WO2003105777A3 - Fiber cell globulization aminopeptidases and methods for treating or preventing cataracts - Google Patents
Fiber cell globulization aminopeptidases and methods for treating or preventing cataracts Download PDFInfo
- Publication number
- WO2003105777A3 WO2003105777A3 PCT/US2003/019066 US0319066W WO03105777A3 WO 2003105777 A3 WO2003105777 A3 WO 2003105777A3 US 0319066 W US0319066 W US 0319066W WO 03105777 A3 WO03105777 A3 WO 03105777A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- globulization
- methods
- fiber cell
- aminopeptidases
- treating
- Prior art date
Links
- 239000000835 fiber Substances 0.000 title abstract 8
- 102000004400 Aminopeptidases Human genes 0.000 title abstract 6
- 108090000915 Aminopeptidases Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 208000002177 Cataract Diseases 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Disclosed are methods for treating or preventing cataract in a subject by administering to the subject an inhibitor of a fiber cell globulization aminopeptidase or by otherwise inhibiting fiber cell globulization aminopeptidase activity. Methods for inhibiting globulization of fiber cells and for inhibiting opacification of an ocular lens are also disclosed, as are methods for screening test compounds for their usefulness in inhibiting globulization of fiber cells, for their usefulness in inhibiting opacification of an ocular lens, and for their usefulness in treating or preventing cataract. An isolated fiber cell globulization aminopeptidase is also described, as are methods for making such isolated fiber cell globulization aminopeptidases, and antibodies specific for such isolated fiber cell globulization aminopeptidases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003243618A AU2003243618A1 (en) | 2002-06-14 | 2003-06-14 | Fiber cell globulization aminopeptidases and methods for treating or preventing cataracts |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38902102P | 2002-06-14 | 2002-06-14 | |
| US60/389,021 | 2002-06-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003105777A2 WO2003105777A2 (en) | 2003-12-24 |
| WO2003105777A3 true WO2003105777A3 (en) | 2004-02-26 |
Family
ID=29736577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2003/019066 WO2003105777A2 (en) | 2002-06-14 | 2003-06-14 | Fiber cell globulization aminopeptidases and methods for treating or preventing cataracts |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003243618A1 (en) |
| WO (1) | WO2003105777A2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362324B1 (en) * | 1999-06-30 | 2002-03-26 | Millennium Pharmaceuticals, Inc. | 17867 a novel human aminopeptidase |
-
2003
- 2003-06-14 AU AU2003243618A patent/AU2003243618A1/en not_active Abandoned
- 2003-06-14 WO PCT/US2003/019066 patent/WO2003105777A2/en not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362324B1 (en) * | 1999-06-30 | 2002-03-26 | Millennium Pharmaceuticals, Inc. | 17867 a novel human aminopeptidase |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003243618A1 (en) | 2003-12-31 |
| WO2003105777A2 (en) | 2003-12-24 |
| AU2003243618A8 (en) | 2003-12-31 |
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