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WO2003104392A3 - Improved reagents and methods for producing parvoviruses - Google Patents

Improved reagents and methods for producing parvoviruses Download PDF

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Publication number
WO2003104392A3
WO2003104392A3 PCT/US2002/038423 US0238423W WO03104392A3 WO 2003104392 A3 WO2003104392 A3 WO 2003104392A3 US 0238423 W US0238423 W US 0238423W WO 03104392 A3 WO03104392 A3 WO 03104392A3
Authority
WO
WIPO (PCT)
Prior art keywords
parvoviruses
methods
producing
coding sequences
parvovirus
Prior art date
Application number
PCT/US2002/038423
Other languages
French (fr)
Other versions
WO2003104392A9 (en
WO2003104392A2 (en
Inventor
Richard Jude Samulski
Joseph E Rabinowitz
Original Assignee
Univ North Carolina
Richard Jude Samulski
Joseph E Rabinowitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Richard Jude Samulski, Joseph E Rabinowitz filed Critical Univ North Carolina
Priority to AU2002367943A priority Critical patent/AU2002367943A1/en
Publication of WO2003104392A2 publication Critical patent/WO2003104392A2/en
Publication of WO2003104392A9 publication Critical patent/WO2003104392A9/en
Publication of WO2003104392A3 publication Critical patent/WO2003104392A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides polynucleotides comprising chimeric parvovirus (e.g., AAV) rep coding sequences. The polynucleotides optionally encode parvovirus cap coding sequences. Also provided are vectors and cells comprising the inventive polynucleotides. Further provided are improved methods of making hybrid parvovirus stocks using the chimeric rep coding sequences of the invention.
PCT/US2002/038423 2001-12-18 2002-12-02 Improved reagents and methods for producing parvoviruses WO2003104392A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002367943A AU2002367943A1 (en) 2001-12-18 2002-12-02 Improved reagents and methods for producing parvoviruses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34191901P 2001-12-18 2001-12-18
US60/341,919 2001-12-18

Publications (3)

Publication Number Publication Date
WO2003104392A2 WO2003104392A2 (en) 2003-12-18
WO2003104392A9 WO2003104392A9 (en) 2004-04-29
WO2003104392A3 true WO2003104392A3 (en) 2004-08-05

Family

ID=29735975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038423 WO2003104392A2 (en) 2001-12-18 2002-12-02 Improved reagents and methods for producing parvoviruses

Country Status (2)

Country Link
AU (1) AU2002367943A1 (en)
WO (1) WO2003104392A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2772989C2 (en) * 2017-09-19 2022-05-30 Сивек Фармасьютикалз Гмбх INDUCIBLE Rep AAV GENES

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241622B2 (en) 2001-07-13 2012-08-14 University Of Iowa Research Foundation Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
BR122016004944B8 (en) 2001-11-13 2021-07-27 Univ Pennsylvania recombinant adeno-associated virus, prokaryotic host cell, composition and method of generating said virus
EP1453547B1 (en) * 2001-12-17 2016-09-21 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor
KR102390075B1 (en) 2014-03-09 2022-04-26 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
AU2017229347A1 (en) 2016-03-07 2018-11-01 University Of Iowa Research Foundation AAV-mediated expression using a synthetic promoter and enhancer
WO2017205739A1 (en) 2016-05-26 2017-11-30 University Of Iowa Research Foundation cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1
US11142775B2 (en) 2017-01-13 2021-10-12 University Of Iowa Research Foundation Bocaparvovirus small noncoding RNA and uses thereof
EP3456822A1 (en) * 2017-09-19 2019-03-20 CEVEC Pharmaceuticals GmbH Inducible aav rep genes
AU2019231711A1 (en) 2018-03-06 2020-09-24 University Of Florida Research Foundation, Incorporated AAV chimeras
CN108465107B (en) * 2018-06-05 2020-02-21 山东信得科技股份有限公司 Duck type 2 adenovirus and Muscovy duck parvovirus disease combined inactivated vaccine
JP7650800B2 (en) * 2018-12-21 2025-03-25 ロンザ ウォーカーズヴィル，インコーポレーテッド Adeno-associated virus (AAV) producing cell lines and related methods
US10557149B1 (en) * 2019-07-15 2020-02-11 Vigene Biosciences, Inc. Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
WO2023220035A1 (en) * 2022-05-09 2023-11-16 Synteny Therapeutics, Inc. Erythroparvovirus compositions and methods for gene therapy
EP4522210A1 (en) * 2022-05-09 2025-03-19 Synteny Therapeutics, Inc. Erythroparvovirus with a modified genome for gene therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CATHOMEN ET AL: "A chimeric protein containing the N-terminus of the adeno-associated virus rep protein recognizes its target site in an in vivo assay", J. OF VIROLOGY, vol. 74, no. 5, March 2000 (2000-03-01), pages 2372 - 2382, XP002978182 *
YOON ET AL: "Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro", J. OF VIROLOGY, vol. 75, no. 7, April 2001 (2001-04-01), pages 3230 - 3239, XP002978181 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2772989C2 (en) * 2017-09-19 2022-05-30 Сивек Фармасьютикалз Гмбх INDUCIBLE Rep AAV GENES

Also Published As

Publication number Publication date
WO2003104392A9 (en) 2004-04-29
AU2002367943A1 (en) 2003-12-22
AU2002367943A8 (en) 2003-12-22
WO2003104392A2 (en) 2003-12-18

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