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WO2004110336A1 - Systeme perfectionne comportant des circuits electroniques - Google Patents

Systeme perfectionne comportant des circuits electroniques Download PDF

Info

Publication number
WO2004110336A1
WO2004110336A1 PCT/US2004/018512 US2004018512W WO2004110336A1 WO 2004110336 A1 WO2004110336 A1 WO 2004110336A1 US 2004018512 W US2004018512 W US 2004018512W WO 2004110336 A1 WO2004110336 A1 WO 2004110336A1
Authority
WO
WIPO (PCT)
Prior art keywords
card
package
circuitry
closed cell
receptacle
Prior art date
Application number
PCT/US2004/018512
Other languages
English (en)
Other versions
WO2004110336A8 (fr
Inventor
Thanhhung Le
Rune Haraldsson
Original Assignee
Meadwestvaco Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meadwestvaco Corporation filed Critical Meadwestvaco Corporation
Priority to MXPA05013243A priority Critical patent/MXPA05013243A/es
Priority to EP20040754944 priority patent/EP1635761A1/fr
Priority to US10/559,990 priority patent/US7552824B2/en
Priority to CA 2525042 priority patent/CA2525042A1/fr
Priority to BRPI0411075-7A priority patent/BRPI0411075A/pt
Publication of WO2004110336A1 publication Critical patent/WO2004110336A1/fr
Publication of WO2004110336A8 publication Critical patent/WO2004110336A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/0286—Programmable, customizable or modifiable circuits
    • H05K1/0293—Individual printed conductors which are adapted for modification, e.g. fusable or breakable conductors, printed switches

Definitions

  • the present invention relates generally to systems and methods used for monitoring the dispensing, accessing, delivering or using of packaged items. More specifically the present invention is directed to monitoring healthcare behavior, such as compliance with a medication regimen. Accordingly, the embodiments described are improved pharmaceutical packages and pharmaceutical package inserts that include electronic circuitry for use with an electronic monitoring device.
  • the present invention overcomes the deficiencies of the known art and the problems that remain unsolved by providing insertable cards which can be used together to form a package with electronic circuitry, or are easily integrated into existing manufacturing processes and package configurations to provide electronic monitoring functionality.
  • One component of an illustrated embodiment is a fold-over card.
  • This fold-over card includes an array of open cells.
  • Another component of an illustrated embodiment is a blister card.
  • This blister card includes an array of receptacles with open sides for receiving items.
  • a third component of an illustrated embodiment is a backing card that includes an array of breachable closed cells. After the items are deposited into the receptacles, the backing card is attached to the fold-over card in a manner that captures the items and seals the open side of the receptacles.
  • a subsequent component of this embodiment is a trace card comprising an array of breachable closed cells and circuitry that spans these closed cells. Here the circuitry is printed on the trace card using conductive inks and conventional printing methods.
  • the closed cells of the trace card are aligned with the closed cells of the backing card (or the receptacles, in the absence of a closed cell backing card), to facilitate access to the items.
  • the user eventually breaches the circuit associated with the selected items and related closed cell.
  • the item is pushed through the first closed cell, whether the first closed cell is located on the fold-over card or backing card.
  • the user continues to push the item until it breaches the circuit spanning the related closed cell of the trace card.
  • the related closed circuit is broken. The breaking of the circuit is received and stored by an electronic monitoring device as the event of accessing the item.
  • One embodiment comprises a combined fold-over and blister card, together with a backing card and a trace card.
  • Another embodiment comprises a combined blister and backing card, together with a trace card.
  • Yet another embodiment comprises a fold-over card, a blister card, a foil backing, and a trace card with a dielectric overlay, hi practice these additional embodiments may be constructed and used as described above.
  • FIG. 1 is an exploded view of an embodiment of the present invention.
  • FIG. 2 is an exploded view of an embodiment of the present invention.
  • FIG. 3 is a plan view of the circuitry of FIG. 1 and FIG. 2.
  • FIG. 1 illustrates an exploded view of an exemplary Improved Package with Electronic Circuitry (“PEC”) 10, configured for use with the dispensing of medications in tablet form.
  • PEC Electronic Circuitry
  • a punched fold-over card 20 is constructed of inexpensive disposable sheet-like material such as paper, paperboard, cardboard, plastic, or any combination thereof.
  • This fold-over card 20 includes an array of open cells 22, formed by a prior pre-assembly step, such as a cutting, punching, scoring or forming depending on the material used.
  • the illustrated fold-over card 20 further includes score lines 24 to facilitate final assembly as described below, and a locking tab 26 to be used as described below.
  • This blister card 28 includes an array of blister cells 29.
  • a blister card 28 is thermo-formed from a plastic-type material to create blister cells 29, pliable protruding (concave when viewed from side A of the blister card) receptacles for receiving and storing medication in tablet form (not shown) to be accessed by a user.
  • the actual configuration of the blister cards 28 and materials used are merely design choices.
  • side B of the blister card 28 is receivingly mated to side C of the fold-over card 20 so that each blister cell 29 is aligned with and nested within a respective open cell 22. In this configuration the blister cells 29 are ready to receive the medication tablets.
  • side A of the blister card 28 may be mated with side D of the fold-over card 20 so that each blister cell 29 is aligned with a respective open cell 22 and ready to receive the medication tablets.
  • the order of assembling these two cards 20, 28 does not determine when the medication tablets are deposited into the blister cavities 29. Accordingly the manufacturer does not need to alter its assembly process with regard to the components and steps described so far.
  • This backing-card 30 includes an array of closed cells 32, which are best described as locations designed to facilitate breaching a card by pushing through a perforated or scored cell gate.
  • the backing card 30 is constructed of non-conductive material.
  • the backing card 30 is attached to the fold-over card 28 in a manner that captures the tablets and seals the blister cells 29.
  • the backing card 30 may perform any or all additional functions, including receiving graphics, structural support, and insulting against the electronics described below.
  • the backing card 30 is attached to side A of the blister card 28 and/or side C of the fold-over card 20. And for the reasons explained below, each closed cell 32 is aligned with a respective blister cavity 22.
  • the open cells 22 may be replaced with closed cells 32 and side A of the blister card 28 may be attached directly to side D of the fold-over card 20 after the tablets are deposited into the blister cells 29.
  • the blister card 28 may be configured to resemble the fold-over card 20 and attached directly to the backing card 30, after the tablets are deposited into the blister cells 29, such that each blister cell 29 is aligned with a respective closed cell 32.
  • a subsequent component of this PEC 10 is a trace card 40 comprising an array of closed cells 32 and circuitry 42.
  • the trace card 40 is constructed of non-conductive material such as but not limited to paper, paperboard, cardboard, plastic, or any combination thereof.
  • the configuration of the trace card 40 mimics the configuration of the fold-over card 20 and backing card 30. It is contemplated that the configuration of the trace card 40 is merely a design choice selected to best fit with new or existing packages or package manufacturing processes.
  • the illustrated circuitry 42 is applied directly. on the trace card 40, in a manner well known by those skilled in the art.
  • the circuitry 42 is printed on the trace card 40 using conventional printing or lithography methods such as but not limited to screen or off-set methods.
  • the inks used in the printing method to form the circuitry 42 are conductive inks, selected based on the performance needs of the individual circuits 44.
  • Conductive inks typically include conductive metals such as but not limited to copper or silver.
  • the ink used to form the illustrated circuitry 42 is a carbon-based conductive ink readily understood by those skilled in the art.
  • each individual closed circuit 44 typically extends from and returns to an electronic monitoring device (EMD, not shown) located at an electronic monitoring receiving area 46, and bridges a closed cell 32.
  • EMD electronic monitoring device
  • each individual closed circuit 44 typically extends from and returns to an electronic monitoring device (EMD, not shown) located at an electronic monitoring receiving area 46, and bridges a closed cell 32.
  • EMD electronic monitoring device
  • the breaking of a circuit 44 signals the removal of a tablet, an event that is captured and recorded by the EMD.
  • Individual circuits 44 may be as wide or as narrow as required by the voltage and resistance requirements of the embodiment in use, but in the illustrated embodiments it is shown to widen the circuitry 42 over cells 32 and score lines 24 to reduce or eliminate false readings. Accordingly, the circuitry 42 comprises cell bridges 48 and score line bridges 50. It is contemplated that individual circuits 44 may be configured to accommodate switches, controls, and similar components that enhance monitoring functions.
  • the closed cells 32 of the trace card 40 are aligned with the closed cells 32 of the backing card 30 (or the blister cells 29, in the .absence of a closed cell backing card), to facilitate access to the tablets.
  • the user eventually breaches the cell bridge 48 associated with the selected tablet.
  • the tablet Upon exerting sufficient force on the tablet from the outside surface of the blister cell 29 the tablet is pushed through the first closed cell 32, whether the first closed cell 32 is located on the fold-over card 20 or backing card 30. The user continues to push the tablet until it breaches the cell bridge 48 spanning the related closed cell 32 of the trace card 40.
  • the related closed circuit 44 Upon breaching the cell bridge 48 and related closed cell 32, the related closed circuit 44 is broken. The breaking of the circuit 44 is received and stored by the EMD as the event of accessing the tablet. Indicia regarding that event, including time of day, date, sequence or any number of event labeling indicia, as programmed in the EMD or devices in communication with EMD, may also be recorded and stored by the EMD. This event related indicia stored by the EMD may be read, retrieved, or transmitted as provided by the EMD in a manner understood by those skilled in the art.
  • FIG. 1 The embodiment illustrated in FIG. 1 is described as being constructed of materials and by methods common to the industry example provided. The advantages of constructing embodiments with inexpensive materials and by manufacturing methods commonly used are readily apparent and do not require further explanation. Likewise, producing a system with a look and feel readily familiar to most consumers provides known advantages. Accordingly the use of insertable cards 20, 30, 40 to provide the flexibility to an existing industry application or existing package configuration is another advantage of the present invention.
  • the PEC 10 may be combined with the outer sleeve taught in
  • FIG. 2 in the healthcare industry it is known to use foil guard technology to seal and protect pharmaceuticals delivered in blister cards 28.
  • a blister card 28 with tablets (not shown) configured to receive a protective film of foil 62 in a manner well known by those skilled in the art, that is, so that the foil 62 seals the blister cells 29 by being positioned immediately adjacent to side A of the blister card 28 and/or side C of the fold-over card 20.
  • a dielectric circuit overlay 64 is provided.
  • the dielectric circuit overlay 64 is a non- conductive ink printed directly over the conductive printed circuitry 42 using the printing processes referenced herein. It will be understood that the overlay 64 may exactly follow and cover each circuit 44 and components 48, 50, or more broadly cover the circuit side of the trace card 40 where non-conductivity between the circuitry 42 and foil 62 is desired. It will be further understood that the overlay 64 may be any non-conductive thin covering, whether inks or plastics convenient to the manufacturer, that provides a sufficient dielectric barrier between the foil 62 and circuitry 42.
  • the pharmaceutical manufacturer can add monitoring and compliance functions with minimum impact to its existing processes.
  • the embodiments taught herein are directed to single-use disposable packing, however such embodiments are not a limitation as reusable packing is contemplated.
  • the blister cells 29 illustrated may be constructed of a durable latex and the backing card 30 illustrated may be constructed of a rigid metal or plastic with closed cells 32 that permit repeated access, such as are available with a hinged or replaceable friction-fit cell gate.
  • the above-described embodiments of the present invention are merely possible examples of implementations set forth for a clear understanding of the principles of the invention. Many variations and modifications may be made to the above-described embodiments of the invention without departing substantially from the spirit and principles of the invention. All such modifications and variations are intended to be included herein within the scope of this disclosure and the present invention and protected by the following claims.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un système comportant des circuits électroniques permettant de surveiller le prélèvement d'articles d'un réceptacle, par exemple des comprimés médicamenteux d'une alvéole d'emballage. Ledit système est constitué de plusieurs plaquettes, y compris une plaquette alvéolaire (20), une plaquette support (30), et une plaquette trace (40). La plaquette alvéolaire comporte au moins un réceptacle saillant (29) dont un côté est ouvert. La plaquette support comporte au moins une cellule fermée pouvant être forcée (32), épousant la plaquette alvéolaire, ainsi, la cellule fermée s'étend à travers le côté ouvert du réceptacle. Enfin, la plaquette trace comporte au moins une cellule fermée pouvant être forcée (32) et des circuits (42), épousant la plaquette support, ainsi, les cellules fermées sont alignées. Dans un autre mode de réalisation, la plaquette support peut être une couche de feuille conductrice (62) et la plaquette trace peut comporter un revêtement diélectrique (64).
PCT/US2004/018512 2003-06-10 2004-06-10 Systeme perfectionne comportant des circuits electroniques WO2004110336A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MXPA05013243A MXPA05013243A (es) 2003-06-10 2004-06-10 Paquete mejorado con circuiteria electronica.
EP20040754944 EP1635761A1 (fr) 2003-06-10 2004-06-10 Systeme perfectionne comportant des circuits electroniques
US10/559,990 US7552824B2 (en) 2003-06-10 2004-06-10 Package with electronic circuitry
CA 2525042 CA2525042A1 (fr) 2003-06-10 2004-06-10 Systeme perfectionne comportant des circuits electroniques
BRPI0411075-7A BRPI0411075A (pt) 2003-06-10 2004-06-10 embalagem com conjunto de circuito eletrÈnico e método de monitorar a remoção de um item de um receptáculo

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47751403P 2003-06-10 2003-06-10
US60/477,514 2003-06-10
US53729704P 2004-01-20 2004-01-20
US60/537,297 2004-01-20

Publications (2)

Publication Number Publication Date
WO2004110336A1 true WO2004110336A1 (fr) 2004-12-23
WO2004110336A8 WO2004110336A8 (fr) 2005-05-19

Family

ID=34576490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/018512 WO2004110336A1 (fr) 2003-06-10 2004-06-10 Systeme perfectionne comportant des circuits electroniques

Country Status (4)

Country Link
EP (1) EP1635761A1 (fr)
CA (1) CA2525042A1 (fr)
MX (1) MXPA05013243A (fr)
WO (1) WO2004110336A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076806A1 (fr) * 2005-01-20 2006-07-27 Intelligent Devices Inc. Systeme, processus d'assurance production et qualite respectant des etiquettes de dispositif de verification de conformite electronique (ecm)
WO2011006857A1 (fr) 2009-07-13 2011-01-20 Dsm Ip Assets B.V. Emballage-coque pour préparations pharmaceutiques
GB2484663A (en) * 2010-10-15 2012-04-25 Future Technology Uk Ltd Tray with Seal Including Barrier Layer Secured Directly to the Tray
WO2015132811A1 (fr) * 2014-03-03 2015-09-11 日本電気株式会社 Dispositif de détection, unité de détection et système de détection

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009135283A1 (fr) * 2008-05-06 2009-11-12 Intelligent Devices Inc. Élément annexe d’emballage coque

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010771A (en) * 1995-10-07 2000-01-04 Bemis Company Inc. Electrical circuit component formed of a conductive liquid printed directly onto a substrate
WO2000018350A1 (fr) * 1998-09-25 2000-04-06 Cypak Ab Formulaire
US20020017996A1 (en) * 2000-07-07 2002-02-14 Niemiec Mark A. Drug delivery management system
EP1214924A2 (fr) * 2000-12-07 2002-06-19 Dieter Dr. Hafner Dispositif de support pour enveloppe de type plaquette alvéolée destinée à recevoir des médicaments sous forme de comprimés ou dragées

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010771A (en) * 1995-10-07 2000-01-04 Bemis Company Inc. Electrical circuit component formed of a conductive liquid printed directly onto a substrate
WO2000018350A1 (fr) * 1998-09-25 2000-04-06 Cypak Ab Formulaire
US20020017996A1 (en) * 2000-07-07 2002-02-14 Niemiec Mark A. Drug delivery management system
EP1214924A2 (fr) * 2000-12-07 2002-06-19 Dieter Dr. Hafner Dispositif de support pour enveloppe de type plaquette alvéolée destinée à recevoir des médicaments sous forme de comprimés ou dragées

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006076806A1 (fr) * 2005-01-20 2006-07-27 Intelligent Devices Inc. Systeme, processus d'assurance production et qualite respectant des etiquettes de dispositif de verification de conformite electronique (ecm)
US7937829B2 (en) 2005-01-20 2011-05-10 Intelligent Devices, Inc. Method for manufacturing a conductive grid for attachment to a blister package
WO2011006857A1 (fr) 2009-07-13 2011-01-20 Dsm Ip Assets B.V. Emballage-coque pour préparations pharmaceutiques
GB2484663A (en) * 2010-10-15 2012-04-25 Future Technology Uk Ltd Tray with Seal Including Barrier Layer Secured Directly to the Tray
GB2484663B (en) * 2010-10-15 2013-01-16 Future Technology Uk Ltd Dispensing containers
WO2015132811A1 (fr) * 2014-03-03 2015-09-11 日本電気株式会社 Dispositif de détection, unité de détection et système de détection

Also Published As

Publication number Publication date
WO2004110336A8 (fr) 2005-05-19
CA2525042A1 (fr) 2004-12-23
EP1635761A1 (fr) 2006-03-22
MXPA05013243A (es) 2006-03-09

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