+

WO2005098429A3 - Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel - Google Patents

Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel Download PDF

Info

Publication number
WO2005098429A3
WO2005098429A3 PCT/US2005/006355 US2005006355W WO2005098429A3 WO 2005098429 A3 WO2005098429 A3 WO 2005098429A3 US 2005006355 W US2005006355 W US 2005006355W WO 2005098429 A3 WO2005098429 A3 WO 2005098429A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic drug
treatment
nanoparticle
disease
real
Prior art date
Application number
PCT/US2005/006355
Other languages
English (en)
Other versions
WO2005098429A2 (fr
Inventor
Richard J Melker
James Chris Sackellares
Mark S Gold
Donn Michael Dennis
Charles R Martin
Jon D Stewart
Original Assignee
Univ Florida
Richard J Melker
James Chris Sackellares
Mark S Gold
Donn Michael Dennis
Charles R Martin
Jon D Stewart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/054,619 external-priority patent/US7104963B2/en
Priority claimed from US10/154,201 external-priority patent/US20020177232A1/en
Priority claimed from US10/178,877 external-priority patent/US6981947B2/en
Priority claimed from US10/274,829 external-priority patent/US7195780B2/en
Priority claimed from US10/345,532 external-priority patent/US6974706B1/en
Priority claimed from US10/722,620 external-priority patent/US7820108B2/en
Priority claimed from US10/744,789 external-priority patent/US20050037374A1/en
Priority claimed from US10/788,501 external-priority patent/US20050054942A1/en
Application filed by Univ Florida, Richard J Melker, James Chris Sackellares, Mark S Gold, Donn Michael Dennis, Charles R Martin, Jon D Stewart filed Critical Univ Florida
Priority to JP2007500789A priority Critical patent/JP2007525670A/ja
Priority to EP05756623A priority patent/EP1718971A2/fr
Priority to US10/588,749 priority patent/US20070258894A1/en
Publication of WO2005098429A2 publication Critical patent/WO2005098429A2/fr
Priority to US11/301,911 priority patent/US20070167853A1/en
Publication of WO2005098429A3 publication Critical patent/WO2005098429A3/fr
Priority to US11/512,856 priority patent/US8211035B2/en
Priority to US13/246,436 priority patent/US20120016252A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4821—Determining level or depth of anaesthesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/01—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes specially adapted for anaesthetising
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M2016/102—Measuring a parameter of the content of the delivered gas
    • A61M2016/1035—Measuring a parameter of the content of the delivered gas the anaesthetic agent concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/437—Composition of exhalation the anaesthetic agent concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Anesthesiology (AREA)
  • Food Science & Technology (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des systèmes et des procédés de diagnostic et/ou de traitement des maladies, ainsi que de surveillance du traitement des maladies. Dans le domaine du diagnostic, l'invention fait intervenir des ensembles nanoparticulaires qui contiennent une nanoparticule; un marqueur de substitution; ainsi que des moyens de détection d'une entité chimique spécifique. Dans certains modes de réalisation, les ensembles nanoparticulaires contiennent une charge qui permet de diagnostiquer et de traiter simultanément une maladie. Dans d'autres modes de réalisation, un médicament thérapeutique et un marqueur de médicament thérapeutique sont administrés à un patient pour surveiller le traitement de la maladie. Des échantillons de liquides corporels sont analysés à l'aide de la technologie des détecteurs pour détecter la présence de marqueurs de substitution et/ou de médicaments thérapeutiques, ce qui permet d'obtenir des moyens efficaces et précis de diagnostic d'une maladie et/ou de surveillance du traitement d'une maladie.
PCT/US2005/006355 2000-11-08 2005-02-28 Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel WO2005098429A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/588,749 US20070258894A1 (en) 2000-11-08 2005-02-28 System and Method for Real-Time Diagnosis, Treatment, and Therapeutic Drug Monitoring
EP05756623A EP1718971A2 (fr) 2000-11-08 2005-02-28 Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel
JP2007500789A JP2007525670A (ja) 2004-02-26 2005-02-28 リアルタイム診断、治療、および治療薬モニタリングのためのシステムおよび方法
US11/301,911 US20070167853A1 (en) 2002-01-22 2005-12-13 System and method for monitoring health using exhaled breath
US11/512,856 US8211035B2 (en) 2002-01-22 2006-08-29 System and method for monitoring health using exhaled breath
US13/246,436 US20120016252A1 (en) 2002-01-22 2011-09-27 System and method for monitoring health using exhaled breath

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US70878900A 2000-11-08 2000-11-08
US10/054,619 US7104963B2 (en) 2002-01-22 2002-01-22 Method and apparatus for monitoring intravenous (IV) drug concentration using exhaled breath
US10/154,201 US20020177232A1 (en) 2001-05-23 2002-05-22 Method and apparatus for detecting illicit substances
US10/178,877 US6981947B2 (en) 2002-01-22 2002-06-24 Method and apparatus for monitoring respiratory gases during anesthesia
US10/274,829 US7195780B2 (en) 2002-10-21 2002-10-21 Nanoparticle delivery system
US10/345,532 US6974706B1 (en) 2003-01-16 2003-01-16 Application of biosensors for diagnosis and treatment of disease
US10/722,620 US7820108B2 (en) 1999-11-08 2003-11-26 Marker detection method and apparatus to monitor drug compliance
US10/744,789 US20050037374A1 (en) 1999-11-08 2003-12-23 Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
US10/788,501 US20050054942A1 (en) 2002-01-22 2004-02-26 System and method for therapeutic drug monitoring
US10/788,501 2004-02-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/788,501 Continuation-In-Part US20050054942A1 (en) 2000-11-08 2004-02-26 System and method for therapeutic drug monitoring

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/301,911 Continuation-In-Part US20070167853A1 (en) 2002-01-22 2005-12-13 System and method for monitoring health using exhaled breath

Publications (2)

Publication Number Publication Date
WO2005098429A2 WO2005098429A2 (fr) 2005-10-20
WO2005098429A3 true WO2005098429A3 (fr) 2006-05-26

Family

ID=34971741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006355 WO2005098429A2 (fr) 2000-11-08 2005-02-28 Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel

Country Status (2)

Country Link
EP (1) EP1718971A2 (fr)
WO (1) WO2005098429A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108732292A (zh) * 2018-04-27 2018-11-02 中国人民解放军第二军医大学 血浆中舒芬太尼的快速检测方法及装置

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103474A2 (fr) * 2006-03-07 2007-09-13 University Of Florida Research Foundation, Inc. Système de suivi d'adhésion aux médicaments
US8818782B2 (en) 2007-06-27 2014-08-26 Roche Diagnostics Operations, Inc. System for developing patient specific therapies based on dynamic modeling of patient physiology and method thereof
ES2733350T3 (es) 2007-06-27 2019-11-28 Hoffmann La Roche Sistema para el diagnóstico, tratamiento y pronóstico médicos para acontecimientos solicitados y procedimiento del mismo
US9050061B2 (en) 2009-08-31 2015-06-09 Empire Technology Development Llc Health care device with a sample capture system to evaluate a health condition
TR201802101T4 (tr) 2009-09-09 2018-03-21 Sensa Bues Ab Verilen nefeste ilaç tespiti.
EP2518499B1 (fr) 2011-03-09 2015-06-10 Sensa Bues AB Dispositif d'échantillonnage portable et procédé pour la détection de drogue dans le souffle expiré
EP2706912A2 (fr) * 2011-05-09 2014-03-19 Tel HaShomer Medical Research Infrastructure and Services Ltd. Fourniture de preuves quant au positionnement correct d'un conduit intravasculaire
US10359417B2 (en) 2012-03-08 2019-07-23 Sensa Bues Ab Portable sampling device and method for detection of biomarkers in exhaled breath
EP2706355A1 (fr) 2012-09-11 2014-03-12 Sensa Bues AB Système et procédé pour l'élution et le test des substances à partir d'un échantillon d'aérosol expiré
CN110770570A (zh) * 2017-07-28 2020-02-07 富士胶片株式会社 传感器
CN111743871B (zh) * 2020-07-14 2022-04-19 天方药业有限公司 盐酸酚苄明片剂及其制备方法
CN112697901B (zh) * 2020-12-08 2022-05-17 安徽农业大学 用于筛选抗热应激肉羊的血清代谢标志物及筛选方法和应用
CN115886786A (zh) * 2022-10-31 2023-04-04 南华大学附属第一医院 基于信息融合的累积式呼气检测方法与系统
CN117309847B (zh) * 2023-11-28 2024-01-26 成都理工大学 一种基于磁性核壳型纳米球的三硝基甲苯检测传感器
CN119147603A (zh) * 2024-09-19 2024-12-17 北京市科学技术研究院城市安全与环境科学研究所 一种电化学适配体传感器及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity
WO2004037316A2 (fr) * 2002-10-21 2004-05-06 University Of Florida Systeme de distribution de nanoparticules
WO2004065404A1 (fr) * 2003-01-16 2004-08-05 University Of Florida Research Foundation, Inc. Nouvelle application de biocapteurs au diagnostic et au traitement de maladies
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
WO2005033707A1 (fr) * 2003-10-02 2005-04-14 University Of Florida Research Foundation, Inc. Nouvelle application de nanotechnologie et de technologies de capteur pour des diagnostics ex-vivo

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037374A1 (en) * 1999-11-08 2005-02-17 Melker Richard J. Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment
US20030185760A1 (en) * 2002-03-26 2003-10-02 Gregory Lanza Paramagnetic particles that provide improved relaxivity
WO2004037316A2 (fr) * 2002-10-21 2004-05-06 University Of Florida Systeme de distribution de nanoparticules
WO2004065404A1 (fr) * 2003-01-16 2004-08-05 University Of Florida Research Foundation, Inc. Nouvelle application de biocapteurs au diagnostic et au traitement de maladies
WO2005033707A1 (fr) * 2003-10-02 2005-04-14 University Of Florida Research Foundation, Inc. Nouvelle application de nanotechnologie et de technologies de capteur pour des diagnostics ex-vivo

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108732292A (zh) * 2018-04-27 2018-11-02 中国人民解放军第二军医大学 血浆中舒芬太尼的快速检测方法及装置
CN108732292B (zh) * 2018-04-27 2020-07-14 中国人民解放军第二军医大学 血浆中舒芬太尼的快速检测方法及装置

Also Published As

Publication number Publication date
EP1718971A2 (fr) 2006-11-08
WO2005098429A2 (fr) 2005-10-20

Similar Documents

Publication Publication Date Title
WO2005098429A3 (fr) Systeme et procede de diagnostic, de traitement et de pharmacovigilance therapeutique en temps reel
WO2007001342A3 (fr) Recueil de condensat d'haleine expiree (ebc) et systeme d'essai et procede associe
WO2003069332A3 (fr) Detection et/ou surveillance de maladies liees a la synucleine
AU2002327308A1 (en) Methods for evaluating pathologic conditions using extracellular rna
WO2004078252A3 (fr) Systeme et procede multi-canaux et multidimensionnels
AU4694499A (en) Trace level detection of analytes using artificial olfactometry
WO2003028531A3 (fr) Detection d'arn tumoral dans le plasma et le serum
WO2005020797A3 (fr) Dispositifs biocapteurs implantables pour le controle de molecules de marqueurs cardiaques
WO2005010486A3 (fr) Groupe special de marquers biologiques pour cancer colorectal
WO1998045322A3 (fr) Reactifs pour diagnostics et procede correspondant
WO2002059604A3 (fr) Proteines, genes et leur utilisation pour le diagnostic et le traitement de la sclerose en plaques
WO2006073682A3 (fr) Test diagnostique
WO2002014537A3 (fr) Diagnostic et traitement de la dysautonomie et autres états de dysautonomie
WO2004031414A3 (fr) Technique de diagnostic du cancer de la prostate
Cavazos-Rocha et al. Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection
WO2000031531A8 (fr) Surveillance de l'observation de prescriptions medicales par un patient et de la biodisponibilite des medicaments par deproteinisation des fluides corporels
US9974483B2 (en) Non-invasive blood measuring device
AU2003214900A1 (en) Method and apparatus for monitoring intravenous (iv) drug concentration using exhaled breath
WO2003011215A3 (fr) Procede et systeme destines au traitement d'un patient avec une substance biologique permettant d'optimiser la therapie et d'empecher un effet indesirable
WO2006089219A3 (fr) Detection de neoepitope de maladie a l'aide de reseaux de proteines
WO2001063293A3 (fr) Proteines et genes et leur utilisation dans le diagnostic et le traitement de la schizophrenie
WO2006070290A3 (fr) Agents et procedes pour le diagnostic et le suivi precoces de la maladie d'alzheimer et d'autres troubles neurologiques
ATE498020T1 (de) 5t4 rna in plasma und serum als marker für neoplastische erkrankungen
DE502004012230D1 (de) Verfahren zur diagnose von erkrankungen unter bestimmung von apolipoprotein c-i
WO2003061622A3 (fr) Procede et dispositif pour introduire des cellules vivantes dans un fluide corporel biologique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 11301911

Country of ref document: US

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005756623

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2007500789

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2005756623

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10588749

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 11301911

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10588749

Country of ref document: US

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载