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WO2003106425A3 - Phenyl- et pyridyl-diazaheterocycles ayant une activite modulatrice du tnf - Google Patents

Phenyl- et pyridyl-diazaheterocycles ayant une activite modulatrice du tnf Download PDF

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Publication number
WO2003106425A3
WO2003106425A3 PCT/FR2003/001813 FR0301813W WO03106425A3 WO 2003106425 A3 WO2003106425 A3 WO 2003106425A3 FR 0301813 W FR0301813 W FR 0301813W WO 03106425 A3 WO03106425 A3 WO 03106425A3
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WO
WIPO (PCT)
Prior art keywords
diazaheterocycles
tnf
pyridyl
phenyl
modulating activity
Prior art date
Application number
PCT/FR2003/001813
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English (en)
Other versions
WO2003106425A2 (fr
Inventor
Marco Baroni
Bernard Bourrie
Pierre Casellas
Original Assignee
Sanofi Synthelabo
Marco Baroni
Bernard Bourrie
Pierre Casellas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo, Marco Baroni, Bernard Bourrie, Pierre Casellas filed Critical Sanofi Synthelabo
Priority to EP03760042A priority Critical patent/EP1517896A2/fr
Priority to US10/518,652 priority patent/US20050209216A1/en
Priority to AU2003263237A priority patent/AU2003263237A1/en
Priority to JP2004513258A priority patent/JP2005533790A/ja
Publication of WO2003106425A2 publication Critical patent/WO2003106425A2/fr
Publication of WO2003106425A3 publication Critical patent/WO2003106425A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I) dans laquelle X représente N ou CH; R1 représente un atome d'hydrogène ou d'halogène ou un groupe CF3; W représente un diazohétérocycle ; R2 et R3 représentent indépendamment un atome d'hydrogène ou un groupe méthyle; n est 0 ou 1; A représente une quinoléine ou une isoquinoléine éventuellement substituées.
PCT/FR2003/001813 2002-06-18 2003-06-16 Phenyl- et pyridyl-diazaheterocycles ayant une activite modulatrice du tnf WO2003106425A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03760042A EP1517896A2 (fr) 2002-06-18 2003-06-16 Phenyl- et pyridyl-diazaheterocycles ayant une activite modulatrice du tnf
US10/518,652 US20050209216A1 (en) 2002-06-18 2003-06-16 Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity
AU2003263237A AU2003263237A1 (en) 2002-06-18 2003-06-16 Phenyl- and pyridyl-diazaheterocycles having a tnf-modulating activity
JP2004513258A JP2005533790A (ja) 2002-06-18 2003-06-16 Ｔｎｆ調整作用を有するフェニル−およびピリジル−ジアザ複素環

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/07507 2002-06-18
FR0207507A FR2840896B1 (fr) 2002-06-18 2002-06-18 Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
WO2003106425A2 WO2003106425A2 (fr) 2003-12-24
WO2003106425A3 true WO2003106425A3 (fr) 2004-04-01

Family

ID=29595360

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PCT/FR2003/001813 WO2003106425A2 (fr) 2002-06-18 2003-06-16 Phenyl- et pyridyl-diazaheterocycles ayant une activite modulatrice du tnf

Country Status (6)

Country Link
US (1) US20050209216A1 (fr)
EP (1) EP1517896A2 (fr)
JP (1) JP2005533790A (fr)
AU (1) AU2003263237A1 (fr)
FR (1) FR2840896B1 (fr)
WO (1) WO2003106425A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY144974A (en) * 2005-06-14 2011-11-30 Eisai R&D Man Co Ltd 1,2-di(cyclic) substituted benzene derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2736053A1 (fr) * 1995-06-28 1997-01-03 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
WO2001029026A1 (fr) * 1999-10-22 2001-04-26 Sanofi-Synthelabo Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
WO2001055150A1 (fr) * 2000-01-28 2001-08-02 Sanofi-Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (fr) * 1959-09-25 1900-01-01

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2736053A1 (fr) * 1995-06-28 1997-01-03 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
WO2001029026A1 (fr) * 1999-10-22 2001-04-26 Sanofi-Synthelabo Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
WO2001055150A1 (fr) * 2000-01-28 2001-08-02 Sanofi-Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARLOCCO ET AL: "mon- and disubstituted-3,8-diazabicyclo(3.2.1)octane derivatives as analgesics structurally related to epibatidine: synthesis, activity and modeling", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 5, 1998, pages 674 - 681, XP002105020, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
US20050209216A1 (en) 2005-09-22
EP1517896A2 (fr) 2005-03-30
AU2003263237A1 (en) 2003-12-31
JP2005533790A (ja) 2005-11-10
WO2003106425A2 (fr) 2003-12-24
AU2003263237A8 (en) 2003-12-31
FR2840896A1 (fr) 2003-12-19
FR2840896B1 (fr) 2005-04-08

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