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WO2005051995A3 - Novel advanced glycosylation end product-specific receptor-like protein and nucleic acids encoding same - Google Patents

Novel advanced glycosylation end product-specific receptor-like protein and nucleic acids encoding same Download PDF

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Publication number
WO2005051995A3
WO2005051995A3 PCT/US2004/038870 US2004038870W WO2005051995A3 WO 2005051995 A3 WO2005051995 A3 WO 2005051995A3 US 2004038870 W US2004038870 W US 2004038870W WO 2005051995 A3 WO2005051995 A3 WO 2005051995A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
end product
specific receptor
protein
advanced glycosylation
Prior art date
Application number
PCT/US2004/038870
Other languages
French (fr)
Other versions
WO2005051995A2 (en
Inventor
David J Stone
Erik Gunther
Original Assignee
Curagen Corp
David J Stone
Erik Gunther
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, David J Stone, Erik Gunther filed Critical Curagen Corp
Publication of WO2005051995A2 publication Critical patent/WO2005051995A2/en
Publication of WO2005051995A3 publication Critical patent/WO2005051995A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates generally to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of a novel isoform of the Advanced Glycosylation End product-specific Receptor (RAGE), and its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
PCT/US2004/038870 2003-11-19 2004-11-19 Novel advanced glycosylation end product-specific receptor-like protein and nucleic acids encoding same WO2005051995A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52426603P 2003-11-19 2003-11-19
US60/524,266 2003-11-19

Publications (2)

Publication Number Publication Date
WO2005051995A2 WO2005051995A2 (en) 2005-06-09
WO2005051995A3 true WO2005051995A3 (en) 2005-08-25

Family

ID=34632883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038870 WO2005051995A2 (en) 2003-11-19 2004-11-19 Novel advanced glycosylation end product-specific receptor-like protein and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2005051995A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877192B2 (en) 2004-08-03 2014-11-04 Transtech Pharma, Llc Rage fusion proteins and methods of use
US9034341B2 (en) 2009-04-20 2015-05-19 Transtech Pharma, Llc Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1771565B1 (en) 2004-07-20 2012-09-05 The Feinstein Institute for Medical Research Rage protein derivatives
US20070087406A1 (en) * 2005-05-04 2007-04-19 Pei Jin Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039121A1 (en) * 1996-04-16 1997-10-23 Schering Aktiengesellschaft Advanced glycosylation end-product receptor peptides and uses therefor
WO2000020458A1 (en) * 1998-10-05 2000-04-13 The Trustees Of Columbia University In The City Of New York Methods for determining whether a compound is capable of inhibiting the interaction of a peptide with rage
WO2001092892A2 (en) * 2000-05-30 2001-12-06 Transtech Pharma, Inc. Methods to identify compounds that modulate rage
WO2002030889A2 (en) * 2000-10-13 2002-04-18 The Trustees Of Columbia University In The City Of New York A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury
WO2002059260A2 (en) * 2000-11-17 2002-08-01 Hyseq, Inc. Nucleic acids and polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039121A1 (en) * 1996-04-16 1997-10-23 Schering Aktiengesellschaft Advanced glycosylation end-product receptor peptides and uses therefor
WO2000020458A1 (en) * 1998-10-05 2000-04-13 The Trustees Of Columbia University In The City Of New York Methods for determining whether a compound is capable of inhibiting the interaction of a peptide with rage
WO2001092892A2 (en) * 2000-05-30 2001-12-06 Transtech Pharma, Inc. Methods to identify compounds that modulate rage
WO2002030889A2 (en) * 2000-10-13 2002-04-18 The Trustees Of Columbia University In The City Of New York A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury
WO2002059260A2 (en) * 2000-11-17 2002-08-01 Hyseq, Inc. Nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KISLINGER T ET AL: "N-epsilon-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 44, 29 October 1999 (1999-10-29), pages 31740 - 31749, XP002217809, ISSN: 0021-9258 *
SCHMIDT A M ET AL: "ACTIVATION OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS A MECHANISM FOR CHRONIC VASCULAR DYSFUNCTION IN DIABETIC VASCULOPATHY AND ATHEROSCLEROSIS", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 84, 19 March 1999 (1999-03-19), pages 489 - 497, XP002909514, ISSN: 0009-7330 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877192B2 (en) 2004-08-03 2014-11-04 Transtech Pharma, Llc Rage fusion proteins and methods of use
US9034341B2 (en) 2009-04-20 2015-05-19 Transtech Pharma, Llc Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions

Also Published As

Publication number Publication date
WO2005051995A2 (en) 2005-06-09

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