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WO2004035598A3 - Chalcomycin-derivate - Google Patents

Chalcomycin-derivate Download PDF

Info

Publication number
WO2004035598A3
WO2004035598A3 PCT/EP2003/011549 EP0311549W WO2004035598A3 WO 2004035598 A3 WO2004035598 A3 WO 2004035598A3 EP 0311549 W EP0311549 W EP 0311549W WO 2004035598 A3 WO2004035598 A3 WO 2004035598A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
chalcomycin
acylated
inventive
salts
Prior art date
Application number
PCT/EP2003/011549
Other languages
English (en)
French (fr)
Other versions
WO2004035598A2 (de
Inventor
Maskey Rajendra Prasad
Hartmut Laatsch
Elisabeth Helmke
Friedrich Hansske
Werner Simon
Original Assignee
Biofrontera Discovery Gmbh
Maskey Rajendra Prasad
Hartmut Laatsch
Elisabeth Helmke
Friedrich Hansske
Werner Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofrontera Discovery Gmbh, Maskey Rajendra Prasad, Hartmut Laatsch, Elisabeth Helmke, Friedrich Hansske, Werner Simon filed Critical Biofrontera Discovery Gmbh
Priority to AU2003274036A priority Critical patent/AU2003274036A1/en
Publication of WO2004035598A2 publication Critical patent/WO2004035598A2/de
Publication of WO2004035598A3 publication Critical patent/WO2004035598A3/de
Priority to US11/109,399 priority patent/US20060111309A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft neue Chalcomycin-Derivate, Arzneimittel die diese oder deren Salze enthalten, und die Verwendung der Chalcomycin-Derivate zur Behandlung von Erkrankungen, insbesondere von Infektionen. Die erfindungsgemäßen Chalcomycin-Derivate sind an den Zuckerresten acyliert und auch Derivate an der 9-carbonylfunktion.
PCT/EP2003/011549 2002-10-17 2003-10-17 Chalcomycin-derivate WO2004035598A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003274036A AU2003274036A1 (en) 2002-10-17 2003-10-17 Chalcomycin derivatives
US11/109,399 US20060111309A1 (en) 2002-10-17 2005-04-15 Chalcomycin derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10248453.8 2002-10-17
DE10248453A DE10248453A1 (de) 2002-10-17 2002-10-17 Chalcomycin-Derivate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/109,399 Continuation US20060111309A1 (en) 2002-10-17 2005-04-15 Chalcomycin derivatives

Publications (2)

Publication Number Publication Date
WO2004035598A2 WO2004035598A2 (de) 2004-04-29
WO2004035598A3 true WO2004035598A3 (de) 2004-08-26

Family

ID=32102805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011549 WO2004035598A2 (de) 2002-10-17 2003-10-17 Chalcomycin-derivate

Country Status (4)

Country Link
US (1) US20060111309A1 (de)
AU (1) AU2003274036A1 (de)
DE (1) DE10248453A1 (de)
WO (1) WO2004035598A2 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1109835B (de) * 1961-06-29 Parke Davis & Co Herstellung und Gewinnung von Chalcomycin
US4835141A (en) * 1986-12-05 1989-05-30 Pfizer Inc. Neutral macrolide antibiotics from Streptomyces

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065137A (en) * 1959-02-02 1962-11-20 Parke Davis & Co Chalcomycin and its fermentative production
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1109835B (de) * 1961-06-29 Parke Davis & Co Herstellung und Gewinnung von Chalcomycin
US4835141A (en) * 1986-12-05 1989-05-30 Pfizer Inc. Neutral macrolide antibiotics from Streptomyces

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H. ASCHENBACH, W. KARL: "Massenspektrometrische Untersuchungsmethoden zur Strukturaufklärung von Makrolid-Antibiotika", CHEM. BER., vol. 108, 1975, pages 772 - 779, XP002272241 *
R.N. ASOLKAR ET AL.: "Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp. B7064", THE JOURNEL OF ANTIBIOTICS, vol. 55, 2002, pages 893 - 898, XP008028116 *
S. OMURA, M. TISHLER: "Relationship of structures and microbiological activities of the 16-membered macrolides", J. MED. CHEM., vol. 15, 1972, pages 1011 - 1015, XP002272240 *
S.-D. KIM ET AL.: "GERI-155, a new macrolide antibiotic related to chalcomycin", THE JOURNAL OF ANTIBIOTICS, vol. 49, 1996, pages 955 - 957, XP008028127 *
Y.M. GOO ET AL.: "A new 16-membered chalcomycin type macrolide antibiotic, 250-144C", THE JOURNAL OF ANTIBIOTICS, vol. 50, 1997, pages 85 - 88, XP008028118 *

Also Published As

Publication number Publication date
WO2004035598A2 (de) 2004-04-29
AU2003274036A8 (en) 2004-05-04
AU2003274036A1 (en) 2004-05-04
DE10248453A1 (de) 2004-05-13
US20060111309A1 (en) 2006-05-25

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