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WO2004069174A3 - Suivi et de traitement de la sclerose laterale amyotrophique - Google Patents

Suivi et de traitement de la sclerose laterale amyotrophique Download PDF

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Publication number
WO2004069174A3
WO2004069174A3 PCT/US2004/002704 US2004002704W WO2004069174A3 WO 2004069174 A3 WO2004069174 A3 WO 2004069174A3 US 2004002704 W US2004002704 W US 2004002704W WO 2004069174 A3 WO2004069174 A3 WO 2004069174A3
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring
methods
lateral sclerosis
amyotrophic lateral
hml
Prior art date
Application number
PCT/US2004/002704
Other languages
English (en)
Other versions
WO2004069174A2 (fr
Inventor
Michael Mcgrath
Kenneth G Hadlock
Original Assignee
Slil Biomedical Corp
Michael Mcgrath
Kenneth G Hadlock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slil Biomedical Corp, Michael Mcgrath, Kenneth G Hadlock filed Critical Slil Biomedical Corp
Priority to US10/544,059 priority Critical patent/US20060160087A1/en
Priority to EP04707038A priority patent/EP1613263A4/fr
Publication of WO2004069174A2 publication Critical patent/WO2004069174A2/fr
Publication of WO2004069174A3 publication Critical patent/WO2004069174A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a trait à des procédés de suivi de l'évolution ou de la progression de la maladie de la sclérose latérale amyotrophique (SLA) et le suivi d'un traitement de SLA chez un individu par la détermination de la présence ou de l'absence d'expression de Herv-K/HML-2 dans un échantillon biologique dérivé du patient. L'invention a également trait à des procédés pour l'assistance au diagnostic de SLA par la détermination d'expression de Herv-K/HML-2 dans un échantillon biologique dérivé de l'individu. L'invention a trait en outre à des procédés permettant la réduction d'expression de Herv-K/HML-2 dans des cellules et individus infectés. Enfin, l'invention a trait à des réactifs destinés à être utilisés dans lesdits procédés.
PCT/US2004/002704 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique WO2004069174A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/544,059 US20060160087A1 (en) 2003-01-31 2004-01-30 Monitoring and treatment of amyotrophic lateral sclerosis
EP04707038A EP1613263A4 (fr) 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44422403P 2003-01-31 2003-01-31
US60/444,224 2003-01-31

Publications (2)

Publication Number Publication Date
WO2004069174A2 WO2004069174A2 (fr) 2004-08-19
WO2004069174A3 true WO2004069174A3 (fr) 2006-09-28

Family

ID=32850838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002704 WO2004069174A2 (fr) 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique

Country Status (3)

Country Link
US (1) US20060160087A1 (fr)
EP (1) EP1613263A4 (fr)
WO (1) WO2004069174A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
AU2003276679A1 (en) * 2002-06-13 2003-12-31 Chiron Corporation Vectors for expression of hml-2 polypeptides
US7840270B2 (en) * 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US7879914B2 (en) * 2005-09-23 2011-02-01 Pathlogica LLC Methods for treating viral infections using polyamine analogs
US8676323B2 (en) * 2006-03-09 2014-03-18 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
US20080097153A1 (en) * 2006-08-24 2008-04-24 Ignagni Anthony R Method and apparatus for grasping an abdominal wall
US9079016B2 (en) 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
HUE033487T2 (en) 2007-03-09 2017-12-28 Pathologica Llc MGBG for osteopontin control and multiple sclerosis treatment
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US8478412B2 (en) 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
NZ715686A (en) 2009-07-16 2017-08-25 Pathologica Llc Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
WO2011031877A1 (fr) 2009-09-09 2011-03-17 The General Hospital Corporation Utilisation de microvésicules dans l'analyse de profils d'acide nucléique
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2012031008A2 (fr) * 2010-08-31 2012-03-08 The General Hospital Corporation Matières biologiques liées au cancer dans des microvésicules
EP2625292B1 (fr) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarqueurs de cancer
AU2011326366B2 (en) 2010-11-10 2017-02-23 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
EP2665471B1 (fr) 2011-01-19 2017-12-27 Pathologica, LLC. Formes posologiques pharmaceutiques orales à libération contrôlée comprenant de la mgbg
WO2013155365A1 (fr) * 2012-04-12 2013-10-17 University Of Maryland Marqueurs pour le diagnostic de la sclérose latérale amyotrophique
CN109432073A (zh) 2013-01-08 2019-03-08 帕萨罗杰卡有限公司 Mgbg在制备治疗或预防进行性ms及其进展的药物中的用途
EP3161159B1 (fr) 2014-06-25 2020-08-05 The General Hospital Corporation Ciblage de hsatii (human satellite ii)
KR20170002138A (ko) * 2015-06-29 2017-01-06 삼성에스디아이 주식회사 배터리 팩
US20190038659A1 (en) 2015-09-29 2019-02-07 The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of treating and preventing amyotrophic lateral sclerosis
EP3351265A1 (fr) * 2017-01-20 2018-07-25 Geneuro SA Anticorp du herv-k enveloppe et ses utilisations
BR112021014576A2 (pt) 2019-01-25 2021-10-05 Brown University Composições e métodos para tratamento, prevenção ou reversão de inflamação e distúrbios associados à idade
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation
US20220332799A1 (en) * 2019-09-04 2022-10-20 Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) Herv inhibitors for use in treating tauopathies

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034135A (en) * 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5919369A (en) * 1992-02-06 1999-07-06 Hemocleanse, Inc. Hemofiltration and plasmafiltration devices and methods
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) * 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5858723A (en) * 1995-12-05 1999-01-12 Behringwerke Aktiengesellschaft Polypeptides and antibodies for diagnosing and treating seminoma
EP0893691A1 (fr) * 1997-07-23 1999-01-27 Mach, Bernard François, Prof. Procédés pour le diagnostic et la thérapie des maladies autoimmunes associées avec super-antigènes rétroviraux, en particulier le diabète mellitus insulinodépendant
US6464976B1 (en) * 1999-09-07 2002-10-15 Canji, Inc. Methods and compositions for reducing immune response
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
EP1415005B1 (fr) * 2000-12-07 2012-11-21 Novartis Vaccines and Diagnostics, Inc. Retrovirus endogenes regules positivement dans le cancer de la prostate

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOLLER ET AL.: "Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.", JOURNAL OF VIROLOGY, vol. 71, no. 6, 1997, pages 481 - 488, XP002967165 *
BOLLER ET AL.: "Evidence That HERV-K Is the Endogenous Retrovirus Sequence That Codes for the Human Teratocarcinoma-Derived Retrovirus HTDV.", VIROLOGY, vol. 196, 1993, pages 349 - 353, XP003001108 *
HADLOCK ET AL., NEUROLOGY, vol. 62, no. 7 SUPPL., 2004, pages A37 - A38, XP008071244 *
LOWER ET AL., PROC NATL. ACAD SCI USA, vol. 90, 1993, pages 4480 - 4484, XP002996595 *
See also references of EP1613263A4 *

Also Published As

Publication number Publication date
US20060160087A1 (en) 2006-07-20
EP1613263A4 (fr) 2007-11-28
EP1613263A2 (fr) 2006-01-11
WO2004069174A2 (fr) 2004-08-19

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