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WO2003038395A8 - Remote nmr/mri detection of laser polarized gases - Google Patents

Remote nmr/mri detection of laser polarized gases

Info

Publication number
WO2003038395A8
WO2003038395A8 PCT/US2002/032471 US0232471W WO03038395A8 WO 2003038395 A8 WO2003038395 A8 WO 2003038395A8 US 0232471 W US0232471 W US 0232471W WO 03038395 A8 WO03038395 A8 WO 03038395A8
Authority
WO
WIPO (PCT)
Prior art keywords
encoding
detector
signal
nmr
detection steps
Prior art date
Application number
PCT/US2002/032471
Other languages
French (fr)
Other versions
WO2003038395A2 (en
WO2003038395A3 (en
Inventor
Alexander Pines
Sunil Saxena
Megan Spence
Adam Moule
Juliette A Seeley
Kimberly L Pierce
Song-I Han
Joseph Granwehr
Original Assignee
Univ California
Alexander Pines
Sunil Saxena
Megan Spence
Adam Moule
Juliette A Seeley
Kimberly L Pierce
Song-I Han
Joseph Granwehr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Alexander Pines, Sunil Saxena, Megan Spence, Adam Moule, Juliette A Seeley, Kimberly L Pierce, Song-I Han, Joseph Granwehr filed Critical Univ California
Priority to EP02782147A priority Critical patent/EP1590647A2/en
Priority to JP2003540616A priority patent/JP2005515406A/en
Priority to AU2002348428A priority patent/AU2002348428A1/en
Publication of WO2003038395A2 publication Critical patent/WO2003038395A2/en
Publication of WO2003038395A8 publication Critical patent/WO2003038395A8/en
Publication of WO2003038395A3 publication Critical patent/WO2003038395A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Superconductor Devices And Manufacturing Methods Thereof (AREA)
  • Testing Or Calibration Of Command Recording Devices (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

An apparatus and method for remote NMR/MRI spectroscopy having an encoding Gail with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps, This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb-Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.
PCT/US2002/032471 2001-10-31 2002-10-09 Remote nmr/mri detection of laser polarized gases WO2003038395A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02782147A EP1590647A2 (en) 2001-10-31 2002-10-09 Remote nmr/mri detection of laser polarized gases
JP2003540616A JP2005515406A (en) 2001-10-31 2002-10-09 Remote NMR / MRI detection of laser polarized gas
AU2002348428A AU2002348428A1 (en) 2001-10-31 2002-10-09 Remote nmr/mri detection of laser polarized gases

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US33524001P 2001-10-31 2001-10-31
US33517301P 2001-10-31 2001-10-31
US60/335,173 2001-10-31
US60/335,240 2001-10-31
US39904102P 2002-07-25 2002-07-25
US60/399,041 2002-07-25
US40941002P 2002-09-09 2002-09-09
US60/409,410 2002-09-09

Publications (3)

Publication Number Publication Date
WO2003038395A2 WO2003038395A2 (en) 2003-05-08
WO2003038395A8 true WO2003038395A8 (en) 2004-04-29
WO2003038395A3 WO2003038395A3 (en) 2008-10-16

Family

ID=27502513

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2002/032471 WO2003038395A2 (en) 2001-10-31 2002-10-09 Remote nmr/mri detection of laser polarized gases
PCT/US2002/032481 WO2003038396A2 (en) 2001-10-31 2002-10-09 Method for detecting macromolecular conformational change and binding information

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032481 WO2003038396A2 (en) 2001-10-31 2002-10-09 Method for detecting macromolecular conformational change and binding information

Country Status (4)

Country Link
EP (1) EP1590647A2 (en)
JP (1) JP2005515406A (en)
AU (2) AU2002348428A1 (en)
WO (2) WO2003038395A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1555538A1 (en) * 2004-01-15 2005-07-20 Bruker BioSpin MRI GmbH Method of fast multidimensional NMR spectroscopy
FR2881226B1 (en) * 2005-01-27 2007-04-27 Commissariat Energie Atomique INCREASING THE POLARIZATION OF NUCLEAR SPINS OF A MOLECULE VIA HARTMANN-HAHN-TYPE POLARIZATION TRANSFER USING THE SOURCE-CREATED MEDIUM DIPOLAR FIELD
JP4696262B2 (en) * 2005-05-18 2011-06-08 独立行政法人産業技術総合研究所 Hyperpolarized rare gas production apparatus, nuclear magnetic resonance spectrometer using hyperpolarized rare gas, and magnetic resonance imaging apparatus
US7359059B2 (en) * 2006-05-18 2008-04-15 Honeywell International Inc. Chip scale atomic gyroscope
JP5424578B2 (en) * 2007-06-05 2014-02-26 キヤノン株式会社 Magnetic sensing method, atomic magnetic sensor, and magnetic resonance imaging apparatus
CN114207127B (en) * 2019-08-09 2024-11-29 国立研究开发法人产业技术综合研究所 Artificial gene and gene mutation method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426058B1 (en) * 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
US6591128B1 (en) * 2000-11-09 2003-07-08 Koninklijke Philips Electronics, N.V. MRI RF coil systems having detachable, relocatable, and or interchangeable sections and MRI imaging systems and methods employing the same

Also Published As

Publication number Publication date
AU2002356556A8 (en) 2009-07-30
JP2005515406A (en) 2005-05-26
AU2002348428A8 (en) 2008-11-13
WO2003038396A2 (en) 2003-05-08
AU2002356556A1 (en) 2003-05-12
WO2003038395A2 (en) 2003-05-08
WO2003038396A3 (en) 2009-06-11
AU2002348428A1 (en) 2003-05-12
EP1590647A2 (en) 2005-11-02
WO2003038395A3 (en) 2008-10-16

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