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WO2004077010A3 - Water channel assays - Google Patents

Water channel assays Download PDF

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Publication number
WO2004077010A3
WO2004077010A3 PCT/US2004/003022 US2004003022W WO2004077010A3 WO 2004077010 A3 WO2004077010 A3 WO 2004077010A3 US 2004003022 W US2004003022 W US 2004003022W WO 2004077010 A3 WO2004077010 A3 WO 2004077010A3
Authority
WO
WIPO (PCT)
Prior art keywords
water channel
channel assays
modulate
assays
agents
Prior art date
Application number
PCT/US2004/003022
Other languages
French (fr)
Other versions
WO2004077010A2 (en
Inventor
Mark Daniels
Mark Yeager
Original Assignee
Scripps Research Inst
Mark Daniels
Mark Yeager
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Mark Daniels, Mark Yeager filed Critical Scripps Research Inst
Publication of WO2004077010A2 publication Critical patent/WO2004077010A2/en
Publication of WO2004077010A3 publication Critical patent/WO2004077010A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention is directed to methods for identifying agents that can modulate water channel activity. Such agents can modulate the movement of water into or out of various cell types.
PCT/US2004/003022 2003-02-03 2004-02-03 Water channel assays WO2004077010A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44484603P 2003-02-03 2003-02-03
US60/444,846 2003-02-03

Publications (2)

Publication Number Publication Date
WO2004077010A2 WO2004077010A2 (en) 2004-09-10
WO2004077010A3 true WO2004077010A3 (en) 2004-12-09

Family

ID=32927457

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/003022 WO2004077010A2 (en) 2003-02-03 2004-02-03 Water channel assays

Country Status (1)

Country Link
WO (1) WO2004077010A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006028009A1 (en) * 2006-06-19 2007-12-20 Universität Duisburg-Essen AQP5 polymorphism
US9316633B2 (en) 2006-11-16 2016-04-19 The Regents Of The University Of California Methods for identifying inhibitors of solute transporters
CN101977928B (en) 2007-12-27 2014-12-10 伊沃基因有限公司 Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064219A2 (en) * 2000-02-28 2001-09-07 Janssen Pharmaceutica N.V. Use of cytoskeleton modifying compounds against intracranial pressure changes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064219A2 (en) * 2000-02-28 2001-09-07 Janssen Pharmaceutica N.V. Use of cytoskeleton modifying compounds against intracranial pressure changes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KARLSSON M ET AL: "Reconstitution of water channel function of an aquaporin overexpressed and purified from Pichia pastoris", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 537, no. 1-3, 27 February 2003 (2003-02-27), pages 68 - 72, XP004411980, ISSN: 0014-5793 *
TAMARAPPOO B K ET AL: "HIGH-THROUGHPUT SCREENING OF COMBINATORIAL DRUG LIBRARIES TO IDENTIFY NON-MERCURIAL AQUAPOTIN INHIBITORS", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 10, 1999, pages 25A, XP000861840, ISSN: 1046-6673 *
UMENISHI FUMINORI ET AL: "Functional expression of the mercurial insensitive water channel (MIWC/AQP4) in the methylotrophic yeast Pichia pastoris", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7, no. 9, 1996, & 29TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF NEPHROLOGY; NEW ORLEANS, LOUISIANA, USA; NOVEMBER 3-6, 1996, pages 1274, XP009038156, ISSN: 1046-6673 *
VERKMAN A S: "APPLICATIONS OF AQUAPORIN INHIBITORS", DRUG NEWS AND PERSPECTIVES, XX, XX, vol. 14, no. 7, September 2001 (2001-09-01), pages 412 - 420, XP008006509, ISSN: 0214-0934 *

Also Published As

Publication number Publication date
WO2004077010A2 (en) 2004-09-10

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