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WO2005053609A3 - Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante - Google Patents

Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante Download PDF

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Publication number
WO2005053609A3
WO2005053609A3 PCT/US2004/039220 US2004039220W WO2005053609A3 WO 2005053609 A3 WO2005053609 A3 WO 2005053609A3 US 2004039220 W US2004039220 W US 2004039220W WO 2005053609 A3 WO2005053609 A3 WO 2005053609A3
Authority
WO
WIPO (PCT)
Prior art keywords
nad
methods
deacetylase inhibitors
dependent deacetylase
dependent
Prior art date
Application number
PCT/US2004/039220
Other languages
English (en)
Other versions
WO2005053609A2 (fr
Inventor
Jie Zhang
Weizheng Xu
Original Assignee
Guilford Pharm Inc
Jie Zhang
Weizheng Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc, Jie Zhang, Weizheng Xu filed Critical Guilford Pharm Inc
Publication of WO2005053609A2 publication Critical patent/WO2005053609A2/fr
Publication of WO2005053609A3 publication Critical patent/WO2005053609A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des méthodes de traitement du cancer, de troubles cardiovasculaires et de troubles neurologiques à l'aide d'inhibiteurs de désacétylase NAD+ dépendante.
PCT/US2004/039220 2003-11-26 2004-11-23 Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante WO2005053609A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52530303P 2003-11-26 2003-11-26
US60/525,303 2003-11-26

Publications (2)

Publication Number Publication Date
WO2005053609A2 WO2005053609A2 (fr) 2005-06-16
WO2005053609A3 true WO2005053609A3 (fr) 2005-09-01

Family

ID=34652323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039220 WO2005053609A2 (fr) 2003-11-26 2004-11-23 Methodes d'utilisation d'inhibiteurs de desacetylase nad+ dependante

Country Status (1)

Country Link
WO (1) WO2005053609A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US8691534B2 (en) 2006-12-29 2014-04-08 Celgene Corporation Preparation of romidepsin
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
US9101579B2 (en) 2012-11-14 2015-08-11 Celgene Corporation Inhibition of drug resistant cancer cells
US9134325B2 (en) 2012-09-07 2015-09-15 Celgene Corporation Resistance biomarkers for HDAC inhibitors
US9463215B2 (en) 2013-12-27 2016-10-11 Celgene Corporation Romidepsin formulations and uses thereof
US9518094B2 (en) 2010-07-12 2016-12-13 Celgene Corporation Romidepsin solid forms and uses thereof
US9539303B2 (en) 2006-04-24 2017-01-10 Celgene Corporation Treatment of Ras-expressing tumors

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2005002672A2 (fr) 2003-07-01 2005-01-13 President And Fellows Of Harvard College Compositions pour la manipulation de la duree de vie et de la reaction de stress de cellules et d'organismes
CN101247793B (zh) 2003-12-29 2013-04-10 哈佛大学校长及研究员协会 治疗或预防肥胖和胰岛素抗性病症的组合物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
WO2006066133A2 (fr) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2006138418A2 (fr) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Amelioration de la performance cognitive avec des activateurs de sirtuine
CA2615105A1 (fr) 2005-07-14 2007-01-25 Takeda San Diego, Inc. Inhibiteurs de l'histone deacetylase
EP1991226B1 (fr) 2006-02-28 2013-03-20 Merck Sharp & Dohme Corp. Inhibiteurs de l'histone désacétylase
GB0816269D0 (en) 2008-09-05 2008-10-15 Univ Ramot Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of alzheimers disease
CA2797719C (fr) * 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Inhibiteurs de petites molecules de l'activite de l'enzyme de deubiquination usp1
EP2600855A2 (fr) 2010-08-04 2013-06-12 Pellficure Pharmaceuticals, Inc. Thérapie combinée pour le traitement du carcinome de la prostate
WO2014074976A1 (fr) * 2012-11-09 2014-05-15 Musc Foundation For Research Development Compositions et méthodes de traitement de maladies ou de lésions neurologiques
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
KR101876750B1 (ko) * 2016-07-26 2018-07-11 한밭대학교 산학협력단 신규한 2-아민 치환 1,4-나프토퀴논 화합물 및 이를 포함하는 암의 예방 또는 치료용 약제학적 조성물
CN112770735A (zh) * 2018-07-29 2021-05-07 Musc研究发展基金会 用于治疗神经或线粒体疾病的化合物
CN113368087A (zh) * 2020-03-10 2021-09-10 复旦大学附属华山医院 胡桃醌其衍生物及其在制备化疗脑肿瘤的药物中的用途
KR20240169284A (ko) * 2023-05-24 2024-12-03 경희대학교 산학협력단 AhR-매개 질환의 예방, 개선 또는 치료용 약학적 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511990B1 (en) * 1999-09-08 2003-01-28 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
WO2003007933A1 (fr) * 2001-07-16 2003-01-30 The University Court Of The University Of Aberdeen Derives de napthoquinone en tant qu'inhibiteurs de l'agregation des tau pour le traitement de la maladie d'alzheimer et des troubles de neurodegenerescence associes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511990B1 (en) * 1999-09-08 2003-01-28 Sloan-Kettering Institute For Cancer Research Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
WO2003007933A1 (fr) * 2001-07-16 2003-01-30 The University Court Of The University Of Aberdeen Derives de napthoquinone en tant qu'inhibiteurs de l'agregation des tau pour le traitement de la maladie d'alzheimer et des troubles de neurodegenerescence associes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HODNETT E. ET AL: "Subtituted 1,4-Naphthoquinones vs. the Ascitic Sarcoma 180 of Mice.", J.MED.CHEM., vol. 23, no. 4, 1983, pages 570 - 574, XP002988938 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US9539303B2 (en) 2006-04-24 2017-01-10 Celgene Corporation Treatment of Ras-expressing tumors
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
US9259452B2 (en) 2006-06-08 2016-02-16 Gelgene Corporation Deacetylase inhibitor therapy
US8691534B2 (en) 2006-12-29 2014-04-08 Celgene Corporation Preparation of romidepsin
US9518094B2 (en) 2010-07-12 2016-12-13 Celgene Corporation Romidepsin solid forms and uses thereof
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
US9134325B2 (en) 2012-09-07 2015-09-15 Celgene Corporation Resistance biomarkers for HDAC inhibitors
US9101579B2 (en) 2012-11-14 2015-08-11 Celgene Corporation Inhibition of drug resistant cancer cells
US9463215B2 (en) 2013-12-27 2016-10-11 Celgene Corporation Romidepsin formulations and uses thereof
US9468664B2 (en) 2013-12-27 2016-10-18 Celgene Corporation Romidepsin formulations and uses thereof

Also Published As

Publication number Publication date
WO2005053609A2 (fr) 2005-06-16

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