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WO2004078119A3 - Substituted thiophenes with antibacterial activity - Google Patents

Substituted thiophenes with antibacterial activity Download PDF

Info

Publication number
WO2004078119A3
WO2004078119A3 PCT/US2004/005930 US2004005930W WO2004078119A3 WO 2004078119 A3 WO2004078119 A3 WO 2004078119A3 US 2004005930 W US2004005930 W US 2004005930W WO 2004078119 A3 WO2004078119 A3 WO 2004078119A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial activity
substituted thiophenes
disclosed
thiophenes
bacterial
Prior art date
Application number
PCT/US2004/005930
Other languages
French (fr)
Other versions
WO2004078119A2 (en
Inventor
John Berge
Richard Jarvest
Catherine Simone Vict Frydrych
Joseph Guiles
Jian Qiu
Theodore M Tarasow
Original Assignee
Replidyne Inc
John Berge
Richard Jarvest
Catherine Simone Vict Frydrych
Joseph Guiles
Jian Qiu
Theodore M Tarasow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0304809.7A external-priority patent/GB0304809D0/en
Application filed by Replidyne Inc, John Berge, Richard Jarvest, Catherine Simone Vict Frydrych, Joseph Guiles, Jian Qiu, Theodore M Tarasow filed Critical Replidyne Inc
Priority to EP04715720A priority Critical patent/EP1603881A4/en
Priority to AU2004218481A priority patent/AU2004218481A1/en
Priority to JP2006508886A priority patent/JP2006519261A/en
Priority to CA002517523A priority patent/CA2517523A1/en
Publication of WO2004078119A2 publication Critical patent/WO2004078119A2/en
Publication of WO2004078119A3 publication Critical patent/WO2004078119A3/en
Priority to AU2011201854A priority patent/AU2011201854A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.
PCT/US2004/005930 2003-03-03 2004-02-27 Substituted thiophenes with antibacterial activity WO2004078119A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP04715720A EP1603881A4 (en) 2003-03-03 2004-02-27 Substituted thiophenes with antibacterial activity
AU2004218481A AU2004218481A1 (en) 2003-03-03 2004-02-27 Substituted thiophenes with antibacterial activity
JP2006508886A JP2006519261A (en) 2003-03-03 2004-02-27 Substituted thiophene with antibacterial activity
CA002517523A CA2517523A1 (en) 2003-03-03 2004-02-27 Substituted thiophenes with antibacterial activity
AU2011201854A AU2011201854A1 (en) 2003-03-03 2011-04-21 Substituted thiophenes with antibacterial activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0304809.7A GB0304809D0 (en) 2003-03-03 2003-03-03 Novel compounds
GB0304809.7 2003-03-03
US52722903P 2003-12-05 2003-12-05
US60/527,229 2003-12-05

Publications (2)

Publication Number Publication Date
WO2004078119A2 WO2004078119A2 (en) 2004-09-16
WO2004078119A3 true WO2004078119A3 (en) 2004-12-29

Family

ID=32964063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/005930 WO2004078119A2 (en) 2003-03-03 2004-02-27 Substituted thiophenes with antibacterial activity

Country Status (5)

Country Link
EP (1) EP1603881A4 (en)
JP (1) JP2006519261A (en)
AU (2) AU2004218481A1 (en)
CA (1) CA2517523A1 (en)
WO (1) WO2004078119A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2523651A1 (en) * 2003-05-01 2005-02-03 Replidyne, Inc. Antibacterial methods and compositions
US8658670B2 (en) 2006-09-26 2014-02-25 Crestone, Inc. Methods and compounds for treatment of clostridium based infection
US8697720B2 (en) 2006-09-26 2014-04-15 Crestone, Inc. Substituted phenylether-thienopyridone compounds with antibacterial activity
US7994192B2 (en) 2006-09-26 2011-08-09 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
US7973050B2 (en) 2006-09-26 2011-07-05 Crestone, Inc. Enantiomeric compounds with antibacterial activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071522A1 (en) * 1999-05-19 2000-11-30 Smithkline Beecham Plc Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors
WO2000071524A1 (en) * 1999-05-19 2000-11-30 Smithkline Beecham Plc 2-nh-pyridones and pyrimidones as mrs inhibitors
US6320051B1 (en) * 1998-04-29 2001-11-20 Smithkline Beecham Plc Quinolones used as MRS inhibitors and bactericides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228545D0 (en) * 2002-12-06 2003-01-15 Glaxo Group Ltd Novel compounds
CA2523651A1 (en) * 2003-05-01 2005-02-03 Replidyne, Inc. Antibacterial methods and compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320051B1 (en) * 1998-04-29 2001-11-20 Smithkline Beecham Plc Quinolones used as MRS inhibitors and bactericides
WO2000071522A1 (en) * 1999-05-19 2000-11-30 Smithkline Beecham Plc Benzimidazole derivatives and their use as methionyl t-rna synthetase inhibitors
WO2000071524A1 (en) * 1999-05-19 2000-11-30 Smithkline Beecham Plc 2-nh-pyridones and pyrimidones as mrs inhibitors

Also Published As

Publication number Publication date
AU2011201854A1 (en) 2011-05-19
JP2006519261A (en) 2006-08-24
AU2004218481A1 (en) 2004-09-16
WO2004078119A2 (en) 2004-09-16
CA2517523A1 (en) 2004-09-16
EP1603881A4 (en) 2010-07-07
EP1603881A2 (en) 2005-12-14

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