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WO2004037199A3 - Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation - Google Patents

Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation Download PDF

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Publication number
WO2004037199A3
WO2004037199A3 PCT/US2003/033757 US0333757W WO2004037199A3 WO 2004037199 A3 WO2004037199 A3 WO 2004037199A3 US 0333757 W US0333757 W US 0333757W WO 2004037199 A3 WO2004037199 A3 WO 2004037199A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
pain
compositions
management
modification
Prior art date
Application number
PCT/US2003/033757
Other languages
English (en)
Other versions
WO2004037199A2 (fr
Inventor
Jerome B Zeldis
Herbert Faleck
Donald C Manning
Original Assignee
Celgene Corp
Jerome B Zeldis
Herbert Faleck
Donald C Manning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp, Jerome B Zeldis, Herbert Faleck, Donald C Manning filed Critical Celgene Corp
Priority to EP03777871A priority Critical patent/EP1556044A2/fr
Priority to AU2003286663A priority patent/AU2003286663B2/en
Priority to CA002503536A priority patent/CA2503536A1/fr
Priority to NZ540028A priority patent/NZ540028A/en
Priority to BR0315609-5A priority patent/BR0315609A/pt
Priority to MXPA05004182A priority patent/MXPA05004182A/es
Priority to JP2004547126A priority patent/JP2006507284A/ja
Publication of WO2004037199A2 publication Critical patent/WO2004037199A2/fr
Publication of WO2004037199A3 publication Critical patent/WO2004037199A3/fr
Priority to HK06108551A priority patent/HK1088225A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des méthodes permettant de traiter, de prévenir, de modifier et de soulager divers types de douleur. Des méthodes spécifiques consistent, d'une part, à administrer un composé immunomodulateur ou un sel, solvate, hydrate, stéréo-isomère, clathrate ou promédicament pharmaceutiquement acceptable de ce composé, seul ou combiné avec un second agent actif, et/ou, d'autre part, à conduire une thérapie chirurgicale, psychologique ou physique. L'invention concerne également des compositions pharmaceutiques, des formes posologiques monodoses et des trousses convenant pour une utilisation dans les méthodes selon l'invention.
PCT/US2003/033757 2002-10-24 2003-10-24 Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation WO2004037199A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP03777871A EP1556044A2 (fr) 2002-10-24 2003-10-24 Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation
AU2003286663A AU2003286663B2 (en) 2002-10-24 2003-10-24 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
CA002503536A CA2503536A1 (fr) 2002-10-24 2003-10-24 Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation
NZ540028A NZ540028A (en) 2002-10-24 2003-10-24 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
BR0315609-5A BR0315609A (pt) 2002-10-24 2003-10-24 Método de tratar, prevenir, modificar ou controlar dor e composição farmacêutica
MXPA05004182A MXPA05004182A (es) 2002-10-24 2003-10-24 Metodos de uso y composiciones que contienen compuestos inmunomoduladores para el tratamiento, modificacion y manejo del dolor.
JP2004547126A JP2006507284A (ja) 2002-10-24 2003-10-24 疼痛を治療、改変および管理するための免疫調節化合物の使用方法および組成物
HK06108551A HK1088225A1 (en) 2002-10-24 2006-08-01 Compositions comprising immunomodulatory compoundsfor treatment, modification and management of pai n

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42100302P 2002-10-24 2002-10-24
US60/421,003 2002-10-24

Publications (2)

Publication Number Publication Date
WO2004037199A2 WO2004037199A2 (fr) 2004-05-06
WO2004037199A3 true WO2004037199A3 (fr) 2004-12-23

Family

ID=32176661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033757 WO2004037199A2 (fr) 2002-10-24 2003-10-24 Compositions contenant des composes immunomodulateurs pour le traitement, la modification et le soulagement de la douleur et leurs methodes d'utilisation

Country Status (13)

Country Link
EP (1) EP1556044A2 (fr)
JP (1) JP2006507284A (fr)
KR (1) KR20050057672A (fr)
CN (2) CN1326522C (fr)
AU (1) AU2003286663B2 (fr)
BR (1) BR0315609A (fr)
CA (1) CA2503536A1 (fr)
HK (1) HK1088225A1 (fr)
MX (1) MXPA05004182A (fr)
NZ (1) NZ540028A (fr)
TW (1) TW200503683A (fr)
WO (1) WO2004037199A2 (fr)
ZA (1) ZA200503240B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US20050203142A1 (en) * 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
US20050222209A1 (en) * 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
EP1871372A4 (fr) * 2005-04-08 2010-06-02 Neuromed Pharmaceuticals Ltd Thérapie de combinaison qui comprend un agent bloquant les canaux calciques de type n pour le soulagement de la douleur
US20070066512A1 (en) * 2005-09-12 2007-03-22 Dominique Verhelle Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
JP4382735B2 (ja) * 2005-10-06 2009-12-16 独立行政法人科学技術振興機構 神経因性疼痛治療剤
EP2023912A2 (fr) * 2006-05-26 2009-02-18 Celgene Corporation Méthodes et compositions faisant appel à des composés immunomodulateurs utilisés en traitement combiné
MX2009003912A (es) * 2006-10-19 2009-05-11 Celgene Corp Metodos y composiciones usando compuestos inmunomoduladores para el tratamiento y manejo de enfermedades bacterianas por espiroquetas y otras bacterias intracelulares obligadas.
CN101696205B (zh) 2009-11-02 2011-10-19 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215114A (en) * 1976-11-12 1980-07-29 The Upjohn Company Analgesic N-[2-(furyl-methylamino and 2-thienylmethylamino)cycloaliphatic]be
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
US6395754B1 (en) * 1997-05-30 2002-05-28 Celgene Corporation, Et Al. Substituted 2-(2,6-dioxopiperidin-3-yl)- phthalimides and 1-oxoisoindolines and method of reducing TNFα levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE460409T1 (de) * 1996-07-24 2010-03-15 Celgene Corp Substituierte 2-(2,6-dioxopiperidine-3-yl)- phthalimide -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha spiegels
US6281230B1 (en) * 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
SE0101256D0 (sv) * 2001-04-06 2001-04-06 A & Science Invest Ab Treatment of low back pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215114A (en) * 1976-11-12 1980-07-29 The Upjohn Company Analgesic N-[2-(furyl-methylamino and 2-thienylmethylamino)cycloaliphatic]be
US6395754B1 (en) * 1997-05-30 2002-05-28 Celgene Corporation, Et Al. Substituted 2-(2,6-dioxopiperidin-3-yl)- phthalimides and 1-oxoisoindolines and method of reducing TNFα levels
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels

Also Published As

Publication number Publication date
BR0315609A (pt) 2005-08-23
KR20050057672A (ko) 2005-06-16
CN1326522C (zh) 2007-07-18
CN101108185A (zh) 2008-01-23
TW200503683A (en) 2005-02-01
JP2006507284A (ja) 2006-03-02
AU2003286663A1 (en) 2004-05-13
EP1556044A2 (fr) 2005-07-27
MXPA05004182A (es) 2005-06-08
CA2503536A1 (fr) 2004-05-06
CN1732000A (zh) 2006-02-08
AU2003286663B2 (en) 2009-08-13
NZ540028A (en) 2009-07-31
WO2004037199A2 (fr) 2004-05-06
HK1088225A1 (en) 2006-11-03
ZA200503240B (en) 2007-11-28

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