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WO2004070347A3 - Depistage pour modulateurs du stockage des graisses - Google Patents

Depistage pour modulateurs du stockage des graisses Download PDF

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Publication number
WO2004070347A3
WO2004070347A3 PCT/GB2004/000413 GB2004000413W WO2004070347A3 WO 2004070347 A3 WO2004070347 A3 WO 2004070347A3 GB 2004000413 W GB2004000413 W GB 2004000413W WO 2004070347 A3 WO2004070347 A3 WO 2004070347A3
Authority
WO
WIPO (PCT)
Prior art keywords
screening
modulators
fat storage
compounds
fat
Prior art date
Application number
PCT/GB2004/000413
Other languages
English (en)
Other versions
WO2004070347A2 (fr
Inventor
Malcolm George Parker
Original Assignee
Imp College Innovations Ltd
Malcolm George Parker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imp College Innovations Ltd, Malcolm George Parker filed Critical Imp College Innovations Ltd
Priority to JP2006502228A priority Critical patent/JP2006518591A/ja
Priority to CA002515347A priority patent/CA2515347A1/fr
Priority to EP04707568A priority patent/EP1590674A2/fr
Priority to AU2004209335A priority patent/AU2004209335A1/en
Publication of WO2004070347A2 publication Critical patent/WO2004070347A2/fr
Publication of WO2004070347A3 publication Critical patent/WO2004070347A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)

Abstract

L'invention concerne des procédés de dépistage permettant d'identifier des composés qui sont utilisés comme modulateurs du stockage des graisses. En particulier, l'invention concerne des procédés de dépistage de composés modulant la fonction de protéine 140 d'interaction du récepteur (protéine RIP 140).
PCT/GB2004/000413 2003-02-03 2004-02-03 Depistage pour modulateurs du stockage des graisses WO2004070347A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006502228A JP2006518591A (ja) 2003-02-03 2004-02-03 貯蔵脂肪のモジュレータのスクリーニング
CA002515347A CA2515347A1 (fr) 2003-02-03 2004-02-03 Depistage pour modulateurs du stockage des graisses
EP04707568A EP1590674A2 (fr) 2003-02-03 2004-02-03 Depistage pour modulateurs du stockage des graisses
AU2004209335A AU2004209335A1 (en) 2003-02-03 2004-02-03 Screening for modulators of fat storage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0302446.0A GB0302446D0 (en) 2003-02-03 2003-02-03 Screening for modulators of fat storage
GB0302446.0 2003-02-03

Publications (2)

Publication Number Publication Date
WO2004070347A2 WO2004070347A2 (fr) 2004-08-19
WO2004070347A3 true WO2004070347A3 (fr) 2004-12-16

Family

ID=9952335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000413 WO2004070347A2 (fr) 2003-02-03 2004-02-03 Depistage pour modulateurs du stockage des graisses

Country Status (6)

Country Link
EP (1) EP1590674A2 (fr)
JP (1) JP2006518591A (fr)
AU (1) AU2004209335A1 (fr)
CA (1) CA2515347A1 (fr)
GB (1) GB0302446D0 (fr)
WO (1) WO2004070347A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691823B2 (en) * 2004-03-05 2010-04-06 University Of Massachusetts RIP140 regulation of glucose transport
JP2006090948A (ja) * 2004-09-27 2006-04-06 Fuji Photo Film Co Ltd バイオセンサーを用いたスクリーニング方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6266622B1 (en) * 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
US20020004205A1 (en) * 2000-03-30 2002-01-10 Consler Thomas G. Method of investigating functional molecular interactions and reagents for use therein
EP1267171A1 (fr) * 2001-06-14 2002-12-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé de criblage basé sur les co-facteurs pour des modulateurs de récepteurs nucléaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
GB9917405D0 (en) * 1999-07-23 1999-09-22 Univ Dundee Methods of treatment and drug screening methods
DE60040413D1 (de) * 1999-11-12 2008-11-13 Merck & Co Inc Zellen mit defizientem melanocortin-3-rezeptor, transgene mäuse und verfahren zur auswahl von substanzen, die das körpergewicht regulieren können

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6266622B1 (en) * 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
US20020004205A1 (en) * 2000-03-30 2002-01-10 Consler Thomas G. Method of investigating functional molecular interactions and reagents for use therein
EP1267171A1 (fr) * 2001-06-14 2002-12-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé de criblage basé sur les co-facteurs pour des modulateurs de récepteurs nucléaires

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PALOU A ET AL: "Obesity: Molecular bases of a multifactorial problem", EUROPEAN JOURNAL OF NUTRITION, vol. 39, no. 4, August 2000 (2000-08-01), pages 127 - 144, XP002279646, ISSN: 1436-6207 *
WHITE R ET AL: "The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility", NATURE MEDICINE, NATURE AMERICA, NEW YORK, US, vol. 6, no. 12, December 2000 (2000-12-01), pages 1368 - 1374, XP002258567, ISSN: 1078-8956 *
YAMAUCHI TOSHIMASA ET AL: "The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 44, 2 November 2001 (2001-11-02), pages 41245 - 41254, XP002279645, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2004070347A2 (fr) 2004-08-19
AU2004209335A1 (en) 2004-08-19
EP1590674A2 (fr) 2005-11-02
CA2515347A1 (fr) 2004-08-19
GB0302446D0 (en) 2003-03-05
JP2006518591A (ja) 2006-08-17

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