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WO2005003103A3 - Nouveaux heterocycles 2,4,6-trisubstitues et utilisations de ceux-ci - Google Patents

Nouveaux heterocycles 2,4,6-trisubstitues et utilisations de ceux-ci Download PDF

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Publication number
WO2005003103A3
WO2005003103A3 PCT/GB2004/002723 GB2004002723W WO2005003103A3 WO 2005003103 A3 WO2005003103 A3 WO 2005003103A3 GB 2004002723 W GB2004002723 W GB 2004002723W WO 2005003103 A3 WO2005003103 A3 WO 2005003103A3
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WIPO (PCT)
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treatment
tri
substituted
neurodegenerative diseases
membered heterocycles
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PCT/GB2004/002723
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English (en)
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WO2005003103A2 (fr
Inventor
Dean Brown
Joseph Cacciola
Robert T Jacobs
Frances M Mclaren
Ashokkumar Bhikkappa Shenvi
Reed W Smith Jr
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Dean Brown
Joseph Cacciola
Robert T Jacobs
Frances M Mclaren
Ashokkumar Bhikkappa Shenvi
Reed W Smith Jr
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Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Dean Brown, Joseph Cacciola, Robert T Jacobs, Frances M Mclaren, Ashokkumar Bhikkappa Shenvi, Reed W Smith Jr filed Critical Astrazeneca Ab
Publication of WO2005003103A2 publication Critical patent/WO2005003103A2/fr
Publication of WO2005003103A3 publication Critical patent/WO2005003103A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formules (I) et (II), des compositions pharmaceutiques de ceux-ci, ainsi que des procédés pour les utiliser afin de traiter des troubles neurologiques liés à la production de protéines amyloïdes β, tels que la maladie d'Alzheimer.
PCT/GB2004/002723 2003-06-30 2004-06-24 Nouveaux heterocycles 2,4,6-trisubstitues et utilisations de ceux-ci WO2005003103A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48425003P 2003-06-30 2003-06-30
US60/484,250 2003-06-30

Publications (2)

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WO2005003103A2 WO2005003103A2 (fr) 2005-01-13
WO2005003103A3 true WO2005003103A3 (fr) 2005-11-03

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006088705A1 (fr) * 2005-02-14 2006-08-24 Wyeth Guanidine de terphenyle en tant qu'inhibiteurs de la $g(b)-secretase
MX2008016007A (es) 2006-06-15 2009-01-16 Boehringer Ingelheim Int 2-anilino-4-aminoalquilenoaminopirimidinas.
BRPI0713696A2 (pt) 2006-06-15 2012-11-06 Boehringer Ingelheim Int 2-anilino-4-(heterocìclico) amino-pirimidinas
CN101583365B (zh) 2006-12-15 2012-09-26 阿布拉西斯生物科学公司 三嗪衍生物及其治疗应用
WO2008074068A1 (fr) * 2006-12-20 2008-06-26 Prana Biotechnology Limited Dérivés de quinoline substitués utilisés comme agents non-amyloïdogéniques
WO2008100412A1 (fr) * 2007-02-12 2008-08-21 Merck & Co., Inc. Dérivés de la pipéridine
ES2593486T3 (es) 2007-04-18 2016-12-09 Pfizer Products Inc. Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo
GB0719559D0 (en) * 2007-10-05 2007-11-14 Senexis Ltd Compounds
WO2009103652A1 (fr) 2008-02-22 2009-08-27 F. Hoffmann-La Roche Ag Modulateurs de la bêta-amyloïde
CA2736924C (fr) 2008-10-09 2016-06-28 F. Hoffmann-La Roche Ag Modulateurs pour l'amyloide beta
CA2743196A1 (fr) 2008-11-10 2010-05-14 F.Hoffmann-La Roche Ag Modulateurs de la gamma secretase heterocyclique
WO2010144394A1 (fr) 2009-06-09 2010-12-16 Abraxis Bioscience, Llc Dérivés de la triazine substituée au benzyle et leurs applications thérapeutiques
JP2012529519A (ja) 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー スチリル−トリアジン誘導体類及びそれらの治療応用
CA2765030C (fr) 2009-06-09 2015-10-27 California Capital Equity, Llc Derives de la triazine et leurs applications therapeutiques
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
WO2015003360A2 (fr) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
CN107304189A (zh) * 2016-04-18 2017-10-31 北京大学 一种三嗪化合物及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929426A (en) * 1959-05-21 1963-06-26 Ici Ltd New triazine azo dyestuffs
US3271478A (en) * 1963-01-24 1966-09-06 Dal Mon Research Co Polymerizable triazines and products thereof
US3498984A (en) * 1966-10-28 1970-03-03 American Home Prod 4-amino-2-phenyl-6-thiopyrimidines
GB1405132A (en) * 1971-07-29 1975-09-03 Ciba Geigy Ag Azo dyestuffs containing hydroxypyridone residues their manufacture and use
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JPS55112269A (en) * 1979-02-23 1980-08-29 Mitsubishi Chem Ind Ltd Monoazo dye for cellulose-containing fibers
US4281103A (en) * 1978-09-18 1981-07-28 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings, and polyesters formed from these dicarboxylic acids
EP0201633A2 (fr) * 1984-12-20 1986-11-20 Abbott Laboratories Composés d'anilides substitués et leur utilisation
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WO1999016761A1 (fr) * 1997-09-30 1999-04-08 Mitsubishi Chemical Corporation Derives heterocycliques oxygenes
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WO2003032994A2 (fr) * 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929426A (en) * 1959-05-21 1963-06-26 Ici Ltd New triazine azo dyestuffs
US3271478A (en) * 1963-01-24 1966-09-06 Dal Mon Research Co Polymerizable triazines and products thereof
US3498984A (en) * 1966-10-28 1970-03-03 American Home Prod 4-amino-2-phenyl-6-thiopyrimidines
GB1405132A (en) * 1971-07-29 1975-09-03 Ciba Geigy Ag Azo dyestuffs containing hydroxypyridone residues their manufacture and use
US4140496A (en) * 1976-05-10 1979-02-20 Sumitomo Chemical Company, Limited S-Triazine derivatives
US4281103A (en) * 1978-09-18 1981-07-28 Ciba-Geigy Corporation Dicarboxylic acids containing triazine rings, and polyesters formed from these dicarboxylic acids
JPS55112269A (en) * 1979-02-23 1980-08-29 Mitsubishi Chem Ind Ltd Monoazo dye for cellulose-containing fibers
EP0201633A2 (fr) * 1984-12-20 1986-11-20 Abbott Laboratories Composés d'anilides substitués et leur utilisation
EP0834507A1 (fr) * 1996-10-01 1998-04-08 Janssen Pharmaceutica N.V. Dérivés de diamino-1,3,5-triazine substituée
WO1999016761A1 (fr) * 1997-09-30 1999-04-08 Mitsubishi Chemical Corporation Derives heterocycliques oxygenes
WO1999065881A1 (fr) * 1998-06-19 1999-12-23 Nissan Chemical Industries, Ltd. Composes heterocycliques utilises comme agents hypoglecymiques
WO2000025780A1 (fr) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh
WO2000043369A1 (fr) * 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Composes inhibant l'adhesion aux leucocytes a mediation assuree par vla-4
WO2001005783A1 (fr) * 1999-07-15 2001-01-25 Pharmacopeia, Inc. Antagonistes du recepteur b1 de la bradykinine
WO2002100836A2 (fr) * 2001-06-12 2002-12-19 Active Pass Pharmaceuticals, Inc. Composes, compositions et methodes de modulation de la production de beta-amyloide
WO2003007963A1 (fr) * 2001-07-17 2003-01-30 Neotherapeutics, Inc. Derives pyrimidiques et leur utilisation dans le traitement des maladies neurodegeneratives
WO2003032994A2 (fr) * 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nouvelles pyrimidines substituees, procede permettant de les produire et leur utilisation comme medicament
WO2003045923A1 (fr) * 2001-11-28 2003-06-05 Btg International Ltd. Agents preventifs ou remedes contre la maladie d'alzheimer ou inhibiteurs de la fibrose des proteines amyloides contenant des composes heteroaryle a teneur en azote
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