+

WO2004038039A3 - Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants - Google Patents

Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants Download PDF

Info

Publication number
WO2004038039A3
WO2004038039A3 PCT/US2003/033443 US0333443W WO2004038039A3 WO 2004038039 A3 WO2004038039 A3 WO 2004038039A3 US 0333443 W US0333443 W US 0333443W WO 2004038039 A3 WO2004038039 A3 WO 2004038039A3
Authority
WO
WIPO (PCT)
Prior art keywords
imagiong
optical
renilla luciferase
gene expression
reporter gene
Prior art date
Application number
PCT/US2003/033443
Other languages
English (en)
Other versions
WO2004038039A2 (fr
Inventor
Sanjiv Sam Gambhir
Original Assignee
Univ California
Sanjiv Sam Gambhir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Sanjiv Sam Gambhir filed Critical Univ California
Priority to AU2003285930A priority Critical patent/AU2003285930A1/en
Publication of WO2004038039A2 publication Critical patent/WO2004038039A2/fr
Publication of WO2004038039A3 publication Critical patent/WO2004038039A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés de détection et de localisation de la bioluminescence de la luciférase Renilla (RL) produite par un animal. L'invention concerne également des procédés de ciblage de l'émission de lumière de la luciférase Renilla vers des zones sélectionnées, ainsi que des procédés de localisation d'entités dans l'animal.
PCT/US2003/033443 2002-10-21 2003-10-21 Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants WO2004038039A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285930A AU2003285930A1 (en) 2002-10-21 2003-10-21 Optical imagiong of renilla luciferase reporter gene expression in living organisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42041902P 2002-10-21 2002-10-21
US60/420,419 2002-10-21

Publications (2)

Publication Number Publication Date
WO2004038039A2 WO2004038039A2 (fr) 2004-05-06
WO2004038039A3 true WO2004038039A3 (fr) 2004-07-08

Family

ID=32176565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033443 WO2004038039A2 (fr) 2002-10-21 2003-10-21 Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants

Country Status (2)

Country Link
AU (1) AU2003285930A1 (fr)
WO (1) WO2004038039A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183036B2 (en) 2003-10-10 2012-05-22 Promega Corporation Luciferase biosensor
CA2648263A1 (fr) 2006-04-03 2007-10-25 Promega Corporation Biocapteurs a base de luciferase a permutee et non permutee
WO2009142735A2 (fr) 2008-05-19 2009-11-26 Promega Corporation Biocapteurs de luciférase pour l'ampc
US9290794B2 (en) 2010-05-11 2016-03-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
EP2990479B1 (fr) 2010-05-11 2019-03-27 Promega Corporation Biocapteurs de protéase mutante présentant de meilleures caractéristiques de détection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059400A1 (en) * 2001-07-31 2003-03-27 Szalay Aladar A. Light emitting microorganisms and cells for diagnosis and therapy of tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059400A1 (en) * 2001-07-31 2003-03-27 Szalay Aladar A. Light emitting microorganisms and cells for diagnosis and therapy of tumors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHAUMIK S, ET AL: "OPTICAL IMAGING OF RENILLA LUCIFERASE REPORTER GENE EXPRESSION IN LIVING MICE", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 1, 8 January 2002 (2002-01-08), pages 377 - 382, XP002977218 *
WANG W, ET AL: "BIOLUMINESCENT MOLECULAR IMAGING OF ENDOGENOUS AND EXOGENOUS P53-MEDIATED TRANSCRIPTION IN VITRO AND IN VIVO USING AN HCT116 HUMAN COLON CARCINOMA XENOGRAFT MODEL", CANCER BIOLOGY & THERAPY, vol. 2, no. 2, March 2003 (2003-03-01), pages 196 - 202, XP002977219 *
WANG Y, ET AL: "A STUDY OF PROTEIN-PROTEIN INTERACTIONS IN LIVING CELLS USING LUMINESCENCE RESONANCE ENERGY TRANSFER (LRET) FROM RENILLA LUCIFERASE TO AEQUOREA GFP", MOL.GEN.GENET., vol. 264, no. 5, January 2001 (2001-01-01), pages 578 - 587, XP001029977 *
WANG Y, ET AL: "RENILLA LUCIFERASE-AEQUOREA GFP (RUC-GFP) FUSION PROTEIN, A NOVEL DUAL REPORTER FOR REAL-TIME IMAGING OF GENE EXPRESSION IN CELL CULTURES AND IN LIVE ANIMALS", MOLECULAR GENETICS AND GENOMICS, vol. 268, no. 2, October 2002 (2002-10-01), pages 160 - 168, XP002977220 *

Also Published As

Publication number Publication date
AU2003285930A8 (en) 2004-05-13
WO2004038039A2 (fr) 2004-05-06
AU2003285930A1 (en) 2004-05-13

Similar Documents

Publication Publication Date Title
Roell et al. A synthetic C4 shuttle via the β-hydroxyaspartate cycle in C3 plants
Germain-Genevois et al. Detection of brain tumors and systemic metastases using NanoLuc and Fluc for dual reporter imaging
EP1661886A4 (fr) Insecticide s'utilisant en agriculture ou en horticulture et procede d'utilisation correspondant
WO2007084902A9 (fr) Procedes de determination de probabilites genetiques relatives d’un sujet correspondant a une population
NO20045561L (no) 3'[(2Z)-(2-(3,4-dimetylfenyl)-1,5-dihydro-3-metyl-5-okso-41-I-pyrazol-4-yliden]hydrazin]-2'-hydroksy-(1,1'-bifenyl]-3-karboksy lsyre bis-(monoetanolamin)
DE60330841D1 (de) Überexpression von extremozymgenen in pseudomonas und nahe verwandte bakterien
NO20022359L (no) Inhibering av genekspresjon
WO2002077264A3 (fr) Procede de transfection en reseau et utilisation associee
CA2492096A1 (fr) Derives de 1-h-pyrrolidin-2,4-dione spirocyclique cis-alcoxysubstituee utilises comme insecticides
AU4500497A (en) Renilla luciferase and green fluorescent protein fusion genes
EP1302546A3 (fr) Méthode d'évaluation de l'efficacité et de la toxicité des médicaments
WO2007084655A3 (fr) Procédé pour réaliser une détection et une évaluation rapides de la croissance de cellules de culture
Soule et al. The global response of Nostoc punctiforme ATCC 29133 to UVA stress, assessed in a temporal DNA microarray study
DK1495112T3 (da) Cellekulturmedium
WO2004038039A3 (fr) Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants
GB2402675B (en) Resistance dilution
WO2008144052A3 (fr) Imagerie bioluminescente de cellules souches
ATE499440T1 (de) Gen-targeting mit replizierenden dna-molekülen
WO2005035719A3 (fr) Luciferase modifiee
Walker et al. Differential gene expression during substrate probing in larvae of the Caribbean coral Porites astreoides
WO2008137629A3 (fr) Identification de cellules souches embryonnaires à compétence germinale
DE602004030231D1 (de) Pyrimidinonverbindungen als calcilytica
WO2005046581A3 (fr) Proteine p18 dans des manipulations de cellules souches
WO2004081194A3 (fr) Methodes d'identification de traits genetiques chez l'animal
SE0201750D0 (sv) Selective Chromophores

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载