WO2005004849A3 - Formulation pharmaceutique - Google Patents
Formulation pharmaceutique Download PDFInfo
- Publication number
- WO2005004849A3 WO2005004849A3 PCT/EP2004/007667 EP2004007667W WO2005004849A3 WO 2005004849 A3 WO2005004849 A3 WO 2005004849A3 EP 2004007667 W EP2004007667 W EP 2004007667W WO 2005004849 A3 WO2005004849 A3 WO 2005004849A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- pharmaceutical formulation
- levothyroxine sodium
- amount
- total weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE602004018142T DE602004018142D1 (de) | 2003-07-10 | 2004-07-08 | Pharmazeutische formulierung mit levothyroxin-natrium |
AU2004255466A AU2004255466B2 (en) | 2003-07-10 | 2004-07-08 | Pharmaceutical formulation comprising levothyroxine sodium |
KR1020067000484A KR101136655B1 (ko) | 2003-07-10 | 2004-07-08 | 레보타이록신 나트륨을 포함하는 제약 제제 |
EP04740922A EP1643976B1 (fr) | 2003-07-10 | 2004-07-08 | Formulation pharmaceutique comprenant du levothyroxine sodium |
BRPI0412391A BRPI0412391B8 (pt) | 2003-07-10 | 2004-07-08 | formulação farmacêutica compreendendo levotiroxina sódica, seu uso e processo para sua preparação e |
MXPA06000353A MXPA06000353A (es) | 2003-07-10 | 2004-07-08 | Formulacion farmaceutica que comprende levotiroxina sodica. |
DK04740922T DK1643976T3 (da) | 2003-07-10 | 2004-07-08 | Farmaceutisk formulering omfattende levothyroxinnatrium |
NZ544174A NZ544174A (en) | 2003-07-10 | 2004-07-08 | Pharmaceutical formulation comprising levothyroxine sodium |
JP2006518170A JP4880457B2 (ja) | 2003-07-10 | 2004-07-08 | レボチロキシンナトリウムを含む医薬処方 |
US10/564,148 US7955621B2 (en) | 2003-07-10 | 2004-07-08 | Pharmaceutical formulation comprising levothyroxine sodium |
PL04740922T PL1643976T3 (pl) | 2003-07-10 | 2004-07-08 | Kompozycja farmaceutyczna zawierająca lewotyroksynę sodową |
CA2531853A CA2531853C (fr) | 2003-07-10 | 2004-07-08 | Formulation pharmaceutique comprenant du sodium de levothyroxine |
IL172619A IL172619A (en) | 2003-07-10 | 2005-12-15 | Pharmaceutical formulations comprising (a) levothyroxine sodium, (b) micro crystalline cellulose, and (c) pregelatinised starch, use thereof in the manufacture of medicaments for the treatment of thyroid hormone disorders in a mammal and a process for preparing said pharmaceutical formulations |
NO20060208A NO338465B1 (no) | 2003-07-10 | 2006-01-13 | Farmasøytisk preparat omfattende levotyroksinnatrium, fremgangsmåte for fremstilling samt anvendelse derav |
IS8287A IS2616B (is) | 2003-07-10 | 2006-02-07 | Lyfjablanda sem felur í sér levóþýroxínnatríum |
HK06109617.8A HK1089094A1 (en) | 2003-07-10 | 2006-08-29 | Pharmaceutical formulation comprising levothyroxine sodium |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0316206.2 | 2003-07-10 | ||
GBGB0316206.2A GB0316206D0 (en) | 2003-07-10 | 2003-07-10 | Pharmaceutical formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005004849A2 WO2005004849A2 (fr) | 2005-01-20 |
WO2005004849A3 true WO2005004849A3 (fr) | 2005-05-06 |
Family
ID=27741962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/007667 WO2005004849A2 (fr) | 2003-07-10 | 2004-07-08 | Formulation pharmaceutique |
Country Status (29)
Country | Link |
---|---|
US (1) | US7955621B2 (fr) |
EP (1) | EP1643976B1 (fr) |
JP (2) | JP4880457B2 (fr) |
KR (1) | KR101136655B1 (fr) |
CN (1) | CN100430051C (fr) |
AR (1) | AR045719A1 (fr) |
AT (1) | ATE415949T1 (fr) |
AU (1) | AU2004255466B2 (fr) |
BR (1) | BRPI0412391B8 (fr) |
CA (1) | CA2531853C (fr) |
CO (1) | CO5700710A2 (fr) |
DE (1) | DE602004018142D1 (fr) |
DK (1) | DK1643976T3 (fr) |
ES (1) | ES2319193T3 (fr) |
GB (1) | GB0316206D0 (fr) |
HK (1) | HK1089094A1 (fr) |
IL (1) | IL172619A (fr) |
IS (1) | IS2616B (fr) |
MA (1) | MA27898A1 (fr) |
MX (1) | MXPA06000353A (fr) |
MY (1) | MY140127A (fr) |
NO (1) | NO338465B1 (fr) |
NZ (1) | NZ544174A (fr) |
PL (1) | PL1643976T3 (fr) |
PT (1) | PT1643976E (fr) |
RU (1) | RU2349345C2 (fr) |
TW (1) | TWI329026B (fr) |
WO (1) | WO2005004849A2 (fr) |
ZA (1) | ZA200510224B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20110713A1 (it) | 2011-04-29 | 2012-10-30 | Bracco Imaging Spa | Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina |
ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
WO2007077252A1 (fr) * | 2006-01-06 | 2007-07-12 | Intervet International B.V. | Composition d'hormone thyroidienne liquide concentree |
IT1395454B1 (it) * | 2009-03-24 | 2012-09-21 | Altergon Sa | Composizioni e forme farmaceutiche per somministrazione orale di ormoni tiroidei in grado di contrastare l'azione di agenti sequestranti nel tratto gastrointestinale |
ITMI20112066A1 (it) * | 2011-11-14 | 2013-05-15 | Altergon Sa | Preparazione farmaceutica orale monodose di ormoni tiroidei t3 e t4 |
WO2014098886A1 (fr) * | 2012-12-21 | 2014-06-26 | Mylan Inc. | Formulation de lévothyroxine avec de la carraghénine |
US9271951B2 (en) | 2012-12-21 | 2016-03-01 | Mylan Inc. | Levothyroxine formulation with acacia |
WO2014098887A1 (fr) * | 2012-12-21 | 2014-06-26 | Mylan Inc. | Formulation de lévothyroxine avec de la gomme arabique |
EP2932963A1 (fr) | 2014-04-16 | 2015-10-21 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Stables firmes galéniques contenant du Lévothyroxine de Sodium |
KR102488488B1 (ko) | 2015-10-07 | 2023-01-12 | 쿄와 기린 가부시키가이샤 | 아릴알킬아민 화합물 함유 의약 조성물 |
JP6168673B2 (ja) | 2015-10-07 | 2017-07-26 | 協和発酵キリン株式会社 | アリールアルキルアミン化合物含有医薬組成物 |
WO2018069805A2 (fr) | 2016-10-10 | 2018-04-19 | Ftf Pharma Private Limited | Procédé de préparation d'une composition liquide de l-thyroxine à usage oral |
DK3576795T3 (da) * | 2017-02-03 | 2021-06-07 | Berlin Chemie Ag | Oralt skjoldbruskkirtelterapeutikum |
IT201800003615A1 (it) * | 2018-03-15 | 2019-09-15 | Altergon Sa | Formulazioni altamente stabili di ormone tiroideo in capsule molli |
CN118894787A (zh) * | 2019-05-05 | 2024-11-05 | 上海葆隆生物科技有限公司 | 一种左甲状腺素钠杂质及其制备 |
KR20220085086A (ko) | 2020-12-14 | 2022-06-22 | 메디케어제약 주식회사 | 갑상선 기능 저하증을 동반한 대사 증후군을 치료하는 약제학적 복합제제 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995020954A1 (fr) * | 1994-02-01 | 1995-08-10 | Knoll Ag | Comprimes contenant des hormones thyroidiennes |
US5955105A (en) * | 1995-11-14 | 1999-09-21 | Knoll Pharmaceutical Company | Stabilized thyroid hormone preparations and methods of making same |
US5958979A (en) * | 1995-10-27 | 1999-09-28 | Henning Berlin Gmbh & Co. | Stabilized medicaments containing thyroid hormones |
US6190696B1 (en) * | 1998-06-08 | 2001-02-20 | Pieter J. Groenewoud | Stabilized thyroxine medications |
WO2001074448A1 (fr) * | 2000-03-30 | 2001-10-11 | Mova Pharmaceutical Corporation | Preparations stables d'hormones thyroidiennes et leur procede de fabrication |
US6555581B1 (en) * | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225204A (en) * | 1991-11-05 | 1993-07-06 | Chen Jivn Ren | Stable dosage of levothyroxine sodium and process of production |
AU4856093A (en) * | 1992-09-22 | 1994-04-12 | Fmc Corporation | Product and process of making microcrystalline cellulose |
JPH11286456A (ja) * | 1998-03-31 | 1999-10-19 | Lion Corp | 複合粉体組成物及び錠剤 |
DE19821625C1 (de) * | 1998-05-15 | 2000-01-05 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
JP2001064177A (ja) * | 1999-08-16 | 2001-03-13 | Schering Ag | ベンズアミド誘導体を有効成分とする製剤 |
JP3435664B2 (ja) | 1999-12-08 | 2003-08-11 | ヤンセンファーマ株式会社 | 口腔内速崩壊型錠剤及びその製造方法 |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
-
2003
- 2003-07-10 GB GBGB0316206.2A patent/GB0316206D0/en not_active Ceased
-
2004
- 2004-07-08 US US10/564,148 patent/US7955621B2/en not_active Expired - Lifetime
- 2004-07-08 CA CA2531853A patent/CA2531853C/fr not_active Expired - Lifetime
- 2004-07-08 MX MXPA06000353A patent/MXPA06000353A/es active IP Right Grant
- 2004-07-08 AT AT04740922T patent/ATE415949T1/de active
- 2004-07-08 PL PL04740922T patent/PL1643976T3/pl unknown
- 2004-07-08 PT PT04740922T patent/PT1643976E/pt unknown
- 2004-07-08 MY MYPI20042725A patent/MY140127A/en unknown
- 2004-07-08 BR BRPI0412391A patent/BRPI0412391B8/pt active IP Right Grant
- 2004-07-08 DK DK04740922T patent/DK1643976T3/da active
- 2004-07-08 RU RU2006104009/15A patent/RU2349345C2/ru active
- 2004-07-08 NZ NZ544174A patent/NZ544174A/en not_active IP Right Cessation
- 2004-07-08 EP EP04740922A patent/EP1643976B1/fr not_active Expired - Lifetime
- 2004-07-08 KR KR1020067000484A patent/KR101136655B1/ko not_active Expired - Lifetime
- 2004-07-08 DE DE602004018142T patent/DE602004018142D1/de not_active Expired - Lifetime
- 2004-07-08 AU AU2004255466A patent/AU2004255466B2/en not_active Expired
- 2004-07-08 AR ARP040102405A patent/AR045719A1/es not_active Application Discontinuation
- 2004-07-08 ES ES04740922T patent/ES2319193T3/es not_active Expired - Lifetime
- 2004-07-08 WO PCT/EP2004/007667 patent/WO2005004849A2/fr active IP Right Grant
- 2004-07-08 TW TW093120412A patent/TWI329026B/zh not_active IP Right Cessation
- 2004-07-08 CN CNB2004800197743A patent/CN100430051C/zh not_active Expired - Lifetime
- 2004-07-08 JP JP2006518170A patent/JP4880457B2/ja not_active Expired - Lifetime
-
2005
- 2005-12-15 IL IL172619A patent/IL172619A/en active IP Right Grant
- 2005-12-15 ZA ZA200510224A patent/ZA200510224B/en unknown
- 2005-12-30 CO CO05131486A patent/CO5700710A2/es not_active Application Discontinuation
-
2006
- 2006-01-06 MA MA28702A patent/MA27898A1/fr unknown
- 2006-01-13 NO NO20060208A patent/NO338465B1/no unknown
- 2006-02-07 IS IS8287A patent/IS2616B/is unknown
- 2006-08-29 HK HK06109617.8A patent/HK1089094A1/xx not_active IP Right Cessation
-
2011
- 2011-07-21 JP JP2011160067A patent/JP2011213736A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995020954A1 (fr) * | 1994-02-01 | 1995-08-10 | Knoll Ag | Comprimes contenant des hormones thyroidiennes |
US5958979A (en) * | 1995-10-27 | 1999-09-28 | Henning Berlin Gmbh & Co. | Stabilized medicaments containing thyroid hormones |
US5955105A (en) * | 1995-11-14 | 1999-09-21 | Knoll Pharmaceutical Company | Stabilized thyroid hormone preparations and methods of making same |
US6190696B1 (en) * | 1998-06-08 | 2001-02-20 | Pieter J. Groenewoud | Stabilized thyroxine medications |
WO2001074448A1 (fr) * | 2000-03-30 | 2001-10-11 | Mova Pharmaceutical Corporation | Preparations stables d'hormones thyroidiennes et leur procede de fabrication |
US6555581B1 (en) * | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
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