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WO2004071267A3 - Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample - Google Patents

Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample Download PDF

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Publication number
WO2004071267A3
WO2004071267A3 PCT/EP2004/001152 EP2004001152W WO2004071267A3 WO 2004071267 A3 WO2004071267 A3 WO 2004071267A3 EP 2004001152 W EP2004001152 W EP 2004001152W WO 2004071267 A3 WO2004071267 A3 WO 2004071267A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
colorectal cancer
nicotinamide
methyltransferase
detection
Prior art date
Application number
PCT/EP2004/001152
Other languages
French (fr)
Other versions
WO2004071267A2 (en
Inventor
Peter Berndt
Marie-Luise Hagmann
Hanno Langen
Stefan Palme
Markus Roessler
Wolfgang Rollinger
Michael Tacke
Werner Zolg
Original Assignee
Roche Diagnostics Gmbh
Hoffmann La Roche
Peter Berndt
Marie-Luise Hagmann
Hanno Langen
Stefan Palme
Markus Roessler
Wolfgang Rollinger
Michael Tacke
Werner Zolg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffmann La Roche, Peter Berndt, Marie-Luise Hagmann, Hanno Langen, Stefan Palme, Markus Roessler, Wolfgang Rollinger, Michael Tacke, Werner Zolg filed Critical Roche Diagnostics Gmbh
Publication of WO2004071267A2 publication Critical patent/WO2004071267A2/en
Publication of WO2004071267A3 publication Critical patent/WO2004071267A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of nicotinamide N­methyltransferase NNMT in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.
PCT/EP2004/001152 2003-02-11 2004-02-09 Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample WO2004071267A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03002651.2 2003-02-11
EP03002651 2003-02-11

Publications (2)

Publication Number Publication Date
WO2004071267A2 WO2004071267A2 (en) 2004-08-26
WO2004071267A3 true WO2004071267A3 (en) 2004-10-21

Family

ID=32864921

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001152 WO2004071267A2 (en) 2003-02-11 2004-02-09 Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample

Country Status (1)

Country Link
WO (1) WO2004071267A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044680A1 (en) * 2004-10-14 2006-04-27 The Cleveland Clinic Foundation Methods of detecting colorectal cancer
EP1966608A1 (en) * 2005-12-21 2008-09-10 Roche Diagnostics GmbH Method of assessing colorectal cancer by measuring hemoglobin and m2-pk in a stool sample
JP6478416B2 (en) 2014-04-07 2019-03-06 塩野義製薬株式会社 Pharmaceutical composition for the treatment of chronic kidney disease
CN106248946A (en) * 2016-08-19 2016-12-21 浙江大学 A kind of enzyme-linked immunologic detecting kit and application thereof
HUE048369T2 (en) 2017-07-17 2020-07-28 Univ Masarykova Method of diagnosis of colorectal cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AHLQUIST D A: "FECAL OCCULT BLOOD TESTING FOR COLORECTAL CANCER CAN WE AFFORD TO DO THIS?", GASTROENTEROLOGY CLINICS OF NORTH AMERICA, XX, XX, vol. 26, no. 1, March 1997 (1997-03-01), pages 41 - 55, XP008021412 *
AOYAMA K ET AL: "Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.", NEUROSCIENCE LETTERS. 26 JAN 2001, vol. 298, no. 1, 26 January 2001 (2001-01-26), pages 78 - 80, XP002237184, ISSN: 0304-3940 *
OKAMURA A ET AL: "INCREASED HEPATIC NICOTINAMIDE N-METHYLTRANSFERASE ACTIVITY AS A MARKER OF CANCER CACHEXIA IN MICE BEARING COLON 26 ADENOCARCINOMA", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 89, no. 6, June 1998 (1998-06-01), pages 649 - 656, XP009008878, ISSN: 0910-5050 *
PARSONS RICHARD B ET AL: "Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 61, no. 2, February 2002 (2002-02-01), pages 111 - 124, XP009033873, ISSN: 0022-3069 *
SIEG ANDREAS ET AL: "Detection of colorectal neoplasms by the highly sensitive hemoglobin-haptoglobin complex in feces", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, vol. 14, no. 6, December 1999 (1999-12-01), pages 267 - 271, XP002288706, ISSN: 0179-1958 *

Also Published As

Publication number Publication date
WO2004071267A2 (en) 2004-08-26

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