WO2004037019A1 - Compositions de metal capables de supprimer l'oxygene actif - Google Patents
Compositions de metal capables de supprimer l'oxygene actif Download PDFInfo
- Publication number
- WO2004037019A1 WO2004037019A1 PCT/JP2002/011145 JP0211145W WO2004037019A1 WO 2004037019 A1 WO2004037019 A1 WO 2004037019A1 JP 0211145 W JP0211145 W JP 0211145W WO 2004037019 A1 WO2004037019 A1 WO 2004037019A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- active oxygen
- gold
- platinum
- oxygen radical
- foil
- Prior art date
Links
- 239000001301 oxygen Substances 0.000 title claims abstract description 79
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 79
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 19
- 239000002184 metal Substances 0.000 title claims abstract description 19
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 49
- 229910052737 gold Inorganic materials 0.000 claims abstract description 35
- 239000010931 gold Substances 0.000 claims abstract description 35
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 13
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052802 copper Inorganic materials 0.000 claims abstract description 9
- 239000010949 copper Substances 0.000 claims abstract description 9
- 229910052709 silver Inorganic materials 0.000 claims abstract description 9
- 239000004332 silver Substances 0.000 claims abstract description 9
- 230000002000 scavenging effect Effects 0.000 claims description 14
- 239000011888 foil Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 2
- 239000002516 radical scavenger Substances 0.000 abstract description 18
- 239000000126 substance Substances 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 235000013402 health food Nutrition 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- -1 oxygen radicals Chemical class 0.000 description 33
- 238000004020 luminiscence type Methods 0.000 description 18
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 230000008030 elimination Effects 0.000 description 5
- 238000003379 elimination reaction Methods 0.000 description 5
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000011889 copper foil Substances 0.000 description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical class [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/704—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
- A23B2/708—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
- A23B2/712—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O in which an absorbent is placed or used
- A23B2/717—Oxygen absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Definitions
- the present invention relates to a metal composition having an ability to scavenge reactive oxygen radicals (Reactive Oxygen Radica1).
- Background art Reactive Oxygen Radica1.
- Active oxygen radicals also called simply active oxygen or free radicals, are reactive atoms and molecules with unstable unpaired electrons.
- reactive oxygen radicals In general, super O key side (- 0 2 -), hydroxy radicals (HO *), hydrogen peroxide (H 2 0 2), 4 kinds of singlet oxygen 0 2) is referred to as reactive oxygen radicals.
- hydroperoxy radicals (HOO *), peroxy radicals (L 00 *), alkoxy radicals (LO *) and the like are also broadly called active oxygen species and radical species.
- active oxygen radicals are produced secondary and tertiary from active oxygen radicals.
- active oxygen radicals which increase at an accelerated rate, cause damage to cells and DNA, peroxidation of lipids, and are involved in many diseases.
- active oxygen radical scavengers have two aspects: elimination of active oxygen and generation of active oxygen.
- the active oxygen radical scavenger which is a hydrogen (H *) donor, is converted into an active oxygen radical such as 0 *, HOOH, HO 0 *, and HO * (HOOH in the above equation). It donates two electrons (e-one) and reduces by two protons (H +) to eliminate active oxygen radicals.
- the normal oxygen molecule O 2 two electrons (e-), donate two protons (H +), thereby generating an active oxygen Also involved in the process.
- active oxygen radical scavengers and media such as aldehydes, amino acids, and peronic acid (acidic saccharides), which have poor direct working ability to process active oxygen radicals alone, are present at the same time. It was revealed that the active oxygen radical scavenger was superior to the active oxygen radical scavenger in eliminating the active oxygen than the active oxygen radical scavenger alone. In addition, it was revealed that there was a combination of active oxygen radical scavenger and mediae in the reaction to eliminate active oxygen radicals.
- active oxygen radical X hereinafter sometimes simply referred to as “X” in the present specification
- active oxygen radical scavenger Y hereinafter referred to as the “donor”
- Y active oxygen radical scavenger
- k Constant reflecting the active oxygen radical processing ability mainly by the combination of Y and Z
- test substance if a faint luminescence phenomenon can be observed in the test substance under the coexistence of X and Y, it can be recognized that the test substance is a medium-Z. In addition, if a weak emission phenomenon can be observed in the test substance under the coexistence of X and Z, the test substance can be recognized as the active oxygen radical scavenger Y.
- test substance is a substance consisting of the active oxygen radical X and the media Zi.
- test substance is a substance consisting of the active oxygen radical X and the active oxygen radical force ranger Y. Can be.
- the phenomenon of the weak light emission (hereinafter, sometimes referred to as “XYZ-based weak light emission” in the present specification) is a basic phenomenon in an oxygen environment, and is a basic and universal phenomenon that occurs near us. This phenomenon is based on the elimination of the active oxygen radical X by converting it into light energy.
- ⁇ works as a hydrogen ( ⁇ *) donor and ⁇ works as a mediator.
- ⁇ can be said to be a second scavenger because even if the activity of ⁇ , called a scavenger, is high, light energy cannot be released without the presence of ⁇ .
- the world of media in the ⁇ -based active oxygen-eliminated luminescence is a completely unknown world with no concept.
- the skin, digestive organs, respiratory organs, heart, blood vessels, eyes, brain, bones, and genitalia of the body are all ⁇ , and play an important role as a mediator of hydrogen in active oxygen scavenging luminescence. Disclosure of the invention
- the inventor of the present application has analyzed the components of various substances having the ability as a media, and as a result of diligent research, found that gold, platinum, silver, and copper have the ability as a media. After elucidation, the present invention was completed.
- the metal composition having the active oxygen scavenging ability proposed by the present invention is made of one or more of gold, platinum, silver, and copper.
- the metal composition of the present invention is 24 gold, 23.9 gold, 23.74 gold, 23.44 gold, 23.21 gold, 22.99 gold, 22.66 gold, 21.68 gold, 18.12 gold , 14.12 gold.
- Table 1 shows the gold, silver and copper content ratios. Table 1 Content of gold, silver and copper
- the shape of gold, platinum, silver, and copper is not particularly limited, but is preferably foil, flake, powder, or granule because the larger the surface area, the higher the capacity of the media becomes. However, if the particle size is reduced, the surface area increases, but in consideration of the cost, foil or flake is more preferable.
- the thickness should be about 0.1 to 0.3 zm, which is the intermediate product of foil or about 0.1 to 0.3 zm obtained by further hammering the supernatant. I like it.
- the content ratio by weight of gold to platinum is preferably 0.01 to 100 with respect to platinum 1.
- the weight ratio of gold to platinum if the amount of gold is less than 0.01 with respect to platinum 1, it is not preferable because the effect of gold is hardly observed, and conversely, it exceeds 100. Because the effect of platinum is not produced, it is unfavorable.
- the active oxygen-eliminated luminescence as Z by XY was observed, but the active oxygen-eliminated luminescence as Y by XZ, the active oxygen-eliminated luminescence as XZ by Y, and the XY as XY by Z. No active oxygen-quenched luminescence was observed. Therefore, the gold leaf is recognized as the medial oxygen Z, but it is not the active oxygen radical scavenger Y, but the active oxygen radical X and the media oxygen Z, but not the active oxygen radical X. It was found that it was not a substance consisting of the active oxygen radical scavenger Y.
- Example 2 Flaky 24 gold foil, flaky 23.9 gold foil, flaky 18.12 gold foil, flaky 14.12 gold foil, flaky 100% platinum foil, flaky 100% silver foil, flaky 100% The active oxygen-eliminated luminescence as Z by XY was measured for each of the copper foil and the flaky aluminum foil.
- Petri dish 5 is flaked 24 gold leaf
- Petri dish 6 is flaked 23.9 gold leaf
- Petri dish 7 is flaked 18.12 gold foil
- Petri dish 8 is flaked 14.12 gold foil
- Petri dish 9 is flaked 100% platinum foil
- Petri dish 10 is flaked 1 ⁇ 0% silver foil
- the Petri dish 11 was a flaky 100% copper foil
- the Petri dish 12 was a flaky aluminum foil.
- the faint emission of the dish 5-12 is detected by the CCD camera performs Fuotonkau down computing, further from the light emission luminance displayed by performing the image processing, the brightness of the active oxygen scavenging emission as Z by XY (cd / m 2 ).
- the metal composition of the present invention has a capability as a media, and has excellent active oxygen scavenging ability, and is therefore useful for maintaining and recovering human health and physical condition. Therefore, the metal composition of the present invention is highly versatile and is expected to be widely used as a raw material for cosmetics, pharmaceuticals, health foods and general foods.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des compositions de métal possédant une capacité sous forme de substance Z, qui peut à peine supprimer un radical oxygène actif par elle-même, mais qui favorise l'effet de suppression de radical oxygène actif lorsqu'elle coexiste avec un capteur de radical oxygène actif et, qui possède une capacité de suppression d'oxygène actif élevée. L'objet susmentionné est obtenu grâce à des compositions métalliques capables supprimer l'oxygène actif. Ces compositions comprennent un ou plusieurs métaux sélectionnés parmi l'or, le platine, l'argent et le cuivre. Ces compositions métalliques sont des produits aux applications variées qui peuvent être utilisés à des fins diverses telles que pour des matériaux destinés à des produits cosmétiques, des médicaments, des aliments diététiques et des aliments ordinaires.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002343768A AU2002343768A1 (en) | 2002-10-28 | 2002-10-28 | Metal compositions capable of removing active oxygen |
| PCT/JP2002/011145 WO2004037019A1 (fr) | 2002-10-28 | 2002-10-28 | Compositions de metal capables de supprimer l'oxygene actif |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2002/011145 WO2004037019A1 (fr) | 2002-10-28 | 2002-10-28 | Compositions de metal capables de supprimer l'oxygene actif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2004037019A1 true WO2004037019A1 (fr) | 2004-05-06 |
Family
ID=32170793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2002/011145 WO2004037019A1 (fr) | 2002-10-28 | 2002-10-28 | Compositions de metal capables de supprimer l'oxygene actif |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2002343768A1 (fr) |
| WO (1) | WO2004037019A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1598071A4 (fr) * | 2003-02-20 | 2006-04-26 | Shetech Co Ltd | Agent de decomposition d'un anion superoxyde |
| EP1656840A1 (fr) * | 2004-11-08 | 2006-05-17 | Fuji Photo Film Co., Ltd. | Agent pour l'élimination de l'oxygène et méthode de production |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991011117A2 (fr) * | 1990-02-05 | 1991-08-08 | Board Of Regents, The University Of Texas System | Complements alimentaires comprenant des vitamines et des sels mineraux |
| JPH1160493A (ja) * | 1997-08-18 | 1999-03-02 | Eiichi Tsukiji | 活性酸素を起因とする疾患の治療および予防薬又はその原料 |
| JPH11346715A (ja) * | 1998-06-09 | 1999-12-21 | Otsuka Yakuhin Kogyo Kk | 白金族コロイド溶液を配合した食品の製造方法 |
| WO2001036337A1 (fr) * | 1999-11-18 | 2001-05-25 | Phild Co., Ltd. | Procede et dispositif de preparation d'une eau contenant des particules d'or ultrafines dissoutes |
-
2002
- 2002-10-28 AU AU2002343768A patent/AU2002343768A1/en not_active Abandoned
- 2002-10-28 WO PCT/JP2002/011145 patent/WO2004037019A1/fr not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991011117A2 (fr) * | 1990-02-05 | 1991-08-08 | Board Of Regents, The University Of Texas System | Complements alimentaires comprenant des vitamines et des sels mineraux |
| JPH1160493A (ja) * | 1997-08-18 | 1999-03-02 | Eiichi Tsukiji | 活性酸素を起因とする疾患の治療および予防薬又はその原料 |
| JPH11346715A (ja) * | 1998-06-09 | 1999-12-21 | Otsuka Yakuhin Kogyo Kk | 白金族コロイド溶液を配合した食品の製造方法 |
| WO2001036337A1 (fr) * | 1999-11-18 | 2001-05-25 | Phild Co., Ltd. | Procede et dispositif de preparation d'une eau contenant des particules d'or ultrafines dissoutes |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1598071A4 (fr) * | 2003-02-20 | 2006-04-26 | Shetech Co Ltd | Agent de decomposition d'un anion superoxyde |
| US7838043B2 (en) | 2003-02-20 | 2010-11-23 | Apt Co., Ltd | Superoxide anion decomposing agent |
| EP1656840A1 (fr) * | 2004-11-08 | 2006-05-17 | Fuji Photo Film Co., Ltd. | Agent pour l'élimination de l'oxygène et méthode de production |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002343768A8 (en) | 2004-05-13 |
| AU2002343768A1 (en) | 2004-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Karakoti et al. | Redox-active radical scavenging nanomaterials | |
| Sokolova et al. | In vitro antioxidant properties of red algal polysaccharides | |
| Yu et al. | The inhibitory effect of selenium nanoparticles on protein glycation in vitro | |
| De Lima et al. | Ruthenium complexes as NO donors for vascular relaxation induction | |
| JP5636146B2 (ja) | アスコルビン酸のグリセリン懸濁液 | |
| Verma et al. | Nanocomposite of Ag nanoparticles and catalytic fluorescent carbon dots for synergistic bactericidal activity through enhanced reactive oxygen species generation | |
| WO2007001188A1 (fr) | Utilisation du fullerene c60 comme stabilsateur d'huile | |
| KR102207608B1 (ko) | 카르복실산으로 유기화된 규소 이온 복합체 및 복합체의 제조방법과 이를 이용한 제품 | |
| Grootveld et al. | Potential advantages of peroxoborates and their ester adducts over hydrogen peroxide as therapeutic agents in oral healthcare products: chemical/biochemical reactivity considerations in vitro, ex vivo and in vivo | |
| KR20140086957A (ko) | 은 이온 항균액의 생성방법, 그 방법으로 생성되는 은 이온 항균액, 또는 은 이온 항균 분말의 생성방법, 그 방법으로 생성되는 은 이온 항균 분말 | |
| JP2010126503A (ja) | Ｌ−アスコルビン酸の安定化方法、調製液体抽出物、固体状抽出物、半流動体抽出物 | |
| WO2004037019A1 (fr) | Compositions de metal capables de supprimer l'oxygene actif | |
| Kolodziejczyk et al. | In vitro study of the antioxidative properties of the glucose derivatives against oxidation of plasma components | |
| CN111820239A (zh) | 一种液体组合物及其制备方法与应用 | |
| JP2002037732A (ja) | 活性酸素消去材、フィルター、健康食品、食品、飲料 | |
| US9018252B2 (en) | Stable compositions of dehydroascorbic acid | |
| JP2004131611A (ja) | 石鹸 | |
| JP2002293725A (ja) | 歯用ホワイトニング剤及びそれを用いた歯の漂白方法 | |
| JP6895436B2 (ja) | ２−Ｏ−α−Ｄ−グリコシル−Ｌ−アスコルビン酸金属塩、その酸化防止剤としての用途及びその粉末の製造方法 | |
| Zhang et al. | Palladium-gold bimetallic nanoparticles stabilized by daptomycin for sensitive colorimetric detection of sulfide ions | |
| JP2001302530A (ja) | 還元型抗酸化物質及びその製造方法 | |
| Rojas et al. | Biocompounds recovery from purple corn cob by-product: extraction kinetics, thermal and physicochemical stability of liquid and powdered anthocyanin-rich extract | |
| JP2006166804A (ja) | 食品素材およびその製造方法 | |
| JP2014214089A (ja) | 低溶出性ピロロキノリンキノン組成物 | |
| Jourd'Heuil et al. | [23] Stability of S-nitrosothiols in presence of copper, zinc-superoxide dismutase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
| DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| 122 | Ep: pct application non-entry in european phase | ||
| NENP | Non-entry into the national phase |
Ref country code: JP |
|
| WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |