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WO2004008151A3 - New combinatorial peptide libraries containing markers and methods for their preparation and utilization - Google Patents

New combinatorial peptide libraries containing markers and methods for their preparation and utilization Download PDF

Info

Publication number
WO2004008151A3
WO2004008151A3 PCT/HU2003/000056 HU0300056W WO2004008151A3 WO 2004008151 A3 WO2004008151 A3 WO 2004008151A3 HU 0300056 W HU0300056 W HU 0300056W WO 2004008151 A3 WO2004008151 A3 WO 2004008151A3
Authority
WO
WIPO (PCT)
Prior art keywords
marker
groups
invention consists
combinatorial
protein
Prior art date
Application number
PCT/HU2003/000056
Other languages
French (fr)
Other versions
WO2004008151A2 (en
Inventor
Ferenc Darvas
Laszlo Uerge
Gyoergy Dorman
Peter Krajcsi
Daniel Szalay
Mariann Beres
Agota Bucsai
Tamas Nagy
Ferenc Kalman
Original Assignee
Comgenex Rt
Ferenc Darvas
Laszlo Uerge
Gyoergy Dorman
Peter Krajcsi
Daniel Szalay
Mariann Beres
Agota Bucsai
Tamas Nagy
Ferenc Kalman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Comgenex Rt, Ferenc Darvas, Laszlo Uerge, Gyoergy Dorman, Peter Krajcsi, Daniel Szalay, Mariann Beres, Agota Bucsai, Tamas Nagy, Ferenc Kalman filed Critical Comgenex Rt
Priority to AU2003251072A priority Critical patent/AU2003251072A1/en
Publication of WO2004008151A2 publication Critical patent/WO2004008151A2/en
Publication of WO2004008151A3 publication Critical patent/WO2004008151A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention consists substantially of combinatorial, protein-marker molecule libraries, having groups that may be chemically and photochemically activated, with or without reporter groups, connected in different diversity points or spatial arrangements via side chains around a common molecular core. The invention consists furthermore of combinatorial libraries of marker units having chemically or photochemically reactive marker groups, reporter groups, and various other types of side chains attached variably to a common molecular, preferably lysine-based, structural core. The invention consists furthermore of a method for combinatorial chemical tethering, where a side chain having a terminal functional group, preferably an amino group, and to which a marker group is optionally attached, is introduced in optimal position ensuring structural diversity and protein binding effectiveness. The invention contributes to simplifying complexity of proteome in different tissues and to the identification of protein markers for diagnosis by alternating different labeling pattern in healthy and diseased tissues.
PCT/HU2003/000056 2002-07-10 2003-07-09 New combinatorial peptide libraries containing markers and methods for their preparation and utilization WO2004008151A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251072A AU2003251072A1 (en) 2002-07-10 2003-07-09 New combinatorial peptide libraries containing markers and methods for their preparation and utilization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0202212A HUP0202212A2 (en) 2002-07-10 2002-07-10 Novel protein marker combinatorial libraries, process for their preparation and their use
HUP0202212 2002-07-10

Publications (2)

Publication Number Publication Date
WO2004008151A2 WO2004008151A2 (en) 2004-01-22
WO2004008151A3 true WO2004008151A3 (en) 2004-07-29

Family

ID=89980607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2003/000056 WO2004008151A2 (en) 2002-07-10 2003-07-09 New combinatorial peptide libraries containing markers and methods for their preparation and utilization

Country Status (3)

Country Link
AU (1) AU2003251072A1 (en)
HU (1) HUP0202212A2 (en)
WO (1) WO2004008151A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG153699A1 (en) * 2003-01-16 2009-07-29 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
CN116354898A (en) * 2023-03-14 2023-06-30 兰州大学 Three-functional probe based on photocrosslinking group and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024517A2 (en) * 1992-05-21 1993-12-09 Furka Arpad Peptide sub-library kits
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO2000001802A2 (en) * 1998-07-01 2000-01-13 Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimentel Cancerforskning) Peptide antagonists of the human urokinase receptor and method for selecting them
WO2003080653A1 (en) * 2002-03-26 2003-10-02 Lars Baltzer Novel polypeptide scaffolds and use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024517A2 (en) * 1992-05-21 1993-12-09 Furka Arpad Peptide sub-library kits
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO2000001802A2 (en) * 1998-07-01 2000-01-13 Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimentel Cancerforskning) Peptide antagonists of the human urokinase receptor and method for selecting them
WO2003080653A1 (en) * 2002-03-26 2003-10-02 Lars Baltzer Novel polypeptide scaffolds and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABSTRACTS OF PAPER. AT THE 223TH NATIONAL MEETING.OF THE AMERICAN CHEMICAL SOCIETY, vol. 223, no. 1-2, April 2002 (2002-04-01), USAMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, pages MEDI 245, XP008030884 *
JOURNAL OF ORGANIC CHEMISTRY., vol. 67, no. 9, February 2002 (2002-02-01), USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3120 - 3123, XP002966571 *

Also Published As

Publication number Publication date
HUP0202212A2 (en) 2004-04-28
WO2004008151A2 (en) 2004-01-22
AU2003251072A8 (en) 2004-02-02
AU2003251072A1 (en) 2004-02-02
HU0202212D0 (en) 2002-09-28

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