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WO2005056002A3 - Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acyl homoserine lactone chez les bacteries pathogenes a gram negatif - Google Patents

Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acyl homoserine lactone chez les bacteries pathogenes a gram negatif Download PDF

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Publication number
WO2005056002A3
WO2005056002A3 PCT/FR2004/003116 FR2004003116W WO2005056002A3 WO 2005056002 A3 WO2005056002 A3 WO 2005056002A3 FR 2004003116 W FR2004003116 W FR 2004003116W WO 2005056002 A3 WO2005056002 A3 WO 2005056002A3
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WIPO (PCT)
Prior art keywords
gram
homoserine lactone
butyrolactone
acyl
pathogenic bacteria
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PCT/FR2004/003116
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English (en)
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WO2005056002A2 (fr
Inventor
Denis Faure
Aurelien Carlier
Yves Dessaux
Original Assignee
Centre Nat Rech Scient
Denis Faure
Aurelien Carlier
Yves Dessaux
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Application filed by Centre Nat Rech Scient, Denis Faure, Aurelien Carlier, Yves Dessaux filed Critical Centre Nat Rech Scient
Publication of WO2005056002A2 publication Critical patent/WO2005056002A2/fr
Publication of WO2005056002A3 publication Critical patent/WO2005056002A3/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/742—Organic compounds containing oxygen
    • A23B2/754—Organic compounds containing oxygen containing carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Utilisation d'un inducteur de la voie de dégradation de la Ϝ-butyrolactone pour augmenter la dégradation enzymatique de la N-acyl homosérine lactone chez les bactéries pathogènes ô Gram négatif sensibles au signal N-acyl homosérine lactone, ô l'exclusion de l'acide butyrique et de l'acide α-hydroxy-β-méthylbutyrique, et applications, notamment dans les domaines de l'agriculture, de l'industrie agroalimentaire et de la médecine humaine et animale.
PCT/FR2004/003116 2003-12-04 2004-12-03 Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acyl homoserine lactone chez les bacteries pathogenes a gram negatif WO2005056002A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0314231 2003-12-04
FR0314231A FR2863168A1 (fr) 2003-12-04 2003-12-04 Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acy homoserine lactone.

Publications (2)

Publication Number Publication Date
WO2005056002A2 WO2005056002A2 (fr) 2005-06-23
WO2005056002A3 true WO2005056002A3 (fr) 2006-02-23

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PCT/FR2004/003116 WO2005056002A2 (fr) 2003-12-04 2004-12-03 Utilisation d'inducteurs de la voie de degradation de la gamma-butyrolactone pour inactiver le signal n-acyl homoserine lactone chez les bacteries pathogenes a gram negatif

Country Status (2)

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FR (1) FR2863168A1 (fr)
WO (1) WO2005056002A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2650716C (fr) 2006-05-01 2014-06-17 Universiteit Gent Hydroxybutyrate et polyhydroxybutyrate en tant que composants d'aliments pour animaux ou d'additifs aux aliments pour animaux
EP2117320B1 (fr) * 2007-01-19 2017-03-22 Centre National De La Recherche Scientifique Produits chimiques stimulateurs de croissance des bacteries entrainant la degradation de n-acyle homoserine lactones (n-acyl-hsl)
CN111705028A (zh) * 2012-06-04 2020-09-25 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
CN110563996B (zh) * 2019-09-10 2021-12-21 大连民族大学 一种革兰氏阴性细菌群体感应淬灭聚合物

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US3086907A (en) * 1958-03-06 1963-04-23 Gen Aniline & Film Corp Method for controlling soil nematodes
US3629451A (en) * 1969-03-03 1971-12-21 Stanley Drug Products Inc Method of treating bacterial infections
US3895116A (en) * 1971-11-29 1975-07-15 Eastman Kodak Co Mixtures of volatile fatty acids having anti-fungal and anti-bacterial activity
US4179522A (en) * 1975-11-27 1979-12-18 Bp Chemicals Limited Certain complex salts of mono carboxylic acids used as preservatives
JPS5758651A (en) * 1980-09-25 1982-04-08 Kayaku:Kk Preparation of diamino acid derivative
US4550026A (en) * 1983-02-15 1985-10-29 Yosuke Akiba Method for preserving food using a preservative gas atmosphere
JPH0255794A (ja) * 1988-08-22 1990-02-26 Asahi Denka Kogyo Kk 抗菌性潤滑剤組成物
WO1995015684A1 (fr) * 1993-12-12 1995-06-15 Agrogene, Ltd. Nouveau procede servant a proteger des vegetaux des infections fongiques
US5462714A (en) * 1992-09-22 1995-10-31 Arda Technologies Antimicrobial composition and methods of use
CA2144021A1 (fr) * 1994-05-10 1995-11-11 V. Gerold Luss Composition microbicide, non toxique et non corrosive
RU2048807C1 (ru) * 1993-10-10 1995-11-27 Научно-исследовательская фирма "Ультрасан" Антибактериальный противовоспалительный препарат
WO1996011572A1 (fr) * 1994-10-14 1996-04-25 Sven Moberg Composition antimicrobienne
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WO1997000676A1 (fr) * 1995-06-21 1997-01-09 Oy Extracta Ltd. Composes antimicrobiens et anti-inflammatoires
WO1997027851A1 (fr) * 1996-02-01 1997-08-07 The Johns-Hopkins University L-homoserine et lactone de l-homoserine employes comme bacteriostatiques de m. tubercolosis et m. bovis
WO1999059574A1 (fr) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. Procede de stimulation de la production de defensine par exposition a de l'isoleucine
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
JP2001206811A (ja) * 2000-01-25 2001-07-31 Kagome Co Ltd 植物疫病の防除剤および防除方法
WO2001057174A1 (fr) * 2000-02-01 2001-08-09 Reckitt Benckiser Inc. Composition de nettoyage de surfaces dures
US20020183387A1 (en) * 2001-06-04 2002-12-05 Bogart Mark H. Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
WO2003018049A2 (fr) * 2001-08-23 2003-03-06 Westgate Biological Limited Utilisation d'apoproteines du serum du lait dans la prophylaxie ou le traitement d'infections microbiennes ou virales
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US3629451A (en) * 1969-03-03 1971-12-21 Stanley Drug Products Inc Method of treating bacterial infections
US3895116A (en) * 1971-11-29 1975-07-15 Eastman Kodak Co Mixtures of volatile fatty acids having anti-fungal and anti-bacterial activity
US4179522A (en) * 1975-11-27 1979-12-18 Bp Chemicals Limited Certain complex salts of mono carboxylic acids used as preservatives
JPS5758651A (en) * 1980-09-25 1982-04-08 Kayaku:Kk Preparation of diamino acid derivative
US4550026A (en) * 1983-02-15 1985-10-29 Yosuke Akiba Method for preserving food using a preservative gas atmosphere
JPH0255794A (ja) * 1988-08-22 1990-02-26 Asahi Denka Kogyo Kk 抗菌性潤滑剤組成物
US5462714A (en) * 1992-09-22 1995-10-31 Arda Technologies Antimicrobial composition and methods of use
RU2048807C1 (ru) * 1993-10-10 1995-11-27 Научно-исследовательская фирма "Ультрасан" Антибактериальный противовоспалительный препарат
WO1995015684A1 (fr) * 1993-12-12 1995-06-15 Agrogene, Ltd. Nouveau procede servant a proteger des vegetaux des infections fongiques
CA2144021A1 (fr) * 1994-05-10 1995-11-11 V. Gerold Luss Composition microbicide, non toxique et non corrosive
WO1996011572A1 (fr) * 1994-10-14 1996-04-25 Sven Moberg Composition antimicrobienne
WO1996029392A1 (fr) * 1995-03-23 1996-09-26 Unisearch Limited Procedes et regulation microbienne
WO1997000676A1 (fr) * 1995-06-21 1997-01-09 Oy Extracta Ltd. Composes antimicrobiens et anti-inflammatoires
WO1997027851A1 (fr) * 1996-02-01 1997-08-07 The Johns-Hopkins University L-homoserine et lactone de l-homoserine employes comme bacteriostatiques de m. tubercolosis et m. bovis
WO1999059574A1 (fr) * 1998-05-21 1999-11-25 Magainin Pharmaceuticals, Inc. Procede de stimulation de la production de defensine par exposition a de l'isoleucine
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
US20030060457A1 (en) * 1998-07-31 2003-03-27 Schaffer Priscilla A. Cellular proteins as targets for the treatment of pathogens resistant to drugs that target pathogen-encoded proteins
JP2001206811A (ja) * 2000-01-25 2001-07-31 Kagome Co Ltd 植物疫病の防除剤および防除方法
WO2001057174A1 (fr) * 2000-02-01 2001-08-09 Reckitt Benckiser Inc. Composition de nettoyage de surfaces dures
US20020183387A1 (en) * 2001-06-04 2002-12-05 Bogart Mark H. Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
WO2003018049A2 (fr) * 2001-08-23 2003-03-06 Westgate Biological Limited Utilisation d'apoproteines du serum du lait dans la prophylaxie ou le traitement d'infections microbiennes ou virales

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CARLIER A ET AL: "The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activity.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 69, no. 8, August 2003 (2003-08-01), pages 4989 - 4993, XP002288910, ISSN: 0099-2240 *
DATABASE WPI Section Ch Week 199014, Derwent World Patents Index; Class D22, AN 1990-104332, XP002295418 *
DATABASE WPI Section Ch Week 199630, Derwent World Patents Index; Class B05, AN 1996-298701, XP002288911 *
DATABASE WPI Section Ch Week 200173, Derwent World Patents Index; Class C05, AN 2001-629504, XP002288912 *
PATENT ABSTRACTS OF JAPAN vol. 006, no. 135 (C - 115) 22 July 1982 (1982-07-22) *
UROZ STÉPHANE ET AL: "Novel bacteria degrading N-acylhomoserine lactones and their use as quenchers of quorum-sensing-regulated functions of plant-pathogenic bacteria.", MICROBIOLOGY (READING, ENGLAND) AUG 2003, vol. 149, no. Pt 8, August 2003 (2003-08-01), pages 1981 - 1989, XP002288909, ISSN: 1350-0872 *

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FR2863168A1 (fr) 2005-06-10

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