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WO2004005335A3 - Hormone de croissance multimerisee - Google Patents

Hormone de croissance multimerisee Download PDF

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Publication number
WO2004005335A3
WO2004005335A3 PCT/DK2003/000428 DK0300428W WO2004005335A3 WO 2004005335 A3 WO2004005335 A3 WO 2004005335A3 DK 0300428 W DK0300428 W DK 0300428W WO 2004005335 A3 WO2004005335 A3 WO 2004005335A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth hormone
multimerised
fusion proteins
hormone fusion
multimers
Prior art date
Application number
PCT/DK2003/000428
Other languages
English (en)
Other versions
WO2004005335A2 (fr
Inventor
Thor Las Holtet
Original Assignee
Borean Pharma As
Thor Las Holtet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Borean Pharma As, Thor Las Holtet filed Critical Borean Pharma As
Priority to AU2003239777A priority Critical patent/AU2003239777A1/en
Publication of WO2004005335A2 publication Critical patent/WO2004005335A2/fr
Publication of WO2004005335A3 publication Critical patent/WO2004005335A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des polypeptides de l'hormone de croissance multimérisée, l'hormone de croissance étant soudée à un domaine de multimérisation, tel qu'un élément structural trimérisant la tétranectine. Ainsi, on obtient des multimères d'hormone de croissance, p.ex. des dimères d'hormone de croissance et des trimères d'hormone de croissance, ayant une activité biologique accrue.
PCT/DK2003/000428 2002-07-05 2003-06-23 Hormone de croissance multimerisee WO2004005335A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003239777A AU2003239777A1 (en) 2002-07-05 2003-06-23 Multimerised growth hormone fusion proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39338302P 2002-07-05 2002-07-05
DKPA200201062 2002-07-05
US60/393,383 2002-07-05
DKPA200201062 2002-07-05

Publications (2)

Publication Number Publication Date
WO2004005335A2 WO2004005335A2 (fr) 2004-01-15
WO2004005335A3 true WO2004005335A3 (fr) 2004-02-26

Family

ID=30116815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000428 WO2004005335A2 (fr) 2002-07-05 2003-06-23 Hormone de croissance multimerisee

Country Status (2)

Country Link
AU (1) AU2003239777A1 (fr)
WO (1) WO2004005335A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009005466A (es) 2006-11-22 2009-08-17 Adnexus A Bristol Myers Sqibb Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i.
JP2011520961A (ja) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー 多価フィブロネクチンをベースとする足場ドメインタンパク質
US8791063B2 (en) * 2011-08-25 2014-07-29 Hoffmann-La Roche, Inc. Shortened tetranectin-apolipoprotein A-I fusion protein, a lipid particle containing it, and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037621A2 (fr) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Für Proteinoptimierung Mbh Proteines multimeres
WO1997024445A1 (fr) * 1995-12-30 1997-07-10 Delta Biotechnology Limited Proteines de fusion recombinees d'hormone de croissance et d'albumine serique
WO1998056906A1 (fr) * 1997-06-11 1998-12-17 Thoegersen Hans Christian Module formant des trimeres
WO2002048189A2 (fr) * 2000-12-13 2002-06-20 Borean Pharma A/S Échantillothèques combinatoires de protéines présentant la structure en échafaudage des domaines lectonoïdes de type c
WO2003054152A2 (fr) * 2001-12-10 2003-07-03 Nuvelo, Inc. Nouveaux acides nucleiques et polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037621A2 (fr) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Für Proteinoptimierung Mbh Proteines multimeres
WO1997024445A1 (fr) * 1995-12-30 1997-07-10 Delta Biotechnology Limited Proteines de fusion recombinees d'hormone de croissance et d'albumine serique
WO1998056906A1 (fr) * 1997-06-11 1998-12-17 Thoegersen Hans Christian Module formant des trimeres
WO2002048189A2 (fr) * 2000-12-13 2002-06-20 Borean Pharma A/S Échantillothèques combinatoires de protéines présentant la structure en échafaudage des domaines lectonoïdes de type c
WO2003054152A2 (fr) * 2001-12-10 2003-07-03 Nuvelo, Inc. Nouveaux acides nucleiques et polypeptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JEREMY THORNER ET AL: "Applicatins of Chimeric Genes and Hybrid Proteins", METHODS IN ENZYMOLOGY, vol. 328, 2000, pages 260 - 283, XP002260661, ISSN: 0076-6879 *
LORENTSEN R H ET AL: "The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.", THE BIOCHEMICAL JOURNAL. ENGLAND 1 APR 2000, vol. 347 Pt 1, 1 April 2000 (2000-04-01), pages 83 - 87, XP002260660, ISSN: 0264-6021 *
MICHEL JAQUINOD ET AL: "Mass Spectrometric Characterisation of Post-Translational Modification and Genetic Variation in Human Tetranectin", BIOL. CHEM., vol. 380, November 1999 (1999-11-01), pages 1307 - 1314, XP002260659 *
NIELSEN B B ET AL: "Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.", FEBS LETTERS. NETHERLANDS 28 JUL 1997, vol. 412, no. 2, 28 July 1997 (1997-07-28), pages 388 - 396, XP002260662, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
AU2003239777A8 (en) 2004-01-23
WO2004005335A2 (fr) 2004-01-15
AU2003239777A1 (en) 2004-01-23

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