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WO2004035819A3 - Oligonucleotides utiles dans la detection d'acides nucleiques d'interet - Google Patents

Oligonucleotides utiles dans la detection d'acides nucleiques d'interet Download PDF

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Publication number
WO2004035819A3
WO2004035819A3 PCT/DK2003/000715 DK0300715W WO2004035819A3 WO 2004035819 A3 WO2004035819 A3 WO 2004035819A3 DK 0300715 W DK0300715 W DK 0300715W WO 2004035819 A3 WO2004035819 A3 WO 2004035819A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
detecting
oligonucleotide analogues
analyzing nucleic
nucleic acid
Prior art date
Application number
PCT/DK2003/000715
Other languages
English (en)
Other versions
WO2004035819A8 (fr
WO2004035819A2 (fr
Inventor
Sakari Kauppinen
Carsten Alsbo
Peter Stein Nielsen
Daniel Charlton Jeffares
Tobias Mourier
Soeren Moerk
Peter Arctander
Niels Tommerup
Niels Tolstrup
Henrik Vissing
Original Assignee
Exiqon As
Sakari Kauppinen
Carsten Alsbo
Peter Stein Nielsen
Daniel Charlton Jeffares
Tobias Mourier
Soeren Moerk
Peter Arctander
Niels Tommerup
Niels Tolstrup
Henrik Vissing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exiqon As, Sakari Kauppinen, Carsten Alsbo, Peter Stein Nielsen, Daniel Charlton Jeffares, Tobias Mourier, Soeren Moerk, Peter Arctander, Niels Tommerup, Niels Tolstrup, Henrik Vissing filed Critical Exiqon As
Priority to AU2003273778A priority Critical patent/AU2003273778A1/en
Priority to EP03757735A priority patent/EP1556510A2/fr
Publication of WO2004035819A2 publication Critical patent/WO2004035819A2/fr
Publication of WO2004035819A3 publication Critical patent/WO2004035819A3/fr
Publication of WO2004035819A8 publication Critical patent/WO2004035819A8/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des acides nucléiques améliorés et des procédés destinés au profilage d'expression des ARNm, pour identifier et profiler des variants épissés déterminés d'ARNm et pour détecter les mutations, les délétions ou les duplications d'exons déterminés ou d'autres variants épissés, p.ex., des altérations associées avec des maladies telles que le cancer dans un échantillon d'acide nucléique, p.ex. dans un échantillon biologique ou un échantillons de patient.
PCT/DK2003/000715 2002-10-21 2003-10-21 Oligonucleotides utiles dans la detection d'acides nucleiques d'interet WO2004035819A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003273778A AU2003273778A1 (en) 2002-10-21 2003-10-21 Oligonucleotide analogues for detecting and analyzing nucleic acids
EP03757735A EP1556510A2 (fr) 2002-10-21 2003-10-21 OLIGONUCLEOTIDE ANALOGUE DANS LA DETECTION ET l'ANALYSE D'ACIDES NUCLEIQUES

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42027802P 2002-10-21 2002-10-21
US60/420,278 2002-10-21
DKPA200300752 2003-05-19
DKPA200300752 2003-05-19

Publications (3)

Publication Number Publication Date
WO2004035819A2 WO2004035819A2 (fr) 2004-04-29
WO2004035819A3 true WO2004035819A3 (fr) 2004-08-26
WO2004035819A8 WO2004035819A8 (fr) 2004-09-30

Family

ID=32109043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000715 WO2004035819A2 (fr) 2002-10-21 2003-10-21 Oligonucleotides utiles dans la detection d'acides nucleiques d'interet

Country Status (3)

Country Link
EP (1) EP1556510A2 (fr)
AU (1) AU2003273778A1 (fr)
WO (1) WO2004035819A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106068329A (zh) * 2014-01-08 2016-11-02 基诺泰科有限公司 利用5’‑瓣状内切核酸酶活性被抑制的dna聚合酶并通过实时聚合酶链反应来检测突变基因的方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1576192B1 (fr) 2002-12-23 2014-10-29 Agilent Technologies, Inc. Essais comparatifs d'hybridation de genomes utilisant des oligonucleotides immobilises, et compositions permettant de les mettre en oeuvre
US8321138B2 (en) 2005-07-29 2012-11-27 Agilent Technologies, Inc. Method of characterizing quality of hybridized CGH arrays
JP2007536939A (ja) * 2004-05-14 2007-12-20 アモークス インコーポレーティッド 免疫細胞バイオセンサーおよびその使用方法
CA2614507A1 (fr) * 2004-07-09 2006-08-17 Amaox, Ltd. Biocapteurs de cellules immunes et procedes d'utilisation
US8461124B2 (en) 2007-03-15 2013-06-11 Jyoti Chattopadhyaya Five- and six-membered conformationally locked 2′,4′-carbocyclic ribo-thymidines for the treatment of infections and cancer
CN101849008A (zh) 2007-09-19 2010-09-29 应用生物系统有限公司 用于减少RNAi中的脱靶表型效应的siRNA的不依赖于序列的修饰形式和其稳定形式
EP2625292B1 (fr) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarqueurs de cancer
US8273235B2 (en) 2010-11-05 2012-09-25 Roshan V Chapaneri Dark colored chromium based electrodeposits
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
EP3587432A4 (fr) * 2017-02-21 2021-01-06 Osaka University Composé d'acide nucléique et oligonucléotide
WO2019161105A1 (fr) 2018-02-14 2019-08-22 Deep Genomics Incorporated Thérapie oligonucléotidique pour la maladie de wilson

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014226A2 (fr) * 1997-09-12 1999-03-25 Exiqon A/S Analogues d'oligonucleotides
WO2001081632A1 (fr) * 2000-04-25 2001-11-01 Affymetrix, Inc. Technique de surveillance de l'expression de genes alternativement episses
WO2002061387A2 (fr) * 2000-10-25 2002-08-08 Exiqon A/S Plates-formes du type substrat ouvert se pretant a l'analyse de biomolecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014226A2 (fr) * 1997-09-12 1999-03-25 Exiqon A/S Analogues d'oligonucleotides
WO2001081632A1 (fr) * 2000-04-25 2001-11-01 Affymetrix, Inc. Technique de surveillance de l'expression de genes alternativement episses
WO2002061387A2 (fr) * 2000-10-25 2002-08-08 Exiqon A/S Plates-formes du type substrat ouvert se pretant a l'analyse de biomolecules

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DWAINE A. BRAASCH ET AL: "Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA", CHEMISTRY & BIOLOGY, vol. 8, 2001, pages 1 - 7, XP002285000 *
NIELS TOLSTRUP ET AL: "OligoDesign: optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling", NUCLEIC ACIDS RESEARCH, vol. 31, no. 13, 2003, pages 3758 - 3762, XP002285001 *
See also references of EP1556510A2 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106068329A (zh) * 2014-01-08 2016-11-02 基诺泰科有限公司 利用5’‑瓣状内切核酸酶活性被抑制的dna聚合酶并通过实时聚合酶链反应来检测突变基因的方法
CN106068329B (zh) * 2014-01-08 2020-03-27 基诺泰科有限公司 一种通过实时聚合酶链反应检测突变基因的方法

Also Published As

Publication number Publication date
WO2004035819A8 (fr) 2004-09-30
WO2004035819A2 (fr) 2004-04-29
AU2003273778A1 (en) 2004-05-04
AU2003273778A8 (en) 2004-05-04
EP1556510A2 (fr) 2005-07-27

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