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WO2003039487A3 - Cyclo(prolyl-glycine) and methods of use to treat neural disorders - Google Patents

Cyclo(prolyl-glycine) and methods of use to treat neural disorders Download PDF

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Publication number
WO2003039487A3
WO2003039487A3 PCT/US2002/036235 US0236235W WO03039487A3 WO 2003039487 A3 WO2003039487 A3 WO 2003039487A3 US 0236235 W US0236235 W US 0236235W WO 03039487 A3 WO03039487 A3 WO 03039487A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclo
methods
prolyl
glycine
neural disorders
Prior art date
Application number
PCT/US2002/036235
Other languages
French (fr)
Other versions
WO2003039487A2 (en
Inventor
Jian Guan
Peter David Gluckman
Frank Sieg
Original Assignee
Neuronz Ltd
Neuronz Biosciences Inc
Jian Guan
Peter David Gluckman
Frank Sieg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuronz Ltd, Neuronz Biosciences Inc, Jian Guan, Peter David Gluckman, Frank Sieg filed Critical Neuronz Ltd
Priority to AU2002340465A priority Critical patent/AU2002340465A1/en
Publication of WO2003039487A2 publication Critical patent/WO2003039487A2/en
Publication of WO2003039487A3 publication Critical patent/WO2003039487A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Embodiments of pharmaceutical compositions comprising cyclo(Pro-Gly) and methods for use in treating neural degeneration are provided. Cyclic PG substantially prevents toxic neural degeneration and cell death, and promotes neurite outgrowth in neurons, especially cerebellar neurons. The neuroprotective and neurorenenerative effects of cPG are useful to treat behavioural neurological deficits involving motor control pathways.
PCT/US2002/036235 2001-11-09 2002-11-12 Cyclo(prolyl-glycine) and methods of use to treat neural disorders WO2003039487A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002340465A AU2002340465A1 (en) 2001-11-09 2002-11-12 Cyclo(prolyl-glycine) and methods of use to treat neural disorders

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
NZ51537101 2001-11-09
NZ515371 2001-11-09
NZ515432 2001-11-13
NZ51543201 2001-11-13
NZ515551 2001-11-16
NZ51555101 2001-11-16

Publications (2)

Publication Number Publication Date
WO2003039487A2 WO2003039487A2 (en) 2003-05-15
WO2003039487A3 true WO2003039487A3 (en) 2004-01-15

Family

ID=27353943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036235 WO2003039487A2 (en) 2001-11-09 2002-11-12 Cyclo(prolyl-glycine) and methods of use to treat neural disorders

Country Status (2)

Country Link
AU (1) AU2002340465A1 (en)
WO (1) WO2003039487A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
PL1664050T3 (en) * 2003-09-03 2016-08-31 Neuren Pharmaceuticals Ltd Neuroprotective bicyclic compounds and pharmaceutical compositions containing them
US8791117B2 (en) * 2003-09-03 2014-07-29 Neuren Pharmaceuticals Limited Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals
WO2010104093A1 (en) * 2009-03-10 2010-09-16 参天製薬株式会社 Prophylactic or therapeutic agent for optic nerve disorders comprising 4,6-dichloro-1h-indole-2-carboxylic acid derivative or salt thereof as active ingredient
WO2011037644A1 (en) * 2009-09-25 2011-03-31 Neuren Pharmaceuticals Limited Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy
CN105879006A (en) * 2016-02-01 2016-08-24 四川好医生攀西药业有限责任公司 Pharmaceutical composition for treating diabetic foot ulcer as well as preparation method and application of pharmaceutical composition
CN105879005A (en) * 2016-02-01 2016-08-24 四川好医生攀西药业有限责任公司 Pharmaceutical composition for treating ulcerative colitis as well as preparation method and application of pharmaceutical composition
CN105902999A (en) * 2016-02-01 2016-08-31 四川好医生攀西药业有限责任公司 Pharmaceutical composition for treating peptic ulcer and its preparation method and use
MY204405A (en) * 2017-08-28 2024-08-27 The Cgp Lab Ltd Improvements in igf-1 analysis, adjustment and disease management of non-neurological and/or neurological conditions
CN112423774A (en) * 2018-05-15 2021-02-26 L·H·L·特兰 Therapeutic compositions and methods of use for treating mild cognitive impairment, depression and psychological disorders
JP6598412B1 (en) * 2019-06-04 2019-10-30 ゼライス株式会社 Food for improving cognitive function
BR112022021304A2 (en) 2020-04-20 2022-12-06 Hung Loi Tran Lloyd METHODS FOR PROPHYLAXIS AND TREATMENT OF COVID AND COVID-19.
JP2024545685A (en) * 2021-12-17 2024-12-10 ザ シージーピー ラボ リミテッド Animal, fungal and marine sources of CGP and increased CGP concentrations for disease management and for the treatment of non-neurological and/or neurological conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013650A2 (en) * 1998-09-03 2000-03-16 Neuronz Limited Neuroprotection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013650A2 (en) * 1998-09-03 2000-03-16 Neuronz Limited Neuroprotection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] OSTROVSKAYA ET AL.: "GVS-111, novel dipeptide cognition enhancer", XP002970721, accession no. STN Database accession no. 1998:597878 *
GUDASHEVA ET AL.: "Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain", FEBS LETTERS, vol. 391, 1996, pages 149 - 152, XP002970720 *
PROCEEDINGS OF THE EUROPEAN PEPTIDE SYMPOSIUM, 24TH, 1996, EDINBURGH *

Also Published As

Publication number Publication date
AU2002340465A1 (en) 2003-05-19
WO2003039487A2 (en) 2003-05-15

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