+

WO2004043993A3 - Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical - Google Patents

Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical Download PDF

Info

Publication number
WO2004043993A3
WO2004043993A3 PCT/FR2003/003336 FR0303336W WO2004043993A3 WO 2004043993 A3 WO2004043993 A3 WO 2004043993A3 FR 0303336 W FR0303336 W FR 0303336W WO 2004043993 A3 WO2004043993 A3 WO 2004043993A3
Authority
WO
WIPO (PCT)
Prior art keywords
ampiphilic
novel
biomedical
medical use
fluorocarbon
Prior art date
Application number
PCT/FR2003/003336
Other languages
English (en)
Other versions
WO2004043993A2 (fr
Inventor
Bernard Pucci
Ange Polidori
Christiane Contino-Pepin
Gregory Durand
Sylvain Jasseron
Sandrine Perino
Original Assignee
Ts Pharma
Univ D Avignon Et Des Pays Du
Bernard Pucci
Ange Polidori
Christiane Contino-Pepin
Gregory Durand
Sylvain Jasseron
Sandrine Perino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ts Pharma, Univ D Avignon Et Des Pays Du, Bernard Pucci, Ange Polidori, Christiane Contino-Pepin, Gregory Durand, Sylvain Jasseron, Sandrine Perino filed Critical Ts Pharma
Priority to AU2003290170A priority Critical patent/AU2003290170A1/en
Priority to US10/533,983 priority patent/US20060167223A1/en
Priority to JP2004550759A priority patent/JP2006520741A/ja
Priority to EP03782534A priority patent/EP1558630A2/fr
Publication of WO2004043993A2 publication Critical patent/WO2004043993A2/fr
Publication of WO2004043993A3 publication Critical patent/WO2004043993A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nouvelles molécules amphiphiles fluorocarbonées susceptibles d'être utilisées comme vecteur de principes actifs, des molécules actives comportant un tel vecteur et leur utilisation dans le domaine de la pharmacie, notamment pour la préparation de médicaments.
PCT/FR2003/003336 2002-11-08 2003-11-07 Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical WO2004043993A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003290170A AU2003290170A1 (en) 2002-11-08 2003-11-07 Novel ampiphilic fluorocarbon molecular vectors for biomedical and medical use
US10/533,983 US20060167223A1 (en) 2002-11-08 2003-11-07 Novel ampiphilic fluorocarbon molecular vectors for biomedical and medical use
JP2004550759A JP2006520741A (ja) 2002-11-08 2003-11-07 生物医学的及び医学的使用のための新規な両親媒性（ａｍｐｉｐｈｉｌｉｃ）フッ素化炭化水素分子ベクター
EP03782534A EP1558630A2 (fr) 2002-11-08 2003-11-07 Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0214077A FR2846969A1 (fr) 2002-11-08 2002-11-08 Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical
FR02/14077 2002-11-08

Publications (2)

Publication Number Publication Date
WO2004043993A2 WO2004043993A2 (fr) 2004-05-27
WO2004043993A3 true WO2004043993A3 (fr) 2004-07-29

Family

ID=32116516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/003336 WO2004043993A2 (fr) 2002-11-08 2003-11-07 Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical

Country Status (6)

Country Link
US (1) US20060167223A1 (fr)
EP (1) EP1558630A2 (fr)
JP (1) JP2006520741A (fr)
AU (1) AU2003290170A1 (fr)
FR (1) FR2846969A1 (fr)
WO (1) WO2004043993A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
GB0408164D0 (en) * 2004-04-13 2004-05-19 Immune Targeting Systems Ltd Antigen delivery vectors and constructs
FR2883563B1 (fr) * 2005-03-24 2007-06-01 Ts Pharma Sarl Nouveaux vecteurs cationiques bolaformes hemifluorocarbones et leurs applications
EP2691118B1 (fr) * 2011-03-31 2019-05-01 Schäfer, Konstanze Composés perfluorés pour le transfert non viral d'acides nucléiques
US11318206B2 (en) 2014-03-28 2022-05-03 Aposense Ltd Compounds and methods for trans-membrane delivery of molecules
JP6669719B2 (ja) * 2014-03-28 2020-03-18 アポセンス リミテッドＡｐｏｓｅｎｓｅ Ｌｔｄ． 分子の膜貫通送達のための化合物および方法
US9993563B2 (en) 2014-03-28 2018-06-12 Aposense Ltd. Compounds and methods for trans-membrane delivery of molecules
US9889202B2 (en) 2014-03-28 2018-02-13 Aposense Ltd. Compounds and methods for trans-membrane delivery of molecules
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
EP3256470B1 (fr) * 2014-12-23 2023-07-26 Dana-Farber Cancer Institute, Inc. Procédés pour induire la dégradation ciblée de protéines par des molécules bifonctionnelles
IL267919B2 (en) 2017-01-09 2024-03-01 Aposense Ltd Compounds and methods for transmembrane transfer of molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446023A (en) * 1992-08-06 1995-08-29 Alliance Pharmaceutical Corporation Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT8820888A0 (it) * 1988-06-08 1988-06-08 Eniricerche Spa Peptidi di sintesi immunologicamente attivi per lapreparazione di vaccini antimalarici.
GB9019558D0 (en) * 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
KR100928878B1 (ko) * 1998-03-19 2009-11-30 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446023A (en) * 1992-08-06 1995-08-29 Alliance Pharmaceutical Corporation Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHAUDIER Y ET AL: "Synthesis and preliminary assessments of hybrid hydrocarbon-fluorocarbon anionic and non-ionic surfactants", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 21, 21 May 2001 (2001-05-21), pages 3583 - 3585, XP004238694, ISSN: 0040-4039 *
CONTINO-PEPIN C ET AL: "AMPHIPHILIC OLIGOMERS: A NEW KIND OF MACROMOLECULAR CARRIER OF ANTIMITOTIC DRUGS", CURRENT MEDICINAL CHEMISTRY. ANTI-CANCER AGENTS, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 2, no. 6, November 2002 (2002-11-01), pages 645 - 665, XP009013445, ISSN: 1568-0118 *
GUEDJ C ET AL: "Vesicles and other supramolecular systems from biocompatible synthetic glycolipids with hydrocarbon and/or fluorocarbon chains.", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 72, no. 2, 1994, pages 153 - 173, XP009013441, ISSN: 0009-3084 *
HAVIV FORTUNA ET AL: "In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 5, 1994, pages 701 - 705, XP002278652, ISSN: 0022-2623 *
HOCART S J ET AL: "EFFECT OF REDUCTIVE ALKYLATION OF D LYSINE IN POSITION 6 ON THE HISTAMINE-RELEASING ACTIVITY LHRH", JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 4, 1987, pages 739 - 743, XP002278653, ISSN: 0022-2623 *
JASSERON SYLVAIN ET AL: "Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 7, 2002, 8 April, 2002, pages 1067 - 1070, XP002247711, ISSN: 0960-894X *
TONG G ET AL: "THE SYNTHESIS OF OLIGONUCLEOTIDE-POLYAMIDE CONJUGATE MOLECULES SUITABLE AS PCR PRIMERS", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 58, no. 8, 9 April 1993 (1993-04-09), pages 2223 - 2231, XP000562640, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
WO2004043993A2 (fr) 2004-05-27
EP1558630A2 (fr) 2005-08-03
AU2003290170A8 (en) 2004-06-03
JP2006520741A (ja) 2006-09-14
FR2846969A1 (fr) 2004-05-14
US20060167223A1 (en) 2006-07-27
AU2003290170A1 (en) 2004-06-03

Similar Documents

Publication Publication Date Title
WO2004000389A3 (fr) Microperforateur a dissolution rapide pour administration de produits pharmaceutiques et autres applications
GB9902652D0 (en) Process
WO2005044224A3 (fr) Systeme d'administration de medicament, faisant appel a des nanocoques polymeres
WO2002005829A3 (fr) Procede permettant de reduire les changements dans la flore gastro-intestinale nuisibles du point de vue ecologique intervenus chez des patients suivant un traitement medicamenteux
WO2004072031A3 (fr) Composes d'amides substitues tri(cyclo)
EG25011A (en) Amino-piperidin-1-yl-xanthines, the production thereof and the use of the same as medicaments.
WO2003087254A3 (fr) Compositions adhesives hydrophiles
WO2003045878A3 (fr) Composes acide 2, $g(v)-diaminocarboxylique
DE60100866D1 (de) Cyklosporin, Hyaluronsäure und Polysorbate enthaltenes Augenarzneimittel
AU2003239609A1 (en) 2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
WO2004043993A3 (fr) Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical
WO2003018059A3 (fr) Preparations combinatoires de derives de propanolamine substitues par aryle avec d'autres principes actifs et leur utilisation
AU2002243005A1 (en) Vital cell preparations containing lactic acid bacterium as the active ingredient and lactic acid bacterium-containing foods
WO2002024697A1 (fr) Composes spiro et inhibiteurs de molecules d'adhesion contenant ces composes comme ingredient actif
MXPA03008186A (es) Amidas de acidos carboxilicos antitromboticas, su preparacion y su uso como medicamentos.
WO2002069979A3 (fr) Preparations pharmaceutiques
ZA200501714B (en) Analogues of vitamin d
MXPA02011533A (es) Nuevas formulaciones de alfa-2,4-disulfofenil-n-terc-butilnitrona.
WO2002000208A3 (fr) Preparations de derives d'acide 3-n-formylhydroxylaminopropylphosphonique ou de derives d'acide 3-n-acetylhydroxylaminopropylphosphonique combines avec des principes actifs pharmaceutiques speciaux
WO2003037295A3 (fr) Formulations contenant un lipide-polyethylene glycol
ATE408619T1 (de) Lh-rh-antagonisten, deren herstellung und verwendung als arzneimittel
WO2004071386A3 (fr) Compositions comportant des microcapsules contenant des nanoparticules magnetiques et des molecules biologiquement actives, preparation et utilisation associees
AU2003294952A1 (en) 3,3-dimethyl-8-oxoisoquinolines for medical purposes, methods for the production thereof, medicaments containing said compounds and the use of the same
WO2003087220A3 (fr) Emulsions solides a base d'elastomere thermoplastique
ATE285784T1 (de) Pharmazeutische formulierung und ihre verwendung für die herstellung eines medikaments zur behandlung von herz-kreislauf-erkrankungen

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004550759

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003782534

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003782534

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006167223

Country of ref document: US

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 10533983

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10533983

Country of ref document: US

WWW Wipo information: withdrawn in national office

Ref document number: 2003782534

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载