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WO2003104401A3 - Gene lie au cancer cible en chimiotherapie - Google Patents

Gene lie au cancer cible en chimiotherapie Download PDF

Info

Publication number
WO2003104401A3
WO2003104401A3 PCT/US2003/017722 US0317722W WO03104401A3 WO 2003104401 A3 WO2003104401 A3 WO 2003104401A3 US 0317722 W US0317722 W US 0317722W WO 03104401 A3 WO03104401 A3 WO 03104401A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
target
disclosed
chemotherapy
linked gene
Prior art date
Application number
PCT/US2003/017722
Other languages
English (en)
Other versions
WO2003104401A2 (fr
Inventor
Reinhard Ebner
Original Assignee
Avalon Pharmaceuticals
Reinhard Ebner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalon Pharmaceuticals, Reinhard Ebner filed Critical Avalon Pharmaceuticals
Priority to AU2003238897A priority Critical patent/AU2003238897A1/en
Publication of WO2003104401A2 publication Critical patent/WO2003104401A2/fr
Publication of WO2003104401A3 publication Critical patent/WO2003104401A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des séquences géniques liées au cancer, et des séquences d'acides aminés dérivées, ainsi que des méthodes de dosage d'agents antitumoraux potentiels en fonction de leur modulation de l'expression desdits gènes liés au cancer. L'invention concerne également des anticorps destinés à réagir avec les polypeptides de l'invention, ainsi que des méthodes d'utilisation des anticorps dans le traitement d'états cancéreux, par exemple par utilisation de l'anticorps pour cibler les cellules cancéreusesin vivo afin de leur administrer des agents thérapeutiques. L'invention concerne enfin des méthodes de diagnostic dans lesquelles sont utilisées les séquences géniques.
PCT/US2003/017722 2002-06-05 2003-06-04 Gene lie au cancer cible en chimiotherapie WO2003104401A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003238897A AU2003238897A1 (en) 2002-06-05 2003-06-04 Cancer-linked gene as target for chemotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38609302P 2002-06-05 2002-06-05
US60/386,093 2002-06-05

Publications (2)

Publication Number Publication Date
WO2003104401A2 WO2003104401A2 (fr) 2003-12-18
WO2003104401A3 true WO2003104401A3 (fr) 2006-04-20

Family

ID=29736133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017722 WO2003104401A2 (fr) 2002-06-05 2003-06-04 Gene lie au cancer cible en chimiotherapie

Country Status (2)

Country Link
AU (1) AU2003238897A1 (fr)
WO (1) WO2003104401A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5808054B2 (ja) 2009-12-25 2015-11-10 中外製薬株式会社 Ｎｏｇ樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法
SG196836A1 (en) 2010-10-06 2014-02-13 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
JP6291254B2 (ja) * 2011-10-28 2018-03-14 中外製薬株式会社 癌幹細胞特異的分子

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLARKE D.A. ET AL: "Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone", ONCOGENE, vol. 19, no. 36, 24 August 2000 (2000-08-24), pages 4125 - 4133, XP001094984 *
JUNG C.P. ET AL: "Flavopiridol Increases Sensitization to Gemcitabine in Human Gastrointestinal Cancer Cell Lines and Correlates with Down-Regulation of Ribonucleotide Reductase M2 Subunit", CLINICAL CANCER RESEARCH, vol. 7, no. 8, August 2001 (2001-08-01), pages 2527 - 2536, XP001179559 *
OLIE R.A. ET AL: "A Novel Antisense Oligonucleotide Targeting Survivin Expression Induces Apoptosis and Sensitizes Lung Cancer Cells to Chemotherapy", CANCER RESEARCH, vol. 60, no. 11, 1 June 2000 (2000-06-01), pages 2805 - 2809, XP002210584 *
WEBB C.P. ET AL: "The Geldanamycins Are Potent Inhibitors of the Hepatocyte Growth Factor/Scatter Factor-Met-Urokinase Plasminogen Activator-Plasmin Proteolytic Network", CANCER RESEARCH, vol. 60, no. 2, 15 January 2000 (2000-01-15), pages 342 - 349, XP002996129 *

Also Published As

Publication number Publication date
AU2003238897A1 (en) 2003-12-22
WO2003104401A2 (fr) 2003-12-18
AU2003238897A8 (en) 2003-12-22

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