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WO2004066948A3 - Mapcaxs as modifiers of the apc and axin pathways and methods of use - Google Patents

Mapcaxs as modifiers of the apc and axin pathways and methods of use Download PDF

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Publication number
WO2004066948A3
WO2004066948A3 PCT/US2004/002338 US2004002338W WO2004066948A3 WO 2004066948 A3 WO2004066948 A3 WO 2004066948A3 US 2004002338 W US2004002338 W US 2004002338W WO 2004066948 A3 WO2004066948 A3 WO 2004066948A3
Authority
WO
WIPO (PCT)
Prior art keywords
apc
methods
axin
mapcaxs
modifiers
Prior art date
Application number
PCT/US2004/002338
Other languages
French (fr)
Other versions
WO2004066948A2 (en
Inventor
Steven Brian Gendreau
Eva Lorena Morablanco
Kim Lickteig
Haiguang Zhang
Original Assignee
Exelixis Inc
Steven Brian Gendreau
Eva Lorena Morablanco
Kim Lickteig
Haiguang Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Steven Brian Gendreau, Eva Lorena Morablanco, Kim Lickteig, Haiguang Zhang filed Critical Exelixis Inc
Publication of WO2004066948A2 publication Critical patent/WO2004066948A2/en
Publication of WO2004066948A3 publication Critical patent/WO2004066948A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4704—Inhibitors; Supressors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Human MAPCAX genes are identified as modulators of the APC and axin pathways, and thus are therapeutic targets for disorders associated with defective APC and axin function. Methods for identifying modulators of APC and axin, comprising screening for agents that modulate the activity of MAPCAX are provided.
PCT/US2004/002338 2003-01-29 2004-01-28 Mapcaxs as modifiers of the apc and axin pathways and methods of use WO2004066948A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US44348403P 2003-01-29 2003-01-29
US60/443,484 2003-01-29
US44735803P 2003-02-11 2003-02-11
US60/447,358 2003-02-11
US46178903P 2003-04-10 2003-04-10
US60/461,789 2003-04-10
US47068403P 2003-05-14 2003-05-14
US60/470,684 2003-05-14
US47965003P 2003-06-19 2003-06-19
US60/479,650 2003-06-19

Publications (2)

Publication Number Publication Date
WO2004066948A2 WO2004066948A2 (en) 2004-08-12
WO2004066948A3 true WO2004066948A3 (en) 2005-12-08

Family

ID=32831197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002338 WO2004066948A2 (en) 2003-01-29 2004-01-28 Mapcaxs as modifiers of the apc and axin pathways and methods of use

Country Status (1)

Country Link
WO (1) WO2004066948A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003220920B2 (en) * 2002-03-14 2008-11-06 National Institute Of Advanced Industrial Science And Technology Novel N-Acetylglucosamine transferase, nucleic acid encoding the same and use thereof in diagnosing cancer and / or tumor
AU2003243151A1 (en) 2002-08-16 2004-03-03 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
WO2004050007A2 (en) * 2002-11-29 2004-06-17 Develogen Ag Mammalian bt-42 proteins involved in the regulation of energy homeostasis
WO2004061109A1 (en) * 2002-12-27 2004-07-22 National Institute Of Advanced Industrial Science And Technology Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
JPWO2006090679A1 (en) * 2005-02-23 2008-07-24 株式会社 東北テクノアーチ Method for detecting DNA damage using Flag1 gene or gene product thereof as marker
JP2008546409A (en) * 2005-06-20 2008-12-25 エクセリクシス， インク． GFAT as a modifier of the Axin pathway and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307019B1 (en) * 1997-07-10 2001-10-23 The Trustees Of Columbia University In The City Of New York Axin gene and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307019B1 (en) * 1997-07-10 2001-10-23 The Trustees Of Columbia University In The City Of New York Axin gene and uses thereof

Also Published As

Publication number Publication date
WO2004066948A2 (en) 2004-08-12

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