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WO2004006849A3 - Combinations of drugs for the treatment of neoplasms - Google Patents

Combinations of drugs for the treatment of neoplasms Download PDF

Info

Publication number
WO2004006849A3
WO2004006849A3 PCT/US2003/021984 US0321984W WO2004006849A3 WO 2004006849 A3 WO2004006849 A3 WO 2004006849A3 US 0321984 W US0321984 W US 0321984W WO 2004006849 A3 WO2004006849 A3 WO 2004006849A3
Authority
WO
WIPO (PCT)
Prior art keywords
neoplasms
drugs
combinations
treatment
neoplasm
Prior art date
Application number
PCT/US2003/021984
Other languages
French (fr)
Other versions
WO2004006849A2 (en
Inventor
Alexis Borisy
Curtis Keith
Michael A Foley
Brent R Stockwell
Debra A Gaw
Original Assignee
Combinatorx Inc
Alexis Borisy
Curtis Keith
Michael A Foley
Brent R Stockwell
Debra A Gaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc, Alexis Borisy, Curtis Keith, Michael A Foley, Brent R Stockwell, Debra A Gaw filed Critical Combinatorx Inc
Priority to AU2003251904A priority Critical patent/AU2003251904A1/en
Publication of WO2004006849A2 publication Critical patent/WO2004006849A2/en
Publication of WO2004006849A3 publication Critical patent/WO2004006849A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
PCT/US2003/021984 2002-07-15 2003-07-15 Combinations of drugs for the treatment of neoplasms WO2004006849A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251904A AU2003251904A1 (en) 2002-07-15 2003-07-15 Combinations of drugs for the treatment of neoplasms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39615102P 2002-07-15 2002-07-15
US60/396,151 2002-07-15

Publications (2)

Publication Number Publication Date
WO2004006849A2 WO2004006849A2 (en) 2004-01-22
WO2004006849A3 true WO2004006849A3 (en) 2004-06-03

Family

ID=30115980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021984 WO2004006849A2 (en) 2002-07-15 2003-07-15 Combinations of drugs for the treatment of neoplasms

Country Status (2)

Country Link
AU (1) AU2003251904A1 (en)
WO (1) WO2004006849A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817257B1 (en) 2000-11-30 2009-03-20 Sanofi Synthelabo CYCLOHEXYL (ALKYL) -PROPANOLAMINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2003251904A1 (en) * 2002-07-15 2004-02-02 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
GB0403165D0 (en) * 2004-02-12 2004-03-17 Ct Novel uses for proton pump inhibitors
EP1768984B1 (en) 2004-07-16 2010-10-20 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
WO2006020722A2 (en) 2004-08-11 2006-02-23 Arqule, Inc. Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting
EP2152686B1 (en) 2007-04-30 2014-12-17 ArQule, Inc. Hydroxy sulfonate of quinone compounds and their uses
WO2009043093A1 (en) * 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Hif inhibition
CN113398122A (en) * 2020-03-17 2021-09-17 中国医学科学院药物研究所 Application of triazole compounds in preparation of anti-glioma drugs
BR112022022409A2 (en) 2020-05-06 2023-02-07 Ajax Therapeutics Inc 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
CN111840281B (en) * 2020-07-15 2023-02-17 中山大学 The role of albendazole or its pharmaceutically acceptable salt in the treatment of cholangiocarcinoma
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN113648308A (en) * 2021-09-14 2021-11-16 东莞市人民医院 Application of orendazole as an anti-ovarian cancer drug
US12162881B2 (en) 2021-11-09 2024-12-10 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of JAK2
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020165261A1 (en) * 2001-01-24 2002-11-07 Alexis Borisy Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
WO2004006849A2 (en) * 2002-07-15 2004-01-22 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020165261A1 (en) * 2001-01-24 2002-11-07 Alexis Borisy Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
WO2004006849A2 (en) * 2002-07-15 2004-01-22 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AM. J. GASTROENTEROLOGY, vol. 95, no. 1, January 2000 (2000-01-01), pages 248 - 254 *
DATABASE CAPLUS [online] BORISY, A. ET AL.: "Benzimidazole compound-pentamidine compound combinations for the treatment of neoplasms", XP002975593, accession no. STN Database accession no. 2004:60255 *
DATABASE MEDLINE [online] DEGER, E. ET AL.: "A new therapeutic approach for the treatment of cystic echinococosis: percutaneous albendazole sulphoxide injection without reaspiration", accession no. STN Database accession no. 20102130 *
DATABASE USPATFULL [online] BORISY ET AL.: "Combinations of drugs (e.g. a benzimadozole and pentamidine) for treatment of neoplastic disorders", XP002975594, accession no. STN Database accession no. 2002:295212 *

Also Published As

Publication number Publication date
WO2004006849A2 (en) 2004-01-22
AU2003251904A1 (en) 2004-02-02
AU2003251904A8 (en) 2004-02-02

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