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WO2004027031A3 - Tryptophan hydroxylase assay - Google Patents

Tryptophan hydroxylase assay Download PDF

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Publication number
WO2004027031A3
WO2004027031A3 PCT/US2003/029320 US0329320W WO2004027031A3 WO 2004027031 A3 WO2004027031 A3 WO 2004027031A3 US 0329320 W US0329320 W US 0329320W WO 2004027031 A3 WO2004027031 A3 WO 2004027031A3
Authority
WO
WIPO (PCT)
Prior art keywords
tryptophan hydroxylase
tph
hydroxylase assay
assay
tryptophan
Prior art date
Application number
PCT/US2003/029320
Other languages
French (fr)
Other versions
WO2004027031A2 (en
Inventor
Janet Clark
Susan P Rohrer
Stephen E Alves
Original Assignee
Merck & Co Inc
Janet Clark
Susan P Rohrer
Stephen E Alves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Janet Clark, Susan P Rohrer, Stephen E Alves filed Critical Merck & Co Inc
Priority to EP03754698A priority Critical patent/EP1543140A4/en
Priority to US10/528,309 priority patent/US20060275761A1/en
Priority to CA002497934A priority patent/CA2497934A1/en
Publication of WO2004027031A2 publication Critical patent/WO2004027031A2/en
Publication of WO2004027031A3 publication Critical patent/WO2004027031A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to methods of evaluation and detection of the expression of tryptophan hydroxylase (TPH) gene and induction of TPH by estrogen receptor-beta (ERβ) agonists, utilizing TPH riboprobe and/or primers.
PCT/US2003/029320 2002-09-19 2003-09-15 Tryptophan hydroxylase assay WO2004027031A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03754698A EP1543140A4 (en) 2002-09-19 2003-09-15 Tryptophan hydroxylase assay
US10/528,309 US20060275761A1 (en) 2002-09-19 2003-09-15 Tryptophan hydroxylase assay
CA002497934A CA2497934A1 (en) 2002-09-19 2003-09-15 Tryptophan hydroxylase assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41209402P 2002-09-19 2002-09-19
US60/412,094 2002-09-19

Publications (2)

Publication Number Publication Date
WO2004027031A2 WO2004027031A2 (en) 2004-04-01
WO2004027031A3 true WO2004027031A3 (en) 2004-08-05

Family

ID=32030804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029320 WO2004027031A2 (en) 2002-09-19 2003-09-15 Tryptophan hydroxylase assay

Country Status (3)

Country Link
EP (1) EP1543140A4 (en)
CA (1) CA2497934A1 (en)
WO (1) WO2004027031A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101087606B (en) 2004-12-09 2010-12-29 默沙东公司 Estrogen receptor modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589331A (en) * 1992-04-24 1996-12-31 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting abnormal serotonergic function

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589331A (en) * 1992-04-24 1996-12-31 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting abnormal serotonergic function

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAMPIER ET AL: "Evidence for tryptophan hydroxylase and hydroxy-indol-o-methyl-transferase mRNAs in human blood platelets", LIFE SCIENCES, vol. 60, no. 24, 1997, pages 2191 - 2197, XP002978081 *
PECINS-THOMPSON ET AL: "Ovarian Steroid Regulation of Tryptophan Hydroxylase mRNA Expression in Rhesus Macaques", THE J. OF NEUROSCIENCE, vol. 16, no. 21, 1 November 1996 (1996-11-01), pages 7021 - 7029, XP002381509 *
See also references of EP1543140A4 *

Also Published As

Publication number Publication date
EP1543140A4 (en) 2006-06-28
CA2497934A1 (en) 2004-04-01
EP1543140A2 (en) 2005-06-22
WO2004027031A2 (en) 2004-04-01

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