WO2004081174A3 - Marqueur pour detecter une cellule souche mesenchymateuse et procede pour distinguer une cellule souche mesenchymateuse au moyen d'un marqueur - Google Patents
Marqueur pour detecter une cellule souche mesenchymateuse et procede pour distinguer une cellule souche mesenchymateuse au moyen d'un marqueur Download PDFInfo
- Publication number
- WO2004081174A3 WO2004081174A3 PCT/JP2004/002457 JP2004002457W WO2004081174A3 WO 2004081174 A3 WO2004081174 A3 WO 2004081174A3 JP 2004002457 W JP2004002457 W JP 2004002457W WO 2004081174 A3 WO2004081174 A3 WO 2004081174A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- marker
- stem cell
- mesenchymal stem
- detecting
- gene
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04715524A EP1605044A4 (fr) | 2003-03-10 | 2004-02-27 | Marqueur pour detecter une cellule souche mesenchymateuse et procede pour distinguer une cellule souche mesenchymateuse au moyen d'un marqueur |
US10/548,681 US20060166214A1 (en) | 2003-03-10 | 2004-02-27 | Marker for detecting mesenchymal stem cell and method of distinguishing mesenchymal stem cell using the marker |
AU2004219820A AU2004219820B2 (en) | 2003-03-10 | 2004-02-27 | Marker for detecting mesenchymal stem cell and method of distinguishing mesenchymal stem cell using the marker |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003063077 | 2003-03-10 | ||
JP2003-63077 | 2003-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004081174A2 WO2004081174A2 (fr) | 2004-09-23 |
WO2004081174A3 true WO2004081174A3 (fr) | 2004-12-02 |
Family
ID=32984419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2004/002457 WO2004081174A2 (fr) | 2003-03-10 | 2004-02-27 | Marqueur pour detecter une cellule souche mesenchymateuse et procede pour distinguer une cellule souche mesenchymateuse au moyen d'un marqueur |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060166214A1 (fr) |
EP (2) | EP1860186B1 (fr) |
JP (1) | JP2004290189A (fr) |
KR (1) | KR100818689B1 (fr) |
CN (2) | CN1761749A (fr) |
AT (1) | ATE488588T1 (fr) |
AU (1) | AU2004219820B2 (fr) |
DE (1) | DE602004030172D1 (fr) |
WO (1) | WO2004081174A2 (fr) |
Families Citing this family (56)
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EP1870455A4 (fr) * | 2005-03-31 | 2010-01-20 | Two Cells Co Ltd | Procédé de distinction d'une cellule souche mésenchymateuse utilisant un marqueur moléculaire et son usage |
JPWO2006112390A1 (ja) * | 2005-04-14 | 2008-12-11 | 国立循環器病センター総長 | 脂肪由来前駆細胞およびその利用 |
US20060246498A1 (en) * | 2005-04-28 | 2006-11-02 | Ramot At Tel Aviv University Ltd. | HNRPLL polypeptides, polynucleotides encoding same and compositions and methods of using same |
JP4958094B2 (ja) * | 2005-09-22 | 2012-06-20 | 国立大学法人広島大学 | 間葉系幹細胞の均質性識別方法、その方法を利用して得られる均質間葉系幹細胞 |
ES2406063T3 (es) * | 2005-12-08 | 2013-06-05 | Medarex, Inc. | Anticuerpos monoclonales humanos contra la proteína Tirosina Quinasa 7(PTK7) y su uso |
CN100475836C (zh) * | 2005-12-09 | 2009-04-08 | 中国人民解放军军事医学科学院野战输血研究所 | 间充质干细胞亲和肽的筛选与用途 |
EP1982176A1 (fr) * | 2006-01-30 | 2008-10-22 | Dako Denmark A/S | Quantification ultra-rapide de lymphocytes-t specifiques d'antigenes dans du sang entier par cytometrie de flux |
JP2008092919A (ja) * | 2006-10-16 | 2008-04-24 | Hiroshima Univ | 病変間葉系幹細胞の検出マーカーの利用 |
JP5670055B2 (ja) * | 2007-01-30 | 2015-02-18 | ファーマサイクリックス,インク. | ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 |
WO2008116468A2 (fr) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Complexes peptidiques du cmh et leurs utilisations dans des maladies infectieuses |
KR100888924B1 (ko) | 2007-06-04 | 2009-03-16 | 주식회사 제이비줄기세포연구소 | 인간 제대혈 유래 중간엽 줄기세포와 섬유아세포 분별방법 |
EP3023436A1 (fr) | 2007-07-03 | 2016-05-25 | Dako Denmark A/S | Procédés améliorés pour produire, marquer et utiliser des multimères du cmh |
US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
US20090305905A1 (en) * | 2007-12-13 | 2009-12-10 | Robert Bradbury | Compositions and methods relating to characterization and therapeutic application of pristine stem cells |
DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
WO2010009735A2 (fr) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Analyse et réparation combinatoires |
GB0817244D0 (en) * | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
WO2010037402A1 (fr) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Vaccins moléculaires contre les maladies infectieuses |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
JP2010189302A (ja) * | 2009-02-17 | 2010-09-02 | Hiroshima Univ | 病変間葉系幹細胞が関連する疾患の治療剤および間葉系幹細胞の検出マーカーの利用 |
PT2453921E (pt) * | 2009-07-14 | 2015-09-25 | Novartis Ag | Diferenciação de células estaminais mesenquimais |
WO2012048275A2 (fr) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Procédés et systèmes configurables pour la culture et la récolte de cellules dans un système de bioréacteur à fibres creuses |
ES2384790B1 (es) * | 2010-12-10 | 2013-05-20 | Instituto De Salud Carlos Iii | Células madre mesenquimales aisladas a partir de sangre periférica. |
CA2830140C (fr) * | 2011-03-16 | 2019-08-06 | Tohoku University | Sonde pour analyser un tissu biologique et procede d'utilisation de celle-ci |
KR101374247B1 (ko) | 2011-09-23 | 2014-03-13 | 가톨릭대학교기술지주 주식회사 | 고해상도 mica 대립유전자 검출용 sprex―dna 칩 키트 |
CN108588025A (zh) * | 2012-02-17 | 2018-09-28 | 斯格本斯眼科研究所 | 人视网膜祖细胞的表型谱 |
PL2841564T3 (pl) * | 2012-04-24 | 2018-08-31 | Stemlab, S.A. | Sposób oraz kompozycja z komórkami macierzystymi do podtrzymywania tkanki serca |
CN102732633B (zh) * | 2012-07-06 | 2014-02-26 | 广州好芝生物科技有限公司 | 人idh基因突变的检测引物和试剂盒 |
CN102925579B (zh) * | 2012-11-16 | 2014-12-17 | 上海赛安医学检验所有限公司 | Idh2基因突变的快速检测方法 |
KR102144604B1 (ko) | 2013-02-01 | 2020-08-14 | 도호쿠 다이가쿠 | 생체 조직으로부터의 세포의 분리 방법 |
GB201310354D0 (en) * | 2013-06-11 | 2013-07-24 | Ge Healthcare Uk Ltd | Method for cell differentiation |
WO2015073913A1 (fr) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expansion de cellules dans un bioréacteur |
JP6339814B2 (ja) * | 2014-02-05 | 2018-06-06 | 株式会社島津製作所 | がん転移マーカー及びその分析方法 |
EP3122866B1 (fr) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Remplacement passif de milieu |
US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
WO2016086403A1 (fr) * | 2014-12-05 | 2016-06-09 | Meridigen Biotech Co., Ltd. | Procédé de différenciation de cellules souches mésenchymateuses |
CN104844705B (zh) * | 2015-01-30 | 2018-08-03 | 暨南大学 | Kctd12蛋白在细胞周期调控中的应用 |
CN104655857B (zh) * | 2015-02-10 | 2017-05-31 | 南京大学 | 一种微生物细胞内多聚磷酸盐的定量检测方法 |
JP6754932B2 (ja) * | 2015-03-17 | 2020-09-16 | 国立研究開発法人産業技術総合研究所 | 幹細胞を検出するための方法及びキット |
WO2017004592A1 (fr) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Croissance cellulaire à l'aide de stimuli mécaniques |
CN105018524B (zh) * | 2015-07-13 | 2020-03-27 | 广州赛琅生物技术有限公司 | 一种细胞寿命延长及成血管能力增强的人干细胞的制备方法及其试剂盒 |
WO2017205667A1 (fr) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Expansion cellulaire |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
CN106771256B (zh) * | 2017-01-23 | 2019-02-01 | 福建医科大学 | 骨骼肌组织冰冻切片肌球蛋白三磷酸腺苷酶染色方法 |
CN110177871B (zh) | 2017-03-03 | 2023-05-09 | 日本乐敦制药株式会社 | 间充质干细胞和肝疾病治疗剂 |
CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
SG10202107869QA (en) * | 2017-04-10 | 2021-08-30 | Immatics Biotechnologies Gmbh | Peptides and combination thereof for use in the immunotherapy against cancers |
EP3898666A2 (fr) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panneau comprenant des multimères de borrelia cmh |
PL241520B1 (pl) * | 2020-03-27 | 2022-10-17 | Polski Bank Komorek Macierzystych Spolka Akcyjna | Zastosowanie panelu genów do określania potencjału teratogennego komórek mezenchymalnych i pochodzenia perinatalnego |
WO2022204315A1 (fr) | 2021-03-23 | 2022-09-29 | Terumo Bct, Inc. | Capture et multiplication cellulaire |
EP4408979A1 (fr) * | 2021-09-30 | 2024-08-07 | Polski Bank Komórek Macierzystych S.A. | Analyse d'expression d'un groupe de gènes spécifique pour déterminer si la population de cellules mésenchymateuses dérivées de tissu adipeux (at-msc) sélectionnée pour une application clinique peut subir une transformation en cellules néoplasiques |
US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
CN114622019A (zh) * | 2022-03-23 | 2022-06-14 | 新乡医学院 | Birc5基因作为人骨髓间充质干细胞成骨分化抑制剂的应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998020731A1 (fr) * | 1996-11-15 | 1998-05-22 | Osiris Therapeutics, Inc. | Compositions mixtes de cellules msc et de precurseurs de megacaryocytes et procede pour isoler les cellules msc associees aux megacaryocytes, en separant les megacaryocytes |
JP2003052365A (ja) * | 2001-08-20 | 2003-02-25 | Japan Science & Technology Corp | 哺乳動物からの間葉系幹細胞の分離及びその利用方法 |
EP1288293A1 (fr) * | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Cellules souches neuronales humaines originaires d'une couche de cellules mesenchymateuses amniotiques humaines |
Family Cites Families (5)
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---|---|---|---|---|
US5340739A (en) * | 1988-07-13 | 1994-08-23 | Brigham & Women's Hospital | Hematopoietic cell specific transcriptional regulatory elements of serglycin and uses thereof |
WO1999041381A1 (fr) | 1998-02-13 | 1999-08-19 | Peter Sonderegger | Neuroserpine |
US20030211602A1 (en) * | 2000-04-28 | 2003-11-13 | Anthony Atala | Isolation of mesenchymal stem cells and use thereof |
AU2001264559A1 (en) * | 2000-06-05 | 2001-12-17 | Avalon Pharmaceuticals | Cancer gene determination and therapeutic screening using signature gene sets |
WO2002028999A2 (fr) * | 2000-10-03 | 2002-04-11 | Gene Logic, Inc. | Profils d'expression genique dans les cellules granulocytaires |
-
2004
- 2004-02-27 KR KR1020057016952A patent/KR100818689B1/ko not_active Expired - Fee Related
- 2004-02-27 AU AU2004219820A patent/AU2004219820B2/en not_active Ceased
- 2004-02-27 CN CNA2004800075500A patent/CN1761749A/zh active Pending
- 2004-02-27 EP EP07017847A patent/EP1860186B1/fr not_active Expired - Lifetime
- 2004-02-27 EP EP04715524A patent/EP1605044A4/fr not_active Withdrawn
- 2004-02-27 AT AT07017847T patent/ATE488588T1/de not_active IP Right Cessation
- 2004-02-27 WO PCT/JP2004/002457 patent/WO2004081174A2/fr not_active Application Discontinuation
- 2004-02-27 DE DE602004030172T patent/DE602004030172D1/de not_active Expired - Lifetime
- 2004-02-27 US US10/548,681 patent/US20060166214A1/en not_active Abandoned
- 2004-02-27 CN CNA200810081304XA patent/CN101265503A/zh active Pending
- 2004-03-10 JP JP2004067037A patent/JP2004290189A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998020731A1 (fr) * | 1996-11-15 | 1998-05-22 | Osiris Therapeutics, Inc. | Compositions mixtes de cellules msc et de precurseurs de megacaryocytes et procede pour isoler les cellules msc associees aux megacaryocytes, en separant les megacaryocytes |
JP2003052365A (ja) * | 2001-08-20 | 2003-02-25 | Japan Science & Technology Corp | 哺乳動物からの間葉系幹細胞の分離及びその利用方法 |
EP1288293A1 (fr) * | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Cellules souches neuronales humaines originaires d'une couche de cellules mesenchymateuses amniotiques humaines |
Non-Patent Citations (1)
Title |
---|
UMEZAWA A.: "Kanyokei kansaibo ni yoru zoki saisei sono hyomen kogen marker ni chakumoku suru", KAGAKU TO SEIBUTSU, vol. 40, no. 6, 2002, pages 362 - 369, XP002984780 * |
Also Published As
Publication number | Publication date |
---|---|
DE602004030172D1 (de) | 2010-12-30 |
EP1860186A3 (fr) | 2008-03-12 |
WO2004081174A2 (fr) | 2004-09-23 |
EP1605044A4 (fr) | 2006-12-06 |
EP1860186B1 (fr) | 2010-11-17 |
KR100818689B1 (ko) | 2008-04-02 |
CN101265503A (zh) | 2008-09-17 |
AU2004219820B2 (en) | 2008-06-12 |
ATE488588T1 (de) | 2010-12-15 |
JP2004290189A (ja) | 2004-10-21 |
US20060166214A1 (en) | 2006-07-27 |
AU2004219820A1 (en) | 2004-09-23 |
CN1761749A (zh) | 2006-04-19 |
KR20050115278A (ko) | 2005-12-07 |
EP1860186A2 (fr) | 2007-11-28 |
EP1605044A2 (fr) | 2005-12-14 |
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