, imidazolylsulfinyl, imidazolylsulfonyl, pyrimidinylthio, pyrimidinylsufinyl, pyrimidinylsulfonyl, piperidylthio, piperidylsulfinyl and piperidylsulfonyl.
  • Examples of "(l-6C)alkoxycarbonyl” include methoxycarbonyl, ethoxycarbonyl, n- and t-butoxycarbonyl.
  • Examples of “(l-6C)alkoxycarbonylamino” include methoxycarbonylamino, ethoxycarbonylamino, n- and t-butoxycarbonylamino.
  • Examples of "( 1 -6C)alkylsulphonyl-N-(( 1 -6C)alkyl)amino” include methylsulphonyl-N-methylamino, ethylsulphonyl-N-methylamino and propylsulphonyl-N-ethylamino.
  • Examples of "(1- 6C)alkylsulphonylamino” include methylsulphonylamino, ethylsulphonylamino and propylsulphonylamino.
  • Examples of "(l-6C)alkanoylamino” include formamido, acetamido and propionylamino.
  • substituents contain two substituents on an alkyl chain, in which both are linked by a heteroatom (for example two alkoxy substituents), then these two substituents are not substituents on the same carbon atom of the alkyl chain.
  • optional substituents on any group may be attached to any available atom as appropriate unless otherwise specified, including heteroatoms provided that they are not thereby quaternised.
  • composite terms are used to describe groups comprising more that one functionality such as -(l-6C)alkylNHSO 2 (l-6C)alkyl. Such terms are to be interpreted in accordance with the meaning which is understood by a person skilled in the art for each component part.
  • -(l-6)alkylNHSO 2 (l-6C)alkyl includes -methylaminosulphonylmethyl, -methylaminosulphonylethyl, -ethylaminosulphonylmethyl, and -propylaminosulphonylbutyl.
  • substituents are chosen from "0, 1, 2 or 3" groups it is to be understood that this definition includes all substituents being chosen from one of the specified groups or the substituents being chosen from two or more of the specified groups.
  • An analogous convention applies to substituents chose from "0, 1 or 2" groups and "1 or 2" groups.
  • Substituents may be present at any suitable position on, for example, an alkyl group.
  • hydroxy substituted (l-6C)alkyl includes hydroxymethyl, 1 -hydroxyethyl, 2-hydroxyethyl and 3-hydroxypropyl.
  • Heterocyclyl is a saturated, partially saturated or unsaturated, optionally substituted monocyclic ring containing 5 to 7 atoms of which 1, 2, 3 or 4 ring atoms are chosen from nitrogen, sulphur or oxygen, which may, unless otherwise specified, be carbon or nitrogen linked, wherein a -CH 2 - group can optionally be replaced by a -C(O)-and a ring sulphur atom may be optionally oxidised to form the S-oxide(s).
  • heterocyclyl examples and suitable values of the term "heterocyclyl” are morpholino, morpholinyl, piperidino, piperidyl, pyridyl, pyranyl, pyrrolyl, imidazolyl, thiazolyl, thienyl, dioxolanyl, thiadiazolyl, piperazinyl, isothiazolidinyl, triazolyl, tetrazol l, pyrrolidinyl, 2-oxazolidinonyl, 5-isoxazolonyl, thiomorpholino, pyrrolinyl, homopiperazinyl, 3,5-dioxapiperidinyl, 3-oxopyrazolin-5-yl, tetrahydropyranyl, tetrahydrothiopyranyl, 1-oxotetrahydrothiopyranyl, 1,1-dioxotetrahydrothiopyranyl, pyrimid
  • a “heterocyclyl” is morpholino, morpholinyl, piperidino, piperidyl, pyridyl, pyranyl, pyrrolyl, imidazolyl, thiazolyl, thienyl, thiadiazolyl, piperazinyl, isothiazolidinyl, 1,3,4-triazolyl, tetrazolyl, pyrrolidinyl, thiomorpholino, pyrrolinyl, homopiperazinyl,
  • heterocyclyl is oxazolyl, 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, tetrazolyl, thizoyl, thiadiazolyl, pyridyl, imidazolyl, furyl, thienyl, morpholine, pyrimidyl, pyrazinyl, pyridazinyl, pyrazolyl, pyrazolinyl, and piperazinyl.
  • Suitable optional substituents for "heterocyclyl” as a saturated or partially saturated ring are 1, 2 or 3 substituents independently selected from halo, cyano, hydroxy, (l-4C)alkyl, (l-4C)alkoxy and (l-4C)alkylS(O) b (wherein b is 0, 1 or 2).
  • Further suitable substituents for "heterocyclyl” as a saturated or partially saturated ring are 1, 2 or 3 substituents independently selected from fluoro, chloro, cyano, hydroxy, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.
  • Suitable optional susbtituents for "heterocyclyl" as an unsaturated ring are 1, 2 or 3 substituents independently selected from halo, cyano, nitro, amino, hydroxy, (l-4C)alkyl, (1- 4C)alkoxy, (l-4C)alkylS(O) b - (wherein b is 0, 1 or 2), N-((l-4C)alkyl)amino and N,N-((1- 4C)alkyl) 2 amino.
  • heterocyclyl as an unsaturated ring
  • substituents independently selected from fluoro, chloro, cyano, nitro, amino, methylamino, dimethylamino, hydroxy, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.
  • heterocyclyl(l-4C)alkyl examples are morpholinomethyl, morpholinethyl, morpholinylmethyl, morpholinylethyl, piperidinomethyl, piperidinoethyl, piperidylmethyl, piperidylethyl, imidazolylmethyl, imidazolylethyl, oxazolylmethyl, oxazolylethyl, 1,3,4- oxadiazolylmethyl, 1,2,4-oxadiazolylmethyl, 1,2,4-oxadiazolylethyl, pyridylmethyl, pyridylethyl, furylmethyl, furylethyl, (thienyl)methyl, (thienyl)ethyl, pyrazinylmethyl, pyrazinylethyl, piperazinylmethyl and piperazinylethyl.
  • aryl are optionally substituted phenyl and naphthyl.
  • aryl(l-4C)alkyl are benzyl, phenethyl, naphthylmethyl and naphthylethyl.
  • Suitable optional substituents for "aryl” groups are 1, 2 or 3 substituents independently selected from halo, cyano, nitro, amino, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, (l-4C)alkylS(O) b (wherein b is 0, 1 or 2), N-((l-4C)alkyl)amino and NN-((l-4C)alkyl) 2 amino.
  • aryl groups are 1, 2 or 3 substituents independently selected from fluoro, chloro, cyano, nitro, amino, methylamino, dimethylamino, hydroxy, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.
  • Heteroarylene is a diradical of a heteroaryl group.
  • a heteroaryl group is an aryl, monocyclic ring containing 5 to 7 atoms of which 1, 2, 3 or 4 ring atoms are chosen from nitrogen, sulphur or oxygen.
  • heteroarylene examples include oxazolylene, oxadiazolylene, pyridylene, pyrimidinylene, imidazolylene, triazolylene, tetrazolylene, pyrazinylene, pyridazinylene, pyrrolylene, thienylene and furylene.
  • Suitable optional substituents for heteroaryl groups are 1, 2 or 3 substituents independently selected from halo, cyano, nitro, amino, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, (l-4C)alkylS(O) b (wherein b is 0, 1 or 2), N-((l-4C)alkyl)amino and N,N-((1- 4C)alkyl) 2 amino.
  • heteroaryl groups are 1, 2 or 3 substituents independently selected from fluoro, chloro, cyano, nitro, amino, methylamino, dimethylamino, hydroxy, methyl, ethyl, methoxy, methylthio, methylsulfinyl and methylsulfonyl.
  • A, Y, R to R , r, m and n are as follows. Such values may be used where appropriate with any of the definitions, claims, aspects or embodiments defined hereinbefore or hereinafter.
  • compounds of formula (1) in an alternative embodiment are provided pharmaceutically-acceptable salts of compounds of formula (1), in a further alternative embodiment are provided in-vivo hydrolysable esters of compounds of formula (1), and in a further alternative embodiment are provided pharmaceutically-acceptable salts of in-vivo hydrolysable esters of compounds of formula (1).
  • pro-drugs of compounds of formula (1) are provided in a further alternative embodiment are provided pharmaceutically-acceptable salts of pro- drugs of compounds of formula (1).
  • esters of compounds of the formula (1) are such esters of compounds of the formula (1) wherein Y comprises a group containing a carboxy group. Suitable esters are those hereinbefore described for carboxy groups.
  • A is phenylene.
  • A is heteroarylene.
  • A is selected from phenylene, pyridylene, pyrimidinylene, pyrrolylene, imidazolylene, triazolylene, tetrazolylene, oxazolylene, oxadiazolylene, thienylene and furylene.
  • A when A is heteroarylene, there is a nitrogen in a bridgehead position.
  • A when A is heteroarylene, the heteroatoms are not in bridgehead positions. It will be appreciated that the preferred (more stable) bridgehead position is as shown below
  • m is 1 or 2. In another aspect of the invention m is 1. In another aspect of the invention m is 0. In one aspect of the present invention R 4 is selected from halo, cyano, hydroxy, fluoromethyl, difluoromethyl and trifluoromethyl. In another aspect of the invention R 4 is halo. Preferably R 4 is selected from chloro and bromo. In a further aspect R 4 is selected from chloro, fluoro and methyl. In a further aspect R 4 is selected from chloro and fluoro More preferably R 4 is chloro. In one aspect of the invention n is 0 or 1. In one aspect preferably n is 1. In another aspect, preferably n is 0.
  • n 2
  • the two R 1 groups together with the carbon atoms of A to which they are attached, form a 4 to 7 membered saturated ring, optionally containing 1 or 2 heteroatoms independently selected from O, S and N, conveniently such a ring is a 5 or 6 membered ring.
  • such a 5 or 6 membered ring contains two O atoms (ie a cyclic acetal).
  • the two R 1 groups together form such a cyclic acetal, preferably it is not substituted.
  • the two R 1 groups together are the group -O-CH2-O-.
  • R 1 is selected from halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl and (l-4C)alkoxy.
  • R 1 is selected from halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, -S(O) b (l-4C)alkyl (wherein b is 0, 1 or 2), -OS(O) 2 (l- 4C)alkyl, (l-4C)alkyl and (l-4C)alkoxy.
  • R 1 is selected from halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, -S(O) b Me (wherein b is 0, 1 or 2), -OS(O) 2 Me, methyl and methoxy.
  • R 1 is (l-4C)alkyl.
  • R 1 is selected from halo and (l-4C)alkoxy.
  • R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and -O-CH2-O-.
  • r is 1 and when r is 1 the group
  • r is 2 and when r is 2 the group
  • r is 2 and when r is 2 the group
  • Y is selected from -C(O)R 2 , -C(O)OR 2 , -C(O)NR 2 R 3 , -C(O)NOH, -C(O)NSH, -C(N)OH, and-C(N)SH.
  • Y is selected from -SO 2 H, -SO 3 H, -SO 2 N(OH)R 2 , -SO 2 NR 2 R 3 and -S(O) c R 2 (wherein c is 0, 1 or 2).
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl and -N(l-4C)alkyl.
  • R 2 and R 3 are independently selected from hydrogen, heterocyclyl, aryl and (l-4C)alkyl [optionally substituted by 1 or 2 R groups].
  • R 2 and R 3 are independently selected from hydrogen and (1- 4C)alkyl [optionally substituted by 1 or 2 R 8 groups].
  • such rings are selected from morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, dihydropyridine, tetrahydropyridine, piperazine, piperidine.
  • Suitable optional substituents for a ring comprising NR 2 R 3 are 1 or 2 substituents independently selected from halo, hydroxy and (l-4C)alkoxy.
  • the ring has 2 substituents and they are both hydroxy.
  • the ring has 2 substituents and they are both halo, particularly both are fluoro.
  • a ring comprising NR R contains an additional ring atom selected from O, N and S.
  • R and R are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (l-4C)alkyl [optionally substituted by 1 or 2 R 8 groups];or an NR 2 R 3 group forms morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, dihydropyridine, tetrahydropyridine, piperazine, piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from halo, hydroxy and (1- 4C)alkoxy.
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (l-4C)alkyl [optionally substituted by 1 or 2 R 8 groups];or an NR 2 R 3 giOup forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from chloro, fluoro, hydroxy and methoxy;
  • R is independently selected from hydrogen, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, cyano(l-4C)alkyl, amino(l-4C)alkyl [optionally substituted on nitrogen by 1 or 2 groups selected from (l ⁇ 4C)alkyl, hydroxy, hydroxy(l-4C)alkyl, dihydroxy(l-4C)alkyl, -CO 2 (l-4C)alkyl
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, amino(l-4C)alkyl, halo(l-4C)alkyl, dihalo(l-4C)alkyl, trihalo(l-4C)alkyl, hydroxy(l-4C)alkyl, dihydroxy(l-4C)alkyl, (l-4C)alkoxy(l-4C)alkoxy, (l-4C)alkoxy(l-4C)alkyl, hydroxy(l-4C)alkoxy, (l-4C)alkanoyl, (l-4C)alkylS(O) b - (wherein b is 0, 1 or 2, (l-4C)alkylS(O) c (l-4C)alkyl- (wherein c is 0, 1 or 2), ), -N(OH)CHO, -COCOOR 9 , -C(O)N(R 9 )(R 10 ), -NH
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, (l-4C)alkanoyl, -COCOOR 9 , -C(O)N(R 9 )(R 10 ), -NHC(O)R 9 , -N(OH)CHO, -C(O)NHSO 2 (l-4C)alkyl, -NHSO 2 R 9 , (R 9 )(R 10 )NSO 2 -, -COCH 2 OR ⁇ , -COCH 2 OH, (R 9 )(R 10 )N- , -COOR 9 , -CH 2 OR 9 , -CH 2 COOR 9 and -CH 2 OCOR 9 .
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl, (l-4C)alkoxy, (l-4C)alkanoyl, -COCOOR 9 , -C(O)N(R 9 )(R 10 ), -NHC(O)R 9 , -N(OH)CHO, -COOR 9 , -CH 2 OR 9 , -CH 2 COOR 9 and -CH 2 OCOR 9 .
  • R 9 and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) optionally substituted by 1 or 2 R 11 ).
  • R 11 is (l-4C)alkyl.
  • a compound of the formula (I), or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is phenylene; n is 0, 1 or 2; m is 1 or 2;
  • R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and-O-CH 2 -O-;
  • R 4 is halo;
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl
  • R 9 and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) optionally substituted by 1 or 2 R 11 ); R ⁇ is (l-4C)alkyl.
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is phenylene; n is 0, 1 or 2; m is 1 or 2; R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and -O-CH 2 -O-; R 4 is halo;
  • A is phenylene; n is O; m is 1; R 4 is chloro;
  • Y is selected from-C(O)R 2 , -C(O)OR 2 , -C(O)NR 2 R 3 , -(l-4C)alkyl [optionally substituted by a substituent selected from hydroxy, (l-4C)alkoxy, aryloxy, heterocyclyloxy, -S(O) b R 2
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (1-
  • 4C)alkyl [optionally substituted by 1 or 2 R 8 groups] ;or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from chloro, fluoro, hydroxy and methoxy;
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl
  • R 9 and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) optionally substituted by 1 or 2 R ⁇ );
  • R 11 is (l-4C)alkyl.
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is phenylene; n is O; m is 1; R 4 is chloro;
  • 4C)alkyl [optionally substituted by 1 or 2 R 8 groups] ;or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, dihydropyridine, tetrahydropyridine, piperazine or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from halo, hydroxy and (l-4C)alkoxy; R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl,
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (1- 4C)alkyl [optionally substituted by 1 or 2 R 8 groups] ;or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is phenylene; n is O; m is 1; R 4 is chloro;
  • R 9 and R 10 together with the nitrogen to which they are attached form a 4- to 6-membered ring as hereinbefore defined;
  • R ⁇ is (l-4C)alkyl.
  • A is phenylene; n is O; m is l;
  • R 4 is chloro
  • Y is selected from -C(O)OR 2 , -C(O)NR 2 R 3 , -(l-4C)alkyl [optionally substituted by a substituent selected from hydroxy, (l-4C)alkoxy, -S(O) b R 2 (wherein b is 0, 1 or 2), -O-
  • R and R are independently selected from hydrogen, heterocyclyl, -O(l-4C)alkyl, -N(l- 4C)alkyl, (l-4C)alkyl [optionally substituted by 1 or 2 R 8 groups]; or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from chloro, fluoro, hydroxy and methoxy;
  • R 8 is independently selected from hydrogen, hydroxy, -C(O)N(R 9 )(R 10 ), -NHC(O)R 9 , -COOR 9 , -CH 2 OR 9 , -CH 2 COOR 9 , -CH 2 OCOR 9 , aryl, heterocyclyl, and 5- and 6-membered cyclic acetals and mono- and di-methyl derivatives thereof;
  • R and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) or R 9 and R 10 together with the nitrogen to which they are attached form a 4- to 6-membered ring as hereinbefore defined.
  • R 2 and R 3 are independently selected from hydrogen, heterocyclyl, -O(l-4C)alkyl, -N(l- 4C)alkyl, (l-4C)alkyl [optionally substituted by 1 or 2 R 8 groups]; or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from chloro, fluoro, hydroxy and methoxy;
  • R 8 is independently selected from hydrogen, hydroxy, -C(O)N(R 9 )(R 10 ), -NHC(O)R 9 , -COOR 9 , -CH 2 OR 9 , -CH 2 COOR 9 , -CH 2 OCOR 9 , aryl, heterocyclyl, and 5- and 6-membered cyclic acetals and mono- and di-methyl derivatives thereof;
  • R and R 1 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) or R 9 and R 10 together with the nitrogen to which they are attached form a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring.
  • R 9 and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) or R 9 and R 10 together with the nitrogen to which they are attached form a morpholine ring.
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is heteroarylene; n is 0, 1 or 2; m is 1 or 2;
  • R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and -O-CH 2 -O-;
  • R 4 is halo;
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (1- 4C)alkyl [optionally substituted by 1 or 2 R 8 groups] ;or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, dihydropyridine, t
  • R 11 is (l-4C)alkyl.
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is heteroarylene; n is 0, 1 or 2; m is 1 or 2;
  • R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and -O-CH2-O-;
  • R is halo
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drug thereof wherein A is heteroarylene; n is 0, 1 or 2; m is 1 or 2;
  • R 1 is selected from fluoro, chloro, methyl, ethyl, methoxy and -O-CH 2 -O-;
  • R 4 is halo; Y is selected from-C(O)R 2 , -C(O)OR 2 , -C(O)NR 2 R 3 , -(l-4C)alkyl [optionally substituted by a substituent selected from hydroxy, (l-4C)alkoxy, aryloxy, heterocyclyloxy, -S(O) b R 2
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (1- 4C)alkyl [optionally substituted by 1 or 2
  • R » ⁇ 11 is (l-4C)alkyl.
  • a compound of the formula (I) or a pharmaceutically-acceptable salt or pro-drag thereof wherein A is heteroarylene; n is O; m is 1;
  • R 4 is chloro
  • A is heteroarylene; n is O; m is 1;
  • R 4 is chloro; Y is selected from-C(O)R 2 , -C(O)OR 2 , -C(O)NR 2 R 3 , -(l-4C)alkyl [optionally substituted by a substituent selected from hydroxy, (l-4C)alkoxy, aryloxy, heterocyclyloxy, -S(O) b R 2
  • R 2 and R 3 are independently selected from hydrogen, -O(l-4C)alkyl, -N(l-4C)alkyl, (1-
  • 4C)alkyl [optionally substituted by 1 or 2 R 8 groups]; or an NR 2 R 3 group forms a morpholine, thiomorpholine (and oxidised versions thereof), pyrrolidine, or piperidine ring and wherein the ring is optionally substituted by 1 or 2 substituents independently selected from chloro, fluoro, hydroxy and methoxy;
  • R 8 is independently selected from hydrogen, hydroxy, (l-4C)alkyl
  • R 9 and R 10 are independently selected from hydrogen, hydroxy and (l-4C)alkyl) optionally substituted by l or 2 R ⁇ ); R 11 is (l-4C)alkyl.
  • Particular compounds of the invention are each of the Examples or a pharmaceutically- acceptable salt or pro-drag thereof, each of which provides a further independent aspect of the invention.
  • Preferred compounds of the invention are of the formula (1 A), wherein Y, R 1 to R 4 , m and n are as defined in any aspect or embodiment described hereinbefore or hereinafter.
  • Another aspect of the present invention provides a process for preparing a compound of formula (1) or a pharmaceutically acceptable salt or an in-vivo hydrolysable ester thereof which process (wherein A, Y, R 1 , R 4 , m, r and n are, unless otherwise specified, as defined in formula (1)) comprises of: a) reacting an acid of the formula (2):
  • Standard peptide coupling reagents known in the art can be employed as suitable coupling reagents, or for example carbonyldiimidazole, l-ethyl-3-(3-dimethylaminopropyl)carbodi-imide hydrochloride (EDCI) and dicyclohexyl-carbodiimide (DCCI), optionally in the presence of a catalyst such as 1- hydroxybenzotriazole, dimethylaminopyridine or 4-pyrrolidinopyridine, optionally in the presence of a base for example triethylamine, di-isopropylethylamine, pyridine, or 2,6-di- ⁇ /£y/-pyridines such as 2,6-lutidine or 2,6-di-tert-butylpyridine.
  • a catalyst such as 1- hydroxybenzotriazole, dimethylaminopyridine or 4-pyrrolidinopyridine
  • a base for example triethylamine, di-iso
  • Suitable solvents include dimethylacetamide, dichloromethane, benzene, tetrahydrofuran and dimethylformamide.
  • the coupling reaction may conveniently be performed at a temperature in the range of -40 to 40°C.
  • Suitable activated acid derivatives include acid halides, for example acid chlorides, and active esters, for example pentafluorophenyl esters.
  • the reaction of these types of compounds with amines is well known in the art, for example they may be reacted in the presence of a base, such as those described above, and in a suitable solvent, such as those described above.
  • the reaction may conveniently be performed at a temperature in the range of -40 to 40°C.
  • the acids of formula (2) are commercially available or they are known compounds or they are prepared by processes known in the art.
  • Compounds of formula (3) where Y is -C(O)R are known compounds or they are prepared by processes known in the art.
  • Y is -C(O)OR 2
  • the amines of formula (3) may be prepared according to Scheme 3:
  • R 1 and/or R 2 may be introduced by acylation, (for example reacting with acetoxyacetic acid and l-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDAC)), alkylation, reductive alkylation, sulphonation or related processes, followed by O-deprotection when appropriate
  • acylation for example reacting with acetoxyacetic acid and l-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDAC)
  • EDAC l-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride
  • alkylation for example reacting with acetoxyacetic acid and l-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDAC)
  • EDAC l-(3-di
  • Amines of formula (3) may alternatively be obtained by applying the processes described for the preparation of compounds of formula (3a) to compounds of formula (5) in which W is NH 2 or a nitrogen atom with one or two suitable protecting groups.
  • Compounds of the formula (3) may be made by deprotection of compounds of formula (C), which are are commercially available, known compounds, prepared by processes known in the art or may be prepared by the novel route shown in Scheme 3A, wherein Y is -SR, or -CH(CO 2 R') 2 . (wherein R represents R 2 as defined hereinbefore, or a group which may be converted to a group R 2 using standard chemistry; and wherein R' is (l-6C)alkyl).
  • the malonate ester can be transformed to a variety of functional groups by standard methods l ⁇ iown in the art.
  • Deprotection of a compound of formula (C) by removal of the Boc group by any suitable process known in the art gives a compound of formula (3).
  • Suitable conditions for the above processes are exemplified in Intermediates 16 and 22 (compounds of formula (B)) and Intermediates 15, 21, 24 and 25 (compounds of formula (C)).
  • Compounds of the formula (B) are novel and provide a further independent aspect of the invention.
  • Further particular compounds of the formula (B) are those wherein A is phenylene.
  • Step 1 is performed on a compound known in the literature (Ger. Offen. 1997, 78). Steps 2, 3, 4, and 5 are performed using standard techniques known in the art. It will be appreciated the regiosiomers of the beta-ketoesters (Scheme 5) would lead to the preparation of the four possible pyridyl regioisomers of the beta amino ester. It will be appreciated that, in a similar manner, compounds of the formula (3) wherein A is heteroarylene containing a bridgehead nitrogen can be prepared from the appropriate suitably functionalised cycloalkyl fused heterocycles.
  • Such reactions and modifications include, for example, introduction of a substituent by means of an aromatic substitution reaction, reduction of substituents, alkylation of substituents and oxidation of substituents.
  • the reagents and reaction conditions for such procedures are well known in the chemical art.
  • aromatic substitution reactions include the introduction of a nitro group using concentrated nitric acid, the introduction of an acyl group using, for example, an acyl halide and Lewis acid (such as aluminium trichloride) under Friedel Crafts conditions; the introduction of an alkyl group using an alkyl halide and Lewis acid (such as aluminium trichloride) under Friedel Crafts conditions; and the introduction of a halogen group.
  • modifications include the reduction of a nitro group to an amino group by for example, catalytic hydrogenation with a nickel catalyst or treatment with iron in the presence of hydrochloric acid with heating; oxidation of alkylthio to alkylsulphinyl or alkylsulphonyl.
  • oxidation of alkylthio to alkylsulphinyl or alkylsulphonyl it will also be appreciated that in some of the reactions mentioned herein it may be necessary/desirable to protect any sensitive groups in the compounds. The instances where protection is necessary or desirable and suitable methods for protection are l ⁇ iown to those skilled in the art. Conventional protecting groups may be used in accordance with standard practice (for illustration see T.W. Green, Protective Groups in Organic Synthesis, John Wiley and Sons, 1991).
  • a suitable protecting group for an amino or alkylamino group is, for example, an acyl group, for example an alkanoyl group such as acetyl, an alkoxycarbonyl group, for example a methoxycarbonyl, ethoxycarbonyl or t-butoxycarbonyl group, an arylmethoxycarbonyl group, for example benzyloxycarbonyl, or an aroyl group, for example benzoyl.
  • the deprotection conditions for the above protecting groups necessarily vary with the choice of protecting group.
  • an acyl group such as an alkanoyl or alkoxycarbonyl group or an aroyl group may be removed for example, by hydrolysis with a suitable base such as an alkali metal hydroxide, for example lithium or sodium hydroxide.
  • a suitable base such as an alkali metal hydroxide, for example lithium or sodium hydroxide.
  • an acyl group such as a t-butoxycarbonyl group may be removed, for example, by treatment with a suitable acid as hydrochloric, sulphuric or phosphoric acid or trifluoroacetic acid and an arylmethoxycarbonyl group such as a benzyloxycarbonyl group may be removed, for example, by hydrogenation over a catalyst such as palladium-on-carbon, or by treatment with a Lewis acid for example boron tris(trifluoroacetate).
  • a suitable alternative protecting group for a primary amino group is, for example, a phthaloyl group which may be removed by treatment with an alkylamine, for example dimethylaminopropylamine, or with hydrazine.
  • a suitable protecting group for a hydroxy group is, for example, an acyl group, for example an alkanoyl group such as acetyl, an aroyl group, for example benzoyl, or an arylmethyl group, for example benzyl.
  • the deprotection conditions for the above protecting groups will necessarily vary with the choice of protecting group.
  • an acyl group such as an alkanoyl or an aroyl group may be removed, for example, by hydrolysis with a suitable base such as an alkali metal hydroxide, for example lithium or sodium hydroxide.
  • a suitable base such as an alkali metal hydroxide, for example lithium or sodium hydroxide.
  • an arylmethyl group such as a benzyl group may be removed, for example, by hydrogenation over a catalyst such as palladium-on-carbon.
  • a suitable protecting group for a carboxy group is, for example, an esterifying group, for example a methyl or an ethyl group which may be removed, for example, by hydrolysis with a base such as sodium hydroxide, or for example a t-butyl group which may be removed, for example, by treatment with an acid, for example an organic acid such as trifluoroacetic acid, or for example a benzyl group which may be removed, for example, by hydrogenation over a catalyst such as palladium-on-carbon.
  • the protecting groups may be removed at any convenient stage in the synthesis using conventional techniques well known in the chemical art.
  • the compounds defined in the present invention possesses glycogen phosphorylase inhibitory activity. This property may be assessed, for example, using the procedure set out below.
  • Assay The activity of the compounds is determined by measuring the inhibitory effect of the compounds on glycogen degradation, the production of glucose- 1 -phosphate from glycogen is monitored by the multienzyme coupled assay, as described in EP 0 846 464 A2, general method of Pesce et al ( Pesce, M A, Bodourian, S H, Harris, R C, and Nicholson, J F (1977) Clinical Chemistry 23, 1171 - 1717). The reactions were in 384well microplate format in a volume of 50 ⁇ l.
  • the change in fluorescence due to the conversion of the co-factor NAD to NADH is measured at 340nM excitation, 465nm emission in a Tecan Ultra Multifunctional Microplate Reader.
  • the reaction is in 50mM HEPES, 3.5mM KH 2 PO 4 , 2.5mM MgCl 2 , 2.5mM ethylene glycol-bis(b-aminoethyl ether) N.NN'N'-tetraacetic acid, lOOmM KC1, 8mM D-(+)-glucose pH7.2, containing 0.5mM dithiothreitol, the assay buffer solution.
  • Human recombinant liver glycogen phosphorylase a (hrl GP ⁇ ) 20nM is pre-incubated in assay buffer solution with 6.25mM NAD, 1.25mg type HI glycogen at 1.25 mg ml "1 the reagent buffer, for 30 minutes.
  • the coupling enzymes, phosphoglucomutase and glucose-6-phosphate dehydrogenase ( Sigma) are prepared in reagent buffer, final concentration 0.25Units per well. 20 ⁇ l of the hrl GPa solution is added to lO ⁇ l compound solution and the reaction started with the addition of 20ul coupling enzyme solution.
  • Compounds to be tested are prepared in lO ⁇ l 5% DMSO in assay buffer solution, with final concentration of 1% DMSO in the assay.
  • the non-inhibited activity of GP ⁇ is measured in the presence of lO ⁇ l 5% DMSO in assay buffer solution and maximum inhibition measured in the presence of 5mgs ml "1 N- ethylmaleimide.
  • ROUs Relative Fluoresence Units
  • the assay is performed at a test concentration of inhibitor of lO ⁇ M or lOO ⁇ M.
  • Typical IC 50 values for compounds of the invention when tested in the above assay are in the range lOO ⁇ M to InM. For example, Example 2 was found to have an IC 50 of 868nm. The inhibitory activity of compounds was further tested in rat primary hepatocytes.
  • Rat hepatocytes were isolated by the collagenase perfusion technique, general method of Seglen (P.O. Seglen, Methods Cell Biology (1976) 13 29-83). Cells were cultured on Nunclon six well culture plates in DMEM (Dulbeco's Modified Eagle's Medium) with high level of glucose containing 10% foetal calf serum, NEAA (non essential amino acids), Glutamine, penicillin /streptomycin ((100units/100ug)/ml) for 4 to 6 hours. The hepatocytes were then cultured in the DMEM solution without foetal calf serum and with lOnM insulin and lOnM dexamethasone.
  • DMEM Dynamic fetal
  • NEAA non essential amino acids
  • Glutamine penicillin /streptomycin
  • a pharmaceutical composition which comprises a compound of the formula (1), or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof, as defined hereinbefore in association with a pharmaceutically-acceptable diluent or carrier.
  • compositions of the invention may be in a form suitable for oral use (for example as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixirs), for topical use (for example as creams, ointments, gels, or aqueous or oily solutions or suspensions), for administration by inhalation (for example as a finely divided powder or a liquid aerosol), for administration by insufflation (for example as a finely divided powder) or for parenteral administration (for example as a sterile aqueous or oily solution for intravenous, subcutaneous, intramuscular or intramuscular dosing or as a suppository for rectal dosing).
  • oral use for example as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixir
  • compositions of the invention may be obtained by conventional procedures using conventional pharmaceutical excipients, well known in the art.
  • compositions intended for oral use may contain, for example, one or more colouring, sweetening, flavouring and/or preservative agents.
  • the compositions of the invention are in a form suitable for oral dosage.
  • Suitable pharmaceutically acceptable excipients for a tablet formulation include, for example, inert diluents such as lactose, sodium carbonate, calcium phosphate or calcium carbonate, granulating and disintegrating agents such as corn starch or algenic acid; binding agents such as starch; lubricating agents such as magnesium stearate, stearic acid or talc; preservative agents such as ethyl or propyl p-hydroxybenzoate, and anti-oxidants, such as ascorbic acid. Tablet formulations may be uncoated or coated either to modify their disintegration and the subsequent absorption of the active ingredient within the gastrointestinal tract, or to improve their stability and/or appearance, in either case, using conventional coating agents and procedures well known in the art.
  • inert diluents such as lactose, sodium carbonate, calcium phosphate or calcium carbonate
  • granulating and disintegrating agents such as corn starch or algenic acid
  • binding agents such as starch
  • lubricating agents
  • Compositions for oral use may be in the form of hard gelatin capsules in which the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules in which the active ingredient is mixed with water or an oil such as peanut oil, liquid paraffin, or olive oil.
  • an inert solid diluent for example, calcium carbonate, calcium phosphate or kaolin
  • water or an oil such as peanut oil, liquid paraffin, or olive oil.
  • Aqueous suspensions generally contain the active ingredient in finely powdered form together with one or more suspending agents, such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents such as lecithin or condensation products of an alkylene oxide with fatty acids (for example polyoxethylene stearate), or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol
  • the aqueous suspensions may also contain one or more preservatives (such as ethyl or propyl p-hydroxybenzoate, anti- oxidants (such as ascorbic acid), colouring agents, flavouring agents, and/or sweetening agents (such as sucrose, saccharine or aspartame).
  • Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil (such as arachis oil, olive oil, sesame oil or coconut oil) or in a mineral oil (such as liquid paraffin).
  • the oily suspensions may also contain a thickening agent such as beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set out above, and flavouring agents may be added to provide a palatable oral preparation.
  • compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid.
  • Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water generally contain the active ingredient together with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients such as sweetening, flavouring and colouring agents, may also be present.
  • the pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions.
  • the oily phase may be a vegetable oil, such as olive oil or arachis oil, or a mineral oil, such as for example liquid paraffin or a mixture of any of these.
  • Suitable emulsifying agents may be, for example, naturally-occurring gums such as gum acacia or gum tragacanth, naturally-occurring phosphatides such as soya bean, lecithin, an esters or partial esters derived from fatty acids and hexitol anhydrides (for example sorbitan monooleate) and condensation products of the said partial esters with ethylene oxide such as polyoxyethylene sorbitan monooleate.
  • the emulsions may also contain sweetening, flavouring and preservative agents.
  • Syrups and elixirs may be formulated with sweetening agents such as glycerol, propylene glycol, sorbitol, aspartame or sucrose, and may also contain a demulcent, preservative, flavouring and/or colouring agent.
  • the pharmaceutical compositions may also be in the form of a sterile injectable aqueous or oily suspension, which may be formulated according to known procedures using one or more of the appropriate dispersing or wetting agents and suspending agents, which have been mentioned above.
  • a sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example a solution in 1,3-butanediol.
  • Compositions for administration by inhalation may be in the form of a conventional pressurised aerosol arranged to dispense the active ingredient either as an aerosol containing finely divided solid or liquid droplets.
  • Conventional aerosol propellants such as volatile fluorinated hydrocarbons or hydrocarbons may be used and the aerosol device is conveniently arranged to dispense a metered quantity of active ingredient.
  • Chapter 25.2 in Volume 5 of Comprehensive Medicinal Chemistry (Corwin Hansch; Chairman of Editorial Board), Pergamon Press 1990 The amount of active ingredient that is combined with one or more excipients to produce a single dosage form will necessarily vary depending upon the host treated and the particular route of administration.
  • a formulation intended for oral administration to humans will generally contain, for example, from 0.5 mg to 2 g of active agent compounded with an appropriate and convenient amount of excipients which may vary from about 5 to about 98 percent by weight of the total composition.
  • Dosage unit forms will generally contain about 1 mg to about 500 mg of an active ingredient.
  • the compound of formula (1) will normally be administered to a warm-blooded animal at a unit dose within the range 5-5000 mg per square meter body area of the animal, i.e.
  • a unit dose form such as a tablet or capsule will usually contain, for example 1-250 mg of active ingredient.
  • a daily dose in the range of 1-50 mg/kg is employed.
  • the daily dose will necessarily be varied depending upon the host treated, the particular route of administration, and the severity of the illness being treated. Accordingly the optimum dosage may be determined by the practitioner who is treating any particular patient.
  • the inhibition of glycogen phosphorylase activity described herein may be applied as a sole therapy or may involve, in addition to the subject of the present invention, one or more other substances and/or treatments. Such conjoint treatment may be achieved by way of the simultaneous, sequential or separate administration of the individual components of the treatment.
  • Simultaneous treatment may be in a single tablet or in separate tablets.
  • the compounds of the present invention or their pharmaceutically acceptable salts may be administered in combination with one or more of the following agent(s): 1) Insulin and insulin analogues; 2) Insulin secretagogues including sulphonylureas (for example glibenclamide, glipizide), prandial glucose regulators (for example repaglinide, nateglinide) and glucokinase activators 3) Agents that improve incretin action (for example dipeptidyl peptidase IV inhibitors, GLP-1 agonists) 4) Insulin sensitising agents including PPARgamma agonists (for example pioglitazone and rosiglitazone); and agents with combined PPARalpha and gamma activity 5) Agents that modulate hepatic glucose balance (for example metformin, fructose 1, 6 bisphosphat
  • nifedipine Angiotensin receptor antagonists (eg candesartan), ⁇ antagonists and diuretic agents (eg. furosemide, benzthiazide); 12)Haemostasis modulators such as, antithrombotics, activators of fibrinolysis and antiplatelet agents; thrombin antagonists; factor Xa inhibitors; factor Vila inhibitors); antiplatelet agents (eg. aspirin, clopidogrel); anticoagulants (heparin and Low molecular weight analogues, hirudin) and warfarin; 13) Agents which antagonise the actions of glucagon; and 14) Anti-inflammatory agents, such as non-steroidal anti-inflammatory drugs (eg. aspirin) and steroidal anti-inflammatory agents (eg. cortisone).
  • non-steroidal anti-inflammatory drugs eg. aspirin
  • steroidal anti-inflammatory agents eg. cortisone
  • a compound of the formula (1) for use as a medicament in the treatment of type 2 diabetes, insulin resistance, syndrome X, hyperinsulinaemia, hyperglucagonaemia, cardiac ischaemia or obesity in a warm-blooded animal such as man.
  • a compound of the formula (1), or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof as defined hereinbefore in the manufacture of a medicament for use in the treatment of type 2 diabetes, insulin resistance, syndrome X, hyperinsulinaemia, hyperglucagonaemia, cardiac ischaemia or obesity in a warm-blooded animal such as man.
  • a compound of the formula (1), or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof as defined hereinbefore in the manufacture of a medicament for use in the treatment of type 2 diabetes in a warm-blooded animal such as man.
  • a method of producing a glycogen phosphorylase inhibitory effect in a warm-blooded animal, such as man, in need of such treatment which comprises administering to said animal an effective amount of a compound of formula (1).
  • a method of treating type 2 diabetes, insulin resistance, syndrome X, hyperinsulinaemia, hyperglucagonaemia, cardiac ischaemia or obesity in a warm-blooded animal, such as man, in need of such treatment which comprises administering to said animal an effective amount of a compound of formula (1).
  • a method of treating type 2 diabetes in a warm-blooded animal, such as man, in need of such treatment which comprises administering to said animal an effective amount of a compound of formula (1).
  • the size of the dose required for the therapeutic or prophylactic treatment of a particular cell-proliferation disease will necessarily be varied depending on the host treated, the route of administration and the severity of the illness being treated.
  • a unit dose in the range, for example, 1-100 mg kg, preferably 1-50 mg/kg is envisaged.
  • the compounds of formula (1) and their pharmaceutically acceptable salts are also useful as pharmacological tools in the development and standardisation of in vitro and in vivo test systems for the evaluation of the effects of inhibitors of cell cycle activity in laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part of the search for new therapeutic agents.
  • laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part of the search for new therapeutic agents.
  • the alternative and preferred embodiments of the compounds of the invention described herein also apply.
  • chromatography means flash chromatography on silica gel; thin layer chromatography (TLC) was carried out on silica gel plates;
  • Bond Elut column is referred to, this means a column containing 10 g or 20 g or 50 g of silica of 40 micron particle size, the silica being contained in a 60 ml disposable syringe and supported by a porous disc, obtained from Varian, Harbor City, California, USA under the name "Mega Bond Elut SI"; "Mega Bond Elut” is a trademark; where a Biotage cartridge is referred to this means a cartridge containing KP-SB TM silica, 60 ⁇ , particle size 32-63mM, supplied by Biotage, a division of Dyax Corp.,
  • NMR data is in the form of delta values for major diagnostic protons, given in parts per million (ppm) relative to tetramethylsilane (TMS) as an internal standard, determined at 300 MHz using perdeuterio dimethyl sulphoxide (DMSO- ⁇ 6 ) as solvent unless otherwise indicated, other solvents (where indicated in the text) include deuterated chloroform
  • Methyl (lR,2R)-2-aminoindane-l -carboxylate trifluoroacetic acid salt (Intermediate 1; 201 mg, 0.65 mmol), 5-chloro-lH-indole-2-carboxylic acid ( 129 mg, 0.66 mmol) and DIPEA (0.229 ml, 1.3 mmol) were dissolved in DCM (3 mL). ⁇ OBT (89mg, 0.66 mmol) and EDCI (134g, 0.69 mmol) were added and the mixture stirred at ambient temperature for 16 h.
  • Example 5 N-r(lR.2R)-l-( ⁇ r(2-Hydroxyethyl)amino1sulfonyUmethyl)-2,3-dihydro-lg- inden-2-yl1-5-methyl-l-ff-indoIe-2-carboxamide
  • Example 6 N-r(lR-2R)-l-( ⁇ r(2-Hvdro ⁇ yethyl)aminolsulfonyUmethyl)-2,3-dihydro-l-H r - inden-2-yl]-l-ff-indole-2-carboxamide
  • Example 14 The following examples were made by the process of Example 14, using 2-( ⁇ [(lR,2R)-2- amino-2,3-dihydro-lH-inden-l-yl]methyl ⁇ sulfonyl)ethanol hydrochloride (Intermediate 17) as the amine and the appropriate commercially available carboxylic acid:
  • Example l5 5-Chloro-N-((lR,2R)-l- ⁇ r(2-hvdroxyethyl)sulfonyllmethyl>-2.3-dihvdro- - inden-2-yl)-lRr-indole-2-carboxamide
  • Example 16 iy-((lR,2R)-l- ⁇ r(2-Hvdroxyethyl)sulfonyllmethvU-2,3-dihvdro-l -inden-2- yl)-5-methyl-l-fif-indole-2-carboxamide
  • Example 17 iV
  • Example 18 iy-((lR,2R)-l-r(2-Amino-2-oxoethvI)thio1-2,3-dihvdro-lH-inden-2-yl ⁇ -5- chloro-lff-indole-2-carboxamide
  • Tetrabutylammonium fluoride (10.0 mL, 2.0M in THF, 20.0 mmol) was added to a solution of tert-butyl [(lR,2R)-l-( ⁇ [tert-butyl(dimethyl)silyl]oxy ⁇ methyl)-2,3-dihydro-lH-inden-2- yl]carbamate (Intermediate 5; 4.1 g, 10.9 mmol) in T ⁇ F (50 mL) and stirred at ambient temperature for 4 h.
  • Methyl (lR,2S)-2-hydroxyindane-l -carboxylate (Intermediate 10; 10.56 g, 55.0 mmol) was dissolved in dry THF (100 mL) under a nitrogen atmosphere at 0 °C. LiBB (55.0 mL, 2.0M in THF, 110.0 mmol) was added and the reaction stirred between 0 to 5 °C for 0.5 h, allowed to warm to ambient temperature and stirred for a further 2h. The mixture was poured into saturated NaHCO 3, extracted with ethyl acetate (200 mL) and the organic phase washed with water (2 x 50 mL), brine (50 mL) and dried (MgSO ).
  • De-ionised water (20 L) was warmed to 34°C, bakers yeast (3 Kg) added and the mixture stirred for 0.5hr.
  • Methyl 2-oxoindane-l -carboxylate 40g, 0.21 mmol was added, the suspension stirred for 3 days and filtered through Celite.
  • the aqueous filtrate was extracted with ethyl acetate (4 x 2.5L) and the organic extracts dried (MgSO ), filtered and the volatiles removed by evaporation under reduced pressure.

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Abstract

L'invention concerne un composé représenté par la formule (1) ou un sel pharmaceutiquement acceptable, (1) dans lequel, par exemple, A représente par phenylène or hétéroarylène; Y est choisi parmi -C(O)R2, -C(O)OR2, -C(O)NR2R3, - alkyl(C1-4) [éventuellement substitué] alcényle-(C2-4), -SO2NR2R3, et -S(O)CR2 (où c représente 0, 1 ou 2). Ces composés possèdent une activité inhibitrice de la glycogènes phosphorylase, et sont par conséquent intéressants pour le traitement d'états pathologiques associés à une activité accrue de la glycogène phorphorylase. L'invention concerne en outre des procédés permettant de produire ces composés et des compositions pharmaceutiques les contenant.
PCT/GB2004/003364 2003-08-07 2004-08-04 Derives d'indolamide possedant une activite inhibitrice de la glycogene phosphorylase WO2005013975A1 (fr)

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US10/566,068 US20060211760A1 (en) 2003-08-07 2004-08-04 Indolamide derivatives which possess glycogen phosphorylase inhibitory activity
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WO2014022528A1 (fr) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
WO2014130608A1 (fr) 2013-02-22 2014-08-28 Merck Sharp & Dohme Corp. Composés bicycliques antidiabétiques
WO2014139388A1 (fr) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques
WO2015051725A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
WO2018106518A1 (fr) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
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US7115648B2 (en) 2002-03-06 2006-10-03 Astrazeneca Ab Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
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ES2315676T3 (es) 2009-04-01
EP1658067A1 (fr) 2006-05-24
US20060211760A1 (en) 2006-09-21
DE602004017748D1 (de) 2008-12-24
GB0318464D0 (en) 2003-09-10
HK1089965A1 (en) 2006-12-15
EP1658067B1 (fr) 2008-11-12
JP2007501780A (ja) 2007-02-01
ATE413876T1 (de) 2008-11-15

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