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WO2004098649A3 - Appareil et procede pour examiner un objet au moyen de rayons x a dispersion elastique et d'un produit de contraste - Google Patents

Appareil et procede pour examiner un objet au moyen de rayons x a dispersion elastique et d'un produit de contraste Download PDF

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Publication number
WO2004098649A3
WO2004098649A3 PCT/IB2004/050579 IB2004050579W WO2004098649A3 WO 2004098649 A3 WO2004098649 A3 WO 2004098649A3 IB 2004050579 W IB2004050579 W IB 2004050579W WO 2004098649 A3 WO2004098649 A3 WO 2004098649A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
ray radiation
examining
elastically scattered
examination area
Prior art date
Application number
PCT/IB2004/050579
Other languages
English (en)
Other versions
WO2004098649A2 (fr
Inventor
Jens-Peter Schlomka
Geoffrey Harding
Gerhard Martens
Original Assignee
Philips Intellectual Property
Koninkl Philips Electronics Nv
Jens-Peter Schlomka
Geoffrey Harding
Gerhard Martens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Intellectual Property, Koninkl Philips Electronics Nv, Jens-Peter Schlomka, Geoffrey Harding, Gerhard Martens filed Critical Philips Intellectual Property
Priority to EP04731078A priority Critical patent/EP1622649A2/fr
Publication of WO2004098649A2 publication Critical patent/WO2004098649A2/fr
Publication of WO2004098649A3 publication Critical patent/WO2004098649A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/483—Diagnostic techniques involving scattered radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

L'invention concerne un produit de contraste s'appliquant sur une région d'examen d'un objet devant être examiné, notamment un patient, en vue d'un examen radiographique de ladite région d'examen au moyen de rayons X. Le produit de contraste est caractérisé en ce qu'il comporte des particules de dispersion permettant de former des rayons X à dispersion élastique. Dans le signal détecté, ces particules de dispersion rendent la région d'examen visible par rapport aux régions voisines.
PCT/IB2004/050579 2003-05-06 2004-05-04 Appareil et procede pour examiner un objet au moyen de rayons x a dispersion elastique et d'un produit de contraste WO2004098649A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04731078A EP1622649A2 (fr) 2003-05-06 2004-05-04 Appareil et procede pour examiner un objet au moyen de rayons x a dispersion elastique et d'un produit de contraste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03101251.1 2003-05-06
EP03101251 2003-05-06

Publications (2)

Publication Number Publication Date
WO2004098649A2 WO2004098649A2 (fr) 2004-11-18
WO2004098649A3 true WO2004098649A3 (fr) 2005-01-13

Family

ID=33427173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/050579 WO2004098649A2 (fr) 2003-05-06 2004-05-04 Appareil et procede pour examiner un objet au moyen de rayons x a dispersion elastique et d'un produit de contraste

Country Status (2)

Country Link
EP (1) EP1622649A2 (fr)
WO (1) WO2004098649A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007533993A (ja) * 2004-04-21 2007-11-22 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 扇ビーム干渉性散乱コンピュータ断層撮影
DE102005026940A1 (de) * 2005-06-06 2006-12-14 Schering Ag Röntgenanordnung zur Bilddarstellung eines Untersuchungsobjektes und Verwendung der Röntgenanordnung
CN104700390B (zh) * 2013-12-09 2019-07-23 通用电气公司 双能ct造影剂增强扫描图像中的钙化部分识别方法
CN104700389B (zh) * 2013-12-09 2019-08-13 通用电气公司 双能ct扫描图像中的对象识别方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801203A (en) * 1951-03-22 1957-07-30 Byk Gulden Lomberg Chem Fab X-ray method of digestive enzyme diagnosis using protected core of contrast agent
EP0498482A2 (fr) * 1991-01-25 1992-08-12 NanoSystems L.L.C. Agents de contraste pour application en imagerie médicale
WO1996020735A2 (fr) * 1994-12-30 1996-07-11 Nanosystems L.L.C. Compositions orales a usage gastro-intestinal d'agents de contraste aux rayons x en combinaison avec des tensioactifs
WO1996024335A1 (fr) * 1995-02-09 1996-08-15 Nanosystems L.L.C. Tensioactif a base de sucre pour nanocristaux
WO1997003657A1 (fr) * 1995-07-21 1997-02-06 Brown University Research Foundation Procede de preparation de microparticules a l'aide de phenomenes d'inversion de phase
WO2000033890A1 (fr) * 1998-12-08 2000-06-15 The Regents Of The University Of California Agent de contraste particulaire opaque aux rayons x pour imagerie microvasculaire a rayons x
WO2001024834A1 (fr) * 1997-09-12 2001-04-12 See Jackie R Procedes de preparation d'agents micro encapsules s'utilisant dans la detection des tumeurs par tomographie par ordinateur
US6470067B1 (en) * 2000-02-28 2002-10-22 Koninklijke Philips Electronics N.V. Computed tomography apparatus for determining the pulse momentum transfer spectrum in an examination zone
DE10127267A1 (de) * 2001-06-05 2002-12-19 Siemens Ag Bildgebendes medizinsches Röntgengerät
WO2003075961A2 (fr) * 2002-03-08 2003-09-18 James Hainfeld Supports et procedes d'amelioration d'imagerie medicale
US20040001894A1 (en) * 2002-06-26 2004-01-01 Leibowitz Jonathan S. Topical compositions and glove for protection against radiation exposure

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801203A (en) * 1951-03-22 1957-07-30 Byk Gulden Lomberg Chem Fab X-ray method of digestive enzyme diagnosis using protected core of contrast agent
EP0498482A2 (fr) * 1991-01-25 1992-08-12 NanoSystems L.L.C. Agents de contraste pour application en imagerie médicale
WO1996020735A2 (fr) * 1994-12-30 1996-07-11 Nanosystems L.L.C. Compositions orales a usage gastro-intestinal d'agents de contraste aux rayons x en combinaison avec des tensioactifs
WO1996024335A1 (fr) * 1995-02-09 1996-08-15 Nanosystems L.L.C. Tensioactif a base de sucre pour nanocristaux
WO1997003657A1 (fr) * 1995-07-21 1997-02-06 Brown University Research Foundation Procede de preparation de microparticules a l'aide de phenomenes d'inversion de phase
WO2001024834A1 (fr) * 1997-09-12 2001-04-12 See Jackie R Procedes de preparation d'agents micro encapsules s'utilisant dans la detection des tumeurs par tomographie par ordinateur
WO2000033890A1 (fr) * 1998-12-08 2000-06-15 The Regents Of The University Of California Agent de contraste particulaire opaque aux rayons x pour imagerie microvasculaire a rayons x
US6470067B1 (en) * 2000-02-28 2002-10-22 Koninklijke Philips Electronics N.V. Computed tomography apparatus for determining the pulse momentum transfer spectrum in an examination zone
DE10127267A1 (de) * 2001-06-05 2002-12-19 Siemens Ag Bildgebendes medizinsches Röntgengerät
WO2003075961A2 (fr) * 2002-03-08 2003-09-18 James Hainfeld Supports et procedes d'amelioration d'imagerie medicale
US20040001894A1 (en) * 2002-06-26 2004-01-01 Leibowitz Jonathan S. Topical compositions and glove for protection against radiation exposure

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BATCHELAR D L ET AL: "Material-specific analysis using coherent-scatter imaging", MEDICAL PHYSICS, vol. 29, no. 8, 1 August 2002 (2002-08-01), pages 1651 - 1660, XP002288997, ISSN: 0094-2405 *
MCINTIRE GREGORY L ET AL: "Pulmonary delivery of nanoparticles of insoluble, iodinated CT X-ray contrast agents to lung draining lymph nodes in dogs", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 87, no. 11, November 1998 (1998-11-01), pages 1466 - 1470, XP002149780, ISSN: 0022-3549 *
PEPLOW D E ET AL: "Measured molecular coherent scattering form factors of animal tissues, plastics and human breast tissue", PHYSICS IN MEDICINE AND BIOLOGY, vol. 43, no. 9, 1998, pages 2431 - 2452, XP002288996, ISSN: 0031-9155 *
RONGVED P ET AL: "Starch microspheres as carriers for X-ray imaging contrast agents: Synthesis and stability of new amino-acid linker derivatives", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 297, no. 4, 14 February 1997 (1997-02-14), pages 325 - 331, XP004172597, ISSN: 0008-6215 *
YU S-B ET AL: "METAL-BASED X-RAY CONTRAST MEDIA", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 99, no. 9, September 1999 (1999-09-01), pages 2353 - 2377, XP000852436, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
EP1622649A2 (fr) 2006-02-08
WO2004098649A2 (fr) 2004-11-18

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