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WO2003035832A3 - Ctsls en tant que modificateurs des voies de passage de p53 et de apaf-1 et leurs procedes d'utilisation - Google Patents

Ctsls en tant que modificateurs des voies de passage de p53 et de apaf-1 et leurs procedes d'utilisation Download PDF

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Publication number
WO2003035832A3
WO2003035832A3 PCT/US2002/033541 US0233541W WO03035832A3 WO 2003035832 A3 WO2003035832 A3 WO 2003035832A3 US 0233541 W US0233541 W US 0233541W WO 03035832 A3 WO03035832 A3 WO 03035832A3
Authority
WO
WIPO (PCT)
Prior art keywords
apaf
methods
ctsls
modifiers
pathways
Prior art date
Application number
PCT/US2002/033541
Other languages
English (en)
Other versions
WO2003035832A2 (fr
Inventor
Michael A Costa
Tak Hung
Lori Friedman
Gregory D Plowman
Original Assignee
Exelixis Inc
Michael A Costa
Tak Hung
Lori Friedman
Gregory D Plowman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Michael A Costa, Tak Hung, Lori Friedman, Gregory D Plowman filed Critical Exelixis Inc
Priority to AU2002337915A priority Critical patent/AU2002337915A1/en
Publication of WO2003035832A2 publication Critical patent/WO2003035832A2/fr
Publication of WO2003035832A3 publication Critical patent/WO2003035832A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des gènes CTSL identiques en tant que modulateurs de la voie de passage de p53 ou de Apaf-1 et qui sont, par conséquent, des cibles thérapeutiques pour des troubles liés à une fonction déficiente de p53 ou de Apaf-1. L'invention concerne également des procédés d'identification de modulateurs de p53 ou de Apaf-1 consistant à rechercher des agents modulateurs de l'activité de CTSL.
PCT/US2002/033541 2001-10-22 2002-10-21 Ctsls en tant que modificateurs des voies de passage de p53 et de apaf-1 et leurs procedes d'utilisation WO2003035832A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002337915A AU2002337915A1 (en) 2001-10-22 2002-10-21 Ctsls as modifiers of the p53 and apaf-1 pathways and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33874901P 2001-10-22 2001-10-22
US60/338,749 2001-10-22

Publications (2)

Publication Number Publication Date
WO2003035832A2 WO2003035832A2 (fr) 2003-05-01
WO2003035832A3 true WO2003035832A3 (fr) 2003-12-04

Family

ID=23326012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033541 WO2003035832A2 (fr) 2001-10-22 2002-10-21 Ctsls en tant que modificateurs des voies de passage de p53 et de apaf-1 et leurs procedes d'utilisation

Country Status (2)

Country Link
AU (1) AU2002337915A1 (fr)
WO (1) WO2003035832A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2240768A1 (fr) * 2008-02-04 2010-10-20 Galapagos N.V. Cibles et composés moléculaires, et procédés pour les identifier, destinés au traitement de maladies neurodégénératives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039348A1 (fr) * 1998-12-24 2000-07-06 Small Molecule Therapeutics, Inc. Methodes et compositions pour identifier des modulateurs de protease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039348A1 (fr) * 1998-12-24 2000-07-06 Small Molecule Therapeutics, Inc. Methodes et compositions pour identifier des modulateurs de protease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEVEC T. ET AL.: "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin", L.J. EXP. MED., vol. 183, 1996, pages 1331 - 1338, XP002963960 *
VILLADANGOS J.A. ET AL.: "Proteolysis in MHC classII antigen presentation: who's in charge?", IMMUNITY, vol. 12, March 2000 (2000-03-01), pages 233 - 239, XP002963961 *

Also Published As

Publication number Publication date
WO2003035832A2 (fr) 2003-05-01
AU2002337915A1 (en) 2003-05-06

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