WO2004071389A3 - Non-steroidal infalmmation inhibitors - Google Patents
Non-steroidal infalmmation inhibitors Download PDFInfo
- Publication number
- WO2004071389A3 WO2004071389A3 PCT/EP2004/001507 EP2004001507W WO2004071389A3 WO 2004071389 A3 WO2004071389 A3 WO 2004071389A3 EP 2004001507 W EP2004001507 W EP 2004001507W WO 2004071389 A3 WO2004071389 A3 WO 2004071389A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- represents hydrogen
- nr8cor9
- conr8r9
- coor7
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052794 bromium Inorganic materials 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052731 fluorine Inorganic materials 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR6a, or CHR6b; R1 represents hydrogen, halogen such as F, Cl or Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R2 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R3 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7, CONR8R9; R4 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R5 represents H, C1-6 alkyl, or C1-6 alkenyl; R6a represents hydrogen, C1-6 alkyl, CO2C1-3 alkyl, COC1-3 alkyl or SO2C1-3 alkyl; R6b represents hydrogen, or C1-6 alkyl; R7 represents hydrogen, C1-6 alkyl, C1-3 alkyleneSiC1-3 alkyl such as -CH2CH2Si(CH3)3; R8 and R9 independently represent hydrogen or C1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303523A GB0303523D0 (en) | 2003-02-15 | 2003-02-15 | Compounds |
| GB0303523.5 | 2003-02-15 | ||
| GB0305717.1 | 2003-03-13 | ||
| GB0305721A GB0305721D0 (en) | 2003-03-13 | 2003-03-13 | Compounds |
| GB0305721.3 | 2003-03-13 | ||
| GB0305717A GB0305717D0 (en) | 2003-03-13 | 2003-03-13 | Compounds |
| GB0316865A GB0316865D0 (en) | 2003-07-18 | 2003-07-18 | Compounds |
| GB0316865.5 | 2003-07-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004071389A2 WO2004071389A2 (en) | 2004-08-26 |
| WO2004071389A3 true WO2004071389A3 (en) | 2004-12-02 |
Family
ID=32872852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2004/001507 WO2004071389A2 (en) | 2003-02-15 | 2004-02-13 | Non-steroidal infalmmation inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2004071389A2 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1633296A (en) | 2002-03-26 | 2005-06-29 | 贝林格尔·英格海姆药物公司 | Glucocorticoid mimetic, its preparation method, pharmaceutical composition and use thereof |
| UY28526A1 (en) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| WO2006000398A1 (en) * | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | 2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| DE602005015027D1 (en) * | 2004-12-27 | 2009-07-30 | Boehringer Ingelheim Pharma | GLUCOCORTICOID MIMETICS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS AND THEIR USE |
| GB0513297D0 (en) * | 2005-06-29 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| WO2008000777A2 (en) * | 2006-06-29 | 2008-01-03 | Glaxo Group Limited | Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use |
| BRPI0720131A2 (en) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | MIMETIC GLYCORTICOIDS, METHODS FOR MAKING THEM, PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME. |
| US20100035926A1 (en) * | 2006-12-20 | 2010-02-11 | Ian Baxter Campbell | Pyrazole derivatives as non-steroidal glucocorticoid receptor ligands |
| KR20110020902A (en) | 2008-06-06 | 2011-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | Glucocorticoid analogs, methods for their preparation, pharmaceutical compositions and uses thereof |
| US9382245B2 (en) | 2013-10-11 | 2016-07-05 | Yale University | Compounds and methods for treating HIV infections |
| TW202304462A (en) * | 2021-03-23 | 2023-02-01 | 美商美國禮來大藥廠 | Glucocorticoid receptor agonists |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032584A2 (en) * | 1998-11-27 | 2000-06-08 | Schering Aktiengesellschaft | Nonsteroidal antiinflammatories |
| WO2002010143A1 (en) * | 2000-07-28 | 2002-02-07 | Schering Aktiengesellschaft | Non-steroidal inflammation inhibitors |
-
2004
- 2004-02-13 WO PCT/EP2004/001507 patent/WO2004071389A2/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032584A2 (en) * | 1998-11-27 | 2000-06-08 | Schering Aktiengesellschaft | Nonsteroidal antiinflammatories |
| WO2002010143A1 (en) * | 2000-07-28 | 2002-02-07 | Schering Aktiengesellschaft | Non-steroidal inflammation inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004071389A2 (en) | 2004-08-26 |
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