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WO2004069174A3 - Suivi et de traitement de la sclerose laterale amyotrophique - Google Patents

Suivi et de traitement de la sclerose laterale amyotrophique Download PDF

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Publication number
WO2004069174A3
WO2004069174A3 PCT/US2004/002704 US2004002704W WO2004069174A3 WO 2004069174 A3 WO2004069174 A3 WO 2004069174A3 US 2004002704 W US2004002704 W US 2004002704W WO 2004069174 A3 WO2004069174 A3 WO 2004069174A3
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring
methods
lateral sclerosis
amyotrophic lateral
hml
Prior art date
Application number
PCT/US2004/002704
Other languages
English (en)
Other versions
WO2004069174A2 (fr
Inventor
Michael Mcgrath
Kenneth G Hadlock
Original Assignee
Slil Biomedical Corp
Michael Mcgrath
Kenneth G Hadlock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slil Biomedical Corp, Michael Mcgrath, Kenneth G Hadlock filed Critical Slil Biomedical Corp
Priority to US10/544,059 priority Critical patent/US20060160087A1/en
Priority to EP04707038A priority patent/EP1613263A4/fr
Publication of WO2004069174A2 publication Critical patent/WO2004069174A2/fr
Publication of WO2004069174A3 publication Critical patent/WO2004069174A3/fr

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a trait à des procédés de suivi de l'évolution ou de la progression de la maladie de la sclérose latérale amyotrophique (SLA) et le suivi d'un traitement de SLA chez un individu par la détermination de la présence ou de l'absence d'expression de Herv-K/HML-2 dans un échantillon biologique dérivé du patient. L'invention a également trait à des procédés pour l'assistance au diagnostic de SLA par la détermination d'expression de Herv-K/HML-2 dans un échantillon biologique dérivé de l'individu. L'invention a trait en outre à des procédés permettant la réduction d'expression de Herv-K/HML-2 dans des cellules et individus infectés. Enfin, l'invention a trait à des réactifs destinés à être utilisés dans lesdits procédés.
PCT/US2004/002704 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique WO2004069174A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/544,059 US20060160087A1 (en) 2003-01-31 2004-01-30 Monitoring and treatment of amyotrophic lateral sclerosis
EP04707038A EP1613263A4 (fr) 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44422403P 2003-01-31 2003-01-31
US60/444,224 2003-01-31

Publications (2)

Publication Number Publication Date
WO2004069174A2 WO2004069174A2 (fr) 2004-08-19
WO2004069174A3 true WO2004069174A3 (fr) 2006-09-28

Family

ID=32850838

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002704 WO2004069174A2 (fr) 2003-01-31 2004-01-30 Suivi et de traitement de la sclerose laterale amyotrophique

Country Status (3)

Country Link
US (1) US20060160087A1 (fr)
EP (1) EP1613263A4 (fr)
WO (1) WO2004069174A2 (fr)

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US7840270B2 (en) * 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US7879914B2 (en) * 2005-09-23 2011-02-01 Pathlogica LLC Methods for treating viral infections using polyamine analogs
US8676323B2 (en) * 2006-03-09 2014-03-18 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
US20080097153A1 (en) * 2006-08-24 2008-04-24 Ignagni Anthony R Method and apparatus for grasping an abdominal wall
US9079016B2 (en) 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
HUE033487T2 (en) 2007-03-09 2017-12-28 Pathologica Llc MGBG for osteopontin control and multiple sclerosis treatment
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US8478412B2 (en) 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
NZ715686A (en) 2009-07-16 2017-08-25 Pathologica Llc Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
WO2011031877A1 (fr) 2009-09-09 2011-03-17 The General Hospital Corporation Utilisation de microvésicules dans l'analyse de profils d'acide nucléique
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2012031008A2 (fr) * 2010-08-31 2012-03-08 The General Hospital Corporation Matières biologiques liées au cancer dans des microvésicules
EP2625292B1 (fr) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarqueurs de cancer
AU2011326366B2 (en) 2010-11-10 2017-02-23 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
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Also Published As

Publication number Publication date
US20060160087A1 (en) 2006-07-20
EP1613263A4 (fr) 2007-11-28
EP1613263A2 (fr) 2006-01-11
WO2004069174A2 (fr) 2004-08-19

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