WO2004080389A3 - Hydroxyeicosadienamide compounds - Google Patents
Hydroxyeicosadienamide compounds Download PDFInfo
- Publication number
- WO2004080389A3 WO2004080389A3 PCT/US2004/005222 US2004005222W WO2004080389A3 WO 2004080389 A3 WO2004080389 A3 WO 2004080389A3 US 2004005222 W US2004005222 W US 2004005222W WO 2004080389 A3 WO2004080389 A3 WO 2004080389A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- hydroxyeicosadienamide
- compounds
- aryl group
- substituted aryl
- Prior art date
Links
- PWMCYMIQVKQDJN-UHFFFAOYSA-N OC(C(=O)N)=CC=CCCCCCCCCCCCCCCC Chemical class OC(C(=O)N)=CC=CCCCCCCCCCCCCCCC PWMCYMIQVKQDJN-UHFFFAOYSA-N 0.000 title 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- -1 hydroxyeicosadienamide compound Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a hydroxyeicosadienamide compound an excellent inhibitory effect on elastase release, which is represented by Formula (I): (I), wherein n represents an integer of 0 to 5, and R represents an optionally substituted C1-20 alkyl group, an optionally substituted aryl group, -NRXRY, an optionally substituted unsaturated heterocyclic ring, or -(C1-4 alkylene)-Q or Q, wherein Q is an optionally substituted C4-10 bridged hydrocarbon or an optionally substituted aryl group, or a pharmaceutically acceptable salt or hydrate thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45256203P | 2003-03-07 | 2003-03-07 | |
| US60/452,562 | 2003-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004080389A2 WO2004080389A2 (en) | 2004-09-23 |
| WO2004080389A3 true WO2004080389A3 (en) | 2004-12-09 |
Family
ID=32990663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2004/005222 WO2004080389A2 (en) | 2003-03-07 | 2004-03-05 | Hydroxyeicosadienamide compounds |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2004080389A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2208720A1 (en) | 2009-01-13 | 2010-07-21 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Novel eicosanoid derivatives |
| RU2730512C2 (en) | 2014-01-22 | 2020-08-24 | Макс-Делбрюк-Центрум Фюр Молекуляре Медицин | New derivatives of cyp-eicosanoids |
| US11690825B2 (en) | 2016-03-09 | 2023-07-04 | Board Of Regents, The University Of Texas System | 20-HETE receptor (GPR75) antagonists and methods of use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6359158B1 (en) * | 1998-05-15 | 2002-03-19 | University Of Vermont And State Agricultural College | Methods and products related to 16-HETE analogs |
-
2004
- 2004-03-05 WO PCT/US2004/005222 patent/WO2004080389A2/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6359158B1 (en) * | 1998-05-15 | 2002-03-19 | University Of Vermont And State Agricultural College | Methods and products related to 16-HETE analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004080389A2 (en) | 2004-09-23 |
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