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WO2004015098A3 - Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof - Google Patents

Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof Download PDF

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Publication number
WO2004015098A3
WO2004015098A3 PCT/EP2003/008504 EP0308504W WO2004015098A3 WO 2004015098 A3 WO2004015098 A3 WO 2004015098A3 EP 0308504 W EP0308504 W EP 0308504W WO 2004015098 A3 WO2004015098 A3 WO 2004015098A3
Authority
WO
WIPO (PCT)
Prior art keywords
cam
cell adhesion
adhesion molecule
epithelial cell
nucleic acid
Prior art date
Application number
PCT/EP2003/008504
Other languages
French (fr)
Other versions
WO2004015098A2 (en
Inventor
Gennaro Ciliberto
Nicola Lamonica
Fabio Palombo
Valentina Salucci
Original Assignee
Angeletti P Ist Richerche Bio
Gennaro Ciliberto
Nicola Lamonica
Fabio Palombo
Valentina Salucci
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio, Gennaro Ciliberto, Nicola Lamonica, Fabio Palombo, Valentina Salucci filed Critical Angeletti P Ist Richerche Bio
Priority to AU2003251679A priority Critical patent/AU2003251679A1/en
Publication of WO2004015098A2 publication Critical patent/WO2004015098A2/en
Publication of WO2004015098A3 publication Critical patent/WO2004015098A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DNAs encoding rhesus monkey epithelial cell adhesion molecule (rhEp-CAM) have been isolated, cloned and sequenced. The gene encoding Ep-CAM is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the Ep-CAM tumor-associated antigen, wherein aberrant Ep-CAM expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhEp-CAM and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
PCT/EP2003/008504 2002-08-07 2003-07-31 Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof WO2004015098A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251679A AU2003251679A1 (en) 2002-08-07 2003-07-31 Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40169102P 2002-08-07 2002-08-07
US60/401,691 2002-08-07

Publications (2)

Publication Number Publication Date
WO2004015098A2 WO2004015098A2 (en) 2004-02-19
WO2004015098A3 true WO2004015098A3 (en) 2004-03-18

Family

ID=31715719

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/008504 WO2004015098A2 (en) 2002-08-07 2003-07-31 Rhesus epithelial cell adhesion molecule, nucleic acid encoding the same, and uses thereof

Country Status (2)

Country Link
AU (1) AU2003251679A1 (en)
WO (1) WO2004015098A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5738867A (en) * 1991-11-26 1998-04-14 Jenner Technologies Antitumor vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5738867A (en) * 1991-11-26 1998-04-14 Jenner Technologies Antitumor vaccines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LI W ET AL: "HUMAN COLORECTAL CANCER (CRC) ANTIGEN CO17-1A/GA733 ENCODED BY ADENOVIRUS INHIBITS GROWTH OF ESTABLISHED CRC CELLS IN MICE", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, no. 2, 15 July 1997 (1997-07-15), pages 763 - 769, XP002061096, ISSN: 0022-1767 *
STAIB LUDGER ET AL: "Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients", INTERNATIONAL JOURNAL OF CANCER, vol. 92, no. 1, 1 April 2001 (2001-04-01), pages 79 - 87, XP002267174, ISSN: 0020-7136 *
SZALA S ET AL: "MOLECULAR CLONING OF CDNA FOR THE CARCINOMA-ASSOCIATED ANTIGEN GA 733-2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 87, no. 9, 1 May 1990 (1990-05-01), pages 3542 - 3546, XP000566331, ISSN: 0027-8424 *
ZALOUDIK JAN ET AL: "Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in mice.", CANCER GENE THERAPY. ENGLAND APR 2002, vol. 9, no. 4, April 2002 (2002-04-01), pages 382 - 389, XP001157329, ISSN: 0929-1903 *

Also Published As

Publication number Publication date
AU2003251679A1 (en) 2004-02-25
WO2004015098A2 (en) 2004-02-19
AU2003251679A8 (en) 2004-02-25

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