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WO2004065569A3 - Multi-functional antibodies - Google Patents

Multi-functional antibodies Download PDF

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Publication number
WO2004065569A3
WO2004065569A3 PCT/US2004/001808 US2004001808W WO2004065569A3 WO 2004065569 A3 WO2004065569 A3 WO 2004065569A3 US 2004001808 W US2004001808 W US 2004001808W WO 2004065569 A3 WO2004065569 A3 WO 2004065569A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
functional antibodies
present
antigen recognition
reactive site
Prior art date
Application number
PCT/US2004/001808
Other languages
French (fr)
Other versions
WO2004065569A2 (en
Inventor
Claude Meares
Todd Corneillie
Original Assignee
Univ California
Claude Meares
Todd Corneillie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/350,555 external-priority patent/US7528235B2/en
Priority claimed from US10/625,047 external-priority patent/US7820787B2/en
Priority claimed from US10/631,258 external-priority patent/US20050026263A1/en
Application filed by Univ California, Claude Meares, Todd Corneillie filed Critical Univ California
Publication of WO2004065569A2 publication Critical patent/WO2004065569A2/en
Publication of WO2004065569A3 publication Critical patent/WO2004065569A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides antibodies comprising an antigen recognition domain that specifically binds to a metal chelate: mutant antibodies comprising a reactive site not present in the wild-type of the antibody, wherein the reactive site is in a position proximate to or within the antigen recognition domain; and methods of using such antibodies to diagnose and treat disease.
PCT/US2004/001808 2003-01-23 2004-01-23 Multi-functional antibodies WO2004065569A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/350,555 2003-01-23
US10/350,555 US7528235B2 (en) 2003-01-23 2003-01-23 Multi-functional antibodies
US10/625,047 2003-07-22
US10/625,047 US7820787B2 (en) 2003-01-23 2003-07-22 Multi-functional antibodies
US10/631,258 US20050026263A1 (en) 2003-07-31 2003-07-31 Multi-functional antibodies
US10/631,258 2003-07-31

Publications (2)

Publication Number Publication Date
WO2004065569A2 WO2004065569A2 (en) 2004-08-05
WO2004065569A3 true WO2004065569A3 (en) 2005-03-24

Family

ID=32776952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/001808 WO2004065569A2 (en) 2003-01-23 2004-01-23 Multi-functional antibodies

Country Status (1)

Country Link
WO (1) WO2004065569A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2577815A1 (en) * 2004-08-20 2006-03-30 The Regents Of The University Of California Engineered antibody fragment that irreversibly binds an antigen
KR20140087058A (en) 2005-11-30 2014-07-08 애브비 인코포레이티드 Monoclonal antibodies against amyloid beta protein and uses thereof
WO2007131242A2 (en) * 2006-05-05 2007-11-15 The Regents Of The University Of California Streptavidin-biotin-link antibody-hapten system
CA2657681C (en) 2006-07-14 2019-03-19 Ac Immune S.A. Humanized antibodies against beta amyloid protein
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
TWI453217B (en) * 2007-06-12 2014-09-21 Ac Immune Sa Monoclonal anti-beta-amyloid antibody
CA2808187A1 (en) 2010-08-14 2012-02-23 Abbvie Inc. Amyloid-beta binding proteins
EP3138580B1 (en) * 2012-07-04 2021-03-03 F. Hoffmann-La Roche AG Covalently linked antigen-antibody conjugates
EP2870180B1 (en) 2012-07-04 2024-08-28 F. Hoffmann-La Roche AG Anti-biotin antibodies and methods of use
HUE029435T2 (en) 2012-07-04 2017-02-28 Hoffmann La Roche Anti-theophylline antibodies and methods of use
US10561737B2 (en) * 2014-01-03 2020-02-18 Hoffmann-La Roche Inc. Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
BR112016012666A2 (en) * 2014-01-03 2017-09-26 Hoffmann La Roche conjugate, antibodies, pharmaceutical formulation and uses of conjugate
JP6521464B2 (en) * 2014-01-03 2019-05-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Covalently linked polypeptide toxin-antibody conjugates
WO2015197736A1 (en) 2014-06-26 2015-12-30 F. Hoffmann-La Roche Ag Anti-brdu antibodies and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958374A (en) * 1994-03-28 1999-09-28 The Regents Of The University Of California Method for preparing radionuclide-labeled chelating agent-ligand complexes
WO2001022922A2 (en) * 1999-09-27 2001-04-05 The Regents Of The University Of California Engineering antibodies that bind irreversibly
US20030124057A1 (en) * 2001-11-28 2003-07-03 Immunomedics, Inc. Anti-DOTA antibody

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958374A (en) * 1994-03-28 1999-09-28 The Regents Of The University Of California Method for preparing radionuclide-labeled chelating agent-ligand complexes
WO2001022922A2 (en) * 1999-09-27 2001-04-05 The Regents Of The University Of California Engineering antibodies that bind irreversibly
US20030124057A1 (en) * 2001-11-28 2003-07-03 Immunomedics, Inc. Anti-DOTA antibody

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHMURA ET AL.: "Antibodies with infinite affinity", PNAS, vol. 98, no. 15, 17 July 2001 (2001-07-17), pages 8480 - 8484, XP002984342 *
CORNEILLIE ET AL.: "Converting weak binders into infinite binders", BIOCONJUGATE CHEM., vol. 15, 2004, pages 1389 - 1391, XP002984341 *
CORNEILLIE ET AL.: "Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system", J. AM. CHEM. SOC., vol. 125, 2003, pages 15039 - 15048, XP002984343 *
CORNEILLIE ET AL.: "Irreversible engineering of the multielement-binding antibody 2D12.5 and its complementary ligands", BIOCONJUGATE CHEM., vol. 15, 2004, pages 1392 - 1402, XP002984344 *
GOODWIN ET AL.: "Pharmacokinetics of pretargeted monoclonal antibody 2D12.5 and 88Y-Janus-2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecanetetraacetic acid (DOTA) in BALB/c mice with KHJJ mouese adenocarcinoma: a model for 90Y radioimmunotherapy", CANCER RES., vol. 54, no. 22, 15 November 1994 (1994-11-15), pages 5937 - 5946, XP000199874 *
LUBIC ET AL.: "Biodistribution and dosimetry of pretargeted monoclonal antibody 2D12.5 and Y-Janus-DOTA in BALB/c mice with KHJJ mouse adenocarcinoma", J. NUCL. MED., vol. 42, no. 4, April 2001 (2001-04-01), pages 670 - 678, XP002984340 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies

Also Published As

Publication number Publication date
WO2004065569A2 (en) 2004-08-05

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