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WO2003035907A3 - Methode et moyens d'identification precoce de risques de decompensation cardiaque - Google Patents

Methode et moyens d'identification precoce de risques de decompensation cardiaque Download PDF

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Publication number
WO2003035907A3
WO2003035907A3 PCT/IB2002/004351 IB0204351W WO03035907A3 WO 2003035907 A3 WO2003035907 A3 WO 2003035907A3 IB 0204351 W IB0204351 W IB 0204351W WO 03035907 A3 WO03035907 A3 WO 03035907A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
myocardial
risks
early identification
cardiac decompensation
Prior art date
Application number
PCT/IB2002/004351
Other languages
English (en)
Other versions
WO2003035907A2 (fr
Inventor
Carlo Ventura
Federico Giudiceandrea
Giandomenico Testi
Original Assignee
Carlo Ventura
Federico Giudiceandrea
Giandomenico Testi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Ventura, Federico Giudiceandrea, Giandomenico Testi filed Critical Carlo Ventura
Publication of WO2003035907A2 publication Critical patent/WO2003035907A2/fr
Publication of WO2003035907A3 publication Critical patent/WO2003035907A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Examining Or Testing Airtightness (AREA)

Abstract

L'invention se rapporte à une méthode de diagnostic permettant d'identifier le risque de commencement de décompensations cardiaques. Ladite méthode consiste à analyser le profil de l'expression génétique dans un échantillon biologique de façon à identifier les gènes qui sont normalement actifs dans la différentiation myocardique des cellules souches appartenant à au moins une des classes de : (A) gènes intervenant dans le développement et dans la croissance myocardique, (B) gènes déclencheurs de la mort cellulaire apoptique, et (C) gènes intervenant dans des mécanismes de survie cellulaire myocardique.
PCT/IB2002/004351 2001-10-22 2002-10-21 Methode et moyens d'identification precoce de risques de decompensation cardiaque WO2003035907A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI002205A ITMI20012205A1 (it) 2001-10-22 2001-10-22 Metodo e mezzi per l'identificazione precoce di rischi di scompenso cardiaco
ITMI2001A002205 2001-10-22

Publications (2)

Publication Number Publication Date
WO2003035907A2 WO2003035907A2 (fr) 2003-05-01
WO2003035907A3 true WO2003035907A3 (fr) 2004-02-12

Family

ID=11448536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004351 WO2003035907A2 (fr) 2001-10-22 2002-10-21 Methode et moyens d'identification precoce de risques de decompensation cardiaque

Country Status (2)

Country Link
IT (1) ITMI20012205A1 (fr)
WO (1) WO2003035907A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2431288T3 (es) * 2004-05-13 2013-11-25 B.R.A.H.M.S Gmbh Uso de precursores de encefalinas y/o sus fragmentos en diagnosis médica

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (fr) * 1997-11-10 1999-05-20 Curagen Corporation Genes a expression differentielle en cas d'hypertrophie cardiaque et leur utilisation a des fins de diagnostic et de traitement
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
WO2000028020A2 (fr) * 1998-11-10 2000-05-18 Board Of Regents, The University Of Texas System Methodes permettant d'empecher l'hypertrophie cardiaque et les defaillances cardiaques par inhibition du facteur de transcription du mef2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (fr) * 1997-11-10 1999-05-20 Curagen Corporation Genes a expression differentielle en cas d'hypertrophie cardiaque et leur utilisation a des fins de diagnostic et de traitement
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
WO2000028020A2 (fr) * 1998-11-10 2000-05-18 Board Of Regents, The University Of Texas System Methodes permettant d'empecher l'hypertrophie cardiaque et les defaillances cardiaques par inhibition du facteur de transcription du mef2

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D'ANGELO D D ET AL: "Transgenic Galphaq overexpression induces cardiac contractile failure in mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 22 JUL 1997, vol. 94, no. 15, 22 July 1997 (1997-07-22), pages 8121 - 8126, XP002251029, ISSN: 0027-8424 *
FELDMAN A M ET AL: "Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding", CIRCULATION RESEARCH, vol. 73, no. 1, July 1993 (1993-07-01), pages 184 - 192, XP008020654 *
PARKER T G: "Molecular biology of myocardial hypertrophy and failure: gene expression and trophic signalling", NEW HORIZONS, vol. 3, no. 2, 1995, pages 288 - 300, XP008020581 *

Also Published As

Publication number Publication date
ITMI20012205A1 (it) 2003-04-22
WO2003035907A2 (fr) 2003-05-01

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