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WO2004039360B1 - Compositions pharmaceutiques aqueuses 2,6-diisopropylphenol - Google Patents

Compositions pharmaceutiques aqueuses 2,6-diisopropylphenol

Info

Publication number
WO2004039360B1
WO2004039360B1 PCT/US2003/031086 US0331086W WO2004039360B1 WO 2004039360 B1 WO2004039360 B1 WO 2004039360B1 US 0331086 W US0331086 W US 0331086W WO 2004039360 B1 WO2004039360 B1 WO 2004039360B1
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
amount
formulation according
antimicrobial agent
peg
Prior art date
Application number
PCT/US2003/031086
Other languages
English (en)
Other versions
WO2004039360A1 (fr
Inventor
Zhong Zhang
Orn Almarsson
Hongming Chen
Original Assignee
Transform Pharmaceuticals Inc
Zhong Zhang
Orn Almarsson
Hongming Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/629,308 external-priority patent/US7915317B2/en
Application filed by Transform Pharmaceuticals Inc, Zhong Zhang, Orn Almarsson, Hongming Chen filed Critical Transform Pharmaceuticals Inc
Priority to EP03759636A priority Critical patent/EP1556022A4/fr
Priority to AU2003275360A priority patent/AU2003275360A1/en
Priority to US10/766,631 priority patent/US7550155B2/en
Publication of WO2004039360A1 publication Critical patent/WO2004039360A1/fr
Publication of WO2004039360B1 publication Critical patent/WO2004039360B1/fr
Priority to US12/333,887 priority patent/US8133918B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions pharmaceutiques aqueuses comprenant 2,6-diisopropylphénol (propofol). Une composition selon l'invention peut contenir du propofol et au moins deux excipients sous forme de mélange aqueux. Les compositions contenant du propofol, de préférence stériles, sont administrées par voie parentérale à un animal quelconque, y compris aux humains. Ces compositions sont aussi chimiquement et physiquement stables dans une grande variété de conditions environnementales.
PCT/US2003/031086 2002-07-29 2003-10-02 Compositions pharmaceutiques aqueuses 2,6-diisopropylphenol WO2004039360A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03759636A EP1556022A4 (fr) 2002-10-29 2003-10-02 Compositions pharmaceutiques aqueuses 2,6-diisopropylphenol
AU2003275360A AU2003275360A1 (en) 2002-10-29 2003-10-02 Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US10/766,631 US7550155B2 (en) 2002-07-29 2004-01-28 Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US12/333,887 US8133918B2 (en) 2002-07-29 2008-12-12 Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US42219502P 2002-10-29 2002-10-29
US60/422,195 2002-10-29
US43697902P 2002-12-30 2002-12-30
US60/436,979 2002-12-30
US44349003P 2003-01-29 2003-01-29
US60/443,490 2003-01-29
US46245003P 2003-04-11 2003-04-11
US60/462,450 2003-04-11
US46431403P 2003-04-21 2003-04-21
US60/464,314 2003-04-21
US47040303P 2003-05-14 2003-05-14
US60/470,403 2003-05-14
US48535403P 2003-07-07 2003-07-07
US60/485,354 2003-07-07
US10/629,308 US7915317B2 (en) 2002-07-29 2003-07-29 Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US10/629,308 2003-07-29

Publications (2)

Publication Number Publication Date
WO2004039360A1 WO2004039360A1 (fr) 2004-05-13
WO2004039360B1 true WO2004039360B1 (fr) 2004-06-17

Family

ID=32234547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031086 WO2004039360A1 (fr) 2002-07-29 2003-10-02 Compositions pharmaceutiques aqueuses 2,6-diisopropylphenol

Country Status (3)

Country Link
EP (1) EP1556022A4 (fr)
AU (1) AU2003275360A1 (fr)
WO (1) WO2004039360A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US20220183999A1 (en) * 2019-04-05 2022-06-16 Sorrento Therapeutics, Inc. Cannabidiol Pharmaceutical Compositions
CN114601800B (zh) * 2021-09-28 2023-07-28 天津瑞普生物技术股份有限公司 一种甲磷丙泊酚钠无菌粉针剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
ES2211151T3 (es) * 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
AU5574200A (en) * 1999-06-21 2001-01-09 Kuhnil Pharm. Co., Ltd. Anesthetic composition for intravenous injection comprising propofol
US6623765B1 (en) * 2000-08-01 2003-09-23 University Of Florida, Research Foundation, Incorporated Microemulsion and micelle systems for solubilizing drugs
GB0124071D0 (en) * 2001-10-08 2001-11-28 Kbig Ltd Improvement in the administration of high boiling point aneasthetics

Also Published As

Publication number Publication date
EP1556022A4 (fr) 2010-03-10
WO2004039360A1 (fr) 2004-05-13
AU2003275360A8 (en) 2004-05-25
AU2003275360A1 (en) 2004-05-25
EP1556022A1 (fr) 2005-07-27

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